Resiniferatoxin (BioDeep_00000007219)

 

Secondary id: BioDeep_00000171797

PANOMIX_OTCML-2023 Volatile Flavor Compounds natural product


代谢物信息卡片


Benzeneacetic acid, 4-hydroxy-3-methoxy-, ((2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno(5,4-e)-1,3-benzodioxol-5-yl)methyl ester

化学式: C37H40O9 (628.2672190000001)
中文名称: 超强辣素, 树脂毒素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 13.04%

分子结构信息

SMILES: C=C(C)C12CC(C)C34OC(Cc5ccccc5)(OC1C3C=C(COC(=O)Cc1cc(O)cc(OC)c1)CC1(O)C(=O)C(C)=CC14)O2
InChI: InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1

描述信息

Resiniferatoxin is a heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1). It has a role as a TRPV1 agonist, a plant metabolite, a neurotoxin and an analgesic. It is a diterpenoid, an ortho ester, a tertiary alpha-hydroxy ketone, a member of phenols, a monomethoxybenzene, an organic heteropentacyclic compound, a carboxylic ester and an enone.
Resiniferatoxin (RTX) is a naturally occurring, ultrapotent capsaicin analog that activates the vanilloid receptor in a subpopulation of primary afferent sensory neurons involved in nociception (the transmission of physiological pain).
Resiniferatoxin is a natural product found in Euphorbia resinifera and Euphorbia unispina with data available.
Resiniferatoxin is a naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons.
A heteropentacyclic compound found in Euphorbia poissonii with molecular formula C37H40O9. It is an agonist of the transient receptor potential cation channel subfamily V member 1 (TrpV1).
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic

同义名列表

29 个代谢物同义名

Benzeneacetic acid, 4-hydroxy-3-methoxy-, ((2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno(5,4-e)-1,3-benzodioxol-5-yl)methyl ester; 4-hydroxy-3-methoxy-benzeneacetic acid, [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]methyl ester; [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-2H,3bH-2,9b-epoxyazuleno[4,5:5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate; [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-benzyl-6a-hydroxy-8,10-dimethyl-7-oxo-11a-(prop-1-en-2-yl)-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[4,5:5,6]benzo[1,2-d][1,3]dioxol-5-yl]methyl (4-hydroxy-3-methoxyphenyl)acetate; 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR) -3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate; [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-2-Benzyl-6a-hydroxy-8,10-dimethyl-11a-(prop-1-en-2-yl)-7-oxo-3a,6,6a,7,9a,10,11,11a-octahydro-3bH-2,9b-epoxyazuleno[5,4-E]-1,3-benzodioxol-5-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate; (4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3aR,5R,5aR,8bR,11aR)-3b-benzyloxy-11a-hydroxy-5a-isopropenyl-2,4-dimethyl-1-oxo-1,3a,3b,4,5,5a,8a,8b,11,11a-decahydro-6,8-dioxa-indeno[5,4-e]azulen-10-ylmethyl ester; [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate; 13-benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-(1R,2S,6R,10S,11R,13S,15R,17R)-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-ylmethyl 2-(4-hydroxy-3-methoxyphenyl)acetate; 13-benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-(1R,2S,6R,10S,11R,15R,17R)-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-ylmethyl 2-(4-hydroxy-3-methoxyphenyl)acetate; 13-benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-(2S,6R,10S,11R,15R,17R)-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-ylmethyl 2-(4-hydroxy-3-methoxyphenyl)acetate; 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)daphnetoxin 20-(3-hydroxy-5-methoxybenzeneacetate); RESINIFERATOXIN [WHO-DD]; Resiniferatoxin [USAN]; RESINIFERATOXIN [INN]; Resiniferatoxin(RTX); [3H]resiniferatoxin; (+)-resiniferatoxin; reciniferatoxin; Resiniferatoxin; UNII-A5O6P1UL4I; resinferatoxin; RTX diterpene; A5O6P1UL4I; MTX-71; Lopain; RTX; [(1R,2R,6R,10S,11R,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-2-methoxyphenyl)acetate; Resiniferatoxin



