FA 20:3 (BioDeep_00000628737)

Secondary id: BioDeep_00000405544, BioDeep_00000864683

代谢物信息卡片

8-Pentadecenoic acid, 15-(2-cyclopenten-1-yl)-, (8Z)-

化学式: C20H34O2 (306.2558664)
中文名称: 顺式-8,11,14-二十碳三烯酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.56%

分子结构信息

SMILES: C(/C=C/C/C=C/C/C=C/CC)CCCCCCCCC(=O)O
InChI: InChI=1S/C20H34O2/c21-20(22)18-12-10-8-6-4-2-1-3-5-7-9-11-15-19-16-13-14-17-19/h1,3,13,16,19H,2,4-12,14-15,17-18H2,(H,21,22)

描述信息

COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

79 个代谢物同义名

数据库引用编号

68 个数据库交叉引用编号

ChEBI: CHEBI:190356
ChEBI: CHEBI:36202
ChEBI: CHEBI:36037
ChEBI: CHEBI:165482
ChEBI: CHEBI:82832
ChEBI: CHEBI:93118
ChEBI: CHEBI:53486
ChEBI: CHEBI:165475
ChEBI: CHEBI:93688
KEGG: C03242
PubChem: 131839794
PubChem: 68594743
PubChem: 131839792
PubChem: 102021028
PubChem: 131839767
PubChem: 131839764
PubChem: 131839759
PubChem: 131839755
PubChem: 52921834
PubChem: 9548811
PubChem: 9548837
PubChem: 5312537
PubChem: 5312536
PubChem: 5312535
PubChem: 5312534
PubChem: 5312533
PubChem: 5312532
PubChem: 445084
PubChem: 5312530
PubChem: 5282827
PubChem: 5280581
PubChem: 5282825
PubChem: 5312314
DrugBank: DB00154
ChEMBL: CHEMBL465183
LipidMAPS: LMFA01140045
LipidMAPS: LMFA01140040
LipidMAPS: LMFA01140039
LipidMAPS: LMFA01031210
LipidMAPS: LMFA01031085
LipidMAPS: LMFA01031078
LipidMAPS: LMFA01031070
LipidMAPS: LMFA01031060
LipidMAPS: LMFA01030863
LipidMAPS: LMFA01030767
LipidMAPS: LMFA01030765
LipidMAPS: LMFA01030388
LipidMAPS: LMFA01030386
LipidMAPS: LMFA01030385
LipidMAPS: LMFA01030384
LipidMAPS: LMFA01030383
LipidMAPS: LMFA01030382
LipidMAPS: LMFA01030380
LipidMAPS: LMFA01030379
LipidMAPS: LMFA01030159
LipidMAPS: LMFA01030158
LipidMAPS: LMFA01030157
LipidMAPS: LMFA01020221
MeSH: 8,11,14-Eicosatrienoic Acid
CAS: 90105-02-5
CAS: 7019-85-4
CAS: 2091-27-2
CAS: 1783-84-2
CAS: 2751-14-6
PubChem: 6112
PDB-CCD: LAX
3DMET: B01643
NIKKAJI: J110.768B

