Amanitin (BioDeep_00000006776)
Secondary id: BioDeep_00001868347
代谢物信息卡片
Alpha-Amanitine
化学式: C39H54N10O14S (918.3542)
中文名称: α-毒伞肽
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)N)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O
InChI: InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D000546 - Amanitins
同义名列表
5 个代谢物同义名
Alpha-Amanitine; alpha-Amatoxin; alpha-Amanitin; Amanitin; alpha-Amanitin
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:37415
- KEGG: C08438
- PubChem: 9543442
- PubChem: 2100
- Metlin: METLIN66975
- ChEMBL: CHEMBL4526586
- MeSH: Alpha-Amanitin
- CAS: 23109-05-9
- PMhub: MS000019916
- PubChem: 10632
- KNApSAcK: C00001516
- NIKKAJI: J372.605C
- KNApSAcK: 37415
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Li-Ying Lin, Ya-Ling Tong, Yuan-Qiang Lu. The characteristics of liver injury induced by Amanita and clinical value of α-amanitin detection.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2022 Jun; 21(3):257-266. doi:
10.1016/j.hbpd.2022.01.007. [PMID: 35168873] - Xiuyao Zhang, Xinxin Cai, Xiaoyi Zhang, Ruifen Li, Yunfeng Zhao. [Highly sensitive determination of three kinds of amanitins in urine and plasma by ultra performance liquid chromatography-triple quadrupole mass spectrometry coupled with immunoaffinity column clean-up].
Se pu = Chinese journal of chromatography.
2022 May; 40(5):443-451. doi:
10.3724/sp.j.1123.2021.08018. [PMID: 35478003] - Jiale Gao, Nuoya Liu, Xiaomeng Zhang, En Yang, Yuzhu Song, Jinyang Zhang, Qinqin Han. Utilizing the DNA Aptamer to Determine Lethal α-Amanitin in Mushroom Samples and Urine by Magnetic Bead-ELISA (MELISA).
Molecules (Basel, Switzerland).
2022 Jan; 27(2):. doi:
10.3390/molecules27020538. [PMID: 35056853] - Zhengsheng Mao, Youjia Yu, Hao Sun, Yue Cao, Qiaoyan Jiang, Chunyan Chu, Yang Sun, Shuainan Huang, Jinsong Zhang, Feng Chen. Development of a simple and reliable method for α-amanitin detection in rat plasma and its application to a toxicokinetic study.
Rapid communications in mass spectrometry : RCM.
2021 Nov; 35(21):e9184. doi:
10.1002/rcm.9184. [PMID: 34472672] - Selma Ríos-Meléndez, Emmanuel Valadez-Hernández, Claudio Delgadillo, Maria L Luna-Guevara, Mario A Martínez-Núñez, Mishael Sánchez-Pérez, José L Martínez-Y-Pérez, Analilia Arroyo-Becerra, Luis Cárdenas, Martha Bibbins-Martínez, Ignacio E Maldonado-Mendoza, Miguel Angel Villalobos-López. Pseudocrossidium replicatum (Taylor) R.H. Zander is a fully desiccation-tolerant moss that expresses an inducible molecular mechanism in response to severe abiotic stress.
Plant molecular biology.
2021 Nov; 107(4-5):387-404. doi:
10.1007/s11103-021-01167-3. [PMID: 34189708] - Ria Park, Won-Gu Choi, Min Seo Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Chang Hwan Sohn, Im-Sook Song, Hye Suk Lee. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials.
Journal of toxicology and environmental health. Part A.
2021 10; 84(20):821-835. doi:
10.1080/15287394.2021.1944942. [PMID: 34187333] - Brendan Le Daré, Pierre-Jean Ferron, Aurélien Couette, Catherine Ribault, Isabelle Morel, Thomas Gicquel. In vivo and in vitro α-amanitin metabolism studies using molecular networking.
Toxicology letters.