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lorena M D Cirino, Daviane M C Vergne, Gabrielle B Novais, Amanda Cano, Francine F Padilha, Patrícia Severino, Ricardo L C de Albuquerque Júnior, Juliana C Cardoso, Eliana B Souto. Liposomal formulations of oxybutynin and resiniferatoxin for the treatment of urinary diseases: improvement of drug tolerance upon intravesical. Drug delivery and translational research. 2022 07; 12(7):1738-1752. doi: 10.1007/s13346-021-01082-6. [PMID: 34671947]
  • Isabel Wank, Lisa Kutsche, Silke Kreitz, Peter Reeh, Andreas Hess. Imaging the influence of peripheral TRPV1-signaling on cerebral nociceptive processing applying fMRI-based graph theory in a resiniferatoxin rat model. PloS one. 2022; 17(4):e0266669. doi: 10.1371/journal.pone.0266669. [PMID: 35482725]
  • José Luis Muñoz-Carrillo, Jazmín Monserrat Vargas-Barboza, Paola Trinidad Villalobos-Gutiérrez, Juan Armando Flores-De La Torre, Silverio Jafet Vazquez-Alcaraz, Oscar Gutiérrez-Coronado. Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice. International endodontic journal. 2021 Nov; 54(11):2099-2112. doi: 10.1111/iej.13606. [PMID: 34375451]
  • José Luis Muñoz-Carrillo, Oscar Gutiérrez-Coronado, José Jesús Muñoz-Escobedo, Juan Francisco Contreras-Cordero, Claudia Maldonado-Tapia, María Alejandra Moreno-García. Resiniferatoxin promotes adult worm expulsion in Trichinella spiralis-infected rats by Th2 immune response modulation. Parasite immunology. 2021 08; 43(8):e12840. doi: 10.1111/pim.12840. [PMID: 33914935]
  • Bálint Botz, Gábor Kriszta, Kata Bölcskei, Ádám István Horváth, Attila Mócsai, Zsuzsanna Helyes. Capsaicin-Sensitive Peptidergic Sensory Nerves Are Anti-Inflammatory Gatekeepers in the Hyperacute Phase of a Mouse Rheumatoid Arthritis Model. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041682. [PMID: 33567493]
  • Jing Zou, Xueyang Dong, Ke Wang, Jing Shi, Ning Sun. Electroacupuncture Inhibits Autophagy of Neuron Cells in Postherpetic Neuralgia by Increasing the Expression of miR-223-3p. BioMed research international. 2021; 2021(?):6637693. doi: 10.1155/2021/6637693. [PMID: 33860046]
  • Chieh-Hsin Wu, Ming-Kung Wu, Chun-Ching Lu, Hung-Pei Tsai, Ying-Yi Lu, Chih-Lung Lin. Impact of Hepatoma-Derived Growth Factor Blockade on Resiniferatoxin-Induced Neuropathy. Neural plasticity. 2021; 2021(?):8854461. doi: 10.1155/2021/8854461. [PMID: 33727914]
  • Paramita Basu, Elizabeth Meza, Michael Bergel, Camelia Maier. Estrogenic, Antiestrogenic and Antiproliferative Activities of Euphorbia bicolor (Euphorbiaceae) Latex Extracts and Its Phytochemicals. Nutrients. 2019 Dec; 12(1):. doi: 10.3390/nu12010059. [PMID: 31881661]
  • Mingmin Zhou, Yu Liu, Yan He, Ke Xie, Dajun Quan, Yanhong Tang, He Huang, Congxin Huang. Selective chemical ablation of transient receptor potential vanilloid 1 expressing neurons in the left stellate ganglion protects against ischemia-induced ventricular arrhythmias in dogs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Dec; 120(?):109500. doi: 10.1016/j.biopha.2019.109500. [PMID: 31600641]
  • Jing Zou, Xueyang Dong, Yanling Li, Siqi Tong, Jingwen Wang, Mingxuan Liao, Guofu Huang. Deep Sequencing Identification of Differentially Expressed miRNAs in the Spinal Cord of Resiniferatoxin-Treated Rats in Response to Electroacupuncture. Neurotoxicity research. 2019 Aug; 36(2):387-395. doi: 10.1007/s12640-019-00052-8. [PMID: 31124075]
  • Lejla Zubcevic, Allen L Hsu, Mario J Borgnia, Seok-Yong Lee. Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. eLife. 2019 05; 8(?):. doi: 10.7554/elife.45779. [PMID: 31090543]
  • Purnendu K Sharma, Bharathi Avula, Apoorva Panda, Yan-Hong Wang, Ikhlas A Khan, S Narasimha Murthy. A sensitive bioanalytical method for quantitative determination of resiniferatoxin in rat plasma using ultra-high performance liquid chromatography coupled to tandem mass spectrometry and its application in pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 165(?):284-291. doi: 10.1016/j.jpba.2018.12.024. [PMID: 30576973]
  • Gabriela Adamante, Amanda Spring de Almeida, Flávia Karine Rigo, Edinara da Silva Silveira, Yanka Oliveira Coelho, Samira Dal-Toé De Prá, Alessandra Marcone Milioli, Camila Camponogara, Rosana Casoti, Fernando Bellinaso, Alexandre Vinhal Desideri, Mario Ferreira Conceição Santos, Juliano Ferreira, Sara Marchesan Oliveira, Gabriela Trevisan. Diosmetin as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive activity in mice. Life sciences. 2019 Jan; 216(?):215-226. doi: 10.1016/j.lfs.2018.11.029. [PMID: 30447303]
