FA 20:6;O (BioDeep_00000629496)

 

Secondary id: BioDeep_00000002521


代谢物信息卡片


9-oxo-5E,10Z,14Z-prostatrienoic acid-1,4R-lactone-cyclo[8S,12R]

化学式: C20H28O3 (316.2038338)
中文名称: (15-脱氧-Δ12,14-前列腺素 J2
谱图信息: 最多检出来源 Homo sapiens(blood) 2.15%

分子结构信息

SMILES: C(/[C@@H]1OC(=O)CCCC=CC1)=C\[C@@]1([H])O[C@@]1([H])C/C=C\C/C=C\CC
InChI: InChI=1S/C20H28O3/c1-2-3-6-9-17-14-12-16-13-15-19(21)18(16)10-7-4-5-8-11-20(22)23-17/h4,7,12-18H,2-3,5-6,8-11H2,1H3/b7-4-,14-12+/t16-,17-,18+/m0/s1

描述信息

D007155 - Immunologic Factors

同义名列表

32 个代谢物同义名

11R,12S-epoxy-5Z,9E,14Z,17Z-eicosatetraen-8R-olide; Topsentolide A1; FA 20:6;O; 9-oxo-5E,10Z,14Z-prostatrienoic acid-1,4R-lactone-cyclo[8S,12R]; preclavulone lactone II; 9-oxo-5Z,10Z,14Z-prostatrienoic acid-1,4R-lactone-cyclo[8S,12R]; preclavulone lactone I; 11-oxo-5Z,9,12E,14E-prostatetraenoic acid-cyclo[8R,12]; 8-iso-15-deoxy-d-12,14-PGJ2; ent-15-deoxy-d-12,14-PGJ2; ent-15-deoxy-J2-IsoP; 8-iso-15-deoxy-PGJ2; 8-oxo-6,9E,11E,14Z-prostatetraenoic acid-cyclo[5R,9]; ent-12-deoxy-J2-IsoP; 8-oxo-6,9E,11E,14Z-prostatetraenoic acid-cyclo[5S,9]; 12-deoxy-J2-IsoP; 11-oxo-5E,7E,9,14Z-prostatetraenoic acid-cyclo[8,12R]; ent-5-deoxy-J2-IsoP; 11-oxo-5E,7E,9,14Z-prostatetraenoic acid-cyclo[8,12S]; 5-deoxy-J2-IsoP; 14-oxo-5Z,8E,10E,12-prostatetraenoic acid-cyclo[11,15R]; ent-8-deoxy-J2-IsoP; 14-oxo-5Z,8E,10E,12-prostatetraenoic acid-cyclo[11,15S]; 8-deoxy-J2-IsoP; 9-oxo-5Z,10,13E-prostatrienoic acid-1,15S-lactone; Prostaglandin A2 1,15-lactone; PGA2 1,15-lactone; 11-oxo-5Z,9,12E,14E-prostatetraenoic acid; 15-deoxy-delta-12,14-Prostaglandin J2; 15-deoxy-delta-12,14-PGJ2; 15-Deoxy-Delta12; 15-deoxy-PGJ2



