Tiliacorine (BioDeep_00000007529)

   


代谢物信息卡片


Tiliacorinine

化学式: C36H36N2O5 (576.2624)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 100%

分子结构信息

SMILES: CN1CCC2=CC3=C4C=C2C1CC5=CC(=C(C=C5)O)C6=C(C=CC(=C6)CC7C8=C(O4)C(=C(C=C8CCN7C)OC)O3)OC
InChI: InChI=1S/C36H36N2O5/c1-37-11-9-22-17-31-32-19-24(22)27(37)15-20-5-7-29(39)25(13-20)26-14-21(6-8-30(26)40-3)16-28-34-23(10-12-38(28)2)18-33(41-4)35(42-31)36(34)43-32/h5-8,13-14,17-19,27-28,39H,9-12,15-16H2,1-4H3/t27-,28-/m0/s1

描述信息

同义名列表

3 个代谢物同义名

Tiliacorine; Tiliacorinine; Tiliacorine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 BCL2L1, CASP3, CASP9, EGFR, JAK2, NOS3, PIK3CA, SGCB, STAT3, XIAP
Peripheral membrane protein 1 JAK2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 1 EGFR
Mitochondrion membrane 1 BCL2L1
Nucleus 8 CASP3, CASP9, EGFR, JAK2, NOS3, PARP1, STAT3, XIAP
cytosol 9 BCL2L1, CASP3, CASP9, JAK2, NOS3, PARP1, PIK3CA, STAT3, XIAP
nuclear body 1 PARP1
centrosome 1 BCL2L1
nucleoplasm 6 CASP3, JAK2, NOS3, PARP1, STAT3, XIAP
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 1 EGFR
Cytoplasmic side 1 BCL2L1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 3 CASP3, EGFR, JAK2
Golgi apparatus 1 NOS3
Golgi membrane 2 EGFR, NOS3
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 BCL2L1
neuronal cell body 2 CASP3, INHA
postsynapse 1 JAK2
sarcolemma 1 SGCB
Cytoplasm, cytosol 2 BCL2L1, PARP1
endosome 1 EGFR
plasma membrane 7 EGF, EGFR, JAK2, NOS3, PIK3CA, SGCB, STAT3
synaptic vesicle membrane 1 BCL2L1
Membrane 4 EGF, EGFR, JAK2, PARP1
apical plasma membrane 1 EGFR
basolateral plasma membrane 1 EGFR
caveola 2 JAK2, NOS3
extracellular exosome 1 EGF
endoplasmic reticulum 1 BCL2L1
extracellular space 3 EGF, EGFR, INHA
perinuclear region of cytoplasm 3 EGFR, NOS3, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2L1, CASP9, PARP1
protein-containing complex 3 CASP9, EGFR, PARP1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 EGFR
Secreted 1 INHA
extracellular region 2 EGF, INHA
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 BCL2L1
Single-pass membrane protein 1 BCL2L1
mitochondrial outer membrane 1 BCL2L1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
transcription regulator complex 2 PARP1, STAT3
photoreceptor inner segment 1 INHA
photoreceptor outer segment 1 INHA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 1 BCL2L1
Bcl-2 family protein complex 1 BCL2L1
nuclear membrane 2 BCL2L1, EGFR
nucleolus 1 PARP1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Single-pass type II membrane protein 1 SGCB
Cell membrane, sarcolemma 1 SGCB
Membrane raft 2 EGFR, JAK2
Cytoplasm, cytoskeleton 1 SGCB
focal adhesion 2 EGFR, JAK2
intracellular vesicle 1 EGFR
receptor complex 1 EGFR
chromatin 2 PARP1, STAT3
Chromosome 1 PARP1
cytoskeleton 3 JAK2, NOS3, SGCB
Nucleus, nucleolus 1 PARP1
inhibin A complex 1 INHA
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
Endomembrane system 1 JAK2
endosome lumen 1 JAK2
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 JAK2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
platelet alpha granule lumen 1 EGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 NOS3
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
protein-DNA complex 1 PARP1
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 1 SGCB
sarcoglycan complex 1 SGCB
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
site of DNA damage 1 PARP1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
inhibin B complex 1 INHA
inhibin-betaglycan-ActRII complex 1 INHA
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Marutpong Detarya, Panupong Mahalapbutr, Orawan Waenphimai, Sonexai Kidoikhammouan, Somkid Janeklang, Kanlayanee Sawanyawisuth, Kulthida Vaeteewoottacharn, Wunchana Seubwai, Charupong Saengboonmee, Teerawut Thothaisong, Wachirachai Pabuprapap, Apichart Suksamrarn, Sopit Wongkham. Induction of apoptotic cell death of cholangiocarcinoma cells by tiliacorinine from Tiliacora triandra: A mechanistic insight. Biochimica et biophysica acta. General subjects. 2023 Oct; 1867(12):130486. doi: 10.1016/j.bbagen.2023.130486. [PMID: 37813201]
  • Shasank S Swain, Sanghamitra Pati, Tahziba Hussain. Quinoline heterocyclic containing plant and marine candidates against drug-resistant Mycobacterium tuberculosis: A systematic drug-ability investigation. European journal of medicinal chemistry. 2022 Mar; 232(?):114173. doi: 10.1016/j.ejmech.2022.114173. [PMID: 35168150]
  • Thanutchaporn Nutmakul, Kovit Pattanapanyasat, Noppamas Soonthornchareonnon, Kazuro Shiomi, Mihoko Mori, Sompop Prathanturarug. Speed of action and stage specificity of Bencha-loga-wichian, a Thai traditional antipyretic formulation, against Plasmodium falciparum and the chloroquine-potentiating activity of its active compounds, tiliacorinine and yanangcorinine. Journal of ethnopharmacology. 2020 Aug; 258(?):112909. doi: 10.1016/j.jep.2020.112909. [PMID: 32360802]
  • Somkid Janeklang, Archawin Nakaew, Kulthida Vaeteewoottacharn, Wunchana Seubwai, Patcharee Boonsiri, Gorkem Kismali, Apichart Suksamrarn, Seiji Okada, Sopit Wongkham. In vitro and in vivo antitumor activity of tiliacorinine in human cholangiocarcinoma. Asian Pacific journal of cancer prevention : APJCP. 2014; 15(17):7473-8. doi: 10.7314/apjcp.2014.15.17.7473. [PMID: 25227861]
  • Paul Klausmeyer, Thomas G McCloud, Dominic A Scudiero, Michael J Currens, John H Cardellina Ii, Robert H Shoemaker. Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα. Bioorganic & medicinal chemistry. 2012 Aug; 20(15):4646-52. doi: 10.1016/j.bmc.2012.06.017. [PMID: 22766217]
  • Sanya Sureram, Sarath P D Senadeera, Poonpilas Hongmanee, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop. Antimycobacterial activity of bisbenzylisoquinoline alkaloids from Tiliacora triandra against multidrug-resistant isolates of Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters. 2012 Apr; 22(8):2902-5. doi: 10.1016/j.bmcl.2012.02.053. [PMID: 22418278]