tingenone (BioDeep_00000006892)

 

Secondary id: BioDeep_00000422457, BioDeep_00001870068

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(6aR,6bR,8aS,11R,12aR,14aR)-3-hydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-quinone

化学式: C28H36O3 (420.2664)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.5%

分子结构信息

SMILES: CC1=C(O)C(=O)C=C2C1=CC=C1C2(C)CCC2(C)C3CC(C)C(=O)CC3(C)CCC12C
InChI: InChI=1S/C28H36O3/c1-16-13-23-25(3,15-21(16)30)9-11-27(5)22-8-7-18-17(2)24(31)20(29)14-19(18)26(22,4)10-12-28(23,27)6/h7-8,14,16,23,31H,9-13,15H2,1-6H3/t16-,23-,25+,26+,27+,28-/m1/s1

描述信息

D000970 - Antineoplastic Agents

同义名列表

7 个代谢物同义名

(6aR,6bR,8aS,11R,12aR,14aR)-3-hydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-quinone; (6aR,6bR,8aS,11R,12aR,14aR)-3-hydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-dione; 50802-21-6; tingenone; C08638; 3-hydroxy-4,6a,6b,8a,11,14a-hexamethyl-7,8,9,11,12,12a,13,14-octahydropicene-2,10-dione; Tingenone



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

94 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ADCY3, AIMP2, AKR1B1, ANXA5, BCL2, CASP3, CASP8, CNR2, MAPK8, MAPK9, NOS1, NOS3, TP53, TUBB4B, TXN
Peripheral membrane protein 2 ANXA5, NOS1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 11 AIMP2, BCL2, CASP3, CASP8, MAPK8, MAPK9, NOS1, NOS3, TP53, TUBB4B, TXN
cytosol 13 AIMP2, AKR1B1, ANXA5, BCL2, CASP3, CASP8, MAPK8, MAPK9, NOS1, NOS3, TP53, TUBB4B, TXN
dendrite 1 CNR2
centrosome 1 TP53
nucleoplasm 9 AKR1B1, CASP3, CASP8, MAPK8, MAPK9, NOS1, NOS3, TP53, TXN
Cell membrane 2 ADCY3, GPRC5A
lamellipodium 1 CASP8
Multi-pass membrane protein 2 ADCY3, GPRC5A
Synapse 2 MAPK8, NOS1
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ADCY3, NOS3
Golgi membrane 1 NOS3
neuronal cell body 1 CASP3
sarcolemma 2 ANXA5, NOS1
Cytoplasm, cytosol 1 AIMP2
plasma membrane 6 ADCY3, CNR2, GPRC5A, MAPK9, NOS1, NOS3
Membrane 5 ADCY3, AIMP2, ANXA5, BCL2, TP53
axon 1 MAPK8
caveola 1 NOS3
extracellular exosome 5 AKR1B1, ANXA5, GPRC5A, TUBB4B, TXN
endoplasmic reticulum 3 BCL2, CNR2, TP53
extracellular space 3 AKR1B1, CTRL, IL6
perinuclear region of cytoplasm 2 NOS1, NOS3
Schaffer collateral - CA1 synapse 1 MAPK9
mitochondrion 6 AKR1B1, BCL2, CASP8, MAPK9, NOS1, TP53
protein-containing complex 4 BCL2, CASP8, NOS1, TP53
intracellular membrane-bounded organelle 1 GPRC5A
postsynaptic density 2 CASP3, NOS1
Secreted 2 IL6, TXN
extracellular region 4 ANXA5, IL6, TUBB4B, TXN
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cell projection, cilium 1 ADCY3
ciliary membrane 1 ADCY3
photoreceptor inner segment 1 NOS1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
Extracellular vesicle 1 TUBB4B
dendritic spine 1 NOS1
perikaryon 1 CNR2
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 GPRC5A, TP53
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
vesicle 1 GPRC5A
postsynaptic membrane 1 CNR2
Cell membrane, sarcolemma 1 NOS1
Cell projection, lamellipodium 1 CASP8
Cytoplasm, perinuclear region 1 NOS1
Membrane raft 1 NOS1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 TP53, TUBB4B
focal adhesion 1 ANXA5
microtubule 1 TUBB4B
sarcoplasmic reticulum 1 NOS1
Cell projection, dendritic spine 1 NOS1
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 MAPK9
receptor complex 1 GPRC5A
Zymogen granule membrane 1 ANXA5
cilium 1 ADCY3
chromatin 1 TP53
cell periphery 1 NOS1
mitotic spindle 1 TUBB4B
cytoskeleton 4 CASP8, NOS1, NOS3, TUBB4B
site of double-strand break 1 TP53
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
axonemal microtubule 1 TUBB4B
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 CNR2
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
endoplasmic reticulum lumen 1 IL6
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
endocytic vesicle membrane 1 NOS3
azurophil granule lumen 1 TUBB4B
vesicle membrane 1 ANXA5
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 CNR2
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2


