Coptisine (BioDeep_00000000770)

 

Secondary id: BioDeep_00000398481

PANOMIX_OTCML-2023


代谢物信息卡片


5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene

化学式: C19H14NO4+ (320.0923)
中文名称: 黄连碱
谱图信息: 最多检出来源 Viridiplantae(plant) 89.52%

分子结构信息

SMILES: c1c2c(cc3c1OCO3)-c1cc3ccc4c(c3c[n+]1CC2)OCO4
InChI: InChI=1S/C19H14NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,5-8H,3-4,9-10H2/q+1

描述信息

Coptisine is an alkaloid. It has a role as a metabolite.
Coptisine is a natural product found in Fumaria capreolata, Fumaria muralis, and other organisms with data available.
See also: Sanguinaria canadensis root (part of); Chelidonium majus flowering top (part of).
A natural product found in Coptis japonica.

同义名列表

25 个代谢物同义名

5,7,17,19-tetraoxa-13-azoniahexacyclo[11.11.0.02,10.04,8.015,23.016,20]tetracosa-1(13),2,4(8),9,14,16(20),21,23-octaene; 6,7-Dihydro-[1,3]dioxolo[4,5:7,8]isoquinolino[3,2-a][1,3]dioxolo[4,5-g]isoquinolin-5-ium; 6,7-Dihydro[1,3]dioxolo[4,5-G][1,3]dioxolo[7,8]isoquino[3,2-A]isoquinolin-5-Ium; 6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizinium chloride; Berbinium, 7,8,13,13a-tetradehydro-2,3:9,10-bis(methylenedioxy)-; 7,8,13,13a-tetradehydro-2,3-9,10-bis(methylenedioxy)berbinium; Bis[1,3]benzodioxolo[5,6-a:4,5-g]quinolizinium, 6,7-dihydro-; Bis(1,3)benzodioxolo(5,6-a:4,5-g)quinolizinium, 6,7-dihydro-; 7,8,13,13a-tetradehydro-2,3:9,10-bismethylenedioxyberbinium; 6,7-DIHYDROBIS(1,3)BENZODIOXOLO(5,6-A:4,5-G)QUINOLIZINIUM; ALKALOID A, FROM COPTIS GROENLANDICA; bis[methylenedioxy]protoberberine; BIS(METHYLENEDIOXY)PROTOBERBERINE; XYHOBCMEDLZUMP-UHFFFAOYSA-N; Coptisine chloride; Coptisine sulfate; UNII-0GCL71VN14; COPTISINE [MI]; MEGxp0_001731; NCI60_000465; 0GCL71VN14; Coptisine; Coptisin; YHL II; KPT



