Alendronic acid (BioDeep_00000006590)
Secondary id: BioDeep_00000405483
human metabolite Endogenous Chemicals and Drugs
代谢物信息卡片
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid
化学式: C4H13NO7P2 (249.0167)
中文名称: 阿仑膦酸
谱图信息:
最多检出来源 Homo sapiens(not specific) 20.42%
分子结构信息
SMILES: C(CC(O)(P(=O)(O)O)P(=O)(O)O)CN
InChI: InChI=1S/C4H13NO7P2/c5-3-1-2-4(6,13(7,8)9)14(10,11)12/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12)
描述信息
Alendronate (Fosamax, Merck) is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D (2,800 U, under the name Fosavance). [HMDB]
Alendronate (Fosamax, Merck) is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as well as in combination with vitamin D (2,800 U, under the name Fosavance).
M - Musculo-skeletal system > M05 - Drugs for treatment of bone diseases > M05B - Drugs affecting bone structure and mineralization > M05BA - Bisphosphonates
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D050071 - Bone Density Conservation Agents > D004164 - Diphosphonates
同义名列表
18 个代谢物同义名
(4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid; (4-Amino-1-hydroxybutylidene)bisphosphonic acid; 4 amino 1 Hydroxybutylidene 1,1 biphosphonate; 4-Amino-1-hydroxybutylidene 1,1-biphosphonate; (4-Amino-1-hydroxybutylidene)bisphosphonate; Alendronate monosodium salt, trihydrate; Bisphosphonate, aminohydroxybutane; Aminohydroxybutane bisphosphonate; Alendronate sodium hydrate; Sodium, alendronate; Acidum alendronicum; Alendronate sodium; Acide alendronique; Acido alendronico; ALENDRONIC ACID; Alendronate; Fosamax; Alendronic acid
数据库引用编号
22 个数据库交叉引用编号
- ChEBI: CHEBI:2567
- KEGG: C07752
- KEGGdrug: D88506
- KEGGdrug: D07119
- PubChem: 2088
- HMDB: HMDB0001915
- Metlin: METLIN818
- DrugBank: DB00630
- ChEMBL: CHEMBL870
- Wikipedia: Alendronic_acid
- MeSH: Alendronate
- MetaCyc: ALENDRONATE
- foodb: FDB022734
- chemspider: 2004
- CAS: 66376-36-1
- PMhub: MS000019655
- PubChem: 9954
- PDB-CCD: 212
- PDB-CCD: AHD
- NIKKAJI: J363.022F
- RefMet: Alendronic acid
- KNApSAcK: 2567
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ian Stoppa, Chiara Dianzani, Nausicaa Clemente, Annalisa Bozza, Valentina Bordano, Sara Garelli, Luigi Cangemi, Umberto Dianzani, Luigi Battaglia. Alendronate-Grafted Nanoemulsions for Bone-Targeted Vincristine Delivery: Preliminary Studies on Cell and Animal Models.
Biomolecules.
2024 Feb; 14(2):. doi:
10.3390/biom14020238. [PMID: 38397475] - Kaichuang Sun, Lu Yuan, Shen Chen, Yong Sun, Dengshuai Wei. Alendronate PtIV Prodrug Amphiphile for Enhanced Chemotherapy Targeting and Bone Destruction Inhibition in Osteosarcoma.
Advanced healthcare materials.
2023 Nov; ?(?):e2302746. doi:
10.1002/adhm.202302746. [PMID: 37988194] - Ma Yingjun, Tang Shuo, Jiang Liuyun, Zhang Yan, Su Shengpei. Study on a co-hybrid nano-hydroxyapatite with lignin derivatives and alendronate and the reinforce effect for poly(lactide-co-glycolide).
International journal of biological macromolecules.
2023 Sep; 253(Pt 2):126785. doi:
10.1016/j.ijbiomac.2023.126785. [PMID: 37696379] - Anna Di Vito, Emanuela Chiarella, Jessica Sovereto, Jessica Bria, Ida Daniela Perrotta, Alessandro Salatino, Francesco Baudi, Alessandro Sacco, Alessandro Antonelli, Flavia Biamonte, Tullio Barni, Amerigo Giudice. Novel insights into the pharmacological modulation of human periodontal ligament stem cells by the amino-bisphosphonate Alendronate.
European journal of cell biology.
2023 Aug; 102(4):151354. doi:
10.1016/j.ejcb.2023.151354. [PMID: 37604089] - Jun Liu, Xinxin Zhang, Yufei Zhang, Minyi Qian, Maohui Yang, Song Yang, Lirui Wang. Farnesyl diphosphate synthase exacerbates nonalcoholic steatohepatitis via the activation of AHR-CD36 axis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 07; 37(7):e23035. doi:
10.1096/fj.202300433rr. [PMID: 37310396] - Shengjie Li, Jihui Chang. Novel iontophoretic drug delivery of estradiol with alendronate for osteoporosis treatment.
Pakistan journal of pharmaceutical sciences.
2023 Mar; 36(2):541-546. doi:
. [PMID: 37530163] - Jie Zhong, Weiye Wen, Jinjin Wang, Mengyu Zhang, Yijiang Jia, Xiaowei Ma, Yu-Xiong Su, Yuji Wang, Xinmiao Lan. Bone-Targeted Dual Functional Lipid-coated Drug Delivery System for Osteosarcoma Therapy.
Pharmaceutical research.
2023 Jan; 40(1):231-243. doi:
10.1007/s11095-022-03430-8. [PMID: 36380167] - Wucheng Wen, Pengbo Guo, Hui Yi Xue, Ho Lun Wong. Development of local injectable, bone-targeting nanocarriers of triptolide for treatment of bone-only metastasis.
International journal of pharmaceutics.
