PROSTAGLANDIN A2 (BioDeep_00000629503)

Main id: BioDeep_00000006014

 

natural product


代谢物信息卡片


9-oxo-15S-hydroxy-5Z,10Z,13E-prostatrienoic acid

化学式: C20H30O4 (334.214398)
中文名称: 前列腺素 A2
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCC(C=CC1C=CC(=O)C1CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1

描述信息

同义名列表

4 个代谢物同义名

PROSTAGLANDIN A2; 9-oxo-15S-hydroxy-5Z,10Z,13E-prostatrienoic acid; FA 20:5;O2; PGA2



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ai Lin Daphne Teh, Jaime Jacqueline Jayapalan, Mun Fai Loke, Azida Juana Wan Abdul Kadir, Visvaraja Subrayan. Identification of potential serum metabolic biomarkers for patient with keratoconus using untargeted metabolomics approach. Experimental eye research. 2021 10; 211(?):108734. doi: 10.1016/j.exer.2021.108734. [PMID: 34428458]
  • Lucila Ludmila Paula Gutierrez, Claudia Vieira Marques, Sofia Pizzato Scomazzon, Helena Trevisan Schroeder, João Roberto Fernandes, Juliane da Silva Rossato, Paulo Ivo Homem de Bittencourt. A-family anti-inflammatory cyclopentenone prostaglandins: A novel class of non-statin inhibitors of HMG-CoA reductase. Biochimie. 2021 Mar; 182(?):37-50. doi: 10.1016/j.biochi.2020.12.019. [PMID: 33412161]
  • Fabiano E Xavier, Javier Blanco-Rivero, Esther Sastre, Lina Badimón, Gloria Balfagón. Simultaneous inhibition of TXA(2) and PGI(2) synthesis increases NO release in mesenteric resistance arteries from cirrhotic rats. Clinical science (London, England : 1979). 2010 Jun; 119(7):283-92. doi: 10.1042/cs20090536. [PMID: 20459396]
  • Sun-Young Lee, Ji-Hyun Ahn, Kyoung Won Ko, Jaetaek Kim, Seong Whan Jeong, In-Kyung Kim, Jin Kim, Ho-Shik Kim. Prostaglandin A2 activates intrinsic apoptotic pathway by direct interaction with mitochondria in HL-60 cells. Prostaglandins & other lipid mediators. 2010 Feb; 91(1-2):30-7. doi: 10.1016/j.prostaglandins.2009.12.003. [PMID: 20044024]
  • Paulo I Homem de Bittencourt, Denise J Lagranha, Alexandre Maslinkiewicz, Sueli M Senna, Angela M V Tavares, Lisiane P Baldissera, Daiane R Janner, Joelso S Peralta, Patrícia M Bock, Lucila L P Gutierrez, Gustavo Scola, Thiago G Heck, Maurício S Krause, Lavínia A Cruz, Dulcinéia S P Abdalla, Cláudia J Lagranha, Thais Lima, Rui Curi. LipoCardium: endothelium-directed cyclopentenone prostaglandin-based liposome formulation that completely reverses atherosclerotic lesions. Atherosclerosis. 2007 Aug; 193(2):245-58. doi: 10.1016/j.atherosclerosis.2006.08.049. [PMID: 16996518]
  • Javier Gayarre, David Sánchez, Francisco J Sánchez-Gómez, María C Terrón, Oscar Llorca, Dolores Pérez-Sala. Addition of electrophilic lipids to actin alters filament structure. Biochemical and biophysical research communications. 2006 Nov; 349(4):1387-93. doi: 10.1016/j.bbrc.2006.09.005. [PMID: 16979589]
  • Oliver Schröder, Yulyana Yudina, Alan Sabirsh, Nadine Zahn, Jesper Z Haeggström, Jürgen Stein. 15-deoxy-Delta12,14-prostaglandin J2 inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells. Journal of lipid research. 2006 May; 47(5):1071-80. doi: 10.1194/jlr.m600008-jlr200. [PMID: 16495511]
  • Angela Kolberg, Tatiana Gomes Rosa, Minéia Taíse Puhl, Gustavo Scola, Daiane da Rocha Janner, Alexandre Maslinkiewicz, Denise Jacques Lagranha, Thiago Gomes Heck, Rui Curi, Paulo Ivo Homem de Bittencourt. Low expression of MRP1/GS-X pump ATPase in lymphocytes of Walker 256 tumour-bearing rats is associated with cyclopentenone prostaglandin accumulation and cancer immunodeficiency. Cell biochemistry and function. 2006 Jan; 24(1):23-39. doi: 10.1002/cbf.1290. [PMID: 16170839]
