Selagine (BioDeep_00000007668)
Main id: BioDeep_00000275578
Secondary id: BioDeep_00000405858
PANOMIX_OTCML-2023
代谢物信息卡片
(13Z)-1-amino-13-ethylidene-11-methyl-6-azatricyclo[7.3.1.02,7]trideca-2(7),3,11-trien-5-one
化学式: C15H18N2O (242.1419)
中文名称: (±)-石杉碱甲, 石杉碱甲, 石杉碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 37.5%
分子结构信息
SMILES: CC=C1C2CC(=CC1(C3=C(C2)NC(=O)C=C3)N)C
InChI: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/t10-,15+/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D020011 - Protective Agents
D004791 - Enzyme Inhibitors
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease[1][2][3][4][5].
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value: Target: AChE (±)-Huperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The (±)-Huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. (±)-Huperzine A is a potential therapeutic agent for Alzheimer's disease.
同义名列表
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:9085
- KEGG: C90354
- KEGG: C09897
- PubChem: 449069
- PubChem: 3527751
- PubChem: 445884
- Metlin: METLIN67994
- ChEMBL: CHEMBL4515144
- CAS: 102518-79-6
- CAS: 120786-18-7
- CAS: 92138-20-0
- CAS: 116-28-9
- PMhub: MS000021118
- PubChem: 12083
- KNApSAcK: C00001956
- 3DMET: B03360
- NIKKAJI: J128.649H
- medchemexpress: HY-17387
- medchemexpress: HY-17388
- KNApSAcK: 9085
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
16 个相关的物种来源信息
- 381200 - Huperzia chinensis: 10.1016/S0305-1978(98)00022-2
- 380486 - Huperzia crispata: 10.1016/S0305-1978(98)00022-2
- 2902584 - Huperzia herteriana: 10.1016/S0305-1978(98)00022-2
- 2902587 - Huperzia liangshanica: 10.1016/S0305-1978(98)00022-2
- 380488 - Huperzia miyoshiana: 10.1016/S0305-1978(98)00022-2
- 1715637 - Huperzia quasipolytrichoides: 10.1016/S0305-1978(98)00022-2
- 70001 - Huperzia selago:
- 70001 - Huperzia selago [Syn. Lycopodium selago ]: -
- 355589 - Huperzia serrata:
- 73626 - Lycopodiastrum casuarinoides: 10.1016/S0305-1978(98)00022-2
- 37431 - Lycopodiella inundata: 10.1016/S0305-1978(98)00022-2
- 380491 - Phlegmariurus carinatus: 10.1016/S0305-1978(98)00022-2
- 89711 - Phlegmariurus fordii: 10.1016/S0305-1978(98)00022-2
- 2902593 - Phlegmariurus henryi: 10.1016/S0305-1978(98)00022-2
- 1158256 - Phlegmariurus varius: 10.1021/JF0106087
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuyao Ruan, Jiaqi Li, Hang Ruan, Qing Xia, Xiaolin Hou, Zhi Wang, Teng Guo, Chunyun Zhu, Nianping Feng, Yongtai Zhang. Microneedle-mediated nose-to-brain drug delivery for improved Alzheimer's disease treatment.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Jan; 366(?):712-731. doi:
10.1016/j.jconrel.2024.01.013. [PMID: 38219911] - Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely. Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis.
Nature.
2023 Nov; ?(?):. doi:
10.1038/s41586-023-06716-y. [PMID: 37938780] - Xinran Guo, Yuhan Wu, Qingqing Wang, Jianbing Zhang, Xueping Sheng, Lanrong Zheng, Yule Wang. Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease.
European journal of pharmacology.
2023 Aug; ?(?):175970. doi:
10.1016/j.ejphar.2023.175970. [PMID: 37549727] - Soura Challal, Adrianna Skiba, Mélanie Langlois, Camila V Esguerra, Jean-Luc Wolfender, Alexander D Crawford, Krystyna Skalicka-Woźniak. Natural product-derived therapies for treating drug-resistant epilepsies: From ethnopharmacology to evidence-based medicine.
Journal of ethnopharmacology.
2023 Jun; ?(?):116740. doi:
10.1016/j.jep.2023.116740. [PMID: 37315641] - Ce Zhang, Mingan Li, Wei Xie, Min Li, Chunna You, Tian Wang, Fenghua Fu. Administration of Huperzine A microspheres ameliorates myocardial ischemic injury via α7nAChR-dependent JAK2/STAT3 signaling pathway.
European journal of pharmacology.
2023 Feb; 940(?):175478. doi:
10.1016/j.ejphar.2022.175478. [PMID: 36563953] - Xin-Yue Yang, Lina Geng, Ronghui Li, Ji-Xian Song, Cui-Ling Jia, Ji-Ren An, Meng-Fan Sun, Shan Xu, Ya-Jing Guo, Yashuo Zhao, En-Sheng Ji. Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia.
