Tazobactam (BioDeep_00000006599)

 

Secondary id: BioDeep_00001868359

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S,3S,5S)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide

化学式: C10H12N4O5S (300.0528)
中文名称: 他唑巴坦酸, 他唑巴坦
谱图信息: 最多检出来源 Homo sapiens(blood) 52.17%

分子结构信息

SMILES: CC1(C(N2C(S1(=O)=O)CC2=O)C(=O)O)CN3C=CN=N3
InChI: InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1

描述信息

Tazobactam is only found in individuals that have used or taken this drug.It is a antibacterial penicillin derivative which inhibits the action of bacterial beta-lactamases.Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express beta-lactamase and would normally degrade piperacillin.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CG - Beta-lactamase inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D065093 - beta-Lactamase Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C2140 - Adjuvant > C183118 - Beta-lactamase Inhibitor
D004791 - Enzyme Inhibitors
Tazobactam (CL-298741) is a potent β-lactamases inhibitor and penicillin antibiotic. Tazobactam has antibacterial activity. Tazobactam can be used for pneumonia research[1][2].

同义名列表

14 个代谢物同义名

(2S,3S,5S)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide; (2S,3S,5R)-3-methyl-4,4,7-trioxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4λ⁶-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,3S,5S)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide; Taszobactam sodium; Tazobactam sodium; SCHEMBL13437219; Tazobactamum; Tazobactam; YTR 830H; YTR 830; YTR-830; CL-298741; YTR-830H; Tazobactam



