(+)-4,11-Eudesmadien-3-one (BioDeep_00000000075)
Secondary id: BioDeep_00000620923
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C15H22O (218.1671)
中文名称: α-香附酮, alpha-香附酮
谱图信息:
最多检出来源 Macaca mulatta(otcml) 31.27%
分子结构信息
SMILES: C1(=C2[C@](CCC1=O)(CC[C@H](C2)C(=C)C)C)C
InChI: InChI=1S/C15H22O/c1-10(2)12-5-7-15(4)8-6-14(16)11(3)13(15)9-12/h12H,1,5-9H2,2-4H3
描述信息
(+)-4,11-Eudesmadien-3-one is found in root vegetables. (+)-4,11-Eudesmadien-3-one is a constituent of Cyperus rotundus (nutgrass).
alpha-Cyperone is a natural product found in Cyperus alopecuroides, Cyperus articulatus, and other organisms with data available.
Constituent of Cyperus rotundus (nutgrass). (+)-4,11-Eudesmadien-3-one is found in root vegetables.
同义名列表
26 个代谢物同义名
2(3H)-Naphthalenone, 4,4a,5,6,7,8-hexahydro-1,4a-dimethyl-7-(1-methylethenyl)-, (4aS-cis)-; 2(3H)-Naphthalenone,4,4a,5,6,7,8-hexahydro-1,4a-dimethyl-7-(1-methylethenyl)-, (4aS,7R)-; (4aS-cis)-4,4a,5,6,7,8-Hexahydro-1,4a-dimethyl-7-(1-methylethenyl)-2(3H)-naphthalenone; (4aS,7R)-1,4a-dimethyl-7-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-one; (4aS,7R)-1,4a-Dimethyl-7-(prop-1-en-2-yl)-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one; (4aS,7R)-1,4a-dimethyl-7-prop-1-en-2-yl-3,4,5,6,7,8-hexahydronaphthalen-2-one; 1,4a-dimethyl-7-(prop-1-en-2-yl)-2,3,4,4a,5,6,7,8-octahydronaphthalen-2-one; 1,4a-dimethyl-7-(prop-1-en-2-yl)-3,4,5,6,7,8-hexahydronaphthalen-2-one; (+)-4,11-Eudesmadien-3-one; -Cyperone;(+)--Cyperone; Eudesma-4,11-dien-3-one; 4,11-Selinadien-3-one; (+)-alpha-Cyperone; (+)-Alpha Cyperone; (-)-Alpha Cyperone; .alpha.-Cyperone; UNII-ZL24SG1C2D; alpha-Cyperone; alpha Cyperone; (+)-a-Cyperone; alfa-Cyperone; ZL24SG1C2D; α-Cyperone; a-Cyperone; alpha-Cyperone; alpha-Cyperone
数据库引用编号
20 个数据库交叉引用编号
- KEGG: C17090
- PubChem: 6452086
- PubChem: 273568
- HMDB: HMDB0037061
- ChEMBL: CHEMBL1939885
- MeSH: alpha-cyperone
- ChemIDplus: 0000473085
- KNApSAcK: C00012759
- foodb: FDB016044
- chemspider: 4954527
- chemspider: 240707
- CAS: 473-08-5
- medchemexpress: HY-N0710
- PMhub: MS000014767
- ChEBI: CHEBI:80919
- PubChem: 96023565
- NIKKAJI: J438.375C
- LOTUS: LTS0024573
- wikidata: Q72437046
- KNApSAcK: 80919
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 72329 - Artemisia herba-alba: 10.1016/0031-9422(90)85114-U
- 84873 - Chelonanthus albus: 10.1080/14786410802394132
- 1234173 - Cyperus alopecuroides: 10.1016/S0031-9422(00)00374-5
- 1352543 - Cyperus articulatus: 10.1016/S0031-9422(00)80707-4
- 1352546 - Cyperus corymbosus: 10.1016/S0031-9422(00)80707-4
- 512623 - Cyperus rotundus:
- 9606 - Homo sapiens: -
- 489341 - Monocyclanthus vignei: 10.1016/0031-9422(92)80456-O
- 137129 - Swertia japonica: 10.1246/BCSJ.56.3477
- 2099542 - Zanthoxylum petiolare: 10.1080/10575639608043580
- 33090 - 香附: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinye Li, Chao He, Min Shen, Mingyun Wang, Jingwen Zhou, Dongying Chen, Tong Zhang, Yiqiong Pu. Effects of aqueous extracts and volatile oils prepared from Huaxiang Anshen decoction on p-chlorophenylalanine-induced insomnia mice.
