Cefradine (BioDeep_00000006375)

 

Secondary id: BioDeep_00001868023

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C16H19N3O4S (349.1096)
中文名称: 头孢拉定
谱图信息: 最多检出来源 Homo sapiens(urine) 64.09%

分子结构信息

SMILES: CC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)C3=CCC=CC3)C2SC1
InChI: InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1

描述信息

Cefradine is only found in individuals that have used or taken this drug. It is a semi-synthetic cephalosporin antibiotic.Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

39 个代谢物同义名

(6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid; (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate; 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid; Bristol-myers squibb brand OF cefradine; Cephradine, NON stoichiometric hydrate; Cephradine, non-stoichiometric hydrate; Non-stoichiometric hydrate cephradine; Yamanouchi brand OF cephradine; Reig jofre brand OF cephradine; Alpharma brand OF cephradine; Bouchara brand OF cephradine; Squibb brand OF cephradine; Septa brand OF cephradine; Galen brand OF cephradine; Dexo brand OF cephradine; Dihydrate, cephradine; Cephradine dihydrate; CHEMBL1161461; Cefradinum; Maxisporin; Cephradine; Cephradin; Zeefra gé; Cefradina; Cefradine; Septacef; Velosef; Velocef; Eskacef; Kelsef; Sefril; Anspor; Dexef; Nicef; CED; Cephradine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ABCB1, ACE, ALB, ANPEP, CAT, HMGB1, TUBB2B
Peripheral membrane protein 2 CYP27A1, HMGB1
Mitochondrion membrane 1 CYP27A1
Nucleus 6 ALB, H2AX, HMGA2, HMGB1, PBK, TUBB2B
cytosol 4 ALB, CAT, GPT, SLC16A13
centrosome 2 ALB, H2AX
nucleoplasm 3 H2AX, HMGA2, HMGB1
Cell membrane 8 ABCB1, ACE, ANPEP, HMGB1, RECK, SLC15A2, SLC16A13, TNF
Multi-pass membrane protein 4 ABCB1, SLC15A1, SLC15A2, SLC16A13
Golgi apparatus membrane 1 SLC16A13
cell surface 3 ABCB1, HMGB1, TNF
Golgi apparatus 2 ALB, SLC16A13
Golgi membrane 1 SLC16A13
lysosomal membrane 1 ANPEP
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
Lysosome 1 ACE
endosome 2 ACE, HMGB1
plasma membrane 10 ABCB1, ACE, ANPEP, HMGB1, LCT, RECK, SLC15A1, SLC15A2, SLC16A13, TNF
Membrane 6 ABCB1, ACE, CAT, RECK, SLC15A1, SLC15A2
apical plasma membrane 3 ABCB1, SLC15A1, SLC15A2
brush border 1 SLC15A1
extracellular exosome 9 ABCB1, ACE, ALB, ANPEP, CAT, GPT, H2AX, LYZ, SLC15A2
endoplasmic reticulum 2 ALB, HMGB1
extracellular space 7 ACE, ALB, ANPEP, HMGB1, IL6, LYZ, TNF
Schaffer collateral - CA1 synapse 1 TUBB2B
mitochondrion 2 CAT, CYP27A1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 1 CAT
Single-pass type I membrane protein 2 ACE, LCT
Secreted 4 ACE, ALB, HMGB1, IL6
extracellular region 8 ACE, ALB, CAT, HMGB1, IL6, LYZ, RECK, TNF
mitochondrial matrix 2 CAT, CYP27A1
Extracellular side 1 HMGB1
anchoring junction 1 ALB
external side of plasma membrane 3 ACE, ANPEP, TNF
microtubule cytoskeleton 1 TUBB2B
Wnt signalosome 1 RECK
recycling endosome 1 TNF
Single-pass type II membrane protein 2 ANPEP, TNF
Apical cell membrane 4 ABCB1, LCT, SLC15A1, SLC15A2
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 TUBB2B
focal adhesion 1 CAT
microtubule 1 TUBB2B
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
nuclear speck 1 H2AX
ciliary basal body 1 ALB
chromatin 1 HMGA2
Cytoplasmic vesicle, phagosome membrane 1 SLC15A2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 SLC15A2
mitotic spindle 1 TUBB2B
Chromosome 2 H2AX, HMGB1
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
nuclear chromosome 1 HMGA2
blood microparticle 1 ALB
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 RECK
site of double-strand break 1 H2AX
intercellular bridge 1 TUBB2B
side of membrane 1 RECK
replication fork 1 H2AX
basal plasma membrane 1 ACE
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