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ALB, CST3, MRTFA, PURA
Peripheral membrane protein 1 CYP27A1
Mitochondrion membrane 1 CYP27A1
Nucleus 3 ALB, MRTFA, PURA
cytosol 5 ALB, GPT, LACTB, MRTFA, SLC22A16
dendrite 1 PURA
centrosome 1 ALB
nucleoplasm 1 MRTFA
Cell membrane 3 KIT, SLC22A16, TNF
Multi-pass membrane protein 3 SLC22A16, SLC22A6, SLC22A8
cell surface 2 C3, TNF
glutamatergic synapse 2 MRTFA, PURA
Golgi apparatus 2 ALB, CST3
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 2 PURA, TNF
postsynapse 2 MRTFA, PURA
Presynapse 1 MRTFA
acrosomal vesicle 1 KIT
plasma membrane 8 C3, CST3, GYPB, KIT, SLC22A16, SLC22A6, SLC22A8, TNF
Membrane 4 GYPB, KIT, SLC22A16, SLC22A6
apical plasma membrane 1 SLC22A8
basolateral plasma membrane 2 SLC22A6, SLC22A8
caveola 1 SLC22A6
extracellular exosome 6 ALB, C3, CST3, GPT, SLC22A6, SLC22A8
endoplasmic reticulum 2 ALB, CST3
extracellular space 10 ALB, C3, CPZ, CRP, CSF3, CST3, HABP2, IL6, KIT, TNF
lysosomal lumen 1 CSF3
mitochondrion 2 CYP27A1, LACTB
protein-containing complex 3 ALB, C3, SLC22A6
Single-pass type I membrane protein 1 KIT
Secreted 7 ALB, C3, CRP, CSF3, CST3, HABP2, IL6
extracellular region 8 ALB, C3, CRP, CSF3, CST3, HABP2, IL6, TNF
cytoplasmic side of plasma membrane 1 KIT
Single-pass membrane protein 1 GYPB
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
external side of plasma membrane 2 KIT, TNF
Secreted, extracellular space, extracellular matrix 2 CPZ, HABP2
cell-cell junction 1 KIT
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 CST3
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 TNF
lateral plasma membrane 1 SLC22A8
receptor complex 1 KIT
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
chromosome, telomeric region 1 PURA
blood microparticle 2 ALB, C3
Basolateral cell membrane 2 SLC22A6, SLC22A8
fibrillar center 1 KIT
basal plasma membrane 1 SLC22A6
[Isoform 3]: Cytoplasm 1 KIT
ficolin-1-rich granule lumen 1 CST3
secretory granule lumen 1 C3
endoplasmic reticulum lumen 4 ALB, C3, CST3, IL6
platelet alpha granule lumen 1 ALB
tertiary granule lumen 1 CST3
azurophil granule lumen 1 C3
Basal cell membrane 1 SLC22A6
endocytic vesicle lumen 1 CSF3
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
ankyrin-1 complex 1 GYPB
interleukin-6 receptor complex 1 IL6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Robert Strengen Bigseth, Håkon Sandholdt, Andreas Petersen, Christian Østergaard, Thomas Benfield, Louise Thorlacius-Ussing. Comparable Effectiveness of Cefuroxime and Piperacillin-Tazobactam as Empirical Therapy for Methicillin-Susceptible Staphylococcus aureus Bacteremia. Microbiology spectrum. 2022 06; 10(3):e0153021. doi: 10.1128/spectrum.01530-21. [PMID: 35438533]
  • Hiie Soeorg, Aveli Noortoots, Maarja Karu, Kadri Saks, Jana Lass, Irja Lutsar, Lenne-Triin Kõrgvee. Estimation of cefepime, piperacillin, and tazobactam clearance with iohexol-based glomerular filtration rate in paediatric patients. European journal of clinical pharmacology. 2022 Jun; 78(6):989-1001. doi: 10.1007/s00228-022-03307-0. [PMID: 35275224]
  • Eveline Wallenburg, Rob Ter Heine, Jeroen A Schouten, Jelmer Raaijmakers, Jaap Ten Oever, Eva Kolwijck, David M Burger, Peter Pickkers, Tim Frenzel, Roger J M Brüggemann. An Integral Pharmacokinetic Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients. Clinical pharmacokinetics. 2022 06; 61(6):907-918. doi: 10.1007/s40262-022-01113-6. [PMID: 35377133]