2022 Sep; 625(?):122092. doi:
10.1016/j.ijpharm.2022.122092. [PMID: 35985525] - Pengfei Li, Xiaojian Wu, Ye Li, Jianhua Huang. Denosumab Versus Bisphosphonates for the Prevention of the Vertebral Fractures in Men with Osteoporosis: An Updated Network Meta-Analysis.
Clinical and investigative medicine. Medecine clinique et experimentale.
2022 09; 45(3):E14-22. doi:
10.25011/cim.v45i3.38875. [PMID: 36149052] - Roland Kocijan, Theresa Stockinger, Judith Haschka, Berthold Reichardt, Heinrich Resch, Jochen Zwerina, Martina Behanova. Dispensing anti-osteoporotic drugs changed during the COVID-19 pandemic.
Bone.
2022 Sep; 162(?):116477. doi:
10.1016/j.bone.2022.116477. [PMID: 35779846] - Mei Li, Zhenlin Zhang, Qingyun Xue, Qifu Li, Xiaolan Jin, Jin Dong, Qun Cheng, Li You, Hua Lin, Hai Tang, Lin Shen, Xin Gao, Ji Hu, Aijun Chao, Pengqiu Li, Rui Shi, Shuhui Zheng, Ying Zhang, Xiaojiang Xiong, Wei Yu, Weibo Xia. Efficacy of generic teriparatide and alendronate in Chinese postmenopausal women with osteoporosis: a prospective study.
Archives of osteoporosis.
2022 07; 17(1):103. doi:
10.1007/s11657-022-01131-8. [PMID: 35900607] - S Khalid, S Calderon-Larranaga, A Sami, S Hawley, A Judge, N Arden, T P Van Staa, C Cooper, B Abrahamsen, M Kassim Javaid, D Prieto-Alhambra. Comparative risk of acute myocardial infarction for anti-osteoporosis drugs in primary care: a meta-analysis of propensity-matched cohort findings from the UK Clinical Practice Research Database and the Catalan SIDIAP Database.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Jul; 33(7):1579-1589. doi:
10.1007/s00198-021-06262-1. [PMID: 35138412] - F Gossiel, A Ugur, N F A Peel, J S Walsh, R Eastell. The clinical utility of TRACP-5b to monitor anti-resorptive treatments of osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2022 Jun; 33(6):1357-1363. doi:
10.1007/s00198-022-06311-3. [PMID: 35102444] - Zuhal Atan Uçar, Ayse Sinangil, Yener Koç, I Soykan Barlas, S Tevfik Ecder, Emin Baris Akin. The Effect of Alendronate on Bone Mineral Disorder in Renal Transplant Patients.
Transplantation proceedings.
2022 Apr; 54(3):658-662. doi:
10.1016/j.transproceed.2022.01.016. [PMID: 35272880] - Ruijin Geng, Le Wu, Haipeng Wang, Shuilin Sun, Huiming Huang, Yuanzhen Xiong, Baogang Xie. Preparation and evaluation of alendronate sodium solid lipid nanoparticles with high oral bioavailability in rats.
Pakistan journal of pharmaceutical sciences.
2022 Mar; 35(2):493-499. doi:
". [PMID: 35642405] - Eisuke Tsuda, Chie Fukuda, Akiko Okada, Tsuyoshi Karibe, Yoshiharu Hiruma, Nana Takagi, Yoshitaka Isumi, Tomomaya Yamamoto, Tomoka Hasegawa, Shunsuke Uehara, Masanori Koide, Nobuyuki Udagawa, Norio Amizuka, Seiichiro Kumakura. Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use.
Bone.
2022 02; 155(?):116241. doi:
10.1016/j.bone.2021.116241. [PMID: 34715394] - Qiyun Zhou, Zhiqiang Guan, Shengfu Liu, Yanjiao Xuan, Gang Han, Hua Chen, Xiao Jin, Kun Tao, Zhiyuan Guan. The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice.
Aging.
2022 01; 14(1):272-285. doi:
10.18632/aging.203729. [PMID: 35027504] - Zhaowen Qiu, Chongyun Lin, Yu Zhang, Chun Lin, Jinxiu Deng, Meng Wu. Analysis of the Efficacy and Safety of Teriparatide and Alendronate in the Treatment of Osteoporosis After Renal Transplantation.
Iranian journal of kidney diseases.
2021 Dec; 15(6):451-456. doi:
NULL. [PMID: 34930857] - Tuanny C de Lima do Nascimento, Jennifer Tsi Gerber, Thalyta Verbicaro, Roger M Arce, Mohammed E Elsalanty, José Domingos Fontana, Carmen Lucia Muller Storrer, Rafaela Scariot. Biochemical and X-ray micro-computed tomographic analyses of critical size bone defects grafted with autogenous bone and mercerized bacterial cellulose membranes salified with alendronate.
Journal of oral biosciences.
2021 12; 63(4):408-415. doi:
10.1016/j.job.2021.08.002. [PMID: 34425239] - Claudia Martini, Fernando Nicolas Sosa, Ricardo Malvicini, Natalia Pacienza, Gustavo Yannarelli, María Del C Vila. Alendronate inhibits triglyceride accumulation and oxidative stress in adipocytes and the inflammatory response of macrophages which are associated with adipose tissue dysfunction.
Journal of physiology and biochemistry.
2021 Nov; 77(4):601-611. doi:
10.1007/s13105-021-00826-9. [PMID: 34302624] - N Naganathar, W -P Yau, Z H Mok, Z Y F Tan, S T H Chew. Alendronate use in older patients with reduced renal function: challenges and opportunities in clinical practice.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2021 Oct; 32(10):1981-1988. doi:
10.1007/s00198-021-05907-5. [PMID: 33721033] - Riyoko Tamai, Izumi Mashima, Yusuke Kiyoura. Alendronate Augments Lipid A-Induced IL-1α Release via Activation of ASC but Not Caspase-11.