2021 Aug; 346(?):1-6. doi:
10.1016/j.toxlet.2021.04.006. [PMID: 33872745] - Jennifer A Kaae, Robert H Poppenga, Ashley E Hill. Physical examination, serum biochemical, and coagulation abnormalities, treatments, and outcomes for dogs with toxicosis from α-amanitin-containing mushrooms: 59 cases (2006-2019).
Journal of the American Veterinary Medical Association.
2021 Mar; 258(5):502-509. doi:
10.2460/javma.258.5.502. [PMID: 33620242] - Xiaomin Xu, Jingshun Zhang, Zengxuan Cai, Zhen Meng, Baifen Huang, Qing Chen. [Determination of trace α-amanitin in urine of mushroom poisoning patient by online solid phase extraction-liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2020 Nov; 38(11):1281-1287. doi:
10.3724/sp.j.1123.2020.03010. [PMID: 34213098] - Xiao-Min Xu, Zhen Meng, Jing-Shun Zhang, Qing Chen, Jian-Long Han. Analytical method development for α-amanitin and β-amanitin in plasma at ultra-trace level by online solid phase extraction-high performance liquid chromatography-triple quadrupole mass spectrometry and its application in poisoning events.
Journal of pharmaceutical and biomedical analysis.
2020 Oct; 190(?):113523. doi:
10.1016/j.jpba.2020.113523. [PMID: 32814259] - M A Arici, A Sahin, Z Cavdar, B U Ergur, C Ural, P Akokay, S Kalkan, Y Tuncok. Effects of resveratrol on alpha-amanitin-induced nephrotoxicity in BALB/c mice.
Human & experimental toxicology.
2020 Mar; 39(3):328-337. doi:
10.1177/0960327119888271. [PMID: 31726883] - Xiuzhen Qiu, Weimao Chen, Yiling Luo, Yulin Wang, Yanlian Wang, Huishi Guo. Highly sensitive α-amanitin sensor based on molecularly imprinted photonic crystals.
Analytica chimica acta.
2020 Jan; 1093(?):142-149. doi:
10.1016/j.aca.2019.09.066. [PMID: 31735207] - Zhengmi He, Tao Luo, Fengxia Fan, Ping Zhang, Zuohong Chen. Universal identification of lethal amanitas by using Hyperbranched rolling circle amplification based on α-amanitin gene sequences.
Food chemistry.
2019 Nov; 298(?):125031. doi:
10.1016/j.foodchem.2019.125031. [PMID: 31260975] - Naoto Sano, Yumiko Takebayashi, Alexandra To, Corinne Mhiri, Loï C Rajjou, Hirofumi Nakagami, Motoki Kanekatsu. Shotgun Proteomic Analysis Highlights the Roles of Long-Lived mRNAs and De Novo Transcribed mRNAs in Rice Seeds upon Imbibition.
Plant & cell physiology.
2019 Nov; 60(11):2584-2596. doi:
10.1093/pcp/pcz152. [PMID: 31373371] - Juliana Garcia, Vera Marisa Costa, Antonio Bovolini, José Alberto Duarte, Daniela Ferreira Rodrigues, Maria de Lourdes Bastos, Félix Carvalho. An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication.
Archives of toxicology.
2019 05; 93(5):1449-1463. doi:
10.1007/s00204-019-02426-5. [PMID: 30891624] - Kevin Van der Jeught, Han-Chen Xu, Yu-Jing Li, Xiong-Bin Lu, Guang Ji. Drug resistance and new therapies in colorectal cancer.
World journal of gastroenterology.
2018 Sep; 24(34):3834-3848. doi:
10.3748/wjg.v24.i34.3834. [PMID: 30228778] - Cheng-Hua Zhang, Jun-Ping Zou, Wang-Qiu Deng, Tai-Hui Li, Zi-de Jiang. Molecular cloning and the expression pattern of AePOPB involved in the α-amanitin biosynthesis in Amanita exitialis fruiting bodies.
Gene.