  • Wei Gao, Julie Passarell, Yogesh T Patel, Zufei Zhang, Gina Lin, Jill Fiedler-Kelly, Christopher J Bruno, Elizabeth G Rhee, Carisa S De Anda, Hwa-Ping Feng. Exposure-Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP. Antimicrobial agents and chemotherapy. 2022 05; 66(5):e0139921. doi: 10.1128/aac.01399-21. [PMID: 35471040]
  • Yong Kyun Kim, Hyoung Soo Kim, Sunghoon Park, Hwan-Il Kim, Sun Hee Lee, Dong-Hwan Lee. Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation. The Journal of antimicrobial chemotherapy. 2022 04; 77(5):1353-1364. doi: 10.1093/jac/dkac059. [PMID: 35224630]
  • Nezar M Bahabri, Maha Mahmoud Al-Alawi, Mohammed O Qutub, Wail A Tashkandi, Raha AlTurki, Safiah Saad Janah, Heidi Essam Ali, Albandari F Almutairi, Sherif Khalil. In-vitro activity of ceftolozane/tazobactam against recent clinical bacterial isolates from two Saudi Arabian hospitals. Journal of infection and public health. 2022 Apr; 15(4):486-490. doi: 10.1016/j.jiph.2022.02.009. [PMID: 35221238]
  • Bence Mogyoródi, András B Csékó, Csaba Hermann, János Gál, Zsolt D Iványi. Ceftolozane/tazobactam versus colistin in the treatment of ventilator-associated pneumonia due to extensively drug-resistant Pseudomonas aeruginosa. Scientific reports. 2022 03; 12(1):4455. doi: 10.1038/s41598-022-08307-9. [PMID: 35292686]
  • Thamer A Almangour, Ahmad Aljabri, Mohammed Al Musawa, Abdullah Almohaizeie, Sara Almuhisen, Nader Damfu, Awaly Alfozan, Basem M Alraddadi, Majda Alattas, Mohammed Qutub, Abrar F Alhameed, Malik Khuwaja, Ahlam Alghamdi, Khalifa M Binkhamis, Wafa Alfahad, Fatimah S AlShahrani. Ceftolozane-tazobactam vs. colistin for the treatment of infections due to multidrug-resistant Pseudomonas aeruginosa: a multicentre cohort study. Journal of global antimicrobial resistance. 2022 03; 28(?):288-294. doi: 10.1016/j.jgar.2022.01.023. [PMID: 35121161]
  • Sunish Shah, Derek N Bremmer, Ellen G Kline, David P Nicolau, Ryan K Shields. Ceftolozane/tazobactam for refractory P. aeruginosa endocarditis: A case report and pharmacokinetic analysis. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2022 Jan; 28(1):87-90. doi: 10.1016/j.jiac.2021.08.013. [PMID: 34535403]
  • Chi-Hao Shao, Chih-Hsun Tai, Fang-Ju Lin, Chien-Chih Wu, Jann-Tay Wang, Chi-Chuan Wang. Comparison of risk of acute kidney injury between patients receiving the combination of teicoplanin and piperacillin/tazobactam versus vancomycin and piperacillin/tazobactam. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 Jan; 121(1 Pt 1):117-125. doi: 10.1016/j.jfma.2021.02.004. [PMID: 33637370]
  • Jongsung Hahn, Kyoung Lok Min, Soyoung Kang, Seungwon Yang, Min Soo Park, Jin Wi, Min Jung Chang. Population Pharmacokinetics and Dosing Optimization of Piperacillin-Tazobactam in Critically Ill Patients on Extracorporeal Membrane Oxygenation and the Influence of Concomitant Renal Replacement Therapy. Microbiology spectrum. 2021 12; 9(3):e0063321. doi: 10.1128/spectrum.00633-21. [PMID: 34937189]
  • Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Young-Jae Cho, Amanda Corley, Arne Diehl, Eileen Gilder, Stephan M Jakob, Hyung-Sook Kim, Bianca J Levkovich, Sung Yoon Lim, Shay McGuinness, Rachael Parke, Vincent Pellegrino, Yok-Ai Que, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, David Zacharias, John F Fraser, Kiran Shekar, Jason A Roberts. Population Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: an ASAP ECMO Study. Antimicrobial agents and chemotherapy. 2021 10; 65(11):e0143821. doi: 10.1128/aac.01438-21. [PMID: 34460303]