Inflammation.
2021 Oct; 44(5):2132-2141. doi:
10.1007/s10753-021-01489-w. [PMID: 34080091] - Jéssica S Barbosa, Miguel Pinto, Sandra Barreiro, Carlos Fernandes, Ricardo F Mendes, Pedro Lavrador, Vítor M Gaspar, João F Mano, Fernanda Borges, Fernando Remião, Susana S Braga, Filipe A Almeida Paz. Coordination Compounds As Multi-Delivery Systems for Osteoporosis.
ACS applied materials & interfaces.
2021 Aug; 13(30):35469-35483. doi:
10.1021/acsami.1c09121. [PMID: 34284573] - Fernanda Gonçalves Basso, Laís Medeiros Cardoso, Isabela Massaro Ribeiro, Ellen Rizzi, Taisa Nogueira Pansani, Josimeri Hebling, Carlos Alberto de Souza Costa. Influence of bisphosphonates on oral implantology: Sodium alendronate and zoledronic acid enhance the synthesis and activity of matrix metalloproteinases by gingival fibroblasts seeded on titanium.
Archives of oral biology.
2021 Jul; 127(?):105134. doi:
10.1016/j.archoralbio.2021.105134. [PMID: 33962330] - Antonino Catalano, Federica Bellone, Domenico Santoro, Peter Schwarz, Agostino Gaudio, Giorgio Basile, Maria Carmela Sottile, Sabrina Atena Stoian, Francesco Corica, Nunziata Morabito. Vitamin D Boosts Alendronate Tail Effect on Bone Mineral Density in Postmenopausal Women with Osteoporosis.
Nutrients.
2021 May; 13(6):. doi:
10.3390/nu13061878. [PMID: 34072655] - Junyi Wu, Chen Wang, Guo-Fu Li, En-Tzu Tang, Qingshan Zheng. Quantitative prediction of bone mineral density by using bone turnover markers in response to antiresorptive agents in postmenopausal osteoporosis: A model-based meta-analysis.
British journal of clinical pharmacology.
2021 03; 87(3):1175-1186. doi:
10.1111/bcp.14487. [PMID: 32692857] - Horacio Emanuel Jerez, María Julia Altube, Yamila B Gándola, Lorena González, Marina Cecilia González, María José Morilla, Eder Lilia Romero. Macrophage apoptosis using alendronate in targeted nanoarchaeosomes.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2021 Mar; 160(?):42-54. doi:
10.1016/j.ejpb.2021.01.001. [PMID: 33440242] - Hirotada Otsuka, Yasuo Endo, Hiroshi Ohtsu, Satoshi Inoue, Syunya Noguchi, Masanori Nakamura, Satoshi Soeta. Histidine decarboxylase deficiency inhibits NBP-induced extramedullary hematopoiesis by modifying bone marrow and spleen microenvironments.
International journal of hematology.
2021 Mar; 113(3):348-361. doi:
10.1007/s12185-020-03051-0. [PMID: 33398631] - Tingting Zhao, Lingyu Wang, Yueyang Li, Sijia Chen, Rizhi Wang, David Da Yong Chen. Quantification of the bisphosphonate alendronate using capillary electrophoresis mass spectrometry with dynamic pH barrage junction focusing.
Electrophoresis.
2021 02; 42(4):350-359. doi:
10.1002/elps.202000228. [PMID: 33247852] - Xiaojian She, Jiajia Li, Jinglin Zhu, Taomin Huang, Yan Li. Magnetic solid phase extraction followed by in-situ derivatization with core-shell structured titanium dioxide coated ferriferrous oxide microspheres for determination of alendronate in plasma.
Journal of chromatography. A.
2021 Jan; 1637(?):461809. doi:
10.1016/j.chroma.2020.461809. [PMID: 33360639] - Yoko Miyazaki-Asato, Kiyono Koi, Hiroki Fujimoto, Kae Kakura, Hirofumi Kido, Tsukasa Yanagi, Junro Yamashita. Intramedullary injury combined with osteoporosis therapeutics regulates targeted local osteogenesis.
Scientific reports.
2021 01; 11(1):205. doi:
10.1038/s41598-020-80316-y. [PMID: 33436871] - Ruotian Zhang, Min Yang, Yang Li, Hedong Liu, Maoxian Ren, Zhou-Shan Tao. Effect of alendronate on the femoral metaphyseal defect under carbamazepine in ovariectomized rats.
Journal of orthopaedic surgery and research.
2021 Jan; 16(1):14. doi:
10.1186/s13018-020-02151-1. [PMID: 33407695] - S Hildebrand, J Cunningham. Is there a role for bisphosphonates in vascular calcification in chronic kidney disease?.
Bone.
2021 01; 142(?):115751. doi:
10.1016/j.bone.2020.115751. [PMID: 33188959] - Ying Li, Min Cai, Ruihuan Zhang, Jun Wang, Huijing Zhu, Chunhua Wang, Weiqi Min, Yiheng Chen, Li Yan. Investigating the Preventive Effects of 99Tc-Methylenediphosphonate on a Glucocorticoid-Induced Osteoporosis Rabbit Model.
Current topics in medicinal chemistry.
2021; 21(26):2425-2433. doi:
10.2174/1568026621666210804114744. [PMID: 34348621] - Maha Sabry, Seham Mostafa, Laila Rashed, Marwa Abdelgwad, Samaa Kamar, Suzanne Estaphan. Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats.
PloS one.
2021; 16(2):e0244650. doi:
10.1371/journal.pone.0244650. [PMID: 33571214] - O A Uspenskaya, E S Kachesova, S R Abasnia, E A Shevchenko, I I Fadeeva. [Metabolic bone tissue markers dynamics as criteria for periodontal disease treatment efficiency].