secretory granule membrane 1 ANPEP
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 HMGB1
male germ cell nucleus 1 H2AX
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
XY body 1 H2AX
azurophil granule lumen 1 LYZ
condensed nuclear chromosome 1 H2AX
endoplasmic reticulum-Golgi intermediate compartment 2 ANPEP, HMGB1
SMAD protein complex 1 HMGA2
protein-DNA complex 1 HMGA2
external side of apical plasma membrane 2 ABCB1, LCT
nucleosome 1 H2AX
condensed chromosome 1 HMGB1
site of DNA damage 1 H2AX
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
senescence-associated heterochromatin focus 1 HMGA2
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Atiya Butt, Sehrish Jabeen, Numrah Nisar, Atif Islam, Nafisa Gull, Sadia Sagar Iqbal, Shahzad Maqsood Khan, Basit Yameen. Controlled release of cephradine by biopolymers based target specific crosslinked hydrogels. International journal of biological macromolecules. 2019 Jan; 121(?):104-112. doi: 10.1016/j.ijbiomac.2018.10.018. [PMID: 30291928]
  • C O'Halloran, N Walsh, M C O'Grady, L Barry, C Hooton, G D Corcoran, B Lucey. Assessment of the comparability of CLSI, EUCAST and Stokes antimicrobial susceptibility profiles for Escherichia coli uropathogenic isolates. British journal of biomedical science. 2018 Jan; 75(1):24-29. doi: 10.1080/09674845.2017.1392736. [PMID: 29210602]
  • André Dallmann, Ibrahim Ince, Juri Solodenko, Michaela Meyer, Stefan Willmann, Thomas Eissing, Georg Hempel. Physiologically Based Pharmacokinetic Modeling of Renally Cleared Drugs in Pregnant Women. Clinical pharmacokinetics. 2017 12; 56(12):1525-1541. doi: 10.1007/s40262-017-0538-0. [PMID: 28391404]
  • Dirk R de Waart, Koen van de Wetering, Cindy Kunne, Suzanne Duijst, Coen C Paulusma, Ronald P J Oude Elferink. Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug metabolism and disposition: the biological fate of chemicals. 2012 Mar; 40(3):515-21. doi: 10.1124/dmd.111.041731. [PMID: 22166395]
  • Ahmed Hamouda, Jacqueline Findlay, Leena Al Hassan, Sebastian G B Amyes. Epidemiology of Acinetobacter baumannii of animal origin. International journal of antimicrobial agents. 2011 Oct; 38(4):314-8. doi: 10.1016/j.ijantimicag.2011.06.007. [PMID: 21831604]
  • Nafisa Hassan Ali, Shaheen Faizi, Shahana Urooj Kazmi. Antibacterial activity in spices and local medicinal plants against clinical isolates of Karachi, Pakistan. Pharmaceutical biology. 2011 Aug; 49(8):833-9. doi: 10.3109/13880209.2010.551136. [PMID: 21501041]
  • H Jamalifar, Hr Rahimi, N Samadi, Ar Shahverdi, Z Sharifian, F Hosseini, H Eslahi, Mr Fazeli. Antimicrobial activity of different Lactobacillus species against multi- drug resistant clinical isolates of Pseudomonas aeruginosa. Iranian journal of microbiology. 2011 Mar; 3(1):21-5. doi: NULL. [PMID: 22347578]
  • Daniele Minardi, Gianluca d'Anzeo, Daniele Cantoro, Alessandro Conti, Giovanni Muzzonigro. Urinary tract infections in women: etiology and treatment options. International journal of general medicine. 2011; 4(?):333-43. doi: 10.2147/ijgm.s11767. [PMID: 21674026]
  • Zhuming Wang, Zhenghua Song, Donghua Chen. Study on the binding behavior of bovine serum albumin with cephalosporin analogues by chemiluminescence method. Talanta. 2010 Dec; 83(2):312-9. doi: 10.1016/j.talanta.2010.09.029. [PMID: 21111139]
  • Rose McGready, Vanaporn Wuthiekanun, Elizabeth A Ashley, Saw Oo Tan, Mupawjay Pimanpanarak, Samuel Jacher Viladpai-Nguen, Wilarat Jesadapanpong, Stuart D Blacksell, Stephane Proux, Nicholas P Day, Pratap Singhasivanon, Nicholas J White, François Nosten, Sharon J Peacock. Diagnostic and treatment difficulties of pyelonephritis in pregnancy in resource-limited settings. The American journal of tropical medicine and hygiene. 2010 Dec; 83(6):1322-9. doi: 10.4269/ajtmh.2010.10-0332. [PMID: 21118943]