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Stephanie Kim, Eric Reed, Stefano Monti, Jennifer J Schlezinger. A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens. Environmental health perspectives. 2021 07; 129(7):77006. doi: 10.1289/ehp6886. [PMID: 34323617]
  • Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh. 15-Deoxy-△12,14-Prostaglandin J2 Promotes Resolution of Experimentally Induced Colitis. Frontiers in immunology. 2021; 12(?):615803. doi: 10.3389/fimmu.2021.615803. [PMID: 33633749]
  • A Sikora-Wiorkowska, A Smolen, G Czechowska, K Wiorkowski, A Korolczuk. The role of PPAR gamma agonists - rosiglitazone and 15-deoxy-Δ12,14-prostaglandin J2 in experimental cyclosporine A hepatotoxicity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2019 Dec; 70(6):. doi: 10.26402/jpp.2019.6.07. [PMID: 32084649]
  • Ivelina Urban, Martin Turinsky, Sviatlana Gehrmann, Jakob Morgenstern, Maik Brune, Moritz R Milewski, Andreas H Wagner, Cordula Rumig, Thomas Fleming, Florian Leuschner, Christian A Gleissner, Markus Hecker. 15-Deoxy-Δ12,14-Prostaglandin J2 Reinforces the Anti-Inflammatory Capacity of Endothelial Cells With a Genetically Determined NO Deficit. Circulation research. 2019 07; 125(3):282-294. doi: 10.1161/circresaha.118.313820. [PMID: 31213138]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Tatsurou Yagami, Yasuhiro Yamamoto, Hiromi Koma. Physiological and Pathological Roles of 15-Deoxy-Δ12,14-Prostaglandin J2 in the Central Nervous System and Neurological Diseases. Molecular neurobiology. 2018 03; 55(3):2227-2248. doi: 10.1007/s12035-017-0435-4. [PMID: 28299574]
  • Kan Chen, Jing-Jing Li, Sai-Nan Li, Jiao Feng, Tong Liu, Fan Wang, Wei-Qi Dai, Yu-Jing Xia, Jie Lu, Ying-Qun Zhou, Chuan-Yong Guo. 15-Deoxy-Δ12,14-prostaglandin J2 alleviates hepatic ischemia-reperfusion injury in mice via inducing antioxidant response and inhibiting apoptosis and autophagy. Acta pharmacologica Sinica. 2017 May; 38(5):672-687. doi: 10.1038/aps.2016.108. [PMID: 28216619]
  • Hiromi Koma, Yasuhiro Yamamoto, Ayaka Nishii, Tatsurou Yagami. 15-Deoxy-Δ12,14-prostaglandin J2 induced neurotoxicity via suppressing phosphoinositide 3-kinase. Neuropharmacology. 2017 02; 113(Pt A):416-425. doi: 10.1016/j.neuropharm.2016.10.017. [PMID: 27771378]
  • Elda Grabocka, Dafna Bar-Sagi. Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules. Cell. 2016 Dec; 167(7):1803-1813.e12. doi: 10.1016/j.cell.2016.11.035. [PMID: 27984728]
  • Takahiro Shibata. 15-Deoxy-Δ¹²,¹⁴-prostaglandin J₂ as an electrophilic mediator. Bioscience, biotechnology, and biochemistry. 2015; 79(7):1044-9. doi: 10.1080/09168451.2015.1012149. [PMID: 26011133]
  • S B Wall, J-Y Oh, L Mitchell, A H Laube, S L Campbell, M B Renfrow, A Landar. Rac1 modification by an electrophilic 15-deoxy Δ(12,14)-prostaglandin J2 analog. Redox biology. 2015; 4(?):346-54. doi: 10.1016/j.redox.2015.01.016. [PMID: 25677088]
  • A Korolczuk, M Maciejewski, A Smolen, J Dudka, G Czechowska, I Widelska. The role of peroxisome-proliferator-activating receptor gamma agonists: rosiglitazone and 15-deoxy-delta12,14-prostaglandin J2 in chronic experimental cyclosporine A-induced nephrotoxicity. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2014 Dec; 65(6):867-76. doi: . [PMID: 25554991]