International journal of nanomedicine.
2023; 18(?):843-859. doi:
10.2147/ijn.s393346. [PMID: 36824413] - Zhuhui Shen, Xubing Liu, Jia Yang, Yanli Wang, Kai Yao, Qingmiao Huo, Yanping Fu, Yahui Wei, Bin Guo. The temporal and spatial endophytic fungal community of Huperzia serrata: diversity and relevance to huperzine A production by the host.
BMC microbiology.
2022 11; 22(1):281. doi:
10.1186/s12866-022-02702-y. [PMID: 36424543] - Xiao Li, Wei Li, Pingfang Tian, Tianwei Tan. Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease.
Biotechnology advances.
2022 11; 60(?):108026. doi:
10.1016/j.biotechadv.2022.108026. [PMID: 35914626] - Bo Pang, Dengpan Yin, Yufeng Zhai, Anguo He, Linlin Qiu, Qiao Liu, Nan Ma, Hongjun Shen, Qiaojun Jia, Zongsuo Liang, Dekai Wang. Diversity of endophytic fungal community in Huperzia serrata from different ecological areas and their correlation with Hup A content.
BMC microbiology.
2022 08; 22(1):191. doi:
10.1186/s12866-022-02605-y. [PMID: 35931950] - Cecilia Villegas, Rebeca Perez, Lyvia Lintzmaier Petiz, Talita Glaser, Henning Ulrich, Cristian Paz. Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease.
IUBMB life.
2022 08; 74(8):763-779. doi:
10.1002/iub.2613. [PMID: 35384262] - Mayuri Shukla, Prapimpun Wongchitrat, Piyarat Govitrapong. A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies-Emphasis on Alzheimer's Disease Pathogenesis.
Neurochemical research.
2022 May; 47(5):1166-1182. doi:
10.1007/s11064-022-03530-2. [PMID: 35122609] - Anas Shamsi, Moyad Shahwan, Mohd Shahnawaz Khan, Fahad A Alhumaydhi, Suliman A Alsagaby, Waleed Al Abdulmonem, Bekhzod Abdullaev, Dharmendra Kumar Yadav. Mechanistic Insight into Binding of Huperzine A with Human Serum Albumin: Computational and Spectroscopic Approaches.
Molecules (Basel, Switzerland).
2022 Jan; 27(3):. doi:
10.3390/molecules27030797. [PMID: 35164061] - Amira G Zaki, El-Sayed R El-Sayed. New and potent production platform of the acetylcholinesterase inhibitor huperzine A by gamma-irradiated Alternaria brassicae under solid-state fermentation.
Applied microbiology and biotechnology.
2021 Dec; 105(23):8869-8880. doi:
10.1007/s00253-021-11678-0. [PMID: 34748037] - Ryan S Nett, Yaereen Dho, Yun-Yee Low, Elizabeth S Sattely. A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis.
Proceedings of the National Academy of Sciences of the United States of America.
2021 06; 118(24):. doi:
10.1073/pnas.2102949118. [PMID: 34112718] - Amira G Zaki, Einas H El-Shatoury, Ashraf S Ahmed, Ola E A Al-Hagar. Response surface methodology-mediated improvement of the irradiated endophytic fungal strain, Alternaria brassicae AGF041 for Huperzine A-hyperproduction.
Letters in applied microbiology.
2021 Apr; 72(4):427-437. doi:
10.1111/lam.13435. [PMID: 33278032] - Lingli Cui, Hamza Armghan Noushahi, Yipeng Zhang, Jinxin Liu, Andreea Cosoveanu, Ying Liu, Ling Yan, Jing Zhang, Shaohua Shu. Endophytic Fungal Community of Huperzia serrata: Diversity and Relevance to the Production of Huperzine A by the Plant Host.
Molecules (Basel, Switzerland).
2021 Feb; 26(4):. doi:
10.3390/molecules26040892. [PMID: 33567664] - Raul Riquelme, Freddy Ruz, Artur Mayerhofer, Hernán E Lara. Huperzine-A administration recovers rat ovary function after sympathetic stress.
Journal of neuroendocrinology.
2021 01; 33(1):e12914. doi:
10.1111/jne.12914. [PMID: 33252842] - Xiang-Peng Kong, Hai-Qin Ren, Etta Y L Liu, Ka-Wing Leung, Shu-Chen Guo, Ran Duan, Tina T X Dong, Karl W K Tsim. The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245914. [PMID: 33327436] - Han Wen-Xia, Han Zhong-Wen, Jia Min, Zhang Han, Li Wei-Ze, Yang Li-Bin, Liang Fei, Han Lu, Zhao Ning, Li Xiao-Feng. Five novel and highly efficient endophytic fungi isolated from Huperzia serrata expressing huperzine A for the treatment of Alzheimer's disease.
Applied microbiology and biotechnology.