  • Ádám Horváth, Éva Borbély, Kata Bölcskei, Nikolett Szentes, Tamás Kiss, Mátyás Belák, Tibor Rauch, Tibor Glant, Róza Zákány, Tamás Juhász, Edina Karanyicz, Ferenc Boldizsár, Zsuzsanna Helyes, Bálint Botz. Regulatory role of capsaicin-sensitive peptidergic sensory nerves in the proteoglycan-induced autoimmune arthritis model of the mouse. Journal of neuroinflammation. 2018 Dec; 15(1):335. doi: 10.1186/s12974-018-1364-5. [PMID: 30509328]
  • Shuang-Quan Yu, Shuangtao Ma, Donna H Wang. Selective ablation of TRPV1 by intrathecal injection of resiniferatoxin in rats increases renal sympathoexcitatory responses and salt sensitivity. Hypertension research : official journal of the Japanese Society of Hypertension. 2018 Sep; 41(9):679-690. doi: 10.1038/s41440-018-0073-x. [PMID: 30006640]
  • Bihong Hong, Jipeng Sun, Hongzhi Zheng, Qingqing Le, Changsen Wang, Kaikai Bai, Jianlin He, Huanghuang He, Yanming Dong. Effect of Tetrodotoxin Pellets in a Rat Model of Postherpetic Neuralgia. Marine drugs. 2018 Jun; 16(6):. doi: 10.3390/md16060195. [PMID: 29874779]
  • J L Muñoz-Carrillo, J F Contreras-Cordero, J L Muñoz-López, C H Maldonado-Tapia, J J Muñoz-Escobedo, M A Moreno-García. Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection. Parasite immunology. 2017 Sep; 39(9):. doi: 10.1111/pim.12448. [PMID: 28580764]
  • Nima Ghitani, Arnab Barik, Marcin Szczot, James H Thompson, Chia Li, Claire E Le Pichon, Michael J Krashes, Alexander T Chesler. Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair Pull. Neuron. 2017 Aug; 95(4):944-954.e4. doi: 10.1016/j.neuron.2017.07.024. [PMID: 28817806]
  • Yong Zhu, Qingqi Zeng. Re: Resiniferatoxin for treatment of lifelong premature ejaculation: A preliminary study. International journal of urology : official journal of the Japanese Urological Association. 2017 03; 24(3):243-244. doi: 10.1111/iju.13283. [PMID: 28208208]
  • Samira Dal Toé De Prá, Paula Ronsani Ferro, Alessandra Marcon Milioli, Flávia Karine Rigo, Orlando Justo Chipindo, Camila Camponogara, Rosana Casoti, Melânia Palermo Manfron, Sara Marchesan de Oliveira, Juliano Ferreira, Gabriela Trevisan. Antinociceptive activity and mechanism of action of hydroalcoholic extract and dichloromethane fraction of Amphilophium crucigerum seeds in mice. Journal of ethnopharmacology. 2017 Jan; 195(?):283-297. doi: 10.1016/j.jep.2016.11.032. [PMID: 27864110]
  • László Pecze, Walter Blum, Thomas Henzi, Beat Schwaller. Endogenous TRPV1 stimulation leads to the activation of the inositol phospholipid pathway necessary for sustained Ca2+ oscillations. Biochimica et biophysica acta. 2016 12; 1863(12):2905-2915. doi: 10.1016/j.bbamcr.2016.09.013. [PMID: 27663071]
  • Jessica A Fawley, Mackenzie E Hofmann, Michael C Andresen. Distinct Calcium Sources Support Multiple Modes of Synaptic Release from Cranial Sensory Afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016 08; 36(34):8957-66. doi: 10.1523/jneurosci.1028-16.2016. [PMID: 27559176]
  • Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada. Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder. Journal of pharmacological sciences. 2016 May; 131(1):58-63. doi: 10.1016/j.jphs.2016.04.020. [PMID: 27174863]
  • Éva Borbély, Bálint Botz, Kata Bölcskei, Tibor Kenyér, László Kereskai, Tamás Kiss, János Szolcsányi, Erika Pintér, Janka Zsófia Csepregi, Attila Mócsai, Zsuzsanna Helyes. Capsaicin-sensitive sensory nerves exert complex regulatory functions in the serum-transfer mouse model of autoimmune arthritis. Brain, behavior, and immunity. 2015 Mar; 45(?):50-9. doi: 10.1016/j.bbi.2014.12.012. [PMID: 25524130]
  • Zhen Shi, Shu-jun Jiang, Gui-hua Wang, Ai-li Xu, Li Guo. Pro-inflammatory cytokines in paraventricular nucleus mediate the cardiac sympathetic afferent reflex in hypertension. Autonomic neuroscience : basic & clinical. 2014 Dec; 186(?):54-61. doi: 10.1016/j.autneu.2014.10.001. [PMID: 25454581]