  • Ville Paakinaho, Sanna Kaikkonen, Anna-Liisa Levonen, Jorma J Palvimo. Electrophilic lipid mediator 15-deoxy-Δ12,14-prostaglandin j2 modifies glucocorticoid signaling via receptor SUMOylation. Molecular and cellular biology. 2014 Sep; 34(17):3202-13. doi: 10.1128/mcb.00748-14. [PMID: 24980431]
  • Cecilia I Casali, Karen Weber, Daniela Faggionato, Emanuel Morel Gómez, María C Fernández Tome. Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells. Biochemical pharmacology. 2014 Aug; 90(4):432-9. doi: 10.1016/j.bcp.2014.06.002. [PMID: 24915420]
  • Yukiko Sakaba, Hisataka Awata, Toshiaki Morisugi, Tetsuji Kawakami, Akikazu Sakudo, Yasuharu Tanaka. 15-Deoxy-Δ12,14-prostaglandin J2 induces PPARγ- and p53-independent apoptosis in rabbit synovial cells. Prostaglandins & other lipid mediators. 2014 Jun; 109-111(?):1-13. doi: 10.1016/j.prostaglandins.2014.02.001. [PMID: 24680891]
  • Elke H Heiss, Thi Van Anh Tran, Kristin Zimmermann, Stefan Schwaiger, Corina Vouk, Barbara Mayerhofer, Clemens Malainer, Atanas G Atanasov, Hermann Stuppner, Verena M Dirsch. Identification of chromomoric acid C-I as an Nrf2 activator in Chromolaena odorata. Journal of natural products. 2014 Mar; 77(3):503-8. doi: 10.1021/np400778m. [PMID: 24476568]
  • M Kurtz, E Capobianco, V Careaga, N Martinez, M B Mazzucco, M Maier, A Jawerbaum. Peroxisome proliferator-activated receptor ligands regulate lipid content, metabolism, and composition in fetal lungs of diabetic rats. The Journal of endocrinology. 2014 Mar; 220(3):345-59. doi: 10.1530/joe-13-0362. [PMID: 24389592]
  • Robert Ramer, Udo Walther, Philipp Borchert, Stefan Laufer, Michael Linnebacher, Burkhard Hinz. Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib. Journal of lipid research. 2013 Nov; 54(11):3116-29. doi: 10.1194/jlr.m042283. [PMID: 23943857]
  • Simone Marcone, Desmond J Fitzgerald. Proteomic identification of the candidate target proteins of 15-deoxy-delta12,14-prostaglandin J2. Proteomics. 2013 Jul; 13(14):2135-9. doi: 10.1002/pmic.201200289. [PMID: 23606334]
  • Ying Lu, Qiao Zhou, Fang Zhong, Shanmai Guo, Xu Hao, Cong Li, Weiming Wang, Nan Chen. 15-Deoxy-Δ(12,14)-prostaglandin J(2) modulates lipopolysaccharide-induced chemokine expression by blocking nuclear factor-κB activation via peroxisome proliferator activated receptor-γ-independent mechanism in renal tubular epithelial cells. Nephron. Experimental nephrology. 2013; 123(1-2):1-10. doi: 10.1159/000353232. [PMID: 23887394]
  • Jennifer Lefils-Lacourtablaise, Mairobys Socorro, Alain Géloën, Patricia Daira, Cyrille Debard, Emmanuelle Loizon, Michel Guichardant, Zury Dominguez, Hubert Vidal, Michel Lagarde, Nathalie Bernoud-Hubac. The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism. PloS one. 2013; 8(5):e63997. doi: 10.1371/journal.pone.0063997. [PMID: 23734181]
  • Michelle M C Buckner, L Caetano M Antunes, Navkiran Gill, Shannon L Russell, Stephanie R Shames, B Brett Finlay. 15-Deoxy-Δ12,14-prostaglandin J2 inhibits macrophage colonization by Salmonella enterica serovar Typhimurium. PloS one. 2013; 8(7):e69759. doi: 10.1371/journal.pone.0069759. [PMID: 23922794]
  • Kagami Iida, Takayuki Yonezawa, Sun-Sil Choi, Kazuo Nagai, Je-Tae Woo. Sodium dodecyl sulfate and sodium dodecyl benzenesulfonate are ligands for peroxisome proliferator-activated receptor γ. The Journal of toxicological sciences. 2013; 38(5):697-702. doi: 10.2131/jts.38.697. [PMID: 24025786]