2020 Nov; 104(21):9159-9177. doi:
10.1007/s00253-020-10894-4. [PMID: 32970179] - Xiao Sang, Minhe Yang, Jingqian Su. Research on endophytic fungi for producing huperzine A on a large-scale.
Critical reviews in microbiology.
2020 Nov; 46(6):654-664. doi:
10.1080/1040841x.2020.1819771. [PMID: 32970952] - Amira G Zaki, El-Sayed R El-Sayed, M Abd Elkodous, Gharieb S El-Sayyad. Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery.
Applied microbiology and biotechnology.
2020 Jun; 104(11):4717-4735. doi:
10.1007/s00253-020-10560-9. [PMID: 32285176] - Olga Lidia Cruz-Miranda, Jorge Folch-Mallol, Fernando Martínez-Morales, Reinier Gesto-Borroto, María Luisa Villarreal, Alexandre Cardoso Taketa. Identification of a Huperzine A-producing endophytic fungus from Phlegmariurus taxifolius.
Molecular biology reports.
2020 Jan; 47(1):489-495. doi:
10.1007/s11033-019-05155-1. [PMID: 31659691] - You-Min Ying, Yi-Lian Xu, Hang-Fei Yu, Cai-Xue Zhang, Wei Mao, Cui-Ping Tong, Zhi-Dong Zhang, Qi-Yong Tang, Yun Zhang, Wei-Guang Shan, Zha-Jun Zhan. Biotransformation of Huperzine A by Irpex lacteus-A fungal endophyte of Huperzia serrata.
Fitoterapia.
2019 Oct; 138(?):104341. doi:
10.1016/j.fitote.2019.104341. [PMID: 31470066] - Gang Deng, Chao Wu, Xiaojuan Rong, Shuping Li, Zhengcai Ju, Youxu Wang, Chao Ma, Wenzheng Ding, Huida Guan, Xuemei Cheng, Wei Liu, Changhong Wang. Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Oct; 63(?):153007. doi:
10.1016/j.phymed.2019.153007. [PMID: 31301537] - Yifan Chen, Gang Cheng, Rongfeng Hu, Shengqi Chen, Wenjie Lu, Song Gao, Hongmei Xia, Bin Wang, Chaojie Sun, Xiangjiang Nie, Qiang Shen, Wenyou Fang. A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study.
AAPS PharmSciTech.
2019 Sep; 20(7):301. doi:
10.1208/s12249-019-1513-x. [PMID: 31485857] - Amira G Zaki, Einas H El-Shatoury, Ashraf S Ahmed, Ola E A Al-Hagar. Production and enhancement of the acetylcholinesterase inhibitor, huperzine A, from an endophytic Alternaria brassicae AGF041.
Applied microbiology and biotechnology.
2019 Jul; 103(14):5867-5878. doi:
10.1007/s00253-019-09897-7. [PMID: 31119352] - Minky Son, Chanin Park, Shailima Rampogu, Amir Zeb, Keun Woo Lee. Discovery of Novel Acetylcholinesterase Inhibitors as Potential Candidates for the Treatment of Alzheimer's Disease.
International journal of molecular sciences.
2019 Feb; 20(4):. doi:
10.3390/ijms20041000. [PMID: 30823604] - Po Huang, Bo Li, Yu-Hong Guo, Shuo Feng, Jing Hu, Qing-Quan Liu. [Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Feb; 44(3):582-588. doi:
10.19540/j.cnki.cjcmm.20180925.008. [PMID: 30989926] - Maonian Xu, Starri Heidmarsson, Margret Thorsteinsdottir, Pawel Wasowicz, Hang Sun, Tao Deng, Sesselja Omarsdottir, Elin Soffia Olafsdottir. Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago Complex.
Planta medica.
2019 Jan; 85(2):160-168. doi:
10.1055/a-0752-0295. [PMID: 30290396] - Huan-Feng Zhu, Peng-Wei Yan, Li-Jun Wang, Ya-Tian Liu, Jing Wen, Qian Zhang, Yan-Xin Fan, Yan-Hong Luo. Protective properties of Huperzine A through activation Nrf2/ARE-mediated transcriptional response in X-rays radiation-induced NIH3T3 cells.
Journal of cellular biochemistry.
2018 11; 119(10):8359-8367. doi:
10.1002/jcb.26919. [PMID: 29932247] - San-Lan Wu, Jun Gan, Jing Rao, Si-Jie He, Wen-Wen Zhu, Ying Zhao, Yong-Ning Lv, Jian-Geng Huang, Ya-Ni Liu. Pharmacokinetics and tolerability of oral dosage forms of huperzine a in healthy Chinese male volunteers: a randomized, single dose, three-period, six-sequence crossover study.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2017 Oct; 37(5):795-802. doi:
10.1007/s11596-017-1807-8. [PMID: 29058298] - Jiajun Li, Mei Yue, Dandan Zhou, Meiyu Wang, Hongjian Zhang. Abcb1a but not Abcg2 played a predominant role in limiting the brain distribution of Huperzine A in mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2017 Sep; 107(Pt A):68-73. doi:
10.1016/j.fct.2017.06.005. [PMID: 28587984] - Yuan Du, Haiyue Liang, Leiming Zhang, Fenghua Fu. Administration of Huperzine A exerts antidepressant-like activity in a rat model of post-stroke depression.
