Ursodeoxycholate (BioDeep_00000000066)

 

Secondary id: BioDeep_00000229700

human metabolite Endogenous blood metabolite Bile acids PANOMIX LipidSearch


代谢物信息卡片


(4R)-4-[(1S,2S,5R,7S,9S,10R,11S,14R,15R)-5,9-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-14-yl]pentanoic acid

化学式: C24H40O4 (392.292644)
中文名称: 熊去氧胆酸, 熊脱氧胆酸
谱图信息: 最多检出来源 Homo sapiens(bile_acids) 0.09%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Ursodeoxycholate. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/ursodeoxycholate (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000000066). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@]12C)[C@@]1(C)CC[C@H](C[C@H]1C[C@@H]3O)O
InChI: InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15?,16+,17-,18+,19+,20+,22+,23+,24-/m1/s1

描述信息

Ursodeoxycholic acid is a bile acid found in the bile of bears (Ursidae) as a conjugate with taurine. Used therapeutically, it prevents the synthesis and absorption of cholesterol and can lead to the dissolution of gallstones. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of an ursodeoxycholate.
Ursodeoxycholic acid is an epimer of [chenodeoxycholic acid]. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Ursodiol is a Bile Acid.
Ursodeoxycholic acid or ursodiol is a naturally occurring bile acid that is used dissolve cholesterol gall stones and to treat cholestatic forms of liver diseases including primary biliary cirrhosis. Ursodiol has been linked to rare instances of transient and mild serum aminotransferase elevations during therapy and to rare instances of jaundice and worsening of liver disease in patients with preexisting cirrhosis.
Ursodeoxycholic acid is a natural product found in Myocastor coypus with data available.
Ursodiol is a synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
See also: Dimethicone; pancrelipase; ursodiol (component of).
Ursodeoxycholic acid, also known as ursodeoxycholate or acid deoxyursocholic, belongs to the class of organic compounds known as dihydroxy bile acids, alcohols and derivatives. Dihydroxy bile acids, alcohols and derivatives are compounds containing or derived from a bile acid or alcohol, and which bears exactly two carboxylic acid groups. Ursodeoxycholic acid is a very hydrophobic molecule, practically insoluble in water, and relatively neutral.
An epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [HMDB]

Ursodeoxycholic acid. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=128-13-2 (retrieved 2024-07-02) (CAS RN: 128-13-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