  • Efrat Sharvit, Shirley Abramovitch, Shimon Reif, Rafael Bruck. Amplified inhibition of stellate cell activation pathways by PPAR-γ, RAR and RXR agonists. PloS one. 2013; 8(10):e76541. doi: 10.1371/journal.pone.0076541. [PMID: 24098526]
  • María Eugenia Matzkin, Eliana Herminia Pellizzari, Soledad Paola Rossi, Ricardo Saúl Calandra, Selva Beatriz Cigorraga, Mónica Beatriz Frungieri. Exploring the cyclooxygenase 2 (COX2)/15d-Δ(12,14)PGJ(2) system in hamster Sertoli cells: regulation by FSH/testosterone and relevance to glucose uptake. General and comparative endocrinology. 2012 Nov; 179(2):254-64. doi: 10.1016/j.ygcen.2012.08.020. [PMID: 22974512]
  • Kyunghwa Baek, Je-Yoel Cho, Hyo Rin Hwang, Arang Kwon, Hye-Lim Lee, Hyun-Jung Park, Abdul S Qadir, Hyun-Mo Ryoo, Kyung Mi Woo, Jeong-Hwa Baek. Myeloid Elf-1-like factor stimulates adipogenic differentiation through the induction of peroxisome proliferator-activated receptor γ expression in bone marrow. Journal of cellular physiology. 2012 Nov; 227(11):3603-12. doi: 10.1002/jcp.24064. [PMID: 22307523]
  • Yajun Duan, Yuanli Chen, Wenquan Hu, Xiaoju Li, Xiaoxiao Yang, Xin Zhou, Zhinan Yin, Deling Kong, Zhi Yao, David P Hajjar, Lin Liu, Qiang Liu, Jihong Han. Peroxisome Proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. The Journal of biological chemistry. 2012 Jul; 287(28):23667-77. doi: 10.1074/jbc.m112.350181. [PMID: 22593575]
  • Megumi Fujita, Chiaki Tohji, Yoko Honda, Yasuhiro Yamamoto, Tsutomu Nakamura, Tatsurou Yagami, Motohiro Yamamori, Noboru Okamura. Cytotoxicity of 15-deoxy-Δ(12,14)-prostaglandin J(2) through PPARγ-independent pathway and the involvement of the JNK and Akt pathway in renal cell carcinoma. International journal of medical sciences. 2012; 9(7):555-66. doi: 10.7150/ijms.4455. [PMID: 22991494]
  • Abu Asad Chowdhury, Mohammad Sharifur Rahman, Kohji Nishimura, Mitsuo Jisaka, Tsutomu Nagaya, Takahiro Ishikawa, Fumiaki Shono, Kazushige Yokota. 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes. Prostaglandins & other lipid mediators. 2011 Aug; 95(1-4):53-62. doi: 10.1016/j.prostaglandins.2011.06.002. [PMID: 21699992]
  • Yasuhiro Yamamoto, Megumi Fujita, Hiromi Koma, Motohiro Yamamori, Tsutomu Nakamura, Noboru Okamura, Tatsurou Yagami. 15-Deoxy-Δ12,14-prostaglandin J2 enhanced the anti-tumor activity of camptothecin against renal cell carcinoma independently of topoisomerase-II and PPARγ pathways. Biochemical and biophysical research communications. 2011 Jul; 410(3):563-7. doi: 10.1016/j.bbrc.2011.06.026. [PMID: 21683069]
  • Yasuhiro Yamamoto, Kenkichi Takase, Junji Kishino, Megumi Fujita, Noboru Okamura, Toshiyuki Sakaeda, Masafumi Fujimoto, Tatsurou Yagami. Proteomic identification of protein targets for 15-deoxy-Δ(12,14)-prostaglandin J2 in neuronal plasma membrane. PloS one. 2011 Mar; 6(3):e17552. doi: 10.1371/journal.pone.0017552. [PMID: 21445266]
  • Na Li, Rebecca C Salter, Dipak P Ramji. Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. Journal of cellular biochemistry. 2011 Feb; 112(2):675-83. doi: 10.1002/jcb.22976. [PMID: 21268089]
  • Fu-Tian Tang, Yuan Cao, Tie-Qiao Wang, Li-Jing Wang, Jiao Guo, Xiao-Shi Zhou, Suo-Wen Xu, Wei-Hua Liu, Pei-Qing Liu, He-Qing Huang. Tanshinone IIA attenuates atherosclerosis in ApoE(-/-) mice through down-regulation of scavenger receptor expression. European journal of pharmacology. 2011 Jan; 650(1):275-84. doi: 10.1016/j.ejphar.2010.07.038. [PMID: 20854809]