Pharmacology, biochemistry, and behavior.
2017 07; 158(?):32-38. doi:
10.1016/j.pbb.2017.06.002. [PMID: 28583576] - Xiangmei Zhang, Zhangqian Wang, Saad Jan, Qian Yang, Mo Wang. Expression and functional analysis of the lysine decarboxylase and copper amine oxidase genes from the endophytic fungus Colletotrichum gloeosporioides ES026.
Scientific reports.
2017 06; 7(1):2766. doi:
10.1038/s41598-017-02834-6. [PMID: 28584293] - Baofu Xu, Lei Lei, Xiaocen Zhu, Yiqing Zhou, Youli Xiao. Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid.
Phytochemistry.
2017 Apr; 136(?):23-30. doi:
10.1016/j.phytochem.2016.12.022. [PMID: 28089246] - Mengquan Yang, Wenjing You, Shiwen Wu, Zhen Fan, Baofu Xu, Mulan Zhu, Xuan Li, Youli Xiao. Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A.
BMC genomics.
2017 03; 18(1):245. doi:
10.1186/s12864-017-3615-8. [PMID: 28330463] - Mariana Vázquez García, Gilsane Lino von Poser, Miriam Apel, Rosa Cerros Tlatilpa, Aniceto Mendoza-Ruiz, María Luisa Villarreal, Amelia Teresinha Henriques, Alexandre Cardoso Taketa. Anticholinesterase activity and identification of huperzine A in three Mexican lycopods: Huperzia cuernavacensis, Huperzia dichotoma and Huperzia linifolia (Lycopodiaceae).
Pakistan journal of pharmaceutical sciences.
2017 Jan; 30(1 Suppl):235-239. doi:
". [PMID: 28625948] - Lushuang Xie, Cen Jiang, Zhang Wang, Xiaohong Yi, Yuanyuan Gong, Yunhui Chen, Yan Fu. Effect of Huperzine A on Aβ-induced p65 of astrocyte in vitro.
Bioscience, biotechnology, and biochemistry.
2016 Dec; 80(12):2334-2337. doi:
10.1080/09168451.2016.1222265. [PMID: 27554967] - Ping-Ping Lin, Xue-Ning Li, Fei Yuan, Wei-Li Chen, Meng-Jie Yang, Hong-Rong Xu. Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A.
Biochemical and biophysical research communications.
2016 11; 480(2):248-253. doi:
10.1016/j.bbrc.2016.10.039. [PMID: 27751854] - Lei Sheng, Yi Qu, Jing Yan, Gang-Yi Liu, Wei-Liang Wang, Yi-Jun Wang, Hong-Yi Wang, Meng-Qi Zhang, Chuan Lu, Yun Liu, Jing-Yin Jia, Chao-Ying Hu, Xue-Ning Li, Chen Yu, Hong-Rong Xu. Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects.
Acta pharmacologica Sinica.
2016 Jul; 37(7):994-1001. doi:
10.1038/aps.2016.24. [PMID: 27180987] - U Damar, R Gersner, J T Johnstone, S Schachter, A Rotenberg. Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research.
Expert review of neurotherapeutics.
2016 06; 16(6):671-80. doi:
10.1080/14737175.2016.1175303. [PMID: 27086593] - Shuqun Zhang, Bo Hou, Huaiyu Yang, Zhili Zuo. Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives.
Archives of pharmacal research.
2016 May; 39(5):591-602. doi:
10.1007/s12272-016-0709-9. [PMID: 26832327] - Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitra. Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease.
Chemico-biological interactions.
2016 Apr; 249(?):1-9. doi:
10.1016/j.cbi.2016.02.012. [PMID: 26902639] - Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang. Pharmacological Effects of Active Components of Chinese Herbal Medicine in the Treatment of Alzheimer's Disease: A Review.
The American journal of Chinese medicine.
2016; 44(8):1525-1541. doi:
10.1142/s0192415x16500853. [PMID: 27848250] - Yong-Hao Ye, Cong Li, Jun Yang, Liang Ma, Yu Xiao, Jun Hu, Nasir Ahmed Rajput, Cong-Fen Gao, Ying-Ying Zhang, Ming-Hua Wang. Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis.
Pest management science.