  • Manik C Shill, Naz H Huda, Fahad B Moain, Utpal K Karmakar. Prevalence of uropathogens in diabetic patients and their corresponding resistance pattern: results of a survey conducted at diagnostic centers in dhaka, bangladesh. Oman medical journal. 2010 Oct; 25(4):282-5. doi: 10.5001/omj.2010.82. [PMID: 22043358]
  • M N Islam, M A Khaleque, M Siddika, M A Hossain. Urinary tract infection in children in a tertiary level hospital in bangladesh. Mymensingh medical journal : MMJ. 2010 Oct; 19(4):482-6. doi: . [PMID: 20956885]
  • Kieran M Kennedy, Liam G Glynn, Brendan Dineen. A survey of the management of urinary tract infection in children in primary care and comparison with the NICE guidelines. BMC family practice. 2010 Jan; 11(?):6. doi: 10.1186/1471-2296-11-6. [PMID: 20102638]
  • Sang-Jun Choi, Ju-Hee Ryu, Heon-Woo Lee, Myung-Jae Lee, Ji-Hyung Seo, Seong-Kun Tak, Kyung-Tae Lee. Rapid and simple method for determination of cephradine in human plasma using liquid chromatography-tandem mass spectrometry (LC-MS/MS): application to the bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Dec; 877(31):4059-64. doi: 10.1016/j.jchromb.2009.10.011. [PMID: 19854118]
  • Min Zhou, Xin Li, Yi-qin Cheng, Rong Shen, Ying Zhao, Huai-zhi Zhao, Juan Wang, Dong-mei Shi. [Kneading and dispersing manipulation in treatment of early-stage acute mastitis: a randomized controlled trial]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2009 Dec; 7(12):1130-3. doi: 10.3736/jcim20091207. [PMID: 20015432]
  • Mu Li, Lin-Chuan Liao, You-Yi Yan, Lin Yang, Xiao-Min Liu, Jin Dai, Xiao-Na Ma, Xin Sheng, Hong Huang, Gui Su. [Analysis of multiple cephalosporins in blood and urine by HPLC]. Fa yi xue za zhi. 2009 Dec; 25(6):437-9. doi: NULL. [PMID: 20225621]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Lichuan Niu, Zhenghua Song, Xili He. A study of the chemiluminescence behavior of cephalosporins with luminol and its analytical application. Drug metabolism letters. 2009 Aug; 3(3):144-51. doi: 10.2174/187231209789352157. [PMID: 19702549]
  • David R Foster, Shiyin Yee, Barry E Bleske, Peggy L Carver, Michael J Shea, Sujatha S Menon, Chandrasekharan Ramachandran, Lynda S Welage, Gordon L Amidon. Lack of interaction between the peptidomimetic substrates captopril and cephradine. Journal of clinical pharmacology. 2009 Mar; 49(3):360-7. doi: 10.1177/0091270008329554. [PMID: 19246733]
  • Aude Antignac, Alexander Tomasz. Reconstruction of the phenotypes of methicillin-resistant Staphylococcus aureus by replacement of the staphylococcal cassette chromosome mec with a plasmid-borne copy of Staphylococcus sciuri pbpD gene. Antimicrobial agents and chemotherapy. 2009 Feb; 53(2):435-41. doi: 10.1128/aac.01099-08. [PMID: 19015345]
  • Muhammad Harris Shoaib, Dilnawaz Shaikh, Rabia Ismail Yousuf, Baqir S Naqvi, Khursheed Hashmi. Pharmacokinetic study of cephradine in Pakistani healthy male volunteers. Pakistan journal of pharmaceutical sciences. 2008 Oct; 21(4):400-6. doi: NULL. [PMID: 18930862]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • X Yang, Q Q Yang, Q Y Guo, C Y Yi, H P Mao, J X Lin, Z P Jiang, X Q Yu. Aeromonas salmonicida peritonitis after eating fish in a patient undergoing CAPD. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2008 May; 28(3):316-7. doi: 10.1177/089686080802800323. [PMID: 18474929]
  • Zhoujun Wu, Bo Feng, Jie Weng, Shuxin Qu, Jianxin Wang, Xiong Lu. Biomimetic apatite coatings on titanium coprecipitated with cephradine and salviae miltlorrhizae. Journal of biomedical materials research. Part B, Applied biomaterials. 2008 Feb; 84(2):486-92. doi: 10.1002/jbm.b.30895. [PMID: 17635037]