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

79 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, BCL2, CASP3, IL18, MAPK14, MAPK8, NLRP3, NOS2, PIK3CA, PIK3R6, PTGS2, RELA, TLR4
Peripheral membrane protein 2 PIK3R6, PTGS2
Endosome membrane 2 LDLR, TLR4
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 9 AKT1, BCL2, CASP3, HMOX1, MAPK14, MAPK8, NLRP3, NOS2, RELA
cytosol 12 AKT1, BCL2, CASP3, HMOX1, IL18, MAPK14, MAPK8, NLRP3, NOS2, PIK3CA, PIK3R6, RELA
nucleoplasm 7 AKT1, CASP3, HMOX1, MAPK14, MAPK8, NOS2, RELA
Cell membrane 5 AKT1, LDLR, PIK3R6, TLR4, TNF
Cytoplasmic side 1 HMOX1
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 NLRP3
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 3 LDLR, TLR4, TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RELA
Golgi apparatus 1 LDLR
Golgi membrane 2 INS, NLRP3
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 3 IL18, NLRP3, NOS2
Lysosome 1 LDLR
plasma membrane 7 AKT1, LDLR, NOS2, PIK3CA, PIK3R6, TLR4, TNF
Membrane 7 AKT1, BCL2, HMOX1, LDLR, NLRP3, PIK3R6, TLR4
axon 1 MAPK8
basolateral plasma membrane 1 LDLR
caveola 1 PTGS2
endoplasmic reticulum 4 BCL2, HMOX1, NLRP3, PTGS2
extracellular space 7 HMOX1, IL10, IL17A, IL18, IL6, INS, TNF
perinuclear region of cytoplasm 4 HMOX1, NOS2, PIK3CA, TLR4
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, MAPK14, NLRP3
protein-containing complex 3 AKT1, BCL2, PTGS2
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 2 LDLR, TLR4
Secreted 6 IL10, IL17A, IL18, IL6, INS, NLRP3
extracellular region 8 IL10, IL17A, IL18, IL6, INS, MAPK14, NLRP3, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LDLR
mitochondrial outer membrane 2 BCL2, HMOX1
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 IL17A, LDLR, TLR4, TNF
low-density lipoprotein particle 1 LDLR
microtubule cytoskeleton 1 AKT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 2 LDLR, TLR4
Membrane, clathrin-coated pit 1 LDLR
apical part of cell 1 LDLR
cell-cell junction 1 AKT1
clathrin-coated pit 1 LDLR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
spindle 1 AKT1
Peroxisome 1 NOS2
peroxisomal matrix 1 NOS2
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
Late endosome 1 LDLR
ruffle 1 TLR4
receptor complex 2 LDLR, TLR4
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 1 RELA
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
Endomembrane system 2 LDLR, NLRP3
endosome lumen 1 INS
sorting endosome 1 LDLR
microtubule organizing center 1 NLRP3
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 LDLR
endolysosome membrane 1 LDLR
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
somatodendritic compartment 1 LDLR
PCSK9-LDLR complex 1 LDLR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Fangqiu Xu, Chuyu Shen, Shuoyang Zhang, Yingli Liu, Di Liu, Yu Kuang, Ruiru Li, Cuicui Wang, Xiaoyan Cai, Maohua Shi, Youjun Xiao. Coptisine inhibits aggressive and proliferative actions of fibroblast like synoviocytes and exerts a therapeutic potential for rheumatoid arthritis. International immunopharmacology. 2024 Jan; 128(?):111433. doi: 10.1016/j.intimp.2023.111433. [PMID: 38181676]
  • Chih-Hsin Lin, Yih-Ru Wu, Chih-Ying Chao, Kuo-Hsuan Chang, Chiung-Mei Chen, Wan-Ling Chen, Pei-Ning Yang, Guey-Jen Lee-Chen. Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells. Biological & pharmaceutical bulletin. 2024; 47(4):827-839. doi: 10.1248/bpb.b23-00758. [PMID: 38599826]
  • Qiang Lu, Ying Tang, Shuang Luo, Qihai Gong, Cailan Li. Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases. The American journal of Chinese medicine. 2023 Nov; ?(?):1-36. doi: 10.1142/s0192415x2350091x. [PMID: 37930333]