Stomatologiia.
2021; 100(2):44-49. doi:
10.17116/stomat202110002144. [PMID: 33874660] - Haixia Liu, Yubo Guo, Ruyuan Zhu, Lili Wang, Beibei Chen, Yimiao Tian, Rui Li, Rufeng Ma, Qiangqiang Jia, Hao Zhang, Bingke Xia, Yu Li, Xinxiang Wang, Xiaofeng Zhu, Ronghua Zhang, Dieter Brӧmme, Sihua Gao, Dongwei Zhang, Xiaohua Pei. Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats.
Phytotherapy research : PTR.
2021 Jan; 35(1):424-441. doi:
10.1002/ptr.6817. [PMID: 32755017] - Ke Rong, Xiaoliu Li, Weimin Jiang, Xuhua Wu, Qingquan Xia, Jie Chen, Xiaofan Yin. Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats.
Drug design, development and therapy.
2021; 15(?):1717-1724. doi:
10.2147/dddt.s286610. [PMID: 33935494] - Wen-Bin Zheng, Yi Dai, Jing Hu, Di-Chen Zhao, Ou Wang, Yan Jiang, Wei-Bo Xia, Xiao-Ping Xing, Mei Li. Effects of Bisphosphonates on Osteoporosis Induced by Duchenne Muscular Dystrophy: A Prospective Study.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2020 Dec; 26(12):1477-1485. doi:
10.4158/ep-2020-0073. [PMID: 33471740] - Hiroki Ukai, Ayako Imanishi, Ayaka Kaneda, Erika Kimura, Miku Koyama, Masaki Morishita, Hidemasa Katsumi, Akira Yamamoto. Absorption-Enhancing Mechanisms of Capryol 90, a Novel Absorption Enhancer, for Improving the Intestinal Absorption of Poorly Absorbed Drugs: Contributions to Trans- or Para-Cellular Pathways.
Pharmaceutical research.
2020 Nov; 37(12):248. doi:
10.1007/s11095-020-02963-0. [PMID: 33230672] - Carolina Simão Albano, Anderson Moreira Gomes, Geórgia da Silva Feltran, Célio Junior da Costa Fernandes, Luciana Daniele Trino, Willian Fernando Zambuzzi, Paulo Noronha Lisboa-Filho. Bisphosphonate-based surface biofunctionalization improves titanium biocompatibility.
Journal of materials science. Materials in medicine.
2020 Nov; 31(11):109. doi:
10.1007/s10856-020-06437-y. [PMID: 33159588] - Louise Wulff Bagger, Per Kim Dyhr Hansen, Peter Schwarz, Barbara Rubek Nielsen. Severe hypophosphataemia following oral bisphosphonate treatment in a patient with osteoporosis.
BMJ case reports.
2020 Oct; 13(10):. doi:
10.1136/bcr-2020-235083. [PMID: 33033001] - Ryo Fujita, Masahiro Ota, Dai Sato, Daigo Nakazawa, Hiromi Kimura-Suda, Fumiya Nakamura, Tomohiro Shimizu, Hideyuki Kobayashi, Norimasa Iwasaki, Masahiko Takahata. Comparison of the Efficacy and Renal Safety of Bisphosphonate Between Low-Dose/High-Frequency and High-Dose/Low-Frequency Regimens in a Late-Stage Chronic Kidney Disease Rat Model.
Calcified tissue international.
2020 10; 107(4):389-402. doi:
10.1007/s00223-020-00723-1. [PMID: 32671419] - Maryam Eskandarynasab, Amir Hossein Doustimotlagh, Nasrin Takzaree, Shahroo Etemad-Moghadam, Mojgan Alaeddini, Ahmad Reza Dehpour, Ramin Goudarzi, Alireza Partoazar. Phosphatidylserine nanoliposomes inhibit glucocorticoid-induced osteoporosis: A potential combination therapy with alendronate.
Life sciences.
2020 Sep; 257(?):118033. doi:
10.1016/j.lfs.2020.118033. [PMID: 32621924] - Judd Sher, Catherine Miller, Dileep Sharma. Effect of Bisphosphonates on the Osteogenic Activity of Osteoprogenitor Cells Cultured on Titanium Surfaces.
The International journal of oral & maxillofacial implants.
2020 Sep; 35(5):939-947. doi:
10.11607/jomi.8354. [PMID: 32991644] - Rafael Scaf de Molon, Leslie Cristine Fiori, Mario Henrique Arruda Verzola, Marina Montosa Belluci, Ana Paula de Souza Faloni, Rosa Maria Rodrigues Pereira, Sotirios Tetradis, Silvana Regina Perez Orrico. Long-term evaluation of alendronate treatment on the healing of calvaria bone defects in rats. Biochemical, histological and immunohistochemical analyses.
Archives of oral biology.
2020 Sep; 117(?):104779. doi:
10.1016/j.archoralbio.2020.104779. [PMID: 32559508] - J M Neves, J Cabete, C Fernandes. Nonuraemic cutaneous calciphylaxis: our experience with a challenging disease.
Clinical and experimental dermatology.
2020 Aug; 45(6):745-746. doi:
10.1111/ced.14242. [PMID: 32304580] - Shuhei Kurosawa, Noriko Doki, Yasushi Senoo, Yuya Kishida, Akihito Nagata, Yuta Yamada, Tatsuya Konishi, Satoshi Kaito, Kota Yoshifuji, Naoki Matsuyama, Shuichi Shirane, Tomoyuki Uchida, Kyoko Inamoto, Takashi Toya, Aiko Igarashi, Yuho Najima, Hideharu Muto, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi. Bone turnover markers as an aid to monitor osteoporosis following allogeneic hematopoietic stem cell transplantation.