  • Jinjin Chen, Wei Cai, Yi Feng. Development of intestinal bifidobacteria and lactobacilli in breast-fed neonates. Clinical nutrition (Edinburgh, Scotland). 2007 Oct; 26(5):559-66. doi: 10.1016/j.clnu.2007.03.003. [PMID: 17507117]
  • Yuko Tanihara, Satohiro Masuda, Tomoko Sato, Toshiya Katsura, Osamu Ogawa, Ken-Ichi Inui. Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochemical pharmacology. 2007 Jul; 74(2):359-71. doi: 10.1016/j.bcp.2007.04.010. [PMID: 17509534]
  • Seyed Mehdi Hosseini-Mazinani, Fereshteh Eftekhar, Mahnaz Milani, Soheila Ghandili. Characterization of beta-lactamases from urinary isolates of Escherichia coli in Tehran. Iranian biomedical journal. 2007 Apr; 11(2):95-99. doi: . [PMID: 18051951]
  • Khaled A Al-Moyed, Nabil S Harmal, Abdulilah H Al-Harasy, Hassan A Al-Shamahy. Increasing single and multi-antibiotic resistance in Shigella species isolated from shigellosis patients in Sana'a, Yemen. Saudi medical journal. 2006 Aug; 27(8):1157-60. doi: . [PMID: 16883444]
  • Young-Sook Kang, So-Young Lee, Na Hyung Kim, Hong-Mi Choi, Joug Sei Park, Won Kim, Hwa Jeong Lee. A specific and rapid HPLC assay for the determination of cefroxadine in human plasma and its application to pharmacokinetic study in Korean. Journal of pharmaceutical and biomedical analysis. 2006 Feb; 40(2):369-74. doi: 10.1016/j.jpba.2005.07.026. [PMID: 16137854]
  • Masaki Kobayashi, Yoshitaka Saito, Shirou Itagaki, Takeshi Hirano, Ken Iseki. Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane. Biochimica et biophysica acta. 2005 Aug; 1715(1):19-24. doi: 10.1016/j.bbamem.2005.05.013. [PMID: 16087153]
  • Petra Luckner, Matthias Brandsch. Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2005 Jan; 59(1):17-24. doi: 10.1016/j.ejpb.2004.07.008. [PMID: 15567297]
  • Shirou Itagaki, Yoshitaka Saito, Sayaka Kubo, Yukio Otsuka, Yuta Yamamoto, Masaki Kobayashi, Takeshi Hirano, Ken Iseki. H+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine. The Journal of pharmacology and experimental therapeutics. 2005 Jan; 312(1):77-82. doi: 10.1124/jpet.104.074021. [PMID: 15316092]
  • Stanley G Wu, Edward P C Lai, Paul M Mayer. Molecularly imprinted solid phase extraction-pulsed elution-mass spectrometry for determination of cephalexin and alpha-aminocephalosporin antibiotics in human serum. Journal of pharmaceutical and biomedical analysis. 2004 Nov; 36(3):483-90. doi: 10.1016/j.jpba.2003.05.001. [PMID: 15522521]
  • Masaaki Kai, Hiromi Kinoshita, Kazuko Ohta, Shuuji Hara, Myung Koo Lee, Jianzhong Lu. Sensitive determination of a beta-lactam antibiotic, cefaclor by liquid chromatography with chemiluminescence detection. Journal of pharmaceutical and biomedical analysis. 2003 Jan; 30(6):1765-71. doi: 10.1016/s0731-7085(02)00519-8. [PMID: 12485718]
  • Mitsuru Sugawara, Toru Ogawa, Michiya Kobayashi, Katsumi Miyazaki. Uptake of dipeptide and beta-lactam antibiotics by the basolateral membrane vesicles prepared from rat kidney. Biochimica et biophysica acta. 2003 Jan; 1609(1):39-44. doi: 10.1016/s0005-2736(02)00634-x. [PMID: 12507756]
  • Dorota Haznar, Janusz Pluta. Effect of composition on the physicochemical properties and active substance release from gelatin-alginate sponge. Polimery w medycynie. 2003; 33(4):17-27. doi: ". [PMID: 15058110]
  • Junko Takishima, Hiraku Onishi, Yoshiharu Machida. Prolonged intestinal absorption of cephradine with chitosan-coated ethylcellulose microparticles in rats. Biological & pharmaceutical bulletin. 2002 Nov; 25(11):1498-502. doi: 10.1248/bpb.25.1498. [PMID: 12419970]
  • Daniel Baczyński, Stefan Antosiewicz, Bozena Pietrzak, Zofia Wańkowicz. [Empirical therapy of peritonitis in peritoneal dialysis patients--it is reasonable to use a new therapeutic schedule?]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. 2002 Nov; 13(77):396-8. doi: NULL. [PMID: 12621757]