  • Sonia Brault, Ana Katherine Martinez-Bermudez, Jackson Roberts, Qiao-Ling Cui, Gabriela Fragoso, Sandy Hemdan, Hsueh-Ning Liu, Fernand Gobeil, Christiane Quiniou, Elsa Kermorvant-Duchemin, Christian Lachance, Guillermina Almazan, Daya R Varma, Sylvain Chemtob. Cytotoxicity of the E(2)-isoprostane 15-E(2t)-IsoP on oligodendrocyte progenitors. Free radical biology & medicine. 2004 Aug; 37(3):358-66. doi: 10.1016/j.freeradbiomed.2004.05.007. [PMID: 15223069]
  • Ho-Shik Kim, Hyangshuk Rhim, Seong-Whan Jeong, Jin Woo Kim, In-Kyung Kim. Induction of apoptosis dependent on caspase activities and growth arrest in HL-60 cells by PGA2. Prostaglandins & other lipid mediators. 2002 Sep; 70(1-2):169-83. doi: 10.1016/s0090-6980(02)00064-3. [PMID: 12428687]
  • K Büyükgüzel, H Tunaz, S M Putnam, D Stanley. Prostaglandin biosynthesis by midgut tissue isolated from the tobacco hornworm, Manduca sexta. Insect biochemistry and molecular biology. 2002 Apr; 32(4):435-43. doi: 10.1016/s0965-1748(01)00121-7. [PMID: 11886778]
  • K Still, A Scutt. Stimulation of CFU-f formation by prostaglandin E2 is mediated in part by its degradation product, prostaglandin A2. Prostaglandins & other lipid mediators. 2001 May; 65(1):21-31. doi: 10.1016/s0090-6980(01)00117-4. [PMID: 11352224]
  • A M Joubert, A Panzer, F Joubert, M L Lottering, P C Bianchi, J C Seegers. Comparative study of the effects of polyunsaturated fatty acids and their metabolites on cell growth and tyrosine kinase activity in oesophageal carcinoma cells. Prostaglandins, leukotrienes, and essential fatty acids. 1999 Sep; 61(3):171-82. doi: 10.1054/plef.1999.0087. [PMID: 10582657]
  • Y Chen, J D Morrow, L J Roberts. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. The Journal of biological chemistry. 1999 Apr; 274(16):10863-8. doi: 10.1074/jbc.274.16.10863. [PMID: 10196163]
  • A Jawerbaum, V Novaro, A M Franchi, M Gimeno, E González. High glucose levels modulate eicosanoid production in uterine and placental tissue from non-insulin-dependent diabetic rats during late pregnancy. Prostaglandins, leukotrienes, and essential fatty acids. 1998 Jun; 58(6):389-93. doi: 10.1016/s0952-3278(98)90158-2. [PMID: 10189067]
  • R Evers, N H Cnubben, J Wijnholds, L van Deemter, P J van Bladeren, P Borst. Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1. FEBS letters. 1997 Dec; 419(1):112-6. doi: 10.1016/s0014-5793(97)01442-7. [PMID: 9426231]
  • M Gorospe, X Wang, K Z Guyton, N J Holbrook. Protective role of p21(Waf1/Cip1) against prostaglandin A2-mediated apoptosis of human colorectal carcinoma cells. Molecular and cellular biology. 1996 Dec; 16(12):6654-60. doi: 10.1128/mcb.16.12.6654. [PMID: 8943319]
  • M Hitomi, J Shu, D Strom, S W Hiebert, M L Harter, D W Stacey. Prostaglandin A2 blocks the activation of G1 phase cyclin-dependent kinase without altering mitogen-activated protein kinase stimulation. The Journal of biological chemistry. 1996 Apr; 271(16):9376-83. doi: 10.1074/jbc.271.16.9376. [PMID: 8621603]
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  • M Gorospe, N J Holbrook. Role of p21 in prostaglandin A2-mediated cellular arrest and death. Cancer research. 1996 Feb; 56(3):475-9. doi: . [PMID: 8564956]
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  • G Deliconstantinos, L Kopeikina, G Ramantanis. PGE2 and PGA2 affect the allosteric properties and the activities of calmodulin-dependent guanylate cyclase and Ca2+-stimulated ATPase of Walker-256 tumour microsomal membranes. Anticancer research. 1989 May; 9(3):fluorescence polarization. doi: . [PMID: 2569856]
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