Annals of hematology.
2020 Aug; 99(8):1873-1882. doi:
10.1007/s00277-020-04090-7. [PMID: 32451708] - Andreas Fontalis, Richard Eastell. The challenge of long-term adherence: The role of bone turnover markers in monitoring bisphosphonate treatment of osteoporosis.
Bone.
2020 07; 136(?):115336. doi:
10.1016/j.bone.2020.115336. [PMID: 32234415] - Silvia Gancheva, Maria Zhelyazkova-Savova. Are Bisphosphonates Associated with Adverse Metabolic and Cognitive Effects? A Study in Intact Rats and Rats Fed High-Fat High-Fructose Diet.
Calcified tissue international.
2020 07; 107(1):41-51. doi:
10.1007/s00223-020-00684-5. [PMID: 32211934] - Baofeng Li, Guiyun Huang, Zhenhe Ma, Shourong Qin. Ultrasound-assisted transdermal delivery of alendronate for the treatment of osteoporosis.
Acta biochimica Polonica.
2020 Jun; 67(2):173-179. doi:
10.18388/abp.2020_5162. [PMID: 32558528] - Jian Zhou, Bo Liu, Ming-Zhao Qin, Jin-Ping Liu. Fall Prevention and Anti-Osteoporosis in Osteopenia Patients of 80 Years of Age and Older: A Randomized Controlled Study.
Orthopaedic surgery.
2020 Jun; 12(3):890-899. doi:
10.1111/os.12701. [PMID: 32495521] - M Sanni Ali, Martin Ernst, Danielle E Robinson, Fergus Caskey, Nigel K Arden, Yoav Ben-Shlomo, Mads Nybo, Katrine H Rubin, Andrew Judge, Cyrus Cooper, M K Javaid, Anne P Hermann, Daniel Prieto-Alhambra. Alendronate use and bone mineral density gains in women with moderate-severe (stages 3B-5) chronic kidney disease: an open cohort multivariable and propensity score analysis from Funen, Denmark.
Archives of osteoporosis.
2020 06; 15(1):81. doi:
10.1007/s11657-020-00746-z. [PMID: 32483674] - Shao-Bo Bai, Ying Cheng, Dao-Zhou Liu, Qi-Feng Ji, Miao Liu, Bang-le Zhang, Qi-Bing Mei, Si-Yuan Zhou. Bone-targeted PAMAM nanoparticle to treat bone metastases of lung cancer.
Nanomedicine (London, England).
2020 04; 15(9):833-849. doi:
10.2217/nnm-2020-0024. [PMID: 32163008] - Kousuke Iba, Junichi Takada, Tomoko Sonoda, Toshihiko Yamashita. Effect of continuous long-term treatment for 10 years with bisphosphonate on Japanese osteoporosis patients.
Journal of bone and mineral metabolism.
2020 Mar; 38(2):240-247. doi:
10.1007/s00774-019-01049-1. [PMID: 31667583] - F Gossiel, M A Paggiosi, K E Naylor, E V McCloskey, J Walsh, N Peel, R Eastell. The effect of bisphosphosphonates on bone turnover and bone balance in postmenopausal women with osteoporosis: The T-score bone marker approach in the TRIO study.
Bone.
2020 02; 131(?):115158. doi:
10.1016/j.bone.2019.115158. [PMID: 31740343] - Feng Xin, Haihong Wang, Feng Yuan, Yunzhi Ding. Platelet-Rich Plasma Combined with Alendronate Reduces Pain and Inflammation in Induced Osteoarthritis in Rats by Inhibiting the Nuclear Factor-Kappa B Signaling Pathway.
BioMed research international.
2020; 2020(?):8070295. doi:
10.1155/2020/8070295. [PMID: 33062701] - Jeonghoon Ha, Jung-Min Lee, Yejee Lim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song, Hae Myung Jeon, Moo Il Kang, Ki-Hyun Baek. Effect of bisphosphonate on the prevention of bone loss in patients with gastric cancer after gastrectomy: A randomized controlled trial.
Bone.
2020 01; 130(?):115138. doi:
10.1016/j.bone.2019.115138. [PMID: 31706052] - Shengnan Liu, Jiaqi Bi, Ying Zhang, Qiushi Song, Miao Yu, Xiaowei Sun, Daofei Qu, Shaoting Liu. Preliminary study on the electromagnetic field treatment of osteoporosis in rats.
Technology and health care : official journal of the European Society for Engineering and Medicine.
2020; 28(S1):47-55. doi:
10.3233/thc-209006. [PMID: 32364143] - Robert B Conley, Gemma Adib, Robert A Adler, Kristina E Åkesson, Ivy M Alexander, Kelly C Amenta, Robert D Blank, William Timothy Brox, Emily E Carmody, Karen Chapman-Novakofski, Bart L Clarke, Kathleen M Cody, Cyrus Cooper, Carolyn J Crandall, Douglas R Dirschl, Thomas J Eagen, Ann L Elderkin, Masaki Fujita, Susan L Greenspan, Philippe Halbout, Marc C Hochberg, Muhammad Javaid, Kyle J Jeray, Ann E Kearns, Toby King, Thomas F Koinis, Jennifer Scott Koontz, Martin Kužma, Carleen Lindsey, Mattias Lorentzon, George P Lyritis, Laura Boehnke Michaud, Armando Miciano, Suzanne N Morin, Nadia Mujahid, Nicola Napoli, Thomas P Olenginski, J Edward Puzas, Stavroula Rizou, Clifford J Rosen, Kenneth Saag, Elizabeth Thompson, Laura L Tosi, Howard Tracer, Sundeep Khosla, Douglas P Kiel. Secondary Fracture Prevention: Consensus Clinical Recommendations from a Multistakeholder Coalition.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2020 01; 35(1):36-52. doi:
10.1002/jbmr.3877. [PMID: 31538675] - Chengdong Piao, Zhengwei Li, Jie Ding, Daliang Kong. Comparison of bone biomechanical properties after bone marrow mesenchymal stem cell or alendronate treatment in an osteoporotic animal model.