  • Arlene Weintraub. Prickly painkiller: An experimental plant extract may end intractable pain with a single injection. Scientific American. 2013 Jul; 309(1):14. doi: 10.1038/scientificamerican0713-14. [PMID: 23821854]
  • Viola Spahn, Oliver Fischer, Jeannette Endres-Becker, Michael Schäfer, Christoph Stein, Christian Zöllner. Opioid withdrawal increases transient receptor potential vanilloid 1 activity in a protein kinase A-dependent manner. Pain. 2013 Apr; 154(4):598-608. doi: 10.1016/j.pain.2012.12.026. [PMID: 23398938]
  • Hitoshi Yokoyama, Tomohiko Oguchi, William F Goins, James R Goss, Osamu Nishizawa, William C de Groat, Darren Wolfe, David M Krisky, Joseph C Glorioso, Naoki Yoshimura. Effects of herpes simplex virus vector-mediated enkephalin gene therapy on bladder overactivity and nociception. Human gene therapy. 2013 Feb; 24(2):170-80. doi: 10.1089/hum.2011.180. [PMID: 23316929]
  • Gabriela Trevisan, Mateus Fortes Rossato, Cristiani Isabel Banderó Walker, Jonatas Zeni Klafke, Fernanda Rosa, Sara Marchesan Oliveira, Raquel Tonello, Gustavo Petri Guerra, Aline Augusti Boligon, Ricardo Basso Zanon, Margareth Linde Athayde, Juliano Ferreira. Identification of the plant steroid α-spinasterol as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. The Journal of pharmacology and experimental therapeutics. 2012 Nov; 343(2):258-69. doi: 10.1124/jpet.112.195909. [PMID: 22837009]
  • Xiao-Qing Xiong, Wei-Wei Chen, Ying Han, Ye-Bo Zhou, Feng Zhang, Xing-Ya Gao, Guo-Qing Zhu. Enhanced adipose afferent reflex contributes to sympathetic activation in diet-induced obesity hypertension. Hypertension (Dallas, Tex. : 1979). 2012 Nov; 60(5):1280-6. doi: 10.1161/hypertensionaha.112.198002. [PMID: 23033372]
  • Satoru Yoshikawa, Tomohiko Oguchi, Yasuhito Funahashi, William C de Groat, Naoki Yoshimura. Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. European urology. 2012 Oct; 62(4):704-12. doi: 10.1016/j.eururo.2012.01.044. [PMID: 22341128]
  • Lei Zhang, Xiao-Qing Xiong, Zhi-Dan Fan, Xian-Bing Gan, Xing-Ya Gao, Guo-Qing Zhu. Involvement of enhanced cardiac sympathetic afferent reflex in sympathetic activation in early stage of diabetes. Journal of applied physiology (Bethesda, Md. : 1985). 2012 Jul; 113(1):47-55. doi: 10.1152/japplphysiol.01228.2011. [PMID: 22582215]
  • Chun-Mei Xia, Melisa A Gulick, Sharon J Yu, John R Grider, Karnam S Murthy, John F Kuemmerle, Hamid I Akbarali, Li-Ya Qiao. Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat. Journal of neuroinflammation. 2012 Feb; 9(?):30. doi: 10.1186/1742-2094-9-30. [PMID: 22335898]
  • Liqun Ma, Jian Zhong, Zhigang Zhao, Zhidan Luo, Shuangtao Ma, Jing Sun, Hongbo He, Tianqi Zhu, Daoyan Liu, Zhiming Zhu, Martin Tepel. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovascular research. 2011 Dec; 92(3):504-13. doi: 10.1093/cvr/cvr245. [PMID: 21908651]
  • Matthias A Engel, Andreas Leffler, Florian Niedermirtl, Alexandru Babes, Katharina Zimmermann, Miloš R Filipović, Iwona Izydorczyk, Mirjam Eberhardt, Tatjana I Kichko, Sonja M Mueller-Tribbensee, Mohammad Khalil, Norbert Siklosi, Carla Nau, Ivana Ivanović-Burmazović, Winfried L Neuhuber, Christoph Becker, Markus F Neurath, Peter W Reeh. TRPA1 and substance P mediate colitis in mice. Gastroenterology. 2011 Oct; 141(4):1346-58. doi: 10.1053/j.gastro.2011.07.002. [PMID: 21763243]
  • Daniel Ursu, Kelly Knopp, Ruth E Beattie, Bin Liu, Emanuele Sher. Pungency of TRPV1 agonists is directly correlated with kinetics of receptor activation and lipophilicity. European journal of pharmacology. 2010 Sep; 641(2-3):114-22. doi: 10.1016/j.ejphar.2010.05.029. [PMID: 20576527]
  • Santosh K Mishra, Mark A Hoon. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Molecular and cellular neurosciences. 2010 Jan; 43(1):157-63. doi: 10.1016/j.mcn.2009.10.006. [PMID: 19853036]
  • Hao Sun, De-Pei Li, Shao-Rui Chen, Walter N Hittelman, Hui-Lin Pan. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. The Journal of pharmacology and experimental therapeutics. 2009 Dec; 331(3):851-9. doi: 10.1124/jpet.109.160473. [PMID: 19726694]