2018 Jul; 662(?):123-130. doi:
10.1016/j.gene.2018.04.006. [PMID: 29627524] - Chunlei Li, Fen Wei, Saqib Muhammad, Guangde Yang, Sicen Wang, Xinshe Liu. A cost-effective LC-MS/MS method for identification and quantification of α-amanitin in rat plasma: Application to toxicokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1064(?):36-39. doi:
10.1016/j.jchromb.2017.08.042. [PMID: 28898719] - Klaudia Muszyńska, Dominika Ostrowska, Filip Bartnicki, Ewa Kowalska, Małgorzata Bodaszewska-Lubaś, Paweł Hermanowicz, Heinz Faulstich, Wojciech Strzałka. Selection and analysis of a DNA aptamer binding α-amanitin from Amanita phalloides.
Acta biochimica Polonica.
2017; 64(3):401-406. doi:
10.18388/abp.2017_1615. [PMID: 28787470] - Lei Tan, Rong He, Yongxian Li, Yong Liang, He Li, Youwen Tang. Fabrication of a biomimetic adsorbent imprinted with a common specificity determinant for the removal of α- and β-amanitin from plasma.
Journal of chromatography. A.
2016 Aug; 1459(?):1-8. doi:
10.1016/j.chroma.2016.06.072. [PMID: 27394089] - Tomasz Janus, Ewa Jasionowicz, Barbara Potocka-Banaś, Krzysztof Borowiak. [Amanitine determination as an example of peptide analysis in the biological samples with HPLC-MS technique].
Pomeranian journal of life sciences.
2016 ; 62(3):42-8. doi:
NULL. [PMID: 29537764] - Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen. Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice.
International journal of medicinal mushrooms.
2016; 18(9):841-850. doi:
10.1615/intjmedmushrooms.v18.i9.80. [PMID: 27910775] - Juliana Garcia, Vera Marisa Costa, Alexandra T P Carvalho, Ricardo Silvestre, José Alberto Duarte, Daniel F A R Dourado, Marcelo D Arbo, Teresa Baltazar, Ricardo Jorge Dinis-Oliveira, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho. A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.
Archives of toxicology.
2015 Dec; 89(12):2305-23. doi:
10.1007/s00204-015-1582-x. [PMID: 26385100] - Hong Luo, Brandon DuBois, R Michael Sgambelluri, Evan R Angelos, Xuan Li, Daniel Holmes, Jonathan D Walton. Production of (15)N-labeled α-amanitin in Galerina marginata.
Toxicon : official journal of the International Society on Toxinology.
2015 Sep; 103(?):60-4. doi:
10.1016/j.toxicon.2015.06.018. [PMID: 26100667] - Juliana Garcia, Vera M Costa, Ana Elisa Costa, Sérgio Andrade, Ana Cristina Carneiro, Filipe Conceição, José Artur Paiva, Paula Guedes de Pinho, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho. Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report.
Toxicon : official journal of the International Society on Toxinology.
2015 Sep; 103(?):55-9. doi:
10.1016/j.toxicon.2015.06.012. [PMID: 26091874] - Juliana Garcia, Vera M Costa, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho. Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Aug; 997(?):85-95. doi:
10.1016/j.jchromb.2015.06.001. [PMID: 26100080] - Liming Feng, Lei Tan, He Li, Zhiguang Xu, Guixian Shen, Youwen Tang. Selective fluorescent sensing of α-amanitin in serum using carbon quantum dots-embedded specificity determinant imprinted polymers.
Biosensors & bioelectronics.
2015 Jul; 69(?):265-71. doi:
10.1016/j.bios.2015.03.005. [PMID: 25770458] - Hong Luo, Sung-Yong Hong, R Michael Sgambelluri, Evan Angelos, Xuan Li, Jonathan D Walton. Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.
Chemistry & biology.
2014 Dec; 21(12):1610-7. doi:
10.1016/j.chembiol.2014.10.015. [PMID: 25484237] - Thomas Gicquel, Sylvie Lepage, Manon Fradin, Olivier Tribut, Bénédicte Duretz, Isabelle Morel. Amatoxins (α- and β-Amanitin) and phallotoxin (Phalloidin) analyses in urines using high-resolution accurate mass LC-MS technology.