Biomedizinische Technik. Biomedical engineering.
2019 Dec; 64(6):721-727. doi:
10.1515/bmt-2018-0087. [PMID: 31116701] - Fanguo Kong, Bin Jia, Peng Cui, Duojun Wang. Novel combinatorial transdermal drug delivery of alendronate with risedronate for the treatment of osteoporosis.
Acta biochimica Polonica.
2019 Dec; 66(4):463-467. doi:
10.18388/abp.2019_2863. [PMID: 31846272] - Emiliano Giampà, Mario Di Bonito, Valentino Ferretti, Giuseppe Nuvoli, Franco Paoletti, Marco Piazzini, Mauro Ranieri, Marco A Tuveri, Vincenzo Vinicola. Effects of alendronate and calcifediol compared to alendronate and cholecalciferol in osteoporotic patients.
Minerva endocrinologica.
2019 Dec; 44(4):344-350. doi:
10.23736/s0391-1977.19.03052-9. [PMID: 31971357] - Darrell H S Tan, Terry Lee, Janet Raboud, Attia Qamar, Angela M Cheung, Sharon Walmsley. Alendronate/Vitamin D for attenuating bone mineral density loss during antiretroviral initiation: a pilot randomized controlled trial.
HIV research & clinical practice.
2019 12; 20(6):140-150. doi:
10.1080/25787489.2020.1730114. [PMID: 32106792] - Ifaz T Haider, Narina Simonian, Amanpreet S Saini, Frances M Leung, W Brent Edwards, Thomas J Schnitzer. Open-label clinical trial of alendronate after teriparatide therapy in people with spinal cord injury and low bone mineral density.
Spinal cord.
2019 Oct; 57(10):832-842. doi:
10.1038/s41393-019-0303-3. [PMID: 31164732] - Ken Iseri, Makoto Watanabe, Xiao-Pen Lee, Miho Yamada, Kakei Ryu, Masayuki Iyoda, Naoki Uchida, Keizo Sato, Takanori Shibata. Elimination of intravenous alendronate by hemodialysis: A kinetic study.
Hemodialysis international. International Symposium on Home Hemodialysis.
2019 10; 23(4):466-471. doi:
10.1111/hdi.12773. [PMID: 31328884] - Hidefumi Koiwai, Mikio Kamimura, Jun Takahashi, Yukio Nakamura, Hiroyuki Kato. Unexpected rapid increase in bone mineral density by bisphosphonate therapy after multiple spinal fractures: a case report.
Journal of medical case reports.
2019 Sep; 13(1):288. doi:
10.1186/s13256-019-2219-0. [PMID: 31514730] - Jianrong Zhao, Yingbin Li, Hao Zhang, Dongying Shi, Qingnan Li, Yan Meng, Li Zuo. Preventative effects of metformin on glucocorticoid-induced osteoporosis in rats.
Journal of bone and mineral metabolism.
2019 Sep; 37(5):805-814. doi:
10.1007/s00774-019-00989-y. [PMID: 30706148] - Kamyar Asadipooya, Ada Weinstock. Cardiovascular Outcomes of Romosozumab and Protective Role of Alendronate.
Arteriosclerosis, thrombosis, and vascular biology.
2019 07; 39(7):1343-1350. doi:
10.1161/atvbaha.119.312371. [PMID: 31242037] - Jun-Ming Wan, Jian-Fang Zhang, Kai Huang, Peng-Li Zhang, Shao-Yu Zhu. [Comparison of the clinical effects between Dihuang Decoction and alendronate sodium in the treatment of primary osteoporosis].
Zhongguo gu shang = China journal of orthopaedics and traumatology.
2019 Jun; 32(6):535-538. doi:
10.3969/j.issn.1003-0034.2019.06.010. [PMID: 31277537] - Lei Zhao, Dongdong Bi, Xiaoyu Qi, Yifei Guo, Feng Yue, Xiangtao Wang, Meihua Han. Polydopamine-based surface modification of paclitaxel nanoparticles for osteosarcoma targeted therapy.
Nanotechnology.
2019 Jun; 30(25):255101. doi:
10.1088/1361-6528/ab055f. [PMID: 30736019] - Sivaramakrishnan Ramadurai, Nirod Kumar Sarangi, Sean Maher, Nicola MacConnell, Alan M Bond, Dennis McDaid, Damien Flynn, Tia E Keyes. Microcavity-Supported Lipid Bilayers; Evaluation of Drug-Lipid Membrane Interactions by Electrochemical Impedance and Fluorescence Correlation Spectroscopy.
Langmuir : the ACS journal of surfaces and colloids.
2019 06; 35(24):8095-8109. doi:
10.1021/acs.langmuir.9b01028. [PMID: 31120755] - Ken Iseri, Makoto Watanabe, Hisako Yoshikawa, Hisao Mitsui, Teruhiko Endo, Yuichiro Yamamoto, Masayuki Iyoda, Kakei Ryu, Taro Inaba, Takanori Shibata. Effects of Denosumab and Alendronate on Bone Health and Vascular Function in Hemodialysis Patients: A Randomized, Controlled Trial.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2019 06; 34(6):1014-1024. doi:
10.1002/jbmr.3676. [PMID: 30690785] - Ashiyana Parwin, Abul Kalam Najmi, Mohd Vasim Ismail, Madhu Kaundal, Mohd Akhtar. Protective effects of alendronate in Triton X-100-induced hyperlipidemia in rats.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2019 Jun; 30(6):557-564. doi:
10.5152/tjg.2019.18076. [PMID: 31144662] - Maryam Karimi Fard, Ashraf Aminorroaya, Ali Kachuei, Mohammad Reza Salamat, Moluk Hadi Alijanvand, Sima Aminorroaya Yamini, Mansoor Karimifar, Awat Feizi, Massoud Amini. Alendronate improves fasting plasma glucose and insulin sensitivity, and decreases insulin resistance in prediabetic osteopenic postmenopausal women: A randomized triple-blind clinical trial.