  • Shyang Chang, Shiun-Jeng Li, Shih-Jen Hu, Hsiu-Yao Cheng, Sheng-Hwu Hsieh, Chen-Li Cheng. Dynamic performance evaluation on the synergy of micturition in spinal cord-injured female rats under pharmacological effects. The Chinese journal of physiology. 2009 Apr; 52(2):81-92. doi: NULL. [PMID: 19764343]
  • Joel Castro, Edoardo C Aromataris, Grigori Y Rychkov, Greg J Barritt. A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid. The Biochemical journal. 2009 Mar; 418(3):553-66. doi: 10.1042/bj20081052. [PMID: 19007332]
  • Hyun-Kyung Choi, Sun Choi, Yoonji Lee, Dong Wook Kang, HyungChul Ryu, Han-Joo Maeng, Suk-Jae Chung, Vladimir A Pavlyukovets, Larry V Pearce, Attila Toth, Richard Tran, Yun Wang, Matthew A Morgan, Peter M Blumberg, Jeewoo Lee. Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorganic & medicinal chemistry. 2009 Jan; 17(2):690-8. doi: 10.1016/j.bmc.2008.11.085. [PMID: 19135377]
  • Hong-Yi Zhou, Shao-Rui Chen, Hong Chen, Hui-Lin Pan. Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. The Journal of pharmacology and experimental therapeutics. 2008 Nov; 327(2):375-82. doi: 10.1124/jpet.108.141226. [PMID: 18669865]
  • M D Noble, J Romac, S R Vigna, R A Liddle. A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. Gut. 2008 Nov; 57(11):1566-71. doi: 10.1136/gut.2008.148551. [PMID: 18625695]
  • Kyoko Ueda, Fumio Tsuji, Tomoko Hirata, Masanori Takaoka, Yasuo Matsumura. Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats. Journal of cardiovascular pharmacology. 2008 May; 51(5):513-20. doi: 10.1097/fjc.0b013e31816f6884. [PMID: 18460982]
  • Irina Vetter, Bruce D Wyse, Sarah J Roberts-Thomson, Gregory R Monteith, Peter J Cabot. Mechanisms involved in potentiation of transient receptor potential vanilloid 1 responses by ethanol. European journal of pain (London, England). 2008 May; 12(4):441-54. doi: 10.1016/j.ejpain.2007.07.001. [PMID: 17826200]
  • Nan-Hsiung Feng, Hsang-Hsing Lee, Jeng-Chaun Shiang, Ming-Chieh Ma. Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys. American journal of physiology. Renal physiology. 2008 Feb; 294(2):F316-25. doi: 10.1152/ajprenal.00308.2007. [PMID: 18032552]
  • Chikashi Saitoh, Michael B Chancellor, William C de Groat, Naoki Yoshimura. Effects of intravesical instillation of resiniferatoxin on bladder function and nociceptive behavior in freely moving, conscious rats. The Journal of urology. 2008 Jan; 179(1):359-64. doi: 10.1016/j.juro.2007.08.090. [PMID: 18006008]
  • José A Matta, Gerard P Ahern. Voltage is a partial activator of rat thermosensitive TRP channels. The Journal of physiology. 2007 Dec; 585(Pt 2):469-82. doi: 10.1113/jphysiol.2007.144287. [PMID: 17932142]
  • T E Dawson, J Jamison. Intravesical treatments for painful bladder syndrome/ interstitial cystitis. The Cochrane database of systematic reviews. 2007 Oct; ?(4):CD006113. doi: 10.1002/14651858.cd006113.pub2. [PMID: 17943887]
  • Z Helyes, G Pozsgai, R Börzsei, J Németh, T Bagoly, L Márk, E Pintér, G Tóth, K Elekes, J Szolcsányi, D Reglodi. Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat. Peptides. 2007 Sep; 28(9):1847-55. doi: 10.1016/j.peptides.2007.07.001. [PMID: 17698245]
  • Karen C Thomas, Ashwini S Sabnis, Mark E Johansen, Diane L Lanza, Philip J Moos, Garold S Yost, Christopher A Reilly. Transient receptor potential vanilloid 1 agonists cause endoplasmic reticulum stress and cell death in human lung cells. The Journal of pharmacology and experimental therapeutics. 2007 Jun; 321(3):830-8. doi: 10.1124/jpet.107.119412. [PMID: 17332266]
  • Dorte X Gram, Bo Ahrén, Istvan Nagy, Uffe B Olsen, Christian L Brand, Frank Sundler, René Tabanera, Ove Svendsen, Richard D Carr, Peter Santha, Nils Wierup, Anker J Hansen. Capsaicin-sensitive sensory fibers in the islets of Langerhans contribute to defective insulin secretion in Zucker diabetic rat, an animal model for some aspects of human type 2 diabetes. The European journal of neuroscience. 2007 Jan; 25(1):213-23. doi: 10.1111/j.1460-9568.2006.05261.x. [PMID: 17241282]
  • Wilian M Mattos, Juliano Ferreira, Graziela P Richetti, Rivaldo Niero, Rosendo A Yunes, João B Calixto. Antinociceptive properties produced by the pregnane compound velutinol A isolated from Mandevilla velutina. Neuropeptides. 2006 Apr; 40(2):125-32. doi: 10.1016/j.npep.2005.12.001. [PMID: 16494941]