181 个代谢物同义名

(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7-bis(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoicacid; (4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]valeric acid; (4R)-4-[(1R,3aS,3bR,4S,5aS,7R,9aS,9bS,11aR)-4,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid; (R)-4-((3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid; (4R)-4-[(1S,2S,5R,7S,9S,10R,11S,14R,15R)-5,9-Dihydroxy-2,15-dimethyltetracyclo[8.7.0.02,1.011,1]heptadecan-14-yl]pentanoic acid; Ursodeoxycholic acid for system suitability, European Pharmacopoeia (EP) Reference Standard; Ursodiol, Pharmaceutical Secondary Standard; Certified Reference Material; 17.beta.-(1-Methyl-3-carboxypropyl)etiocholane-3.alpha.,7.beta.-diol; Ursodeoxycholic acid, European Pharmacopoeia (EP) Reference Standard; Ursodeoxycholic acid, British Pharmacopoeia (BP) Reference Standard; 17-beta-(1-Methyl-3-carboxypropyl)etiocholane-3-alpha,7-beta-diol; 3,7-Dihydroxycholan-24-oic acid-, (3.alpha.,5.beta.,7.beta.)- #; Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.beta.)-; Ursodiol, United States Pharmacopeia (USP) Reference Standard; Cholan-24-oic acid, 3,7-dihydroxy-, (3-alpha,5-beta,7-beta)-; Cholan-24-oic acid, 3,7-dihydroxy-, (3alpha,5beta,7beta)-; (3alpha,5beta,7beta,8xi)-3,7-dihydroxycholan-24-oic acid; 5.beta.-Cholan-24-oic acid, 3.alpha.,7.beta.-dihydroxy-; 3.alpha.,7.beta.-Dihydroxy-5.beta.-cholan-24-oic acid; (3alpha,5beta,7beta)-3,7-dihydroxycholan-24-oic acid; 5-beta-Cholan-24-oic acid, 3-alpha,7-beta-dihydroxy-; 3 alpha,7 beta-Dihydroxy-5 beta-cholan-24-oic Acid; 3 alpha,7 beta Dihydroxy 5 beta cholan 24 oic Acid; (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-Oate; 3.alpha.,7.beta.-Dihydroxy-5.beta.-cholanic acid; 3.ALPHA.,7.BETA.-DIHYDROXY-5B-CHOLAN-24-OIC ACID; Sanofi synthelabo brand OF ursodeoxycholic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-oic acid; 3-alpha,7-beta-Dihydroxy-5-beta-cholanoic acid; 4-10-00-01604 (Beilstein Handbook Reference); 3alpha,7beta-DIHYDROXY-5B-CHOLAN-24-OIC ACID; 3alpha, 7beta-dihydroxy-5beta-cholanoic acid; 3alpha,7beta-Dihydroxy-5beta-cholan-24-Oate; ((3a,5b,7b)-3,7-Dihydroxycholan-24-oic acid; (3a,5b,7b)-3,7-dihydroxy-cholan-24-oic acid; (3a,5b,7b)-3,7-dihydroxycholan-24-oic acid; (3Α,5β,7β)-3,7-dihydroxycholan-24-Oic acid; 3alpha,7beta-Dihydroxy-5beta-cholanic acid; Niddapharm brand OF ursodeoxycholic acid; (3a,5b,7b)-3,7-dihydroxy-cholan-24-oate; 3.alpha.,7.beta.