Journal of diabetes investigation.
2019 May; 10(3):731-737. doi:
10.1111/jdi.12944. [PMID: 30267620] - Qin Zhao, Dan-Qi Cheng, Ming Tao, Wen-Jing Ning, Yong-Jiao Yang, Kai-You Meng, Yong Mei, Yu-Qi Feng. Rapid magnetic solid-phase extraction based on alendronate sodium grafted mesoporous magnetic nanoparticle for the determination of trans-resveratrol in peanut oils.
Food chemistry.
2019 May; 279(?):187-193. doi:
10.1016/j.foodchem.2018.12.014. [PMID: 30611478] - Shuaishuai Feng, Zi-Xin Wu, Ziyan Zhao, Jinhu Liu, Kaoxiang Sun, Chuanyou Guo, Hongbo Wang, Zimei Wu. Engineering of Bone- and CD44-Dual-Targeting Redox-Sensitive Liposomes for the Treatment of Orthotopic Osteosarcoma.
ACS applied materials & interfaces.
2019 Feb; 11(7):7357-7368. doi:
10.1021/acsami.8b18820. [PMID: 30682240] - Akira Horikawa, Naohisa Miyakoshi, Michio Hongo, Yuji Kasukawa, Hiroyuki Kodama, Yoichi Shimada. A prospective comparative study of intravenous alendronate and ibandronate for the treatment of osteoporosis.
Medicine.
2019 Feb; 98(6):e14340. doi:
10.1097/md.0000000000014340. [PMID: 30732159] - Luisa Stella Dolci, Silvia Panzavolta, Paola Torricelli, Beatrice Albertini, Laura Sicuro, Milena Fini, Adriana Bigi, Nadia Passerini. Modulation of Alendronate release from a calcium phosphate bone cement: An in vitro osteoblast-osteoclast co-culture study.
International journal of pharmaceutics.
2019 Jan; 554(?):245-255. doi:
10.1016/j.ijpharm.2018.11.023. [PMID: 30423416] - Yutao Tang, Han Xia, Liang Kang, Quan Sun, Zhe Su, Congqiang Hao, Yuan Xue. Effects of Intermittent Parathyroid Hormone 1-34 Administration on Circulating Mesenchymal Stem Cells in Postmenopausal Osteoporotic Women.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Jan; 25(?):259-268. doi:
10.12659/msm.913752. [PMID: 30620727] - Yanhai Xi, Tingwang Jiang, Yinglan Yu, Jiangmin Yu, Mintao Xue, Ning Xu, Jiankun Wen, Weiheng Wang, Hailong He, Yan Shen, Daquan Chen, Xiaojian Ye, Thomas J Webster. Dual targeting curcumin loaded alendronate-hyaluronan- octadecanoic acid micelles for improving osteosarcoma therapy.
International journal of nanomedicine.
2019; 14(?):6425-6437. doi:
10.2147/ijn.s211981. [PMID: 31496695] - Long Chen, Zhou-Shan Tao, Hui Chen, Kailiang Zhou, Dong-Sheng Zhou. Combined treatment with alendronate and Drynaria rhizome extracts : Effect on fracture healing in osteoporotic rats.
Zeitschrift fur Gerontologie und Geriatrie.
2018 Dec; 51(8):875-881. doi:
10.1007/s00391-017-1326-z. [PMID: 29043444] - Thawee Songpatanasilp, Sattaya Rojanasthien, Pansak Sugkraroek, Boonsong Ongphiphadhanakul, Lamar Robert, Chongchit Sripun Robert, Sirichai Luevitoonvechkij, Arthur C Santora. Open-label study of treatment with alendronate sodium plus vitamin D in men and women with osteoporosis in Thailand.
BMC musculoskeletal disorders.
2018 Nov; 19(1):392. doi:
10.1186/s12891-018-2309-y. [PMID: 30400864] - Jing Deng, Zhengping Feng, Yue Li, Tingting Pan, Qifu Li, Changhong Zhao. Efficacy and safety of recombinant human parathyroid hormone (1-34) are similar to those of alendronate in the treatment of postmenopausal osteoporosis.
Medicine.
2018 Nov; 97(47):e13341. doi:
10.1097/md.0000000000013341. [PMID: 30461654] - Tomohiko Urano, Masataka Shiraki, Tatsuhiko Kuroda, Shiro Tanaka, Fumihiko Urano, Kazuhiro Uenishi, Satoshi Inoue. Bisphosphonates prevent age-related weight loss in Japanese postmenopausal women.
Journal of bone and mineral metabolism.
2018 Nov; 36(6):734-740. doi:
10.1007/s00774-017-0891-y. [PMID: 29236162] - El-Sayed M El-Sayed, Abd El-Aziz H Abd El-Aziz, Mohamed M Amine. Nebivolol enhances the effect of alendronate against methylprednisolone-induced osteoporosis in rats.
Journal of biochemical and molecular toxicology.
2018 Oct; ?(?):e22232. doi:
10.1002/jbt.22232. [PMID: 30291735] - Nadereh Rahbar, Ladan Nazernezhad, Maryam Asadinezhad, Zahra Ramezani, Maryam Kouchak. A novel micro-extraction strategy for extraction of bisphosphonates from biological fluids using zirconia nanoparticles coupled with spectrofluorimetry and high performance liquid chromatography.