  • Yi-wen Shen, Chao Lu, Zi-qin Zhao. [Tryptase and fatal anaphylaxic reaction]. Fa yi xue za zhi. 2002 Aug; 18(3):132-4, 136. doi: . [PMID: 12608287]
  • A I A Ibrahim, M Rashid. Comparison of local povidone-iodine antisepsis with parenteral antibacterial prophylaxis for prevention of infective complications of TURP: a prospective randomized controlled study. European urology. 2002 Mar; 41(3):250-6. doi: 10.1016/s0302-2838(02)00013-1. [PMID: 12180224]
  • Shahla Mansouri, Sorreia Shareifi. Antimicrobial resistance pattern of Escherichia coli causing urinary tract infections, and that of human fecal flora, in the southeast of Iran. Microbial drug resistance (Larchmont, N.Y.). 2002; 8(2):123-8. doi: 10.1089/107662902760190662. [PMID: 12118516]
  • A J Howard, J T Magee, K A Fitzgerald, F D Dunstan. Factors associated with antibiotic resistance in coliform organisms from community urinary tract infection in Wales. The Journal of antimicrobial chemotherapy. 2001 Mar; 47(3):305-13. doi: 10.1093/jac/47.3.305. [PMID: 11222563]
  • T Cihlar, E S Ho. Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Analytical biochemistry. 2000 Jul; 283(1):49-55. doi: 10.1006/abio.2000.4633. [PMID: 10929807]
  • A Ovalle, M A Martínez, M Wolff, E Cona, O Valderrama, E Villablanca, L Lobos. [Prospective, randomized, comparative study of the efficacy, safety and cost of cefuroxime versus cephradine in acute pyelonephritis during pregnancy]. Revista medica de Chile. 2000 Jul; 128(7):749-57. doi: . [PMID: 11050836]
  • V M Johnson, J P Allanson, R C Causon. Determination of the cephalosporin antibiotic cephradine in human plasma by high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. B, Biomedical sciences and applications. 2000 Mar; 740(1):71-80. doi: 10.1016/s0378-4347(00)00023-2. [PMID: 10798295]
  • M E Ganapathy, W Huang, D P Rajan, A L Carter, M Sugawara, K Iseki, F H Leibach, V Ganapathy. beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. The Journal of biological chemistry. 2000 Jan; 275(3):1699-707. doi: 10.1074/jbc.275.3.1699. [PMID: 10636865]
  • M Hefnawy, Y El-Shabrawy, F Belal. Spectrofluorometric determination of alpha-aminocephalosporins in biological fluids and pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis. 1999 Dec; 21(4):703-7. doi: 10.1016/s0731-7085(99)00208-3. [PMID: 10701934]
  • T Terada, H Saito, M Mukai, K Inui. Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells. The American journal of physiology. 1997 11; 273(5):F706-11. doi: 10.1152/ajprenal.1997.273.5.f706. [PMID: 9374833]
  • V Ródenas, M S García, C Sánchez-Pedreño, M I Albero. Spectrophotometric methods for the determination of cephradine or ceftazidine in human urine using batch and flow-injection procedures. Journal of pharmaceutical and biomedical analysis. 1997 Jul; 15(11):1687-93. doi: 10.1016/s0731-7085(96)01963-2. [PMID: 9260664]
  • T Terada, H Saito, M Mukai, K Inui. Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics. The Journal of pharmacology and experimental therapeutics. 1997 Jun; 281(3):1415-21. doi: . [PMID: 9190878]
  • H Peltola, L Unkila-Kallio, M J Kallio. Simplified treatment of acute staphylococcal osteomyelitis of childhood. The Finnish Study Group. Pediatrics. 1997 Jun; 99(6):846-50. doi: 10.1542/peds.99.6.846. [PMID: 9190554]
  • T Terada, H Saito, M Mukai, K I Inui. Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1. FEBS letters. 1996 Sep; 394(2):196-200. doi: 10.1016/0014-5793(96)00952-0. [PMID: 8843163]