  • Junjie Zhang, Ao Qi, Lulu Liu, Chun Cai, Hui Xu. Gas Chromatography-Mass Spectrometry-Based Cerebrospinal Fluid Metabolomics to Reveal the Protection of Coptisine against Transient Focal Cerebral Ischemia-Reperfusion Injury via Anti-Inflammation and Antioxidant. Molecules (Basel, Switzerland). 2023 Aug; 28(17):. doi: 10.3390/molecules28176350. [PMID: 37687175]
  • Kuangyang Yang, Qian Xie, Jiaxin Liao, Na Zhao, Jianhui Liang, Ben Liu, Jianhai Chen, Wenxiang Cheng, Xueling Bai, Peng Zhang, Qian Liu, Bing Song, Junyi Danny Wang, Fanghao Zheng, Chun Hu, Lichu Liu, Lei Chen, Yan Wang. Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. Journal of ethnopharmacology. 2023 Jul; 311(?):116476. doi: 10.1016/j.jep.2023.116476. [PMID: 37031825]
  • Ming-Feng He, Jian-Hui Liang, Yan-Ni Shen, Chao-Wei Zhang, Kuang-Yang Yang, Li-Chu Liu, Qian Xie, Chun Hu, Xun Song, Yan Wang. Coptisine Inhibits Influenza Virus Replication by Upregulating p21. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145398. [PMID: 37513270]
  • Yingxin Chen, Xiaotong Huang, Lu Li, Junxian Wu, Yongqi Guo, Yachao Yao, Lihua Zhou. Paper mill sludge-based carbon quantum dots as a specifically ratiometric fluorescent probe for the sensitive and selective detection of coptisine. Luminescence : the journal of biological and chemical luminescence. 2022 Jul; 37(7):1078-1086. doi: 10.1002/bio.4260. [PMID: 35441456]
  • Yue He, Xiaoyin Zhang, Ming Li, Nan Zheng, Shengguo Zhao, Jiaqi Wang. Coptisine: A natural plant inhibitor of ruminal bacterial urease screened by molecular docking. The Science of the total environment. 2022 Feb; 808(?):151946. doi: 10.1016/j.scitotenv.2021.151946. [PMID: 34843773]
  • Lan Xie, Shanshan Feng, Xiaoling Zhang, Wenlong Zhao, Juan Feng, Chengmei Ma, Ruijun Wang, Weifang Song, Jing Cheng. Biological Response Profiling Reveals the Functional Differences of Main Alkaloids in Rhizoma Coptidis. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237389. [PMID: 34885971]
  • Xueshan Wen, Xing Zhang, Shulan Qu, Xugang Chen, Cheng Liu, Yifu Yang. Coptisine induces G2/M arrest in esophageal cancer cell via the inhibition of p38/ERK1/2/claudin-2 signaling pathway. Die Pharmazie. 2021 05; 76(5):202-207. doi: 10.1691/ph.2021.1353. [PMID: 33964993]
  • Yongfu Wang, Jingjing Liu, Ziwei Huang, Yucui Li, Yuanyuan Liang, Chaodan Luo, Chen Ni, Jianhui Xie, Ziren Su, Jiannan Chen, Cailan Li. Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response. European journal of pharmacology. 2021 Apr; 896(?):173912. doi: 10.1016/j.ejphar.2021.173912. [PMID: 33508280]
  • Wei Ren, Fuchun Nan, Shumu Li, Sijin Yang, Jiechao Ge, Zhenwen Zhao. Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro. ChemMedChem. 2021 02; 16(4):646-653. doi: 10.1002/cmdc.202000420. [PMID: 32959534]
  • Shengmei Sun, Pengfei Wang. Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins. Tissue & cell. 2020 Oct; 66(?):101392. doi: 10.1016/j.tice.2020.101392. [PMID: 32933715]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • Nana Wen, Lu Xue, Yongle Yang, Shunbo Shi, Qing-Hua Liu, Congli Cai, Jinhua Shen. Coptisine, a protoberberine alkaloid, relaxes mouse airway smooth muscle via blockade of VDLCCs and NSCCs. Bioscience reports. 2020 02; 40(2):. doi: 10.1042/bsr20190534. [PMID: 32095824]
  • Jiajia Zhai, Zeping Li, Huifeng Zhang, Louyan Ma, Zhengquan Ma, Yi Zhang, Jian Zou, Mo Li, Li Ma, Xiaomiao Li. Coptisine ameliorates renal injury in diabetic rats through the activation of Nrf2 signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2020 01; 393(1):57-65. doi: 10.1007/s00210-019-01710-6. [PMID: 31420722]
  • Xiang-Peng Kong, Etta Y L Liu, Zhi-Cong Chen, Miranda Li Xu, Anna X D Yu, Qi-Yun Wu, Ying-Jie Xia, Ran Duan, Tina T X Dong, Karl W K Tsim. Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244567. [PMID: 31847089]