  • Andrew F Shorr, Christopher J Bruno, Zufei Zhang, Erin Jensen, Wei Gao, Hwa-Ping Feng, Jennifer A Huntington, Brian Yu, Elizabeth G Rhee, Carisa De Anda, Sumit Basu, Marin H Kollef. Ceftolozane/tazobactam probability of target attainment and outcomes in participants with augmented renal clearance from the randomized phase 3 ASPECT-NP trial. Critical care (London, England). 2021 10; 25(1):354. doi: 10.1186/s13054-021-03773-5. [PMID: 34600585]
  • A Pinilla-Rello, R Huarte-Lacunza, A Magallón-Martínez, L Cazorla-Poderoso, O Pereira-Blanco, M Pérez-Moreno, I Larrodé-Leciñena, R M Martínez-Álvarez, A I López-Calleja. [Utilization study in real clinical practice of ceftolozane/tazobactam vs aminoglycosides and/or colistin in the treatment of multirresistant or extremely resistant Pseudomonas aeruginosa]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia. 2021 Oct; 34(5):441-449. doi: 10.37201/req/006.2021. [PMID: 34154319]
  • Sarah Van Vooren, Jan J De Waele, Jerina Boelens, Michael Polet, Veronique Stove, Lynn Vanhaecke, Alain G Verstraete. Development and validation of a liquid chromatography high-resolution mass spectrometry orbitrap method for the sensitive quantification of amoxicillin, piperacillin, tazobactam and meropenem in human faeces. Analytica chimica acta. 2021 Sep; 1177(?):338760. doi: 10.1016/j.aca.2021.338760. [PMID: 34482897]
  • Neena Kanwar, Dithi Banerjee, Christopher J Harrison, Jason G Newland, Xuan Qin, Danielle M Zerr, Theoklis Zaoutis, Rangaraj Selvarangan. Comparative in vitro effectiveness of ceftolozane/tazobactam against pediatric gram-negative drug-resistant isolates. Journal of chemotherapy (Florence, Italy). 2021 Sep; 33(5):288-293. doi: 10.1080/1120009x.2021.1888030. [PMID: 33645447]
  • Matthew W Bjergum, Erin F Barreto, Marc H Scheetz, Andrew D Rule, Paul J Jannetto. Stability and Validation of a High-Throughput LC-MS/MS Method for the Quantification of Cefepime, Meropenem, and Piperacillin and Tazobactam in Serum. The journal of applied laboratory medicine. 2021 09; 6(5):1202-1212. doi: 10.1093/jalm/jfab036. [PMID: 34086904]
  • V Al Jalali, M Wölfl-Duchek, M Taubert, P Matzneller, E Lackner, C Dorn, A Kratzer, B Wulkersdorfer, Z Österreicher, M Zeitlinger. Plasma and soft tissue pharmacokinetics of ceftolozane/tazobactam in healthy volunteers after single and multiple intravenous infusion: a microdialysis study. The Journal of antimicrobial chemotherapy. 2021 08; 76(9):2342-2351. doi: 10.1093/jac/dkab166. [PMID: 34050650]
  • Sofie Rutjens, Siska Croubels, Siegrid De Baere, Mathias Devreese. Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Methods for the Quantification of Cefquinome, Ceftiofur, and Desfuroylceftiofuracetamide in Porcine Feces with Emphasis on Analyte Stability. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154598. [PMID: 34361749]
  • Dušan Krnáč, Katarína Reiffová, Boris Rolinski. A new HPLC-MS/MS analytical method for quantification of tazobactam, piperacillin, and meropenem in human plasma. Journal of separation science. 2021 Jul; 44(14):2744-2753. doi: 10.1002/jssc.202100067. [PMID: 33988308]
  • Marianna Meschiari, Iacopo Franconi, Erica Bacca, Vincenzo Bianco, Gabriella Orlando, Gianluca Cuomo, Andrea Bedini, Cristina Mussini. Ceftazidime/avibactam and ceftolozane/tazobactam for the treatment of extensively drug-resistant Pseudomonas aeruginosa post-neurosurgical infections: three cases and a review of the literature. Infection. 2021 Jun; 49(3):549-553. doi: 10.1007/s15010-020-01539-9. [PMID: 33074365]