2015 Apr; 71(4):607-15. doi:
10.1002/ps.3908. [PMID: 25228142] - Guowei Zhang, Wenjuan Wang, Xiangmei Zhang, Qianqian Xia, Xinmei Zhao, Youngjoon Ahn, Nevin Ahmed, Andreea Cosoveanu, Mo Wang, Jialu Wang, Shaohua Shu. De novo RNA sequencing and transcriptome analysis of Colletotrichum gloeosporioides ES026 reveal genes related to biosynthesis of huperzine A.
PloS one.
2015; 10(3):e0120809. doi:
10.1371/journal.pone.0120809. [PMID: 25799531] - Takuya Ohba, Yuta Yoshino, Mitsue Ishisaka, Naohito Abe, Kazuhiro Tsuruma, Masamitsu Shimazawa, Masayoshi Oyama, Takeshi Tabira, Hideaki Hara. Japanese Huperzia serrata extract and the constituent, huperzine A, ameliorate the scopolamine-induced cognitive impairment in mice.
Bioscience, biotechnology, and biochemistry.
2015; 79(11):1838-44. doi:
10.1080/09168451.2015.1052773. [PMID: 26059088] - Jingqian Su, Minhe Yang. Huperzine A production by Paecilomyces tenuis YS-13, an endophytic fungus isolated from Huperzia serrata.
Natural product research.
2015; 29(11):1035-41. doi:
10.1080/14786419.2014.980245. [PMID: 25427833] - Shaohua Shu, Xinmei Zhao, Wenjuan Wang, Guowei Zhang, Andreea Cosoveanu, Youngjoon Ahn, Mo Wang. Identification of a novel endophytic fungus from Huperzia serrata which produces huperzine A.
World journal of microbiology & biotechnology.
2014 Dec; 30(12):3101-9. doi:
10.1007/s11274-014-1737-6. [PMID: 25212543] - Nguyen Ngoc Chuong, Nguyen Thi Thu Huong, Tran Manh Hung, Tran Cong Luan. Anti-cholinesterase activity of lycopodium alkaloids from Vietnamese Huperzia squarrosa (Forst.) Trevis.
Molecules (Basel, Switzerland).
2014 Nov; 19(11):19172-9. doi:
10.3390/molecules191119172. [PMID: 25415478] - You-Min Ying, Wei-Guang Shan, Zha-Jun Zhan. Biotransformation of huperzine A by a fungal endophyte of Huperzia serrata furnished sesquiterpenoid-alkaloid hybrids.
Journal of natural products.
2014 Sep; 77(9):2054-9. doi:
10.1021/np500412f. [PMID: 25222040] - Zhe Xu, Yang Wang. Huperzine A attenuates hepatic ischemia reperfusion injury via anti-oxidative and anti-apoptotic pathways.
Molecular medicine reports.
2014 Aug; 10(2):701-6. doi:
10.3892/mmr.2014.2288. [PMID: 24888717] - Yi-Wen Zhang, Mei-Hua Bao, Guo Wang, Qiang Qu, Hong-Hao Zhou. Induction of human CYP3A4 by huperzine A, ligustrazine and oridonin through pregnane X receptor-mediated pathways.
Die Pharmazie.
2014 Jul; 69(7):532-6. doi:
. [PMID: 25073399] - Riming Yan, Zhibin Zhang, Ya Wang, Huilin Yang, Qinggui Zeng, Du Zhu. Efficient strategy for maintaining and enhancing the huperzine A production of Shiraia sp. Slf14 through inducer elicitation.
Journal of industrial microbiology & biotechnology.
2014 Jul; 41(7):1175-9. doi:
10.1007/s10295-014-1461-0. [PMID: 24865990] - Xiao-Yuan Mao, Dan-Feng Cao, Xi Li, Ji-Ye Yin, Zhi-Bin Wang, Ying Zhang, Chen-Xue Mao, Hong-Hao Zhou, Zhao-Qian Liu. Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
International journal of molecular sciences.
2014 May; 15(5):7667-83. doi:
10.3390/ijms15057667. [PMID: 24857910] - Xiao-Tian Huang, Zhong-Ming Qian, Xuan He, Qi Gong, Ka-Chun Wu, Li-Rong Jiang, Li-Na Lu, Zhou-Jing Zhu, Hai-Yan Zhang, Wing-Ho Yung, Ya Ke. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease.
Neurobiology of aging.
2014 May; 35(5):1045-54. doi:
10.1016/j.neurobiolaging.2013.11.004. [PMID: 24332448] - Li-Hui Dong, San-Wei Fan, Qing-Zhi Ling, Bei-Bei Huang, Zhao-Jun Wei. Indentification of huperzine A-producing endophytic fungi isolated from Huperzia serrata.
World journal of microbiology & biotechnology.
2014 Mar; 30(3):1011-7. doi:
10.1007/s11274-013-1519-6. [PMID: 24129696] - Xizhong Sui, Changqing Gao. Huperzine A ameliorates damage induced by acute myocardial infarction in rats through antioxidant, anti-apoptotic and anti-inflammatory mechanisms.