  • Klarissa D Hardy, Brian E Cox, Ginger L Milne, Huiyong Yin, L Jackson Roberts. Nonenzymatic free radical-catalyzed generation of 15-deoxy-Δ(12,14)-prostaglandin J₂-like compounds (deoxy-J₂-isoprostanes) in vivo. Journal of lipid research. 2011 Jan; 52(1):113-24. doi: 10.1194/jlr.m010264. [PMID: 20944061]
  • Mansoor Ali Syed, M Joo, Zulfiqar Abbas, D Rodger, J W Christman, D Mehta, R T Sadikot. Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages. Experimental cell research. 2010 Nov; 316(19):3140-9. doi: 10.1016/j.yexcr.2010.08.009. [PMID: 20797396]
  • S-H Kim, G-S Choi, Y-M Ye, I Jou, H-S Park, S M Park. Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthma. Clinical and experimental immunology. 2010 Jun; 160(3):489-97. doi: 10.1111/j.1365-2249.2010.04118.x. [PMID: 20345975]
  • Sandrine Théoleyre, Stéphanie Mottier, Damien Masson, Marc G Denis. HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. Biochemical and biophysical research communications. 2010 Apr; 394(3):453-8. doi: 10.1016/j.bbrc.2009.11.163. [PMID: 19951697]
  • Hai-Xin Zhang, Kunikazu Tanji, Hidemi Yoshida, Makoto Hayakari, Takahiro Shibata, Fumiaki Mori, Koji Uchida, Koichi Wakabayashi. Alteration of biochemical and pathological properties of TDP-43 protein by a lipid mediator, 15-deoxy-Delta(12,14)-prostaglandin J(2). Experimental neurology. 2010 Apr; 222(2):296-303. doi: 10.1016/j.expneurol.2010.01.007. [PMID: 20083106]
  • Farhat L Khanim, Rachel E Hayden, Jane Birtwistle, Alessia Lodi, Stefano Tiziani, Nicholas J Davies, Jon P Ride, Mark R Viant, Ulrich L Gunther, Joanne C Mountford, Heinrich Schrewe, Richard M Green, Jim A Murray, Mark T Drayson, Chris M Bunce. Combined bezafibrate and medroxyprogesterone acetate: potential novel therapy for acute myeloid leukaemia. PloS one. 2009 Dec; 4(12):e8147. doi: 10.1371/journal.pone.0008147. [PMID: 19997560]
  • Jai Prakash, Ruchi Bansal, Eduard Post, Alie de Jager-Krikken, Marjolijn N Lub-de Hooge, Klaas Poelstra. Albumin-binding and tumor vasculature determine the antitumor effect of 15-deoxy-Delta-(12,14)-prostaglandin-J(2) in vivo. Neoplasia (New York, N.Y.). 2009 Dec; 11(12):1348-58. doi: 10.1593/neo.91188. [PMID: 20019843]
  • Ann V Hertzel, Kristina Hellberg, Joseph M Reynolds, Andrew C Kruse, Brittany E Juhlmann, Anne J Smith, Mark A Sanders, Douglas H Ohlendorf, Jill Suttles, David A Bernlohr. Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. Journal of medicinal chemistry. 2009 Oct; 52(19):6024-31. doi: 10.1021/jm900720m. [PMID: 19754198]
  • Katsuhiro Iinuma, Takashi Sato, Noriko Akimoto, Norihisa Noguchi, Masanori Sasatsu, Setsuko Nishijima, Ichiro Kurokawa, Akira Ito. Involvement of Propionibacterium acnes in the augmentation of lipogenesis in hamster sebaceous glands in vivo and in vitro. The Journal of investigative dermatology. 2009 Sep; 129(9):2113-9. doi: 10.1038/jid.2009.46. [PMID: 19282842]
  • Ashlee N Higdon, Brian P Dranka, Bradford G Hill, Joo-Yeun Oh, Michelle S Johnson, Aimee Landar, Victor M Darley-Usmar. Methods for imaging and detecting modification of proteins by reactive lipid species. Free radical biology & medicine. 2009 Aug; 47(3):201-12. doi: 10.1016/j.freeradbiomed.2009.05.009. [PMID: 19446632]