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

76 个相关的物种来源信息

9606 Homo sapiens:
9646 Ailuropoda melanoleuca: 10.1371/JOURNAL.PONE.0143417
113274 Eurhynchium striatum: 10.1016/0031-9422(91)85024-T
53008 Rhytidiadelphus squarrosus: 10.1016/0031-9422(91)85024-T
146586 Scopelophila cataractae: 10.1016/0031-9422(91)83188-Q
94452 Loeskeobryum brevirostre: 10.1016/0031-9422(91)83188-Q
185755 Pogonatum inflexum: 10.1016/0031-9422(91)83188-Q
254107 Grimmia pilifera: 10.1016/0031-9422(91)83188-Q
67428 Thuidium tamariscinum: 10.1016/0031-9422(91)83188-Q
95767 Niphotrichum canescens: 10.1016/0031-9422(91)83188-Q
2006508 Rhizomnium tuomikoskii: 10.1016/0031-9422(91)83188-Q
67399 Pyrrhobryum spiniforme: 10.1016/0031-9422(91)83188-Q
13805 Sphagnum palustre: 10.1016/0031-9422(91)83188-Q
184619 Brachythecium buchananii: 10.1016/0031-9422(91)83188-Q
171374 Thuidium pristocalyx: 10.1016/0031-9422(91)83188-Q
173666 Thuidium glaucinum: 10.1016/0031-9422(91)83188-Q
390907 Thamnobryum plicatulum: 10.1016/0031-9422(91)83188-Q
52976 Bartramia pomiformis: 10.1016/0031-9422(91)83188-Q
3197 Marchantia polymorpha: 10.1016/0031-9422(91)83188-Q
455261 Ctenidium percrassum: 10.1016/0031-9422(91)83188-Q
98946 Myuroclada maximowiczii: 10.1016/0031-9422(91)83188-Q
213177 Wijkia concavifolia: 10.1016/0031-9422(91)83188-Q
99398 Cratoneuron filicinum: 10.1016/0031-9422(91)83188-Q
455291 Vesicularia ferriei: 10.1016/0031-9422(91)83188-Q
193026 Campylopus richardii: 10.1016/0031-9422(91)83188-Q
84223 Thuidium recognitum: 10.1016/0031-9422(91)83188-Q
140636 Ulota crispa: 10.1016/0031-9422(91)83188-Q
417139 Plagiomnium maximoviczii: 10.1016/0031-9422(91)83188-Q
98356 Brotherella henonii: 10.1016/0031-9422(91)83188-Q
1852632 Oncophorus crispifolius: 10.1016/0031-9422(91)83188-Q
52988 Hedwigia ciliata: 10.1016/0031-9422(91)83188-Q
195670 Dolichomitra cymbifolia: 10.1016/0031-9422(91)83188-Q
90297 Plagiothecium euryphyllum: 10.1016/0031-9422(91)83188-Q
2008595 Fissidens nobilis: 10.1016/0031-9422(91)83188-Q
1385677 Dicranum japonicum: 10.1016/0031-9422(91)83188-Q
116055 Sargassum pallidum: 10.1016/S0031-9422(98)00662-1
64518 Mortierella alpina:
979708 Mortierella hygrophila: 10.1007/BF00252518
9606 Homo sapiens:
9646 Ailuropoda melanoleuca: 10.1371/JOURNAL.PONE.0143417
113274 Eurhynchium striatum: 10.1016/0031-9422(91)85024-T
53008 Rhytidiadelphus squarrosus: 10.1016/0031-9422(91)85024-T
146586 Scopelophila cataractae: 10.1016/0031-9422(91)83188-Q
94452 Loeskeobryum brevirostre: 10.1016/0031-9422(91)83188-Q
185755 Pogonatum inflexum: 10.1016/0031-9422(91)83188-Q
254107 Grimmia pilifera: 10.1016/0031-9422(91)83188-Q
67428 Thuidium tamariscinum: 10.1016/0031-9422(91)83188-Q
95767 Niphotrichum canescens: 10.1016/0031-9422(91)83188-Q
2006508 Rhizomnium tuomikoskii: 10.1016/0031-9422(91)83188-Q
67399 Pyrrhobryum spiniforme: 10.1016/0031-9422(91)83188-Q
13805 Sphagnum palustre: 10.1016/0031-9422(91)83188-Q
184619 Brachythecium buchananii: 10.1016/0031-9422(91)83188-Q
171374 Thuidium pristocalyx: 10.1016/0031-9422(91)83188-Q
173666 Thuidium glaucinum: 10.1016/0031-9422(91)83188-Q
390907 Thamnobryum plicatulum: 10.1016/0031-9422(91)83188-Q
52976 Bartramia pomiformis: 10.1016/0031-9422(91)83188-Q
3197 Marchantia polymorpha: 10.1016/0031-9422(91)83188-Q
455261 Ctenidium percrassum: 10.1016/0031-9422(91)83188-Q
98946 Myuroclada maximowiczii: 10.1016/0031-9422(91)83188-Q
213177 Wijkia concavifolia: 10.1016/0031-9422(91)83188-Q
99398 Cratoneuron filicinum: 10.1016/0031-9422(91)83188-Q
455291 Vesicularia ferriei: 10.1016/0031-9422(91)83188-Q
193026 Campylopus richardii: 10.1016/0031-9422(91)83188-Q
84223 Thuidium recognitum: 10.1016/0031-9422(91)83188-Q
140636 Ulota crispa: 10.1016/0031-9422(91)83188-Q
417139 Plagiomnium maximoviczii: 10.1016/0031-9422(91)83188-Q
98356 Brotherella henonii: 10.1016/0031-9422(91)83188-Q
1852632 Oncophorus crispifolius: 10.1016/0031-9422(91)83188-Q
52988 Hedwigia ciliata: 10.1016/0031-9422(91)83188-Q
195670 Dolichomitra cymbifolia: 10.1016/0031-9422(91)83188-Q
90297 Plagiothecium euryphyllum: 10.1016/0031-9422(91)83188-Q
2008595 Fissidens nobilis: 10.1016/0031-9422(91)83188-Q
1385677 Dicranum japonicum: 10.1016/0031-9422(91)83188-Q
116055 Sargassum pallidum: 10.1016/S0031-9422(98)00662-1
64518 Mortierella alpina:
979708 Mortierella hygrophila: 10.1007/BF00252518