  • Jiasi Wu, Yu Luo, Donghang Deng, Siyu Su, Sheng Li, Li Xiang, Yingfan Hu, Ping Wang, Xianli Meng. Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review. Journal of cellular and molecular medicine. 2019 12; 23(12):7946-7960. doi: 10.1111/jcmm.14725. [PMID: 31622015]
  • Li-Li Shi, Wei-Hua Jia, Li Zhang, Chun-Yang Xu, Xi Chen, Lin Yin, Nuo-Qi Wang, Lian-Hua Fang, Gui-Fen Qiang, Xiu-Ying Yang, Guan-Hua Du. Glucose consumption assay discovers coptisine with beneficial effect on diabetic mice. European journal of pharmacology. 2019 Sep; 859(?):172523. doi: 10.1016/j.ejphar.2019.172523. [PMID: 31279667]
  • Lan Gao, Hans-Joachim Schmitz, Karl-Heinz Merz, Dieter Schrenk. Characterization of the cytotoxicity of selected Chelidonium alkaloids in rat hepatocytes. Toxicology letters. 2019 Sep; 311(?):91-97. doi: 10.1016/j.toxlet.2019.04.031. [PMID: 31054355]
  • Thomas Kopp, Mona Abdel-Tawab, Martin Khoeiklang, Boris Mizaikoff. Development of a Selective Adsorbing Material for Binding of Pyrrolizidine Alkaloids in Herbal Extracts, Based on Molecular Group Imprinting. Planta medica. 2019 Sep; 85(13):1107-1113. doi: 10.1055/a-0961-2658. [PMID: 31382302]
  • Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang, Xianli Meng. Coptisine from Coptis chinensis blocks NLRP3 inflammasome activation by inhibiting caspase-1. Pharmacological research. 2019 09; 147(?):104348. doi: 10.1016/j.phrs.2019.104348. [PMID: 31336157]
  • Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine. Pesticide biochemistry and physiology. 2019 Sep; 159(?):51-58. doi: 10.1016/j.pestbp.2019.05.015. [PMID: 31400784]
  • Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di. Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC-MS/MS. Molecules (Basel, Switzerland). 2019 Jun; 24(13):. doi: 10.3390/molecules24132410. [PMID: 31261913]
  • Yingfan Hu, Li Wang, Li Xiang, Jiasi Wu, Wen'ge Huang, Chensi Xu, Xianli Meng, Ping Wang. Pharmacokinetic-Pharmacodynamic Modeling for Coptisine Challenge of Inflammation in LPS-Stimulated Rats. Scientific reports. 2019 02; 9(1):1450. doi: 10.1038/s41598-018-38164-4. [PMID: 30723253]
  • Bing Han, Pu Jiang, Heshan Xu, Wuyang Liu, Jian Zhang, Siqi Wu, Liangyu Liu, Wenyu Ma, Xuegang Li, Xiaoli Ye. 8-Cetylcoptisine, a new coptisine derivative, induces mitochondria-dependent apoptosis and G0/G1 cell cycle arrest in human A549 cells. Chemico-biological interactions. 2019 Feb; 299(?):27-36. doi: 10.1016/j.cbi.2018.11.005. [PMID: 30472432]
  • Cailan Li, Ping Huang, Kambo Wong, Yifei Xu, Lihua Tan, Hanbin Chen, Qiang Lu, Chaodan Luo, Chunlai Tam, Lixiang Zhu, Ziren Su, Jianhui Xie. Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process. Journal of enzyme inhibition and medicinal chemistry. 2018 Dec; 33(1):1362-1375. doi: 10.1080/14756366.2018.1501044. [PMID: 30191728]
  • Shuilian Fu, Saihong Ni, Danni Wang, Tie Hong. Coptisine Suppresses Mast Cell Degranulation and Ovalbumin-Induced Allergic Rhinitis. Molecules (Basel, Switzerland). 2018 Nov; 23(11):. doi: 10.3390/molecules23113039. [PMID: 30469322]
  • Bing Han, Pu Jiang, Zhaoxing Li, Yang Yu, Tao Huang, Xiaoli Ye, Xuegang Li. Coptisine-induced apoptosis in human colon cancer cells (HCT-116) is mediated by PI3K/Akt and mitochondrial-associated apoptotic pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Sep; 48(?):152-160. doi: 10.1016/j.phymed.2017.12.027. [PMID: 30195873]
  • Xinyu Zhao, Yan Wang, Lu Zheng, Chengpeng Sun, Chao Wang, Haijian Cong, Ting Xiang, Lin Zhang, Houli Zhang, Sa Deng, Baojing Zhang, Bin Wu, Xiaokui Huo. Comparative pharmacokinetics study of five alkaloids in rat plasma and related compound-herb interactions mechanism after oral administration of Shuanghua Baihe tablets. Natural product research. 2018 Sep; 32(17):2031-2036. doi: 10.1080/14786419.2017.1365075. [PMID: 28871816]