-Dihydroxycholanic acid; Tramedico brand OF ursodeoxycholic acid; Provalis brand OF ursodeoxycholic acid; (3a,5b,7b)-3,7-Dihydroxycholan-24-Oate; (3Α,5β,7β)-3,7-dihydroxycholan-24-Oate; Farmasa brand OF ursodeoxycholic acid; 3Α,7β-dihydroxy-5β-cholan-24-Oic acid; 5beta-Cholanic Acid-3alpha,7beta-diol; Norgine brand OF ursodeoxycholic acid; Acide ursodesoxycholique (INN-French); 3a,7b-dihydroxy-5b-cholan-24-oic acid; Heumann brand OF ursodeoxycholic acid; Aventis brand OF ursodeoxycholic acid; Acide ursodesoxycholique [INN-French]; Antigen brand OF ursodeoxycholic acid; 3-alpha,7-beta-Dihydroxycholanic acid; Zambon brand OF ursodeoxycholic acid; Acidum ursodeoxycholicum (INN-Latin); Estedi brand OF ursodeoxycholic acid; Acidum ursodeoxycholicum [INN-Latin]; 3A,7A-Dihydroxy-5A-holan-24-oic acid; Orphan brand OF ursodeoxycholic acid; Acido ursodeoxicolico (INN-Spanish); URSODEOXYCHOLIC ACID [EP MONOGRAPH]; URSODEOXYCHOLIC ACID (EP MONOGRAPH); Galen brand OF ursodeoxycholic acid; Acido ursodeoxicolico [INN-Spanish]; Axcan brand OF ursodeoxycholic acid; 3alpha,7beta-dihydroxycholanic acid; Falk brand OF ursodeoxycholic acid; Vita brand OF ursodeoxycholic acid; URSODEOXYCHOLIC ACID [EP IMPURITY]; URSODEOXYCHOLIC ACID (EP IMPURITY); 3a,7b-dihydroxy-5b-cholan-24-oate; 3Α,7β-dihydroxy-5β-cholan-24-Oate; 3-alpha,7-beta-Dioxycholanic acid; CP Brand OF ursodeoxycholic acid; Acido ursodeossicolico [Italian]; 5A-Cholan-24-oic acid-3A,7A-diol; Ursodeoxycholic acid (JP17/INN); 3,7-Dihydroxycholan-24-oic acid; 7.beta.-Hydroxylithocholic acid; Ursodeoxycholic Acid (Ursodiol); 7-beta-Hydroxylithocholic acid; URSODEOXYCHOLIC ACID [WHO-DD]; URSODEOXYCHOLIC ACID [MART.]; URSODEOXYCHOLIC ACID (MART.); Ursodeoxycholic acid, >=99\\%; 7A-Hydroxylithocholic acid; URSODEOXYCHOLIC ACID [JAN]; Ursodeoxycholic acid [INN]; acidum ursodesoxycholicum; Acide ursodesoxycholique; Ursodeoxycholate, Sodium; URSODIOL (USP MONOGRAPH); URSODIOL [USP MONOGRAPH]; Acidum ursodeoxycholicum; Ursocholic acid, deoxy-; Ursodiol (Actigal Urso); acide ursodeoxycholique; acido ursodesossicolico; Sodium Ursodeoxycholate; URSODIOL [ORANGE BOOK]; Acido ursodeossicolico; Acid, Ursodeoxycholic; Ursodesoxycholic acid; Acido ursodeoxicolico; Acid, Deoxyursocholic; Urosdesoxycholic acid; Ursodeoxycholic Acid; Ursodeoxycholoc acid; Deoxyursocholic Acid; Ursodexycholic Acid; Ursodeoxycholicacid; Ursodiol [USAN:USP]; Ursodiol (USAN:USP); Prestwick0_000958; URSODIOL [USP-RS]; URSODIOL (USP-RS); Prestwick3_000958; Urosdesoxycholate; Prestwick1_000958; Prestwick2_000958; ursodeoxycholate; Acid, Ursacholic; URSODIOL [VANDF]; Ursodeoxycholic; Ursacholic Acid; URSODIOL [INCI]; Ursodexycholate; Ursodiol [USAN]; Ursodiol (USP); Actigall (TN); BPBio1_001052; URSODIOL [MI]; Urso Heumann; Cholit-ursan; NCI60_028904; SMP2_000012; Ursobilane; ST 24:1;O4; Urso Forte; Urso (TN); Ursobilin; Ursodamor; Cholofalk; Ursolite; Actigall; Litursol; Peptarom; Ursodiol; Ursolvan; Solutrat; Destolit; Ursofalk; Antigall; Delursan; Ursonorm; Paptarom; Ursochol; Ursogal; Deursil; Usodiol; Arsacol; A05AA02; Ursacol; Urosiol; Ursosan; Urso DS; Lyeton; Udiliv; URUSA; Urdes; Desol; Urdox; Urso; UDCS; UDCA; Ursodeoxycholic acid (UDCA)