International journal of molecular medicine.
2014 Jan; 33(1):227-33. doi:
10.3892/ijmm.2013.1546. [PMID: 24190328] - Meltem Kolgazi, Unal Uslu, Meral Yuksel, Ayliz Velioglu-Ogunc, Feriha Ercan, Inci Alican. The role of cholinergic anti-inflammatory pathway in acetic acid-induced colonic inflammation in the rat.
Chemico-biological interactions.
2013 Sep; 205(1):72-80. doi:
10.1016/j.cbi.2013.06.009. [PMID: 23810507] - Jing-ying Jia, Qian-hua Zhao, Yun Liu, Yu-zhou Gui, Gang-yi Liu, Da-yuan Zhu, Chen Yu, Zhen Hong. Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease.
Acta pharmacologica Sinica.
2013 Jul; 34(7):976-82. doi:
10.1038/aps.2013.7. [PMID: 23624756] - Ramachandra S Naik, Weiyi Liu, Ashima Saxena. Development and validation of a simple assay for the determination of cholinesterase activity in whole blood of laboratory animals.
Journal of applied toxicology : JAT.
2013 Apr; 33(4):290-300. doi:
10.1002/jat.2730. [PMID: 22407886] - Yimin Tao, Li Fang, Yiming Yang, Hualiang Jiang, Huaiyu Yang, Haiyan Zhang, Hu Zhou. Quantitative proteomic analysis reveals the neuroprotective effects of huperzine A for amyloid beta treated neuroblastoma N2a cells.
Proteomics.
2013 Apr; 13(8):1314-24. doi:
10.1002/pmic.201200437. [PMID: 23424162] - Pratikkumar A Patel, Sushant C Patil, Dhaval R Kalaria, Yogeshwar N Kalia, Vandana B Patravale. Comparative in vitro and in vivo evaluation of lipid based nanocarriers of Huperzine A.
International journal of pharmaceutics.
2013 Mar; 446(1-2):16-23. doi:
10.1016/j.ijpharm.2013.02.014. [PMID: 23410989] - Ci Du, Jing Li, Xiang-Rong Tian, Yue Zhu, Qing-Zhong Peng. [Determination of huperzine A and semi-quantitative RT-PCR analysis of lysine decarboxylase gene in different parts of Huperzia serrata from western Hunan].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2013 Mar; 36(3):361-4. doi:
. [PMID: 24010314] - Angela I Calderón, Johayra Simithy-Williams, Rocío Sanchez, Alex Espinosa, Iván Valdespino, Mahabir P Gupta. Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors.
Natural product research.
2013 Mar; 27(4-5):500-5. doi:
10.1080/14786419.2012.701217. [PMID: 22746970] - Yongxin Zhao, Jun Dou, Tao Wu, Haji Akber Aisa. Investigating the antioxidant and acetylcholinesterase inhibition activities of Gossypium herbaceam.
Molecules (Basel, Switzerland).
2013 Jan; 18(1):951-62. doi:
10.3390/molecules18010951. [PMID: 23344203] - Jingcai Zhang, Jie Wei, Hongmin Zhong, Zhimou Guo, Hua Zhang. [Determination of Huperzine A in the extract of Huperzia serrata by high performance liquid chromatography].
Se pu = Chinese journal of chromatography.
2013 Jan; 31(1):79-82. doi:
10.3724/sp.j.1123.2012.08038. [PMID: 23667994] - Xin-Mei Zhao, Zhang-Qian Wang, Shao-Hua Shu, Wen-Juan Wang, Hai-Jie Xu, Young-Joon Ahn, Mo Wang, Xuebo Hu. Ethanol and methanol can improve huperzine A production from endophytic Colletotrichum gloeosporioides ES026.
PloS one.
2013; 8(4):e61777. doi:
10.1371/journal.pone.0061777. [PMID: 23613930] - P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesario. Multitarget drugs of plants origin acting on Alzheimer's disease.
Current medicinal chemistry.
2013; 20(13):1686-93. doi:
10.2174/0929867311320130008. [PMID: 23410167] - Jirong Yue, Bi Rong Dong, Xiufang Lin, Ming Yang, Hong Mei Wu, Taixiang Wu. Huperzine A for mild cognitive impairment.
The Cochrane database of systematic reviews.
2012 Dec; 12(?):CD008827. doi:
10.1002/14651858.cd008827.pub2. [PMID: 23235666] - E L Konrath, B M Neves, C Dos S Passos, P S Lunardi, M G Ortega, J L Cabrera, C A Gonçalves, A T Henriques. Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Nov; 19(14):1321-4. doi:
10.1016/j.phymed.2012.08.009. [PMID: 23022390] - Daniel Cuthbertson, Jasenka Piljac-Žegarac, Bernd Markus Lange. Validation of a microscale extraction and high-throughput UHPLC-QTOF-MS analysis method for huperzine A in Huperzia.
