Jatrophon (BioDeep_00000007182)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Jatrophone

化学式: C20H24O3 (312.1725354)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CC1=CC2=CC(C)CC23OC(=C(C)C3=O)CC(C)(C)C=CC1=O
InChI: InChI=1S/C20H24O3/c1-12-8-15-9-13(2)16(21)6-7-19(4,5)11-17-14(3)18(22)20(15,10-12)23-17/h6-9,12H,10-11H2,1-5H3/b7-6+,13-9-/t12-,20+/m0/s1

描述信息

同义名列表

2 个代谢物同义名

Jatrophon; Jatrophone



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Chun-Yan Zhang, Li-Jun Zhang, Zhi-Cheng Lu, Chen-Yun Ma, Ying Ye, Khalid Rahman, Hong Zhang, Jian-Yong Zhu. Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells. Journal of natural products. 2018 08; 81(8):1701-1710. doi: 10.1021/acs.jnatprod.7b01036. [PMID: 30106289]
  • Janaina Kieling Fröhlich, Taciane Stein, Layzon Antônio da Silva, Maique Weber Biavatti, Carlos Rogério Tonussi, Elenara Lemos-Senna. Antinociceptive and anti-inflammatory activities of the Jatropha isabellei dichloromethane fraction and isolation and quantitative determination of jatrophone by UFLC-DAD. Pharmaceutical biology. 2017 Dec; 55(1):1215-1222. doi: 10.1080/13880209.2017.1295999. [PMID: 28249559]
  • Iram Fatima, Ikbale El-Ayachi, Ling Taotao, M Angeles Lillo, Raisa I Krutilina, Tiffany N Seagroves, Tomasz W Radaszkiewicz, Miroslav Hutnan, Vitezslav Bryja, Susan A Krum, Fatima Rivas, Gustavo A Miranda-Carboni. The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer. PloS one. 2017; 12(12):e0189864. doi: 10.1371/journal.pone.0189864. [PMID: 29281678]
  • Di Geng, Li-Tao Yi, Yao Shi, Zhi-Da Min. Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia. Chinese journal of natural medicines. 2015 Sep; 13(9):704-6. doi: 10.1016/s1875-5364(15)30069-8. [PMID: 26412431]
  • Lucia Helena Martini, Fernanda Jung, Felix Antunes Soares, Liane Nanci Rotta, Deusa Aparecida Vendite, Marcos Emilio dos Santos Frizzo, Rosendo A Yunes, João Batista Calixto, Susana Wofchuk, Diogo O Souza. Naturally occurring compounds affect glutamatergic neurotransmission in rat brain. Neurochemical research. 2007 Nov; 32(11):1950-6. doi: 10.1007/s11064-007-9393-y. [PMID: 17577666]
  • Noélia Duarte, Maria-José U Ferreira. Lagaspholones A and B: two new jatropholane-type diterpenes from Euphorbia lagascae. Organic letters. 2007 Feb; 9(3):489-92. doi: 10.1021/ol062854f. [PMID: 17249794]
  • Wen Zhang, Yue-Wei Guo. Three new jatrophone-type diterpenoids from Euphorbia helioscopia. Planta medica. 2005 Mar; 71(3):283-6. doi: 10.1055/s-2005-837832. [PMID: 15770554]
  • Samir A M Abdelgaleil, Ahmed F el-Aswad, Munehiro Nakatani. Molluscicidal and anti-feedant activities of diterpenes from Euphorbia paralias L. Pest management science. 2002 May; 58(5):479-82. doi: 10.1002/ps.487. [PMID: 11997975]
  • A F dos Santos, A E Sant'Ana. Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated from Jatropha elliptica (Pohl) Muell. Arg. Phytotherapy research : PTR. 1999 Dec; 13(8):660-4. doi: . [PMID: 10594934]
  • J B Calixto, A E Sant'ana. Evidence for the mechanism of the inhibitory action of jatrophone in the isolated rat uterine muscle. General pharmacology. 1990; 21(1):117-22. doi: 10.1016/0306-3623(90)90605-l. [PMID: 1688818]
  • S M Kupchan, C W Sigel, M J Matz, C J Gilmore, R F Bryan. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitor. Journal of the American Chemical Society. 1976 Apr; 98(8):2295-2300. doi: 10.1021/ja00424a050. [PMID: 1254866]
  • J R Lillehaug, K Kleppe, C W Sigel, S M Kupchan. Reaction of biological thiols with the tumor inhibitor jatrophone. Inhibition of RNA polymerase. Biochimica et biophysica acta. 1973 Nov; 327(1):92-100. doi: 10.1016/0005-2744(73)90106-x. [PMID: 4589016]