  • N H Pham, B A Baldo. beta-Lactam drug allergens: fine structural recognition patterns of cephalosporin-reactive IgE antibodies. Journal of molecular recognition : JMR. 1996 Jul; 9(4):287-96. doi: 10.1002/(sici)1099-1352(199607)9:4\%3c287::aid-jmr340\%3e3.0.co;2-l. [PMID: 9131470]
  • H Saito, M Okuda, T Terada, S Sasaki, K Inui. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney. The Journal of pharmacology and experimental therapeutics. 1995 Dec; 275(3):1631-7. doi: . [PMID: 8531138]
  • M G el-Sayed, M Atef, A A el-Komy. Disposition kinetics of cephradine in normal and Escherichia coli infected goats. DTW. Deutsche tierarztliche Wochenschrift. 1994 Feb; 101(2):56-60. doi: NULL. [PMID: 8149902]
  • R Hori, Y Tomita, T Katsura, M Yasuhara, K Inui, M Takano. Transport of bestatin in rat renal brush-border membrane vesicles. Biochemical pharmacology. 1993 May; 45(9):1763-8. doi: 10.1016/0006-2952(93)90431-u. [PMID: 8494534]
  • T Grochowina, K Strzykała, M Makowska, E Guziołek. [Study on the effect of cefradine (sefril) on results of determining concentration of uric acid in serum]. Wiadomosci lekarskie (Warsaw, Poland : 1960). 1993 May; 46(9-10):360-3. doi: NULL. [PMID: 8236993]
  • T Miyakawa, W Zhang, T Uchida, N S Kim, S Goto. In vivo release of water-soluble drugs from stabilized water-in-oil-in-water (W/O/W) type multiple emulsions following intravenous administrations using rats. Biological & pharmaceutical bulletin. 1993 Mar; 16(3):268-72. doi: 10.1248/bpb.16.268. [PMID: 8364471]
  • A Nathan, S Zalipsky, S I Ertel, S N Agathos, M L Yarmush, J Kohn. Copolymers of lysine and polyethylene glycol: a new family of functionalized drug carriers. Bioconjugate chemistry. 1993 Jan; 4(1):54-62. doi: 10.1021/bc00019a008. [PMID: 8431513]
  • M J Kerin, D Greenstein, E M Chisholm, S J Sheehan, R C Kester. Is antibiotic penetration compromised in the ischaemic tissues of patients undergoing amputation?. Annals of the Royal College of Surgeons of England. 1992 Jul; 74(4):274-6. doi: NULL. [PMID: 1416682]
  • E Morita, N Mizuno, M Nishikata, K Takahashi. Effect of gastrointestinal maturation on absorption of beta-lactam antibiotics. Journal of pharmaceutical sciences. 1992 Apr; 81(4):337-40. doi: 10.1002/jps.2600810408. [PMID: 1501068]
  • M E Abdel-Hamid, M S Mahrous, H G Daabees, Y A Beltagy. A rapid first-derivative spectrophotometric analysis of cephalexin and cephradine in human urine. Journal of clinical pharmacy and therapeutics. 1992 Apr; 17(2):91-5. doi: 10.1111/j.1365-2710.1992.tb01273.x. [PMID: 1583084]
  • T Okano, H Maegawa, K Inui, R Hori. Interaction of ofloxacin with organic cation transport system in rat renal brush-border membranes. The Journal of pharmacology and experimental therapeutics. 1990 Dec; 255(3):1033-7. doi: NULL. [PMID: 2175794]
  • R Cadórniga, I T Molina, P Pastoriza, S Negro, C M Evora, J A Gutierrez. Pharmacokinetics of cefroxadine after infusion to healthy volunteers. International journal of clinical pharmacology, therapy, and toxicology. 1990 Oct; 28(10):435-9. doi: NULL. [PMID: 2258253]
  • T L Schwinghammer, C W Norden, E Gill. Pharmacokinetics of cephradine administered intravenously and orally to young and elderly subjects. Journal of clinical pharmacology. 1990 Oct; 30(10):893-9. doi: 10.1002/j.1552-4604.1990.tb03568.x. [PMID: 2229449]
  • R J Middlehurst, J P Rood. Cephradine (Velosef) penetration of mandibular bone. International journal of oral and maxillofacial surgery. 1990 Apr; 19(2):120-1. doi: 10.1016/s0901-5027(05)80208-5. [PMID: 2111359]
  • R Antrum, K Gorst, K Galvin, C Thornton, K Wynne, C Malata, C Ramsden, R Kester, I Harding. A comparison of teicoplanin vs. cephradine and metronidazole in surgical prophylaxis: an interim analysis. Scandinavian journal of infectious diseases. Supplementum. 1990; 72(?):45-53. doi: . [PMID: 1982576]