文献列表

  • Francesco Caruso, Miriam Rossi, Eric Eberhardt, Molly Berinato, Raiyan Sakib, Felipe Surco-Laos, Haydee Chavez. Maytenus octogona Superoxide Scavenging and Anti-Inflammatory Caspase-1 Inhibition Study Using Cyclic Voltammetry and Computational Docking Techniques. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310750. [PMID: 37445927]
  • Mapula Razwinani, Keolebogile Shirley Motaung. The influence of friedelin, resinone, tingenone and betulin of compounds on chondrogenic differentiation of porcine adipose-derived mesenchymal stem cells (pADMSCs). Biochimie. 2022 May; 196(?):234-242. doi: 10.1016/j.biochi.2022.01.018. [PMID: 35121053]
  • Ana Carolina B da C Rodrigues, Larissa M Bomfim, Sara P Neves, Milena B P Soares, Rosane B Dias, Ludmila F Valverde, Clarissa A Gurgel Rocha, Emmanoel V Costa, Felipe M A da Silva, Waldireny C Rocha, Hector H F Koolen, Daniel P Bezerra. Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112034. doi: 10.1016/j.biopha.2021.112034. [PMID: 34411914]
  • Camila Hernandes, Lucyene Miguita, Romario Oliveira de Sales, Elisangela de Paula Silva, Pedro Omori Ribeiro de Mendonça, Bruna Lorencini da Silva, Maria de Fatima Guarizo Klingbeil, Monica Beatriz Mathor, Erika Bevilaqua Rangel, Luciana Cavalheiro Marti, Juliana da Silva Coppede, Fabio Daumas Nunes, Ana Maria Soares Pereira, Patricia Severino. Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030760. [PMID: 32050628]
  • Clarice de Carvalho Veloso, Vanessa Gregório Rodrigues, Renata Cristina Mendes Ferreira, Lucienir Pains Duarte, Andre Klein, Igor Dimitri Duarte, Thiago Roberto Lima Romero, Andrea de Castro Perez. Tingenone, a pentacyclic triterpene, induces peripheral antinociception due to NO/cGMP and ATP-sensitive K(+) channels pathway activation in mice. European journal of pharmacology. 2015 May; 755(?):1-5. doi: 10.1016/j.ejphar.2015.02.038. [PMID: 25748602]
  • Edson Rodrigues-Filho, Fábio A P Barros, João B Fernandes, Raimundo Braz-Filho. Detection and identification of quinonemethide triterpenes in Peritassa campestris by mass spectrometry. Rapid communications in mass spectrometry : RCM. 2002; 16(6):627-33. doi: 10.1002/rcm.615. [PMID: 11870901]
  • W Dymowski, M Furmanowa. [Searching for cytostatic substances in plant tissue of Maytenus molina by in vitro culture. III. Release of substances from active biological fractions from the callus extract of Maytenus wallichiana R. and B]. Acta poloniae pharmaceutica. 1992; 49(1-2):29-33. doi: . [PMID: 8769078]
  • W Dymowski, M Furmanowa. [Investigating cytostatic substances in tissue of plants Maytenus Molina in in-vitro cultures. II. chromatographic test of extracts from callus of Maytenus wallichiana R. et B]. Acta poloniae pharmaceutica. 1990; 47(5-6):51-4. doi: . [PMID: 1669332]
  • S G Goijman, J F Turrens, G B Marini-Bettolo, A O Stoppani. [Inhibition of growth and macromolecular biosynthesis in Trypanosoma cruzi by natural products. Effects of miconidine and tingenone]. Medicina. 1984; 44(4):361-70. doi: . [PMID: 6399926]