Journal of analytical toxicology.
2014 Jul; 38(6):335-40. doi:
10.1093/jat/bku035. [PMID: 24778089] - Ertugrul Kaya, Mustafa Gani Surmen, Kursat Oguz Yaykasli, Selim Karahan, Murat Oktay, Hakan Turan, Serdar Colakoglu, Havva Erdem. Dermal absorption and toxicity of alpha amanitin in mice.
Cutaneous and ocular toxicology.
2014 Jun; 33(2):154-60. doi:
10.3109/15569527.2013.802697. [PMID: 23763309] - Yongxian Li, Lei Tan, He Li, Zhiguang Xu, Xiongjun Zuo, Youwen Tang. An artificial receptor fabricated by target recognition determinant imprinting for selective capture of α-amanitin.
Journal of chromatography. A.
2014 Jan; 1324(?):190-7. doi:
10.1016/j.chroma.2013.11.042. [PMID: 24326132] - Chelsea L Mitchell, Michael C Saul, Liang Lei, Hairong Wei, Thomas Werner. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.
PloS one.
2014; 9(4):e93489. doi:
10.1371/journal.pone.0093489. [PMID: 24695618] - B Marciniak, D Lopaczyńska, E Kowalczyk, J Skośkiewicz, M Witczak, M Majczyk, W Grabowicz, T Ferenc. Evaluation of micronuclei in mice bone marrow and antioxidant systems in erythrocytes exposed to α-amanitin.
Toxicon : official journal of the International Society on Toxinology.
2013 Mar; 63(?):147-53. doi:
10.1016/j.toxicon.2012.11.023. [PMID: 23247044] - Anna Moshnikova, Valentina Moshnikova, Oleg A Andreev, Yana K Reshetnyak. Antiproliferative effect of pHLIP-amanitin.
Biochemistry.
2013 Feb; 52(7):1171-8. doi:
10.1021/bi301647y. [PMID: 23360641] - Xin Wu, Jun Zeng, Jinsong Hu, Qiong Liao, Rong Zhou, Ping Zhang, Zuohong Chen. Hepatoprotective effects of aqueous extract from Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher basidiomycetes) on α-amanitin-induced liver injury in mice.
International journal of medicinal mushrooms.
2013; 15(4):383-91. doi:
10.1615/intjmedmushr.v15.i4.60. [PMID: 23796220] - Jeremy R Haag, Thomas S Ream, Michelle Marasco, Carrie D Nicora, Angela D Norbeck, Ljiljana Pasa-Tolic, Craig S Pikaard. In vitro transcription activities of Pol IV, Pol V, and RDR2 reveal coupling of Pol IV and RDR2 for dsRNA synthesis in plant RNA silencing.
Molecular cell.
2012 Dec; 48(5):811-8. doi:
10.1016/j.molcel.2012.09.027. [PMID: 23142082] - D Tokarz, R Poppenga, J Kaae, M Filigenzi, L J Lowenstine, P Pesavento. Amanitin toxicosis in two cats with acute hepatic and renal failure.
Veterinary pathology.
2012 Nov; 49(6):1032-5. doi:
10.1177/0300985811429307. [PMID: 22184185] - Hong Luo, Heather E Hallen-Adams, John S Scott-Craig, Jonathan D Walton. Ribosomal biosynthesis of α-amanitin in Galerina marginata.
Fungal genetics and biology : FG & B.
2012 Feb; 49(2):123-9. doi:
10.1016/j.fgb.2011.12.005. [PMID: 22202811] - Mok Mai Yee, Leslie W Woods, Robert H Poppenga, Birgit Puschner. Amanitin intoxication in two beef calves in California.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2012 Jan; 24(1):241-4. doi:
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Viruses.
2012 01; 4(1):28-61. doi:
10.3390/v4010028. [PMID: 22355451] - Melina Velasquez, Juan Salgado Salter, Javier Gloazzo Dorosz, Bent L Petersen, José M Estevez. Recent Advances on the Posttranslational Modifications of EXTs and Their Roles in Plant Cell Walls.