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Rulaiha Taylor, Zhenning Yang, Zakiyah Henry, Gina Capece, Vik Meadows, Katherine Otersen, Veronia Basaly, Anisha Bhattacharya, Stephanie Mera, Peihong Zhou, Laurie Joseph, Ill Yang, Anita Brinker, Brian Buckley, Bo Kong, Grace L Guo. Characterization of individual bile acids in vivo utilizing a novel low bile acid mouse model. Toxicological sciences : an official journal of the Society of Toxicology. 2024 May; 199(2):316-331. doi: 10.1093/toxsci/kfae029. [PMID: 38526215]
  • Shu Dai, Rui Wu, Ke Fu, Yanzhi Li, Chenghao Yao, Yanfang Liu, Fang Zhang, Shenglin Zhang, Yiling Guo, Yuxin Yao, Yunxia Li. Exploring the effect and mechanism of cucurbitacin B on cholestatic liver injury based on network pharmacology and experimental verification. Journal of ethnopharmacology. 2024 Mar; 322(?):117584. doi: 10.1016/j.jep.2023.117584. [PMID: 38104874]
  • Yanbo Chang, Xuejing Li, Jinping Jiang, Lanlan Gui, Linfei Wan, Xiangxiang Zhou, Linchuan Liao, Kexin Li, Ke Lan. Separation of bile acid isomer plays a pivotal role in bioequivalence evaluation of ursodeoxycholic acid. Journal of pharmaceutical and biomedical analysis. 2024 Feb; 239(?):115882. doi: 10.1016/j.jpba.2023.115882. [PMID: 38071766]
  • Jianqing She, Gulinigaer Tuerhongjiang, Manyun Guo, Junhui Liu, Xiang Hao, Liangan Guo, Nairong Liu, Wen Xi, Tao Zheng, Bin Du, Bowen Lou, Xiyu Gao, Xiao Yuan, Yue Yu, Yi Zhang, Fan Gao, Xiaozhen Zhuo, Ying Xiong, Xiang Zhang, Jun Yu, Zuyi Yuan, Yue Wu. Statins aggravate insulin resistance through reduced blood glucagon-like peptide-1 levels in a microbiota-dependent manner. Cell metabolism. 2024 02; 36(2):408-421.e5. doi: 10.1016/j.cmet.2023.12.027. [PMID: 38325336]
  • Biljana Lakić, Ranko Škrbić, Snežana Uletilović, Nebojša Mandić-Kovačević, Milkica Grabež, Mirna Popović Šarić, Miloš P Stojiljković, Ivan Soldatović, Zorica Janjetović, Anastasija Stokanović, Nataša Stojaković, Momir Mikov. Beneficial Effects of Ursodeoxycholic Acid on Metabolic Parameters and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind, Placebo-Controlled Clinical Study. Journal of diabetes research. 2024; 2024(?):4187796. doi: 10.1155/2024/4187796. [PMID: 38455850]
  • Yu-Qiong He, Jiu-Ling Deng, Can-Can Zhou, Sheng-Gui Jiang, Feng Zhang, Xia Tao, Wan-Sheng Chen. Ursodeoxycholic acid alleviates sepsis-induced lung injury by blocking PANoptosis via STING pathway. International immunopharmacology. 2023 Dec; 125(Pt B):111161. doi: 10.1016/j.intimp.2023.111161. [PMID: 37948864]
  • Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou. Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways. European journal of medicinal chemistry. 2023 Nov; 260(?):115785. doi: 10.1016/j.ejmech.2023.115785. [PMID: 37678142]
  • Fei Qiao, Feng Ren, Weiting Lu, Haoran Yang, Guiling Mo, Shuangshuang Wang, Lina Liu, Xiangtao Xu. A female of progressive familial intrahepatic cholestasis type 3 caused by heterozygous mutations of ABCB4 gene and her cirrhosis improved after treatment of ursodeoxycholic acid: a case report. BMC medical genomics. 2023 07; 16(1):171. doi: 10.1186/s12920-023-01602-y. [PMID: 37488596]
  • Wei Li, Wei Chen, Xiaoya Niu, Chen Zhao, Pengfei Tu, Jun Li, Wenjing Liu, Yuelin Song. Characterization of Metabolic Correlations of Ursodeoxycholic Acid with Other Bile Acid Species through In Vitro Sequential Metabolism and Isomer-Focused Identification. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124801. [PMID: 37375356]
  • M A Rasskazova, S V Vorobyev, H N Butova. [Possibilities for the use of ursodeoxycholic acid in the treatment of patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease]. Terapevticheskii arkhiv. 2023 May; 95(4):316-321. doi: 10.26442/00403660.2023.04.202125. [PMID: 38158979]
  • Shan Gao, Feng Gao, Jing-Wei Kong, Zhi-Jia Wang, Hao-Cheng Zheng, Xin-Qi Jiang, Shu-Jing Xu, Shan-Lan Li, Ming-Jun Lu, Zi-Qi Dai, Fu-Hao Chu, Bing Xu, Hai-Min Lei. [Therapeutic effect of ursodeoxycholic acid-berberine supramolecular nanoparticles on ulcerative colitis based on supramolecular system induced by weak bond]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 May; 48(10):2739-2748. doi: 10.19540/j.cnki.cjcmm.20230223.301. [PMID: 37282934]
  • Jingfeng Yu, Sihan Sheng, Xiaosu Zou, Zhengwu Shen. Dihydroartemisinin-ursodeoxycholic acid conjugate is a potential treatment agent for inflammatory bowel disease. International immunopharmacology. 2023 Feb; 117(?):109918. doi: 10.1016/j.intimp.2023.109918. [PMID: 36842236]