  • R J Middlehurst, J Pedlar, G R Barker, J P Rood. Cephradine penetration of mandibular bone. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 1989 Jul; 47(7):672-3. doi: 10.1016/s0278-2391(89)80003-5. [PMID: 2732825]
  • J S Bevan, G J Griffiths, J D Williams, O M Gibby. Bilateral renal cortical abscesses in a young woman with type 1 diabetes. Diabetic medicine : a journal of the British Diabetic Association. 1989 Jul; 6(5):454-7. doi: 10.1111/j.1464-5491.1989.tb01205.x. [PMID: 2527687]
  • D A Leigh. Determination of serum and bone concentrations of cephradine and cefuroxime by HPLC in patients undergoing hip and knee joint replacement surgery. The Journal of antimicrobial chemotherapy. 1989 Jun; 23(6):877-83. doi: 10.1093/jac/23.6.877. [PMID: 2759931]
  • I W Barlow, J R Ausobsky, D Wilkinson, R C Kester. Controlled trial of cephradine versus cefuroxime in vascular surgery. International journal of clinical pharmacology research. 1989; 9(3):223-7. doi: . [PMID: 2663737]
  • M D Blanchin, M L Rondot-Dudragne. [Determination of cefaloglycine and cefroxadin in biological media with thin layer chromatography with fluorometric detection]. Journal of chromatography. 1988 Nov; 432(?):407-11. doi: . [PMID: 3220913]
  • J P MacDermott, R E Ewing, J F Somerville, B K Gray. Cephradine prophylaxis in transurethral procedures for carcinoma of the bladder. British journal of urology. 1988 Aug; 62(2):136-9. doi: 10.1111/j.1464-410x.1988.tb04292.x. [PMID: 3044484]
  • R Rooney, M C Neligan, R Hone, A Murray. Serum concentrations of cephalosporins and the cell saver in cardiopulmonary bypass surgery. The Journal of antimicrobial chemotherapy. 1988 Aug; 22(2):266-8. doi: 10.1093/jac/22.2.266. [PMID: 3182423]
  • I G Conn, L E Moffat. Short-term cephradine prophylaxis in elective transurethral prostatectomy. The Journal of hospital infection. 1988 May; 11(4):373-5. doi: 10.1016/0195-6701(88)90091-6. [PMID: 2899590]
  • M C Rouan. Microbore liquid chromatographic determination of cadralazine and cephalexin in plasma with large-volume injection. Journal of chromatography. 1988 Apr; 426(2):335-44. doi: 10.1016/s0378-4347(00)81960-x. [PMID: 3392145]
  • F Fraschini, F Scaglione, F Vago, E Bichisao, C Borghi, M Montanari. Correlation between plasma and tonsillar levels of cefroxadine. Chemotherapy. 1988; 34(1):8-12. doi: 10.1159/000238540. [PMID: 3349862]
  • J W Bins, H Mattie. Saturation of the tubular excretion of beta-lactam antibiotics. British journal of clinical pharmacology. 1988 Jan; 25(1):41-50. doi: 10.1111/j.1365-2125.1988.tb03280.x. [PMID: 3370191]
  • J A McAteer, M F Hiltke, B M Silber, R D Faulkner. Liquid-chromatographic determination of five orally active cephalosporins--cefixime, cefaclor, cefadroxil, cephalexin, and cephradine--in human serum. Clinical chemistry. 1987 Oct; 33(10):1788-90. doi: . [PMID: 3665031]
  • S Soback, G Ziv, B Kurtz, R Paz. Clinical pharmacokinetics of five oral cephalosporins in calves. Research in veterinary science. 1987 Sep; 43(2):166-72. doi: 10.1016/s0034-5288(18)30767-7. [PMID: 3317582]
  • M Martea, Y A Hekster, T B Vree, A J Voets, J H Berden. Pharmacokinetics of cefradine, sulfamethoxazole and trimethoprim and their metabolites in a patient with peritonitis undergoing continuous ambulatory peritoneal dialysis. Pharmaceutisch weekblad. Scientific edition. 1987 Apr; 9(2):110-6. doi: 10.1007/bf01960745. [PMID: 3495778]
  • S Suzuki, T Inoue. Qualitative and quantitative analysis of cephradine in biological materials by high performance liquid chromatography. Forensic science international. 1987 Apr; 33(4):267-74. doi: 10.1016/0379-0738(87)90108-3. [PMID: 3583177]