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Lin Chen, Qihong Jiang, Shiwei Yao, Chenkai Jiang, Hongling Lu, Wenjun Hu, Shaofang Yu, Mingqian Li, Yongcai Feng, Chin Ping Tan, Xingwei Xiang, Guoxin Shen. Sciadonic acid ameliorates cyclophosphamide-induced immunosuppression by modulating the immune response and altering the gut microbiota. Journal of the science of food and agriculture. 2024 May; 104(7):3902-3912. doi: 10.1002/jsfa.13271. [PMID: 38264943]
Hiroshi Kawashima, Katsuhiko Yoshizawa. The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid. Lipids in health and disease. 2023 Oct; 22(1):172. doi: 10.1186/s12944-023-01937-6. [PMID: 37838679]
Nicolas G Bazan, Jeff X Ji, Samuel E Baum. Awakening neural survival mechanisms after stroke: Lipid metabolism in brain-autonomous repair. Neuron. 2023 Oct; 111(19):2945-2948. doi: 10.1016/j.neuron.2023.08.020. [PMID: 37797578]
Joanna Bajerska, Aleksandra Skoczek-Rubińska, Lidia Małczak, Vesna Vucic, Aleksandra Arsic, Milica Kojadinovic, Danijela Ristic-Medic. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. Nutrition research (New York, N.Y.). 2023 May; 115(?):47-60. doi: 10.1016/j.nutres.2023.05.008. [PMID: 37300953]
Liman Luo, Yan Yang, Menglu Fu, Jinlan Luo, Wenhua Li, Ling Tu, Ruolan Dong. 11,12-EET suppressed LPS induced TF expression and thrombus formation by accelerating mRNA degradation rate via strengthening PI3K-Akt signaling pathway and inhibiting p38-TTP pathway. Prostaglandins & other lipid mediators. 2023 Apr; 167(?):106740. doi: 10.1016/j.prostaglandins.2023.106740. [PMID: 37119935]
Lin Chen, Qihong Jiang, Chenkai Jiang, Hongling Lu, Wenjun Hu, Shaofang Yu, Mingqian Li, Chin Ping Tan, Yongcai Feng, Xingwei Xiang, Guoxin Shen. Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota. Food & function. 2023 Mar; 14(6):2870-2880. doi: 10.1039/d2fo02524h. [PMID: 36883533]
Heqiang Lou, Lili Song, Xiaolong Li, Hailing Zi, Weijie Chen, Yadi Gao, Shan Zheng, Zhangjun Fei, Xuepeng Sun, Jiasheng Wu. The Torreya grandis genome illuminates the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis. Nature communications. 2023 03; 14(1):1315. doi: 10.1038/s41467-023-37038-2. [PMID: 36898990]
Anne-Mari Mustonen, Petteri Nieminen. Dihomo-γ-Linolenic Acid (20:3n-6)-Metabolism, Derivatives, and Potential Significance in Chronic Inflammation. International journal of molecular sciences. 2023 Jan; 24(3):. doi: 10.3390/ijms24032116. [PMID: 36768438]
Marcos A Perez, Andrea J Clostio, Isabel R Houston, Jimena Ruiz, Leslie Magtanong, Scott J Dixon, Jennifer L Watts. Ether lipid deficiency disrupts lipid homeostasis leading to ferroptosis sensitivity. PLoS genetics. 2022 09; 18(9):e1010436. doi: 10.1371/journal.pgen.1010436. [PMID: 36178986]
Marzia Savini, Andrew Folick, Yi-Tang Lee, Feng Jin, André Cuevas, Matthew C Tillman, Jonathon D Duffy, Qian Zhao, Isaiah A Neve, Pei-Wen Hu, Yong Yu, Qinghao Zhang, Youqiong Ye, William B Mair, Jin Wang, Leng Han, Eric A Ortlund, Meng C Wang. Lysosome lipid signalling from the periphery to neurons regulates longevity. Nature cell biology. 2022 06; 24(6):906-916. doi: 10.1038/s41556-022-00926-8. [PMID: 35681008]