  • Fang-Ni Chai, Wen-Yu Ma, Jian Zhang, He-Shan Xu, Yuan-Feng Li, Qi-De Zhou, Xue-Gang Li, Xiao-Li Ye. Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul; 103(?):1002-1011. doi: 10.1016/j.biopha.2018.04.052. [PMID: 29710498]
  • Li Lang, Qian Hu, Jingyuan Wang, Zehui Liu, Jin Huang, Weiqiang Lu, Ying Huang. Coptisine, a natural alkaloid from Coptidis Rhizoma, inhibits plasmodium falciparum dihydroorotate dehydrogenase. Chemical biology & drug design. 2018 07; 92(1):1324-1332. doi: 10.1111/cbdd.13197. [PMID: 29582555]
  • Tian-Jin Wu, Jun Lu, Hui Ni, Ping Li, Yan Jiang, Hui-Jun Li. Construction of an optimized method for quality evaluation and species discrimination of Coptidis Rhizoma by ion-pair high performance liquid chromatography combined with response surface methodology. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):152-157. doi: 10.1016/j.jpba.2018.02.019. [PMID: 29494887]
  • Xiaoling Gu, Yang Jin, Fang Dong, Yueqing Cai, Zhengyi You, Junhui You, Liying Zhang, Shuhu Du. Toward rapid analysis, forecast and discovery of bioactive compounds from herbs by jointly using thin layer chromatography and ratiometric surface-enhanced Raman spectroscopy technique. Journal of pharmaceutical and biomedical analysis. 2018 May; 153(?):9-15. doi: 10.1016/j.jpba.2018.02.016. [PMID: 29459236]
  • Chaodan Luo, Hanbin Chen, Yongfu Wang, Guosheng Lin, Cailan Li, Lihua Tan, Ziren Su, Xiaoping Lai, Jianhui Xie, Huifang Zeng. Protective effect of coptisine free base on indomethacin-induced gastric ulcers in rats: Characterization of potential molecular mechanisms. Life sciences. 2018 Jan; 193(?):47-56. doi: 10.1016/j.lfs.2017.12.004. [PMID: 29223540]
  • Han-Bin Chen, Chao-Dan Luo, Jia-Li Liang, Zhen-Biao Zhang, Guo-Sheng Lin, Jia-Zhen Wu, Cai-Lan Li, Li-Hua Tan, Xiao-Bo Yang, Zi-Ren Su, Jian-Hui Xie, Hui-Fang Zeng. Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways. European journal of pharmacology. 2017 Sep; 811(?):222-231. doi: 10.1016/j.ejphar.2017.06.027. [PMID: 28648405]
  • Min Feng, Shu-Zhen Kong, Zhen-Xu Wang, Kai He, Zong-Yao Zou, Yin-Ran Hu, Hang Ma, Xue-Gang Li, Xiao-Li Ye. The protective effect of coptisine on experimental atherosclerosis ApoE-/- mice is mediated by MAPK/NF-κB-dependent pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Sep; 93(?):721-729. doi: 10.1016/j.biopha.2017.07.002. [PMID: 28700976]
  • Yahui Wang, Qiangli Wang, Lu Zhang, Zunli Ke, Yuanyuan Zhao, Dongshan Wang, Hui Chen, Xi Jiang, Ming Gu, Shengjie Fan, Cheng Huang. Coptisine protects cardiomyocyte against hypoxia/reoxygenation-induced damage via inhibition of autophagy. Biochemical and biophysical research communications. 2017 08; 490(2):231-238. doi: 10.1016/j.bbrc.2017.06.027. [PMID: 28606475]
  • Yu Yan, Huifang Zhang, Zhihui Zhang, Junke Song, Yucai Chen, Xiaobo Wang, Yangyang He, Hailin Qin, Lianhua Fang, Guanhua Du. Pharmacokinetics and tissue distribution of coptisine in rats after oral administration by liquid chromatography-mass spectrometry. Biomedical chromatography : BMC. 2017 Jul; 31(7):. doi: 10.1002/bmc.3918. [PMID: 27957743]
  • Jie Liang, Fuxue Chen, Fu Gu, Xin Liu, Feng Li, Dongshu Du. Expression and functional activity of bitter taste receptors in primary renal tubular epithelial cells and M-1 cells. Molecular and cellular biochemistry. 2017 Apr; 428(1-2):193-202. doi: 10.1007/s11010-016-2929-1. [PMID: 28236092]
  • Tao Huang, Yubo Xiao, Lin Yi, Ling Li, Meimei Wang, Cheng Tian, Hang Ma, Kai He, Yue Wang, Bing Han, Xiaoli Ye, Xuegang Li. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Scientific reports. 2017 02; 7(?):38524. doi: 10.1038/srep38524. [PMID: 28165459]
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