  • Xiaoyang Zhang, Osamu Ishizuka, Tomoaki Tanabe, Tomoya Satoh, Tsuyoshi Nakayama, Tetsuya Imamura, Osamu Nishizawa. Effects of goshajinkigan (niu-che-sen-qi-wan) for resiniferatoxin-sensitive afferents on detrusor overactivity induced by acetic acid in conscious rats. The American journal of Chinese medicine. 2006; 34(2):285-93. doi: 10.1142/s0192415x06003837. [PMID: 16552839]
  • Charles Marwick. Researchers investigate potential use of plant as a pain killer. BMJ (Clinical research ed.). 2005 Nov; 331(7525):1104. doi: 10.1136/bmj.331.7525.1104-c. [PMID: 16282403]
  • Andrew J Mannes, Dorothy Cimino Brown, Jason Keller, Lauren Cordes, Roderic G Eckenhoff, Robert M Caudle, Michael J Iadarola, Qing C Meng. Measurement of resiniferatoxin in serum samples by high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Sep; 823(2):184-8. doi: 10.1016/j.jchromb.2005.06.042. [PMID: 16039169]
  • Tony Y H Chen, Jacques Corcos, Michel Camel, Yves Ponsot, Le Mai Tu. Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC). International urogynecology journal and pelvic floor dysfunction. 2005 Jul; 16(4):293-7. doi: 10.1007/s00192-005-1307-4. [PMID: 15818465]
  • Sophia G Moesgaard, Christian L Brand, Jeppe Sturis, Bo Ahrén, Michael Wilken, Jan Fleckner, Richard D Carr, Ove Svendsen, Anker J Hansen, Dorte X Gram. Sensory nerve inactivation by resiniferatoxin improves insulin sensitivity in male obese Zucker rats. American journal of physiology. Endocrinology and metabolism. 2005 Jun; 288(6):E1137-45. doi: 10.1152/ajpendo.00356.2004. [PMID: 15883192]
  • Sigrid E Myrdal, Peter S Steyger. TRPV1 regulators mediate gentamicin penetration of cultured kidney cells. Hearing research. 2005 Jun; 204(1-2):170-82. doi: 10.1016/j.heares.2005.02.005. [PMID: 15925202]
  • Dorte X Gram, Anker J Hansen, Carolyn F Deacon, Christian L Brand, Ulla Ribel, Michael Wilken, Richard D Carr, Ove Svendsen, Bo Ahrén. Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV. European journal of pharmacology. 2005 Feb; 509(2-3):211-7. doi: 10.1016/j.ejphar.2004.12.039. [PMID: 15733558]
  • Frankie H M Cheng, Paul L R Andrews, Benoit Moreaux, Man-P Ngan, John A Rudd, Tasia S W Sam, Man-K Wai, Christina Wan. Evaluation of the anti-emetic potential of anti-migraine drugs to prevent resiniferatoxin-induced emesis in Suncus murinus (house musk shrew). European journal of pharmacology. 2005 Jan; 508(1-3):231-8. doi: 10.1016/j.ejphar.2004.12.022. [PMID: 15680276]
  • Tomasz Brzozowski, Peter C Konturek, Stanislaw J Konturek, Robert Pajdo, Slawomir Kwiecien, Michal Pawlik, Danuta Drozdowicz, Zbigniew Sliwowski, Wieslaw W Pawlik. Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves. European journal of pharmacology. 2004 Sep; 499(1-2):201-13. doi: 10.1016/j.ejphar.2004.07.072. [PMID: 15363968]
  • Larry V Pearce, Pavel A Petukhov, Tamas Szabo, Noemi Kedei, Fero Bizik, Alan P Kozikowski, Peter M Blumberg. Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Organic & biomolecular chemistry. 2004 Aug; 2(16):2281-6. doi: 10.1039/b404506h. [PMID: 15305207]
  • Patries M Herst, An S Tan, Debbie-Jane G Scarlett, Michael V Berridge. Cell surface oxygen consumption by mitochondrial gene knockout cells. Biochimica et biophysica acta. 2004 Jun; 1656(2-3):79-87. doi: 10.1016/j.bbabio.2004.01.008. [PMID: 15178469]
  • Zsuzsanna Helyes, Arpád Szabó, József Németh, Balázs Jakab, Erika Pintér, Agnes Bánvölgyi, László Kereskai, György Kéri, János Szolcsányi. Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund's adjuvant-induced chronic arthritis model in the rat. Arthritis and rheumatism. 2004 May; 50(5):1677-85. doi: 10.1002/art.20184. [PMID: 15146439]
  • R John Aitken, Angela L Ryan, Mark A Baker, Eileen A McLaughlin. Redox activity associated with the maturation and capacitation of mammalian spermatozoa. Free radical biology & medicine. 2004 Apr; 36(8):994-1010. doi: 10.1016/j.freeradbiomed.2004.01.017. [PMID: 15059640]
  • Preeti Puntambekar, Jeremy Van Buren, Manish Raisinghani, Louis S Premkumar, Vickram Ramkumar. Direct interaction of adenosine with the TRPV1 channel protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Apr; 24(14):3663-71. doi: 10.1523/jneurosci.4773-03.2004. [PMID: 15071115]