Alvin Berger. Delta-5® oil, containing the anti-inflammatory fatty acid sciadonic acid, improves skin barrier function in a skin irritation model in healthy female subjects. Lipids in health and disease. 2022 Apr; 21(1):40. doi: 10.1186/s12944-022-01643-9. [PMID: 35443694]
Jie Zhang, Chuang Yang, Hongmei Qiu, Junxia Yang, Ke Wu, Shumei Ding, Chengyan Jiang, Qingsong Jiang. 14,15-EET involved in the development of diabetic cardiac hypertrophy mediated by PPARs. Prostaglandins & other lipid mediators. 2022 04; 159(?):106620. doi: 10.1016/j.prostaglandins.2022.106620. [PMID: 35091081]
Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus. Frontiers in immunology. 2022; 13(?):964901. doi: 10.3389/fimmu.2022.964901. [PMID: 36275708]
Nalin Singh, Anders Vik, Daniel B Lybrand, Christophe Morisseau, Bruce D Hammock. New Alkoxy- Analogues of Epoxyeicosatrienoic Acids Attenuate Cisplatin Nephrotoxicity In Vitro via Reduction of Mitochondrial Dysfunction, Oxidative Stress, Mitogen-Activated Protein Kinase Signaling, and Caspase Activation. Chemical research in toxicology. 2021 12; 34(12):2579-2591. doi: 10.1021/acs.chemrestox.1c00347. [PMID: 34817988]
Neil K Huang, Mary L Biggs, Nirupa R Matthan, Luc Djoussé, W T Longstreth, Kenneth J Mukamal, David S Siscovick, Alice H Lichtenstein. Serum Nonesterified Fatty Acids and Incident Stroke: The CHS. Journal of the American Heart Association. 2021 11; 10(22):e022725. doi: 10.1161/jaha.121.022725. [PMID: 34755529]
Yun Ding, Pengjie Tu, Yiyong Chen, Yangyun Huang, Xiaojie Pan, Wenshu Chen. CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro. Respiratory research. 2021 Nov; 22(1):291. doi: 10.1186/s12931-021-01891-w. [PMID: 34774051]
Dennis Winston T Nilsen, Peder Langeland Myhre, Are Kalstad, Erik Berg Schmidt, Harald Arnesen, Ingebjørg Seljeflot. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction. Nutrients. 2021 Sep; 13(10):. doi: 10.3390/nu13103475. [PMID: 34684479]
Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status. Nutrients. 2021 Sep; 13(10):. doi: 10.3390/nu13103399. [PMID: 34684398]
Christian B Bergmann, Bruce D Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C Caldwell, Dorothy M Supp. TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function. Scientific reports. 2021 08; 11(1):16555. doi: 10.1038/s41598-021-96014-2. [PMID: 34400718]
Shuiqing Hu, Jinlan Luo, Menglu Fu, Liman Luo, Yueting Cai, Wenhua Li, Yuanyuan Li, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu. Soluble epoxide hydrolase deletion attenuated nicotine-induced arterial stiffness via limiting the loss of SIRT1. American journal of physiology. Heart and circulatory physiology. 2021 08; 321(2):H353-H368. doi: 10.1152/ajpheart.00979.2020. [PMID: 34142887]
Shanthi Nagarajan, Zu Yuan Qian, Parthiban Marimuthu, Nabil J Alkayed, Sanjiv Kaul, Anthony P Barnes. Mapping the Molecular Architecture Required for Lipid-Binding Pockets Using a Subset of Established and Orphan G-Protein Coupled Receptors. Journal of chemical information and modeling. 2021 07; 61(7):3442-3452. doi: 10.1021/acs.jcim.1c00335. [PMID: 34242503]