  • A Philipson, G Stiernstedt, M Ehrnebo. Comparison of the pharmacokinetics of cephradine and cefazolin in pregnant and non-pregnant women. Clinical pharmacokinetics. 1987 Feb; 12(2):136-44. doi: 10.2165/00003088-198712020-00004. [PMID: 3829560]
  • K Lindgren. Determination of cefaclor and cephradine in serum by ion-pair reversed-phase chromatography. Journal of chromatography. 1987 Jan; 413(?):351-4. doi: 10.1016/0378-4347(87)80253-0. [PMID: 3558691]
  • K Lindgren. Determination of cefadroxil in serum by high-performance liquid chromatography with cephradine as internal standard. Journal of chromatography. 1987 Jan; 413(?):347-50. doi: 10.1016/0378-4347(87)80252-9. [PMID: 3558690]
  • W Brumfitt, J M Hamilton-Miller. Recurrent urinary infections in women: clinical trial of cephradine as a prophylactic agent. Infection. 1987; 15(5):344-7. doi: 10.1007/bf01647735. [PMID: 3319912]
  • T J Cain, G T Jones, P Woods. Bone levels of cephradine and cefuroxime after intravenous administration in patients undergoing total hip replacement. International orthopaedics. 1987; 11(1):61-3. doi: 10.1007/bf00266059. [PMID: 3557757]
  • A J Jackson, M L Chen. Application of moment analysis in assessing rates of absorption for bioequivalency studies. Journal of pharmaceutical sciences. 1987 Jan; 76(1):6-9. doi: 10.1002/jps.2600760103. [PMID: 3585726]
  • S Iwata, T Yokota, Y Kusumoto, H Shiro, Y Sato, H Akita, S Nanri, T Oikawa, S Kusano, K Sunakawa. [Influence of cefroxadine dry syrup on intestinal bacterial flora]. The Japanese journal of antibiotics. 1986 Aug; 39(8):1967-74. doi: . [PMID: 3540337]
  • W Brumfitt, I Franklin, D Grady, J M Hamilton-Miller. Effect of amoxicillin-clavulanate and cephradine on the fecal flora of healthy volunteers not exposed to a hospital environment. Antimicrobial agents and chemotherapy. 1986 Aug; 30(2):335-7. doi: 10.1128/aac.30.2.335. [PMID: 3767348]
  • A J Davies, R M Lockley, A Jones, M el-Safty, J C Clothier. Comparative pharmacokinetics of cefamandole, cefuroxime and cephradine during total hip replacement. The Journal of antimicrobial chemotherapy. 1986 May; 17(5):637-40. doi: 10.1093/jac/17.5.637. [PMID: 3722034]
  • O Daghero, G Andreoni, R Arione, L Bendiscioli, C Bramato, T Cimino, B Salassa, C Spezia, M L Soranzo. [Cephalosporins and enzymuria]. Minerva medica. 1986 Feb; 77(7-8):231-7. doi: NULL. [PMID: 2869451]
  • B Tanrisever, P J Santella. Cefadroxil. A review of its antibacterial, pharmacokinetic and therapeutic properties in comparison with cephalexin and cephradine. Drugs. 1986; 32 Suppl 3(?):1-16. doi: 10.2165/00003495-198600323-00003. [PMID: 3542485]
  • S R Norrby. Ecological consequences of broad spectrum versus narrow spectrum antibacterial therapy. Scandinavian journal of infectious diseases. Supplementum. 1986; 49(?):189-95. doi: NULL. [PMID: 3547623]
  • A M Tegzess, H A Van Eck, H K Van Saene, R A Meijer-Vogt, S Meijer, W J Van Son, M J Slooff. The effect of the prophylactic use of absorbable and non-absorbable antibiotics on the incidence of urinary tract infections in recipients of cadaveric kidney transplants. The Netherlands journal of medicine. 1986; 29(11):352-6. doi: NULL. [PMID: 3543705]
  • E W Boeschoten, P J Rietra, R T Krediet, M J Visser, L Arisz. CAPD peritonitis: a prospective randomized trial of oral versus intraperitoneal treatment with cephradine. The Journal of antimicrobial chemotherapy. 1985 Dec; 16(6):789-97. doi: 10.1093/jac/16.6.789. [PMID: 3912367]
  • M Searle, G V Raman. Oral treatment of peritonitis complicating continuous ambulatory peritoneal dialysis. Clinical nephrology. 1985 May; 23(5):241-4. doi: NULL. [PMID: 4006333]
  • S K Saha. Peritoneal lavage with metronidazole. Surgery, gynecology & obstetrics. 1985 Apr; 160(4):335-8. doi: NULL. [PMID: 3983798]