  • Massimo Lazzeri, Michele Spinelli, Alberto Zanollo, Damiano Turini. Intravesical vanilloids and neurogenic incontinence: ten years experience. Urologia internationalis. 2004; 72(2):145-9. doi: 10.1159/000075969. [PMID: 14963356]
  • Robert M Caudle, Laszlo Karai, Narasaiah Mena, Brian Y Cooper, Andrew J Mannes, Federico M Perez, Michael J Iadarola, Zoltan Olah. Resiniferatoxin-induced loss of plasma membrane in vanilloid receptor expressing cells. Neurotoxicology. 2003 Dec; 24(6):895-908. doi: 10.1016/s0161-813x(03)00146-3. [PMID: 14637384]
  • Zsuzsanna Helyes, József Németh, Márta Thán, Kata Bölcskei, Erika Pintér, János Szolcsányi. Inhibitory effect of anandamide on resiniferatoxin-induced sensory neuropeptide release in vivo and neuropathic hyperalgesia in the rat. Life sciences. 2003 Sep; 73(18):2345-53. doi: 10.1016/s0024-3205(03)00651-9. [PMID: 12941436]
  • Matthew R Zahner, De-Pei Li, Shao-Rui Chen, Hui-Lin Pan. Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. The Journal of physiology. 2003 Sep; 551(Pt 2):515-23. doi: 10.1113/jphysiol.2003.048207. [PMID: 12829722]
  • Hann-chorng Kuo. Effectiveness of intravesical resiniferatoxin for anticholinergic treatment refractory detrusor overactivity due to nonspinal cord lesions. The Journal of urology. 2003 Sep; 170(3):835-9. doi: 10.1097/01.ju.0000081652.31524.27. [PMID: 12913711]
  • Vivek Kumar, Lucy Templeman, Christopher R Chapple, Russell Chess-Williams. Recent developments in the management of detrusor overactivity. Current opinion in urology. 2003 Jul; 13(4):285-91. doi: 10.1097/00042307-200307000-00004. [PMID: 12811292]
  • Numsen Hail, Reuben Lotan. Examining the role of mitochondrial respiration in vanilloid-induced apoptosis. Journal of the National Cancer Institute. 2002 Sep; 94(17):1281-92. doi: 10.1093/jnci/94.17.1281. [PMID: 12208893]
  • Elfrida R Grant, Adrienne E Dubin, Sui-Po Zhang, Robert A Zivin, Zhong Zhong. Simultaneous intracellular calcium and sodium flux imaging in human vanilloid receptor 1 (VR1)-transfected human embryonic kidney cells: a method to resolve ionic dependence of VR1-mediated cell death. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):9-17. doi: 10.1124/jpet.300.1.9. [PMID: 11752091]
  • A Avelino, C Cruz, I Nagy, F Cruz. Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience. 2002; 109(4):787-98. doi: 10.1016/s0306-4522(01)00496-1. [PMID: 11927161]
  • L De Petrocellis, J B Davis, V Di Marzo. Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. FEBS letters. 2001 Oct; 506(3):253-6. doi: 10.1016/s0014-5793(01)02934-9. [PMID: 11602256]
  • S Tsutsumi, A Tomioka, M Sudo, A Nakamura, K Shirakura, K Takagishi, K Kohama. Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells. Neuroscience letters. 2001 Oct; 312(1):45-9. doi: 10.1016/s0304-3940(01)02185-1. [PMID: 11578842]
  • D Smart, J C Jerman, M J Gunthorpe, S J Brough, J Ranson, W Cairns, P D Hayes, A D Randall, J B Davis. Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology. European journal of pharmacology. 2001 Apr; 417(1-2):51-8. doi: 10.1016/s0014-2999(01)00901-3. [PMID: 11301059]
  • J S Shin, M H Wang, S W Hwang, H Cho, S Y Cho, M J Kwon, S Y Lee, U Oh. Differences in sensitivity of vanilloid receptor 1 transfected to human embryonic kidney cells and capsaicin-activated channels in cultured rat dorsal root ganglion neurons to capsaicin receptor agonists. Neuroscience letters. 2001 Feb; 299(1-2):135-9. doi: 10.1016/s0304-3940(00)01777-8. [PMID: 11166956]
  • P Wahl, C Foged, S Tullin, C Thomsen. Iodo-resiniferatoxin, a new potent vanilloid receptor antagonist. Molecular pharmacology. 2001 Jan; 59(1):9-15. doi: 10.1124/mol.59.1.9. [PMID: 11125018]
  • A Szallasi. Vanilloid receptor ligands: hopes and realities for the future. Drugs & aging. 2001; 18(8):561-73. doi: 10.2165/00002512-200118080-00001. [PMID: 11587243]
  • A Szallasi, V Di Marzo. New perspectives on enigmatic vanilloid receptors. Trends in neurosciences. 2000 Oct; 23(10):491-7. doi: 10.1016/s0166-2236(00)01630-1. [PMID: 11006466]