  • Suzanne L Parker, Saurabh Pandey, Fekade B Sime, Janine Stuart, Jeffrey Lipman, Jason A Roberts, Steven C Wallis. A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane-tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies. Clinical chemistry and laboratory medicine. 2021 04; 59(5):921-933. doi: 10.1515/cclm-2020-1196. [PMID: 33554515]
  • David P Nicolau, Jan De Waele, Joseph L Kuti, Luzelena Caro, Kajal B Larson, Brian Yu, Elaine Gadzicki, Zhen Zeng, Elizabeth G Rhee, Matthew L Rizk. Pharmacokinetics and Pharmacodynamics of Ceftolozane/Tazobactam in Critically Ill Patients With Augmented Renal Clearance. International journal of antimicrobial agents. 2021 Apr; 57(4):106299. doi: 10.1016/j.ijantimicag.2021.106299. [PMID: 33567333]
  • S Alexander Winans, Richelle L Guerrero-Wooley, Susie H Park, Garret Hino, Steven C Forland. Continuous infusion of ceftolozane-tazobactam resulted in high cerebrospinal fluid concentrations of ceftolozane in a patient with multidrug-resistant Pseudomonas aeruginosa meningitis. Infection. 2021 Apr; 49(2):355-359. doi: 10.1007/s15010-020-01510-8. [PMID: 32862306]
  • Christian M Gill, Kamilia Abdelraouf, David P Nicolau. In vivo activity of WCK 4282 (high-dose cefepime/tazobactam) against serine β-lactamase-producing Enterobacterales and Pseudomonas aeruginosa in the neutropenic murine thigh infection model. The Journal of antimicrobial chemotherapy. 2021 03; 76(4):993-1000. doi: 10.1093/jac/dkaa551. [PMID: 33438033]
  • Zana Rubic, Silvija Soprek, Marko Jelic, Anita Novak, Ivana Goic-Barisic, Marina Radic, Arjana Tambic-Andrasevic, Marija Tonkic. Molecular Characterization of β-Lactam Resistance and Antimicrobial Susceptibility to Possible Therapeutic Options of AmpC-Producing Multidrug-Resistant Proteus mirabilis in a University Hospital of Split, Croatia. Microbial drug resistance (Larchmont, N.Y.). 2021 Feb; 27(2):162-169. doi: 10.1089/mdr.2020.0002. [PMID: 32429775]
  • Zufei Zhang, Yogesh T Patel, Jill Fiedler-Kelly, Hwa-Ping Feng, Christopher J Bruno, Wei Gao. Population Pharmacokinetic Analysis for Plasma and Epithelial Lining Fluid Ceftolozane/Tazobactam Concentrations in Patients With Ventilated Nosocomial Pneumonia. Journal of clinical pharmacology. 2021 02; 61(2):254-268. doi: 10.1002/jcph.1733. [PMID: 32949031]
  • Fekade B Sime, Melissa Lassig-Smith, Therese Starr, Janine Stuart, Saurabh Pandey, Suzanne L Parker, Steven C Wallis, Jeffrey Lipman, Jason A Roberts. Cerebrospinal Fluid Penetration of Ceftolozane-Tazobactam in Critically Ill Patients with an Indwelling External Ventricular Drain. Antimicrobial agents and chemotherapy. 2020 12; 65(1):. doi: 10.1128/aac.01698-20. [PMID: 33077655]
  • William C Putnam, Raja Reddy Kallem, Vindhya Edpuganti, Indhu Subramaniyan, Ronald G Hall. Development and validation of a quantitative LC-MS/MS method for the simultaneous determination of ceftolozane and tazobactam in human plasma and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1159(?):122354. doi: 10.1016/j.jchromb.2020.122354. [PMID: 32905989]
  • Jennifer A Huntington, Brian Yu, Linping Li, Erin Jensen, Christopher Bruno, Mathew Boakye, Zufei Zhang, Wei Gao, Hwa-Ping Feng, Elizabeth Rhee. Outcomes in Participants with Renal Impairment from a Phase 3 Clinical Trial for Ceftolozane/Tazobactam Treatment of Nosocomial Pneumonia (ASPECT-NP). Antimicrobial agents and chemotherapy. 2020 11; 64(12):. doi: 10.1128/aac.00731-20. [PMID: 32988827]