  • Gemma Olmos, María I Arenas, Raquel Bienes, María Jose Calzada, Julián Aragonés, Maria Laura Garcia-Bermejo, Manuel O Landazuri, Javier Lucio-Cazaña. 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. Cellular and molecular life sciences : CMLS. 2009 Jul; 66(13):2167-80. doi: 10.1007/s00018-009-0039-x. [PMID: 19458911]
  • Olav A Gressner, Chunfang Gao, Katharina Rehbein, Birgit Lahme, Monika Siluschek, Thomas Berg, Tobias Müller, Axel M Gressner. Elevated concentrations of 15-deoxy-Delta12,14-prostaglandin J2 in chronic liver disease propose therapeutic trials with peroxisome proliferator activated receptor gamma-inducing drugs. Liver international : official journal of the International Association for the Study of the Liver. 2009 May; 29(5):730-5. doi: 10.1111/j.1478-3231.2008.01895.x. [PMID: 19018984]
  • Dong Ryeol Lee, Chae Hwa Kwon, Ji Yeon Park, Yong Keun Kim, Jae Suk Woo. 15-Deoxy-Delta(12,14)-prostaglandin J(2) induces mitochondrial-dependent apoptosis through inhibition of PKA/NF-kappaB in renal proximal epithelial cells. Toxicology. 2009 Apr; 258(1):17-24. doi: 10.1016/j.tox.2009.01.001. [PMID: 19167456]
  • Takeshi Tsuji, Masato Asanuma, Ikuko Miyazaki, Ko Miyoshi, Norio Ogawa. Reduction of nuclear peroxisome proliferator-activated receptor gamma expression in methamphetamine-induced neurotoxicity and neuroprotective effects of ibuprofen. Neurochemical research. 2009 Apr; 34(4):764-74. doi: 10.1007/s11064-008-9863-x. [PMID: 18946735]
  • Tsuyoshi Waku, Takuma Shiraki, Takuji Oyama, Yoshito Fujimoto, Kanako Maebara, Narutoshi Kamiya, Hisato Jingami, Kosuke Morikawa. Structural insight into PPARgamma activation through covalent modification with endogenous fatty acids. Journal of molecular biology. 2009 Jan; 385(1):188-99. doi: 10.1016/j.jmb.2008.10.039. [PMID: 18977231]
  • Jee Hoon Lee, Joo Hong Woo, Sang Uk Woo, Kwang Soo Kim, Sang Myun Park, Eun-hye Joe, Ilo Jou. The 15-deoxy-delta 12,14-prostaglandin J2 suppresses monocyte chemoattractant protein-1 expression in IFN-gamma-stimulated astrocytes through induction of MAPK phosphatase-1. Journal of immunology (Baltimore, Md. : 1950). 2008 Dec; 181(12):8642-9. doi: 10.4049/jimmunol.181.12.8642. [PMID: 19050284]
  • Eun-Hee Kim, Young-Joon Surh. The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis. Biochemical pharmacology. 2008 Dec; 76(11):1544-53. doi: 10.1016/j.bcp.2008.07.043. [PMID: 18771658]
  • Ulf Panzer, Gunther Zahner, Ulrike Wienberg, Oliver M Steinmetz, Anett Peters, Jan-Eric Turner, Hans-Joachim Paust, Gunter Wolf, Rolf A K Stahl, André Schneider. 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Dec; 23(12):3776-85. doi: 10.1093/ndt/gfn361. [PMID: 18596134]
  • Hideki Kimura, Xuan Li, Kunio Torii, Toshiharu Okada, Naoki Takahashi, Hiroshi Fujii, Shunji Ishihara, Haruyoshi Yoshida. A natural PPAR-gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, may act as an enhancer of PAI-1 in human proximal renal tubular cells under hypoxic and inflammatory conditions. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2008 Aug; 23(8):2496-503. doi: 10.1093/ndt/gfn139. [PMID: 18367541]
  • Evangelina Capobianco, Verónica White, Romina Higa, Nora Martínez, Alicia Jawerbaum. Effects of natural ligands of PPARgamma on lipid metabolism in placental tissues from healthy and diabetic rats. Molecular human reproduction. 2008 Aug; 14(8):491-9. doi: 10.1093/molehr/gan039. [PMID: 18621767]
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