Frontiers in plant science.
2012; 3(?):93. doi:
10.3389/fpls.2012.00093. [PMID: 22639676] - Melody S Clark, Nadav Y Denekamp, Michael A S Thorne, Richard Reinhardt, Mario Drungowski, Marcus W Albrecht, Sven Klages, Alfred Beck, Michael Kube, Esther Lubzens. Long-term survival of hydrated resting eggs from Brachionus plicatilis.
PloS one.
2012; 7(1):e29365. doi:
10.1371/journal.pone.0029365. [PMID: 22253713] - Marc Galland, Dominique Job, Loïc Rajjou. The seed proteome web portal.
Frontiers in plant science.
2012; 3(?):98. doi:
10.3389/fpls.2012.00098. [PMID: 22701460] - Kathryn A Harper, Christine D Smart, R Michael Davis. Development of a DNA-based macroarray for the detection and identification of Amanita species.
Journal of forensic sciences.
2011 Jul; 56(4):1003-9. doi:
10.1111/j.1556-4029.2011.01739.x. [PMID: 21392001] - Yong-Qiang An, Li Lin. Transcriptional regulatory programs underlying barley germination and regulatory functions of Gibberellin and abscisic acid.
BMC plant biology.
2011 Jun; 11(?):105. doi:
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Toxicology letters.
2011 Jun; 203(2):142-6. doi:
10.1016/j.toxlet.2011.03.016. [PMID: 21420474] - Karl Morris, Ada Linkies, Kerstin Müller, Krystyna Oracz, Xiaofeng Wang, James R Lynn, Gerhard Leubner-Metzger, William E Finch-Savage. Regulation of seed germination in the close Arabidopsis relative Lepidium sativum: a global tissue-specific transcript analysis.
Plant physiology.
2011 Apr; 155(4):1851-70. doi:
10.1104/pp.110.169706. [PMID: 21321254] - Jan Magdalan, Aleksandra Piotrowska, Agnieszka Gomułkiewicz, Tomasz Sozański, Adam Szeląg, Piotr Dziegięl. Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin.
Human & experimental toxicology.
2011 Jan; 30(1):38-43. doi:
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Frontiers in plant science.
2011; 2(?):102. doi:
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Eukaryotic cell.
2010 Dec; 9(12):1891-900. doi:
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Plant, cell & environment.
2010 Jul; 33(7):1220-33. doi:
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The Plant cell.
2010 May; 22(5):1575-91. doi:
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Biopolymers.
2010; 94(5):659-64. doi:
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PLoS genetics.
2009 Nov; 5(11):e1000725. doi:
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Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2009 Sep; 40(5):901-4. doi:
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Acta biologica Hungarica.
2009 Sep; 60(3):281-91. doi:
10.1556/abiol.60.2009.3.5. [PMID: 19700387] - Hong Luo, Heather E Hallen-Adams, Jonathan D Walton. Processing of the phalloidin proprotein by prolyl oligopeptidase from the mushroom Conocybe albipes.
The Journal of biological chemistry.
2009 Jul; 284(27):18070-7. doi:
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Cell and tissue research.
2009 Mar; 335(3):551-63. doi:
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Medycyna pracy.
2009; 60(5):415-26. doi:
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BMC plant biology.
2008 Dec; 8(?):122. doi:
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Journal of pharmaceutical and biomedical analysis.
2008 Aug; 47(4-5):913-7. doi:
10.1016/j.jpba.2008.03.032. [PMID: 18502601] - Minoru Umehara, Eishi Totsuka, Yoshiya Ishizawa, Masaki Nara, Kenichi Hakamada, Yutaka Umehara, Mutsuo Sasaki. A bioartificial liver that combines plasma dialysis and whole liver perfusion.
Hepato-gastroenterology.
2008 Jul; 55(85):1216-21. doi:
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BMC genomics.
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