  • L Jasmin, G Janni, P T Ohara, S D Rabkin. CNS induced neurogenic cystitis is associated with bladder mast cell degranulation in the rat. The Journal of urology. 2000 Sep; 164(3 Pt 1):852-5. doi: 10.1097/00005392-200009010-00061. [PMID: 10953167]
  • C J Fowler. Intravesical treatment of overactive bladder. Urology. 2000 May; 55(5A Suppl):60-4; discussion 66. doi: 10.1016/s0090-4295(99)00498-7. [PMID: 10767456]
  • A Szallasi, P M Blumberg, L L Annicelli, J E Krause, D N Cortright. The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Molecular pharmacology. 1999 Sep; 56(3):581-7. doi: 10.1124/mol.56.3.581. [PMID: 10462546]
  • B Peitl, G Pethô, R Pórszász, J Németh, J Szolcsányi. Capsaicin-insensitive sensory-efferent meningeal vasodilatation evoked by electrical stimulation of trigeminal nerve fibres in the rat. British journal of pharmacology. 1999 May; 127(2):457-67. doi: 10.1038/sj.bjp.0702561. [PMID: 10385246]
  • M Lazzeri, M Spinelli, P Beneforti, A Zanollo, D Turini. Intravesical resiniferatoxin for the treatment of detrusor hyperreflexia refractory to capsaicin in patients with chronic spinal cord diseases. Scandinavian journal of urology and nephrology. 1998 Sep; 32(5):331-4. doi: 10.1080/003655998750015287. [PMID: 9825395]
  • A Macho, M V Blázquez, P Navas, E Muñoz. Induction of apoptosis by vanilloid compounds does not require de novo gene transcription and activator protein 1 activity. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1998 Mar; 9(3):277-86. doi: . [PMID: 9580328]
  • M Lazzeri, P Beneforti, D Turini. Urodynamic effects of intravesical resiniferatoxin in humans: preliminary results in stable and unstable detrusor. The Journal of urology. 1997 Dec; 158(6):2093-6. doi: 10.1016/s0022-5347(01)68164-3. [PMID: 9366319]
  • J A Davies, V L Buchman, O Krylova, N N Ninkina. Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules. FEBS letters. 1997 Jun; 410(2-3):378-82. doi: 10.1016/s0014-5793(97)00614-5. [PMID: 9237666]
  • G Appendino, A Szallasi. Euphorbium: modern research on its active principle, resiniferatoxin, revives an ancient medicine. Life sciences. 1997; 60(10):681-96. doi: 10.1016/s0024-3205(96)00567-x. [PMID: 9064473]
  • E J Wolvetang, J A Larm, P Moutsoulas, A Lawen. Apoptosis induced by inhibitors of the plasma membrane NADH-oxidase involves Bcl-2 and calcineurin. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. 1996 Oct; 7(10):1315-25. doi: . [PMID: 8891335]
  • J Rinder, A Szallasi, J M Lundberg. Capsaicin-, resiniferatoxin-, and lactic acid-evoked vascular effects in the pig nasal mucosa in vivo with reference to characterization of the vanilloid receptor. Pharmacology & toxicology. 1996 May; 78(5):327-35. doi: 10.1111/j.1600-0773.1996.tb01384.x. [PMID: 8737969]
  • F D Tattersall, W Rycroft, B Francis, D Pearce, K Merchant, A M MacLeod, T Ladduwahetty, L Keown, C Swain, R Baker, M Cascieri, E Ber, J Metzger, D E MacIntyre, R G Hill, R J Hargreaves. Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 1996; 35(8):1121-9. doi: 10.1016/s0028-3908(96)00020-2. [PMID: 9121615]
  • A M Feigin, E V Aronov, B P Bryant, J H Teeter, J G Brand. Capsaicin and its analogs induce ion channels in planar lipid bilayers. Neuroreport. 1995 Nov; 6(16):2134-6. doi: 10.1097/00001756-199511000-00009. [PMID: 8595187]
  • J S Harvey, C Davis, I F James, G M Burgess. Activation of protein kinase C by the capsaicin analogue resiniferatoxin in sensory neurones. Journal of neurochemistry. 1995 Sep; 65(3):1309-17. doi: 10.1046/j.1471-4159.1995.65031309.x. [PMID: 7643108]
  • A Szallasi. Autoradiographic visualization and pharmacological characterization of vanilloid (capsaicin) receptors in several species, including man. Acta physiologica Scandinavica. Supplementum. 1995; 629(?):1-68. doi: . [PMID: 8801775]
  • C S Walpole, S Bevan, G Bovermann, J J Boelsterli, R Breckenridge, J W Davies, G A Hughes, I James, L Oberer, J Winter. The discovery of capsazepine, the first competitive antagonist of the sensory neuron excitants capsaicin and resiniferatoxin. Journal of medicinal chemistry. 1994 Jun; 37(13):1942-54. doi: 10.1021/jm00039a006. [PMID: 8027976]