Damsin (BioDeep_00000007334)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Azuleno[4,5-b]furan-2,9-dione,decahydro-6,9a-dimethyl-3-methylene-, (3aS,6S,6aS,9aR,9bR)-

化学式: C15H20O3 (248.1412)
中文名称: 二氢豚草素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1C(=O)OC2C1CCC(C)C1CCC(=O)C12C
InChI: InChI=1S/C15H20O3/c1-8-4-5-10-9(2)14(17)18-13(10)15(3)11(8)6-7-12(15)16/h8,10-11,13H,2,4-7H2,1,3H3/t8-,10-,11-,13+,15-/m0/s1

描述信息

同义名列表

4 个代谢物同义名

Azuleno[4,5-b]furan-2,9-dione,decahydro-6,9a-dimethyl-3-methylene-, (3aS,6S,6aS,9aR,9bR)-; Damsin; Damsine; Damsin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

71 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, CCN1, CDK2, EGFR, PTGS1, PTGS2, SCYL1, SP1, STAT3
Peripheral membrane protein 3 GORASP1, PTGS1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 EGFR, PTGS1, PTGS2
Mitochondrion membrane 1 ABCG2
Nucleus 6 CCN1, CDK2, EGFR, SCYL1, SP1, STAT3
cytosol 4 CCN1, CDK2, SCYL1, STAT3
mitochondrial membrane 1 ABCG2
centrosome 3 CCN1, CDK2, SCYL1
nucleoplasm 5 ABCG2, CCN1, CDK2, SP1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 5 ABCB1, ABCB5, ABCG2, EGFR, TNF
Cytoplasmic side 1 GORASP1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 ABCB1, ABCB5, ABCG2
Golgi apparatus membrane 1 GORASP1
cell junction 1 EGFR
cell surface 3 ABCB1, EGFR, TNF
glutamatergic synapse 1 EGFR
Golgi apparatus 3 GORASP1, PTGS1, SCYL1
Golgi membrane 2 EGFR, GORASP1
neuronal cell body 1 TNF
endosome 2 CDK2, EGFR
plasma membrane 6 ABCB1, ABCB5, ABCG2, EGFR, STAT3, TNF
Membrane 5 ABCB1, ABCB5, ABCG2, EGFR, SCYL1
apical plasma membrane 3 ABCB1, ABCG2, EGFR
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 2 ABCB1, PTGS1
endoplasmic reticulum 1 PTGS2
extracellular space 4 CCN1, EGFR, SP1, TNF
perinuclear region of cytoplasm 1 EGFR
protein-containing complex 2 EGFR, PTGS2
intracellular membrane-bounded organelle 1 PTGS1
Microsome membrane 2 PTGS1, PTGS2
Single-pass type I membrane protein 1 EGFR
Secreted 1 SP1
extracellular region 2 SP1, TNF
transcription regulator complex 2 CDK2, STAT3
photoreceptor outer segment 1 PTGS1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 2 CDK2, SCYL1
nuclear membrane 1 EGFR
external side of plasma membrane 1 TNF
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 2 ABCB1, ABCG2
Membrane raft 3 ABCG2, EGFR, TNF
focal adhesion 1 EGFR
cis-Golgi network 2 GORASP1, SCYL1
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 CCN1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 2 PTGS1, PTGS2
chromatin 2 SP1, STAT3
phagocytic cup 1 TNF
brush border membrane 1 ABCG2
chromosome, telomeric region 1 CDK2
nuclear envelope 1 CDK2
Endomembrane system 1 PTGS1
euchromatin 1 SP1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 2 CCN1, PTGS2
transcription repressor complex 1 SP1
male germ cell nucleus 1 CDK2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
COPI vesicle coat 1 SCYL1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
clathrin-coated endocytic vesicle membrane 1 EGFR
Cajal body 1 CDK2
endoplasmic reticulum-Golgi intermediate compartment 1 SCYL1
protein-DNA complex 1 SP1
external side of apical plasma membrane 2 ABCB1, ABCG2
female pronucleus 1 CCN1
male pronucleus 1 CCN1
Golgi apparatus, cis-Golgi network 1 SCYL1
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 2 CCN1, CDK2
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cyclin A2-CDK1 complex 1 CCN1
cyclin A2-CDK2 complex 2 CCN1, CDK2
cyclin A1-CDK2 complex 1 CDK2
[Isoform 6]: Nucleus 1 SCYL1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Daniel Svensson, Maribel Lozano, Giovanna R Almanza, Bengt-Olof Nilsson, Olov Sterner, Rodrigo Villagomez. Sesquiterpene lactones from Ambrosia arborescens Mill. inhibit pro-inflammatory cytokine expression and modulate NF-κB signaling in human skin cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Nov; 50(?):118-126. doi: 10.1016/j.phymed.2018.04.011. [PMID: 30466970]
  • Wendy Soria Sotillo, Rodrigo Villagomez, Sandra Smiljanic, Xiaoli Huang, Atena Malakpour, Sebastian Kempengren, Gloria Rodrigo, Giovanna Almanza, Olov Sterner, Stina Oredsson. Anti-cancer stem cell activity of a sesquiterpene lactone isolated from Ambrosia arborescens and of a synthetic derivative. PloS one. 2017; 12(9):e0184304. doi: 10.1371/journal.pone.0184304. [PMID: 28863191]
  • C L Cantrell, S G Franzblau, N H Fischer. Antimycobacterial plant terpenoids. Planta medica. 2001 Nov; 67(8):685-94. doi: 10.1055/s-2001-18365. [PMID: 11731906]
  • L M Abou Basha, M H el Sayad, A F Allam, M M Osman. The effect of Ambrosia maritima (Damsissa) on the viability of Lymnaea cailliaudi; an experimental study. Journal of the Egyptian Society of Parasitology. 1994 Dec; 24(3):513-7. doi: ". [PMID: 7844416]