Journal of ethnopharmacology.
2023 Oct; 319(Pt 3):117331. doi:
10.1016/j.jep.2023.117331. [PMID: 37858748] - Nan Qiao, Qinnan Wang, Ye Tao, Jinna Wu, Yong Fang, Yusheng Ni, Xiaowen Ding. α-Cyperone ameliorates depression in mammary gland hyperplasia and chronic unpredictable mild stress rat by regulating hormone, inflammation, and oxidative stress.
Immunopharmacology and immunotoxicology.
2023 Feb; 45(1):73-82. doi:
10.1080/08923973.2022.2115925. [PMID: 36053011] - Ming Deng, Ping Xie, Junqi Liu, Yan Zhou, Zhonghui Chen, Yonggang Ma, Jianwei Yang. α-Cyperone Improves Rat Spinal Cord Tissue Damage via Akt/Nrf2 and NF-κB Pathways.
The Journal of surgical research.
2022 08; 276(?):331-339. doi:
10.1016/j.jss.2022.02.006. [PMID: 35427911] - Huawei Zhang, Sunlong Li, Jiajie Lu, Jie Jin, Gaosheng Zhu, Libo Wang, Yingzhao Yan, Linjie He, Ben Wang, Xiangyang Wang, Huachen Yu. α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice.
Aging.
2021 07; 13(13):17690-17706. doi:
10.18632/aging.203259. [PMID: 34237707] - Peng Gao, Ning Ding, Jiaxin Lv, Muhammad Noman Ramzan, Qingping Wen. α-Cyperone inhibitory effects on tumor-derived DNA trigger microglia by STING pathway.
Journal of ethnopharmacology.
2021 Jan; 264(?):113246. doi:
10.1016/j.jep.2020.113246. [PMID: 32781257] - Yong Joo Park, Hailing Zheng, Jong Hwan Kwak, Kyu Hyuck Chung. Sesquiterpenes from Cyperus rotundus and 4α,5α-oxidoeudesm-11-en-3-one as a potential selective estrogen receptor modulator.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jan; 109(?):1313-1318. doi:
10.1016/j.biopha.2018.10.186. [PMID: 30551381] - Azam Azimi, Seyed Mahmood Ghaffari, Gholam Hossein Riazi, Seyed Shahriar Arab, Mohammad Mehdi Tavakol, Shahriar Pooyan. α-Cyperone of Cyperus rotundus is an effective candidate for reduction of inflammation by destabilization of microtubule fibers in brain.
Journal of ethnopharmacology.
2016 Dec; 194(?):219-227. doi:
10.1016/j.jep.2016.06.058. [PMID: 27353867] - Seung-Hyun Jung, Su Jung Kim, Bo-Gyu Jun, Kyung-Tae Lee, Seon-Pyo Hong, Myung Sook Oh, Dae Sik Jang, Jung-Hye Choi. α-Cyperone, isolated from the rhizomes of Cyperus rotundus, inhibits LPS-induced COX-2 expression and PGE2 production through the negative regulation of NFκB signalling in RAW 264.7 cells.
Journal of ethnopharmacology.
2013 May; 147(1):208-14. doi:
10.1016/j.jep.2013.02.034. [PMID: 23500883] - Li Liu, Hongyue Ma, Yuping Tang, Wenxing Chen, Yin Lu, Jianming Guo, Jin-Ao Duan. Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.
Bioorganic & medicinal chemistry letters.
2012 Jan; 22(1):154-63. doi:
10.1016/j.bmcl.2011.11.041. [PMID: 22137340]
