Butenafine (BioDeep_00000006655)

 

Secondary id: BioDeep_00001868192

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


N-4-Tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride

化学式: C23H27N (317.21433820000004)
中文名称: 布替萘芬
谱图信息: 最多检出来源 Mus musculus(blood) 53.85%

分子结构信息

SMILES: CC(C)(C)C1=CC=C(C=C1)CN(C)CC2=CC=CC3=CC=CC=C32
InChI: InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3

描述信息

Butenafine is only found in individuals that have used or taken this drug. It is a synthetic benzylamine antifungal agent.Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells.
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

11 个代谢物同义名

N-4-Tert-butylbenzyl-N-methyl-1-naphthalene methylamine hydrochloride; (4-Tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine; [(4-tert-butylphenyl)methyl](methyl)(naphthalen-1-ylmethyl)amine; N-(p-Tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine; (4-Tert-butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine; 4-Tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine; Butenafine hydrochloride; Butenafinum; butenafine; Butenafina; Mentax



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Adriana Bezerra-Souza, Jéssica A Jesus, Márcia D Laurenti, Aikaterini Lalatsa, Dolores R Serrano, Luiz Felipe D Passero. Nanoemulsified Butenafine for Enhanced Performance against Experimental Cutaneous Leishmaniasis. Journal of immunology research. 2021; 2021(?):8828750. doi: 10.1155/2021/8828750. [PMID: 33880383]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Alissa Zhang, Eui-Chang Jung, Hanjiang Zhu, Ying Zou, Xiaoying Hui, Howard Maibach. Vehicle effects on human stratum corneum absorption and skin penetration. Toxicology and industrial health. 2017 May; 33(5):416-425. doi: 10.1177/0748233716656119. [PMID: 27436841]
  • Adriana Bezerra-Souza, Eduardo S Yamamoto, Márcia D Laurenti, Susan P Ribeiro, Luiz Felipe D Passero. The antifungal compound butenafine eliminates promastigote and amastigote forms of Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis. Parasitology international. 2016 Dec; 65(6 Pt A):702-707. doi: 10.1016/j.parint.2016.08.003. [PMID: 27546158]
  • Bruce C Campbell, Kathleen L Chan, Jong H Kim. Chemosensitization as a means to augment commercial antifungal agents. Frontiers in microbiology. 2012; 3(?):79. doi: 10.3389/fmicb.2012.00079. [PMID: 22393330]
  • Lin Song, Xuehua Jiang, Ling Wang. Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Nov; 879(30):3658-62. doi: 10.1016/j.jchromb.2011.09.042. [PMID: 22005007]
  • T A Syed, Z A Qureshi, S M Ali, S Ahmad, S A Ahmad. Treatment of toenail onychomycosis with 2\% butenafine and 5\% Melaleuca alternifolia (tea tree) oil in cream. Tropical medicine & international health : TM & IH. 1999 Apr; 4(4):284-7. doi: 10.1046/j.1365-3156.1999.00396.x. [PMID: 10357864]
  • W Iwatani, T Arika, H Yamaguchi. Two mechanisms of butenafine action in Candida albicans. Antimicrobial agents and chemotherapy. 1993 Apr; 37(4):785-8. doi: 10.1128/aac.37.4.785. [PMID: 8494375]
  • A C Buck. Disorders of micturition in bacterial prostatitis. Proceedings of the Royal Society of Medicine. 1975 Aug; 68(8):508-11. doi: NULL. [PMID: 681]