Biomedical chromatography : BMC.
2012 Oct; 26(10):1191-5. doi:
10.1002/bmc.2677. [PMID: 22275140] - Hongchao Zhang, Hao Liang, Pengqun Kuang, Qipeng Yuan, Yan Wang. Simultaneously preparative purification of Huperzine A and Huperzine B from Huperzia serrata by macroporous resin and preparative high performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Sep; 904(?):65-72. doi:
10.1016/j.jchromb.2012.07.019. [PMID: 22877738] - Qinghai Shi, Jianfeng Fu, Di Ge, Yan He, Jihua Ran, Zhengxiang Liu, Jing Wei, Tong Diao, Youfang Lu. Huperzine A ameliorates cognitive deficits and oxidative stress in the hippocampus of rats exposed to acute hypobaric hypoxia.
Neurochemical research.
2012 Sep; 37(9):2042-52. doi:
10.1007/s11064-012-0826-x. [PMID: 22711335] - Xiaoqing Cai, Yuxia Luan, Yue Jiang, Aixin Song, Wei Shao, Zhonghao Li, Zhongxi Zhao. Huperzine A-phospholipid complex-loaded biodegradable thermosensitive polymer gel for controlled drug release.
International journal of pharmaceutics.
2012 Aug; 433(1-2):102-11. doi:
10.1016/j.ijpharm.2012.05.009. [PMID: 22583846] - Miroslav Pohanka, Filip Zemek, Hana Bandouchova, Jiri Pikula. Toxicological scoring of Alzheimer's disease drug huperzine in a guinea pig model.
Toxicology mechanisms and methods.
2012 Apr; 22(3):231-5. doi:
10.3109/15376516.2011.635320. [PMID: 22112162] - Ying Wang, Xi Can Tang, Hai Yan Zhang. Huperzine A alleviates synaptic deficits and modulates amyloidogenic and nonamyloidogenic pathways in APPswe/PS1dE9 transgenic mice.
Journal of neuroscience research.
2012 Feb; 90(2):508-17. doi:
10.1002/jnr.22775. [PMID: 22002568] - Wei Guo, Shupeng Liu, Jinliang Peng, Xiaohui Wei, Ye Sun, Yangsheng Qiu, Guangwei Gao, Peng Wang, Yuhong Xu. Examining the interactome of huperzine A by magnetic biopanning.
PloS one.
2012; 7(5):e37098. doi:
10.1371/journal.pone.0037098. [PMID: 22615909] - Zhong-Duo Yang, Zhu-Wen Song, Jin Ren, Ming-Jun Yang, Shuo Li. Improved thin-layer chromatography bioautographic assay for the detection of actylcholinesterase inhibitors in plants.
Phytochemical analysis : PCA.
2011 Nov; 22(6):509-15. doi:
10.1002/pca.1310. [PMID: 21433160] - Ya Wang, Qing Gui Zeng, Zhi Bin Zhang, Ri Ming Yan, Ling Yun Wang, Du Zhu. Isolation and characterization of endophytic huperzine A-producing fungi from Huperzia serrata.
Journal of industrial microbiology & biotechnology.
2011 Sep; 38(9):1267-78. doi:
10.1007/s10295-010-0905-4. [PMID: 21107640] - Giang T Ha, Ryan K Wong, Yan Zhang. Huperzine a as potential treatment of Alzheimer's disease: an assessment on chemistry, pharmacology, and clinical studies.
Chemistry & biodiversity.
2011 Jul; 8(7):1189-204. doi:
10.1002/cbdv.201000269. [PMID: 21766442] - Miroslav Pohanka, Martina Hrabinova, Filip Zemek, Lucie Drtinova, Hana Bandouchova, Jiri Pikula. Huperzine induces alteration in oxidative balance and antioxidants in a guinea pig model.
Neuro endocrinology letters.
2011; 32 Suppl 1(?):95-100. doi:
. [PMID: 22167216] - Jun Shi, Qingfei Liu, Yiming Wang, Guoan Luo. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats.
Pharmacology, biochemistry, and behavior.
2010 Oct; 96(4):449-53. doi:
10.1016/j.pbb.2010.07.004. [PMID: 20624417] - D Zhu, J Wang, Q Zeng, Z Zhang, R Yan. A novel endophytic Huperzine A-producing fungus, Shiraia sp. Slf14, isolated from Huperzia serrata.
Journal of applied microbiology.
2010 Oct; 109(4):1469-78. doi:
10.1111/j.1365-2672.2010.04777.x. [PMID: 20602655] - Wei-Han Lim, Jason Q D Goodger, Ashley R Field, Joseph A M Holtum, Ian E Woodrow. Huperzine alkaloids from Australasian and southeast Asian Huperzia.
Pharmaceutical biology.