  • Irene Galani, Vassiliki Papoutsaki, Irene Karantani, Ilias Karaiskos, Lamprini Galani, Panagiota Adamou, Ioannis Deliolanis, Antigoni Kodonaki, Eleni Papadogeorgaki, Margarita Markopoulou, Sofia Maraki, Maria Damala, Eleni Prifti, Eleni Vagiakou, Efthimia Petinaki, Kimon Fountoulis, Sophia Tsiplakou, Helen Kirikou, Maria Souli, Anastasia Antoniadou, Helen Giamarellou. In vitro activity of ceftolozane/tazobactam alone and in combination with amikacin against MDR/XDR Pseudomonas aeruginosa isolates from Greece. The Journal of antimicrobial chemotherapy. 2020 08; 75(8):2164-2172. doi: 10.1093/jac/dkaa160. [PMID: 32449909]
  • Antonio C Arrieta, Jocelyn Y Ang, Zufei Zhang, Kajal B Larson, Brian Yu, Matthew G Johnson, Elizabeth G Rhee, Ed H Feng, Matthew L Rizk. Plasma pharmacokinetics of ceftolozane/tazobactam in pediatric patients with cystic fibrosis. Pediatric pulmonology. 2020 08; 55(8):2025-2032. doi: 10.1002/ppul.24815. [PMID: 32421928]
  • Jason M Pogue, Keith S Kaye, Michael P Veve, Twisha S Patel, Anthony T Gerlach, Susan L Davis, Laura A Puzniak, Tom M File, Shannon Olson, Sorabh Dhar, Robert A Bonomo, Federico Perez. Ceftolozane/Tazobactam vs Polymyxin or Aminoglycoside-based Regimens for the Treatment of Drug-resistant Pseudomonas aeruginosa. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 07; 71(2):304-310. doi: 10.1093/cid/ciz816. [PMID: 31545346]
  • Luzelena Caro, David P Nicolau, Jan J De Waele, Joseph L Kuti, Kajal B Larson, Elaine Gadzicki, Brian Yu, Zhen Zeng, Adedayo Adedoyin, Elizabeth G Rhee. Lung penetration, bronchopulmonary pharmacokinetic/pharmacodynamic profile and safety of 3 g of ceftolozane/tazobactam administered to ventilated, critically ill patients with pneumonia. The Journal of antimicrobial chemotherapy. 2020 06; 75(6):1546-1553. doi: 10.1093/jac/dkaa049. [PMID: 32211756]
  • A R Buonomo, A E Maraolo, R Scotto, M Foggia, E Zappulo, P Congera, S Parente, I Gentile. Efficacy and safety of ceftolozane/tazobactam as therapeutic option for complicated skin and soft tissue infections by MDR/XDR Pseudomonas aeruginosa in patients with impaired renal function: a case series from a single-center experience. Infection. 2020 Apr; 48(2):303-307. doi: 10.1007/s15010-020-01390-y. [PMID: 31981091]
  • Sarah C J Jorgensen, Trang D Trinh, Evan J Zasowski, Abdalhamid M Lagnf, Samuel P Simon, Sahil Bhatia, Sarah M Melvin, Molly E Steed, Natalie A Finch, Taylor Morrisette, Sandy J Estrada, Joshua R Rosenberg, Susan L Davis, Michael J Rybak. Real-World Experience with Ceftolozane-Tazobactam for Multidrug-Resistant Gram-Negative Bacterial Infections. Antimicrobial agents and chemotherapy. 2020 03; 64(4):. doi: 10.1128/aac.02291-19. [PMID: 31932379]
  • Hasan Cenk Mirza, Elvan Hortaç, Aylin Altay Koçak, M Hamiyet Demirkaya, Buket Yayla, Aylin Üsküdar Güçlü, Ahmet Başustaoğlu. In vitro activity of ceftolozane-tazobactam and ceftazidime-avibactam against clinical isolates of meropenem-non-susceptible Pseudomonas aeruginosa: A two-centre study. Journal of global antimicrobial resistance. 2020 03; 20(?):334-338. doi: 10.1016/j.jgar.2019.09.016. [PMID: 31568882]
  • Alina Karoline Nussbaumer-Pröll, Sabine Eberl, Birgit Reiter, Thomas Stimpfl, Christoph Dorn, Markus Zeitlinger. Low pH reduces the activity of ceftolozane/tazobactam in human urine, but confirms current breakpoints for urinary tract infections. The Journal of antimicrobial chemotherapy. 2020 03; 75(3):593-599. doi: 10.1093/jac/dkz488. [PMID: 31794023]
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