Journal of food and drug analysis.
2018 10; 26(4):1303-1311. doi:
10.1016/j.jfda.2018.03.005. [PMID: 30249329] - Young-Seok Lee, Rishab Gupta, Jeong-Taik Kwon, Dae-Chul Cho, Ye Jin Seo, Sung Young Seu, Eui Kyun Park, Inbo Han, Chi-Heon Kim, Joo-Kyung Sung, Kyoung-Tae Kim. Effect of a bisphosphonate and selective estrogen receptor modulator on bone remodeling in streptozotocin-induced diabetes and ovariectomized rat model.
The spine journal : official journal of the North American Spine Society.
2018 10; 18(10):1877-1887. doi:
10.1016/j.spinee.2018.05.020. [PMID: 29793000] - Mithila Boche, Varsha Pokharkar. Positive effect of alendronate on bone turnover in ovariectomised rats' osteoporosis: comparison of transdermal lipid-based delivery with conventional oral administration.
Drug delivery and translational research.
2018 10; 8(5):1078-1089. doi:
10.1007/s13346-018-0558-9. [PMID: 29987552] - Frederico Ribeiro Deliberador, Aline Monise Sebastiani, Jennifer Gerber, Luana Bonetto, Gabriela Tórtora, Allan Fernando Giovanini, Tatiana Miranda Deliberador, Joao César Zielak, Rafaela Scariot. Effect of Local Application of Alendronate and Parathyroid Hormone on Craniofacial Bone Repair - a Preliminary Study.
Brazilian dental journal.
2018 Sep; 29(5):435-445. doi:
10.1590/0103-6440201802120. [PMID: 30517441] - Fatemeh Khanizadeh, Asghar Rahmani, Khairollah Asadollahi, Mohammad Reza Hafezi Ahmadi. Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis.
Archives of endocrinology and metabolism.
2018 Aug; 62(4):438-445. doi:
10.20945/2359-3997000000060. [PMID: 30304108] - Sahu Ipshita, Ida G Kurian, Pankaj Dileep, Shatrughan Kumar, Priyanka Singh, Avani R Pradeep. One percent alendronate and aloe vera gel local host modulating agents in chronic periodontitis patients with class II furcation defects: A randomized, controlled clinical trial.
Journal of investigative and clinical dentistry.
2018 Aug; 9(3):e12334. doi:
10.1111/jicd.12334. [PMID: 29722166] - Er-Yuan Liao, Zhen-Lin Zhang, Wei-Bo Xia, Hua Lin, Qun Cheng, Li Wang, Yong-Qiang Hao, De-Cai Chen, Hai Tang, Yong-De Peng, Li You, Liang He, Zhao-Heng Hu, Chun-Li Song, Fang Wei, Jue Wang, Lei Zhang. Clinical characteristics associated with bone mineral density improvement after 1-year alendronate/vitamin d3 or calcitriol treatment: Exploratory results from a phase 3, randomized, controlled trial on postmenopausal osteoporotic women in China.
Medicine.
2018 Aug; 97(31):e11694. doi:
10.1097/md.0000000000011694. [PMID: 30075569] - Helena Florez, Stanislava Mandelikova, Xavier Filella, Ana Monegal, Núria Guañabens, Pilar Peris. Clinical significance of increased serum levels of FGF-23 in fibrous dysplasia.
Medicina clinica.
2018 07; 151(2):65-67. doi:
10.1016/j.medcli.2017.11.036. [PMID: 29295788] - Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae. A novel alendronate functionalized nanoprobe for simple colorimetric detection of cancer-associated hypercalcemia.
Nanoscale.
2018 Jul; 10(28):13375-13383. doi:
10.1039/c8nr02570c. [PMID: 29786742] - Anne Nsubuga, Massimo Sgarzi, Kristof Zarschler, Manja Kubeil, René Hübner, Robin Steudtner, Bim Graham, Tanmaya Joshi, Holger Stephan. Facile preparation of multifunctionalisable 'stealth' upconverting nanoparticles for biomedical applications.
Dalton transactions (Cambridge, England : 2003).
2018 Jul; 47(26):8595-8604. doi:
10.1039/c8dt00241j. [PMID: 29691531] - Er-Yuan Liao, Zhen-Lin Zhang, Wei-Bo Xia, Hua Lin, Qun Cheng, Li Wang, Yong-Qiang Hao, De-Cai Chen, Hai Tang, Yong-De Peng, Li You, Liang He, Zhao-Heng Hu, Chun-Li Song, Fang Wei, Jue Wang, Lei Zhang. Calcifediol (25-hydroxyvitamin D) improvement and calcium-phosphate metabolism of alendronate sodium/vitamin D3 combination in Chinese women with postmenopausal osteoporosis: a post hoc efficacy analysis and safety reappraisal.
BMC musculoskeletal disorders.
2018 Jul; 19(1):210. doi:
10.1186/s12891-018-2090-y. [PMID: 29970059] - Susmita Bose, Ashley A Vu, Khalid Emshadi, Amit Bandyopadhyay. Effects of polycaprolactone on alendronate drug release from Mg-doped hydroxyapatite coating on titanium.
Materials science & engineering. C, Materials for biological applications.
2018 Jul; 88(?):166-171. doi:
10.1016/j.msec.2018.02.019. [PMID: 29636132] - H K Aggarwal, Deepak Jain, Pulkit Chhabra, R K Yadav. Effects of Short Term Alendronate Administration on Bone Mineral Density in Patients with Chronic Kidney Disease.
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki).
2018 Jul; 39(1):5-13. doi:
10.2478/prilozi-2018-0019. [PMID: 30110263]