2010 Sep; 48(9):1073-8. doi:
10.3109/13880209.2010.485619. [PMID: 20731560] - Lijun Yu, Yunfeng Shi, Jianan Huang, Yushun Gong, Zhonghua Liu, Weixin Hu. Modification and validation of a high-performance liquid chromatography method for quantification of Huperzine A in Huperzia crispata.
Journal of AOAC International.
2010 Sep; 93(5):1428-35. doi:
10.1093/jaoac/93.5.1428. [PMID: 21140653] - Chun-Rong Yang, Xiu-Li Zhao, Hai-Yang Hu, Ke-Xin Li, Xin Sun, Lei Li, Da-Wei Chen. Preparation, optimization and characteristic of huperzine a loaded nanostructured lipid carriers.
Chemical & pharmaceutical bulletin.
2010 May; 58(5):656-61. doi:
10.1248/cpb.58.656. [PMID: 20460792] - Qiao Wang, Guoshen Chen. Pharmacokinetic behavior of huperzine A in plasma and cerebrospinal fluid after intranasal administration in rats.
Biopharmaceutics & drug disposition.
2009 Dec; 30(9):551-5. doi:
10.1002/bdd.686. [PMID: 19780094] - Jian Yan, Lirong Sun, Guisheng Wu, Ping Yi, Fumei Yang, Lin Zhou, Xianmin Zhang, Zhongrong Li, Xiaosheng Yang, Huairong Luo, Minghua Qiu. Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.
Bioorganic & medicinal chemistry.
2009 Oct; 17(19):6937-41. doi:
10.1016/j.bmc.2009.08.017. [PMID: 19726199] - Xiao-Lin Zhang, Hong-Rong Xu, Wei-Li Chen, Nan-Nan Chu, Xue-Ning Li, Gang-Yi Liu, Chen Yu. Matrine determination and pharmacokinetics in human plasma using LC/MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Oct; 877(27):3253-6. doi:
10.1016/j.jchromb.2009.08.026. [PMID: 19726245] - Lei Zhang, Hui Cao, Jun Wen, Ming Xu. Green tea polyphenol (-)-epigallocatechin-3-gallate enhances the inhibitory effect of huperzine A on acetylcholinesterase by increasing the affinity with serum albumin.
Nutritional neuroscience.
2009 Aug; 12(4):142-8. doi:
10.1179/147683009x423283. [PMID: 19622237] - Yanqing Zhang, Junbo Xie, Wen-Qian Chen, Tian-Yan Zhou, Wei Lu. Development of a sensitive high-performance liquid chromatographic method with simple extraction for simultaneous determination of huperzine A and huperzine B in the species containing lycopodium alkaloids.
Journal of AOAC International.
2009 Jul; 92(4):1060-3. doi:
. [PMID: 19714972] - Juan He, Xuan-Qin Chen, Ming-Ming Li, Yu Zhao, Gang Xu, Xiao Cheng, Li-Yan Peng, Min-Jin Xie, Yong-Tang Zheng, Yi-Ping Wang, Qin-Shi Zhao. Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
Organic letters.
2009 Mar; 11(6):1397-400. doi:
10.1021/ol900079t. [PMID: 19245240] - Julian R Haigh, Scott R Johnston, Adam Peppernay, Patrick J Mattern, Gregory E Garcia, Bhupendra P Doctor, Richard K Gordon, Paul S Aisen. Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Chemico-biological interactions.
2008 Sep; 175(1-3):380-6. doi:
10.1016/j.cbi.2008.04.033. [PMID: 18572153] - H Q Lin, Michelle T Ho, Lesley S Lau, Kelvin K Wong, P C Shaw, David C C Wan. Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease.
Chemico-biological interactions.
2008 Sep; 175(1-3):352-4. doi:
10.1016/j.cbi.2008.05.030. [PMID: 18573242] - Xiaoqiang Ma, David R Gang. In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease.
Phytochemistry.
2008 Jul; 69(10):2022-8. doi:
10.1016/j.phytochem.2008.04.017. [PMID: 18538805] - J C Ye, S Zeng, G L Zheng, G S Chen. Pharmacokinetics of Huperzine A after transdermal and oral administration in beagle dogs.
International journal of pharmaceutics.
2008 May; 356(1-2):187-92. doi:
10.1016/j.ijpharm.2008.01.007. [PMID: 18289810] - Wei Li, Jianhua Li, Qin Hu. Determination of huperzine A in human plasma by liquid chromatography-electrospray tandem mass spectrometry: application to a bioequivalence study on Chinese volunteers.
Biomedical chromatography : BMC.
2008 Apr; 22(4):354-60. doi:
10.1002/bmc.938. [PMID: 17939152] - Jing-kun Zhao, De-sheng Wang. [Progress of study on treatment of Alzheimer's disease with active ingredients of Chinese herbal medicines].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Feb; 28(2):177-81. doi:
". [PMID: 18386587]