  • Silvia Marchianò, Michele Biagioli, Elva Morretta, Cristina Di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Carmen Massa, Maria Chiara Monti, Angela Zampella, Eleonora Distrutti, Stefano Fiorucci. Combinatorial therapy with BAR502 and UDCA resets FXR and GPBAR1 signaling and reverses liver histopathology in a model of NASH. Scientific reports. 2023 Jan; 13(1):1602. doi: 10.1038/s41598-023-28647-4. [PMID: 36709356]
  • Haolong Li, Haoting Zhan, Linlin Cheng, Yuan Huang, Xiaomeng Li, Songxin Yan, Yongmei Liu, Li Wang, Yongzhe Li. Plasma lipidomics of primary biliary cholangitis and its comparison with Sjögren's syndrome. Frontiers in immunology. 2023; 14(?):1124443. doi: 10.3389/fimmu.2023.1124443. [PMID: 37215104]
  • Shiori Ishizawa, Akinori Nishi, Noriko Kaifuchi, Chika Shimobori, Miwa Nahata, Chihiro Yamada, Seiichi Iizuka, Katsuya Ohbuchi, Mitsue Nishiyama, Naoki Fujitsuka, Toru Kono, Masahiro Yamamoto. Integrated analysis of effect of daisaikoto, a traditional Japanese medicine, on the metabolome and gut microbiome in a mouse model of nonalcoholic fatty liver disease. Gene. 2022 Dec; 846(?):146856. doi: 10.1016/j.gene.2022.146856. [PMID: 36067864]
  • Silvia Marchianò, Michele Biagioli, Rosalinda Roselli, Angela Zampella, Cristina Di Giorgio, Martina Bordoni, Rachele Bellini, Ginevra Urbani, Elva Morretta, Maria Chiara Monti, Eleonora Distrutti, Stefano Fiorucci. Beneficial effects of UDCA and norUDCA in a rodent model of steatosis are linked to modulation of GPBAR1/FXR signaling. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022 11; 1867(11):159218. doi: 10.1016/j.bbalip.2022.159218. [PMID: 35985473]
  • Ting Gong, Chuangen Li, Shiqiang Li, Xiaojuan Zhang, Zhongming He, Xianhong Jiang, Qiuyue He, Rongjuan Huang, Yong Wang, Xiong Liu. Capsaicin regulates dyslipidemia by altering the composition of bile acids in germ-free mice. Food & function. 2022 Oct; 13(20):10665-10679. doi: 10.1039/d2fo02209e. [PMID: 36172720]
  • Da-Xin Chen, Jian-Feng Chu, Shan Lin, Ling Zhang, Hong-Wei Chen, Zhi-Wei Sun, Jian-Feng Xu, Qiao-Yan Cai, Li-Li Wang, Jun Peng. Therapeutic Effects of Different Animal Bile Powders on Lipid Metabolism Disorders and Their Composition Analysis. Chinese journal of integrative medicine. 2022 Oct; 28(10):918-923. doi: 10.1007/s11655-021-3441-3. [PMID: 33609233]
  • Haining Peng, Yi Zhang, Zhongkai Ren, Ziran Wei, Renjie Chen, Yingze Zhang, Xiaohong Huang, Tengbo Yu. Cartilaginous Metabolomics Reveals the Biochemical-Niche Fate Control of Bone Marrow-Derived Stem Cells. Cells. 2022 09; 11(19):. doi: 10.3390/cells11192951. [PMID: 36230915]
  • Rumei Li, Milaine V Hovingh, Martijn Koehorst, Pim de Blaauw, Henkjan J Verkade, Jan Freark de Boer, Folkert Kuipers. Short-term obeticholic acid treatment does not impact cholangiopathy in Cyp2c70-deficient mice with a human-like bile acid composition. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022 08; 1867(8):159163. doi: 10.1016/j.bbalip.2022.159163. [PMID: 35470044]
  • Surain B Roberts, Gideon M Hirschfield, Lawrence J Worobetz, Catherine Vincent, Jennifer A Flemming, Angela Cheung, Karim Qumosani, Mark Swain, Dusanka Grbic, Hin Hin Ko, Kevork Peltekian, Nazia Selzner, Lusine Abrahamyan, Bishoi Aziz, Ellina Lytvyak, Kattleya Tirona, Aliya F Gulamhusein, Harry L A Janssen, Aldo J Montano-Loza, Andrew L Mason, Bettina E Hansen. Ethnicity, disease severity, and survival in Canadian patients with primary biliary cholangitis. Hepatology (Baltimore, Md.). 2022 Aug; 76(2):303-316. doi: 10.1002/hep.32426. [PMID: 35220609]
  • Holly Lovell, Alice Mitchell, Caroline Ovadia, Noelia Pitrelli, Annette Briley, Claire Singh, Hanns-Ulrich Marschall, Kennedy Cruickshank, Helen Murphy, Paul Seed, Catherine Williamson. A multi-centered trial investigating gestational treatment with ursodeoxycholic acid compared to metformin to reduce effects of diabetes mellitus (GUARD): a randomized controlled trial protocol. Trials. 2022 Jul; 23(1):571. doi: 10.1186/s13063-022-06462-y. [PMID: 35854327]
  • Pengchao Xie, Yan Peng, Liyan Qiu. Responsive oligochitosan nano-vesicles with ursodeoxycholic acid and exenatide for NAFLD synergistic therapy via SIRT1. Carbohydrate polymers. 2022 Jul; 288(?):119388. doi: 10.1016/j.carbpol.2022.119388. [PMID: 35450649]
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