Jacqueline Pontes Monteiro, Carlos A Fuzo, Fábio V Ued, Jim Kaput. Dietary patterns related to zinc and polyunsaturated fatty acids intake are associated with serum linoleic/dihomo-γ-linolenic ratio in NHANES males and females. Scientific reports. 2021 06; 11(1):12215. doi: 10.1038/s41598-021-91611-7. [PMID: 34108562]
Rozenn N Lemaitre, Paul N Jensen, Maxwell Zeigler, Julie Denham, Amanda M Fretts, Jason G Umans, Barbara V Howard, Colleen M Sitlani, Barbara McKnight, Sina A Gharib, Irena B King, David S Siscovick, Bruce M Psaty, Nona Sotoodehnia, Rheem A Totah. Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study. EBioMedicine. 2021 Apr; 66(?):103279. doi: 10.1016/j.ebiom.2021.103279. [PMID: 33752126]
John D Imig, Md Abdul Hye Khan, Anna Burkhan, Guan Chen, Adeniyi Michael Adebesin, John R Falck. Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity. International journal of molecular sciences. 2021 Mar; 22(6):. doi: 10.3390/ijms22062793. [PMID: 33801911]
Menglu Fu, Jing Yu, Zhihui Chen, Ying Tang, Ruolan Dong, Yan Yang, Jinlan Luo, Shuiqing Hu, Ling Tu, Xizhen Xu. Epoxyeicosatrienoic acids improve glucose homeostasis by preventing NF-κB-mediated transcription of SGLT2 in renal tubular epithelial cells. Molecular and cellular endocrinology. 2021 03; 523(?):111149. doi: 10.1016/j.mce.2020.111149. [PMID: 33387601]
Yosuke Tsuchiya, Hisashi Ueda, Kenichi Yanagimoto, Ayaka Kato, Eisuke Ochi. 4-week eicosapentaenoic acid-rich fish oil supplementation partially protects muscular damage following eccentric contractions. Journal of the International Society of Sports Nutrition. 2021 Mar; 18(1):18. doi: 10.1186/s12970-021-00411-x. [PMID: 33648546]
Stefanie Liening, Jana Fischer, Hans Jagusch, Georg Pohnert, Oliver Höcker, Christian Neusüß, Oliver Werz, Gerhard K E Scriba, Ulrike Garscha. 12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets. Prostaglandins & other lipid mediators. 2021 02; 152(?):106480. doi: 10.1016/j.prostaglandins.2020.106480. [PMID: 33172790]
Naoaki Matsuo, Toru Miyoshi, Atsushi Takaishi, Takao Kishinoue, Kentaro Yasuhara, Masafumi Tanimoto, Yukari Nakano, Nobuhiko Onishi, Masayuki Ueeda, Hiroshi Ito. High Plasma Docosahexaenoic Acid Associated to Better Prognoses of Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction. Nutrients. 2021 Jan; 13(2):. doi: 10.3390/nu13020371. [PMID: 33530352]
Tomoaki Okada, Toru Miyoshi, Masayuki Doi, Kosuke Seiyama, Wataru Takagi, Masahiro Sogo, Kazumasa Nosaka, Masahiko Takahashi, Keisuke Okawa, Hiroshi Ito. Secular Decreasing Trend in Plasma Eicosapentaenoic and Docosahexaenoic Acids among Patients with Acute Coronary Syndrome from 2011 to 2019: A Single Center Descriptive Study. Nutrients. 2021 Jan; 13(1):. doi: 10.3390/nu13010253. [PMID: 33477264]
Zhe Jiang, Takuya Hayashi, Kentaro Kashima, Kayo Kurotani, Bungo Shirouchi, Tetsuya Mizoue, Masao Sato. Alteration of Serum Phospholipid n-6 Polyunsaturated Fatty Acid Compositions in Nonalcoholic Fatty Liver Disease in the Japanese Population: A Cross-Sectional Study. Lipids. 2020 11; 55(6):599-614. doi: 10.1002/lipd.12251. [PMID: 32691411]
Ella J Baker, Carina A Valenzuela, Wies T M van Dooremalen, Leyre Martínez-Fernández, Parveen Yaqoob, Elizabeth A Miles, Philip C Calder. Gamma-Linolenic and Pinolenic Acids Exert Anti-Inflammatory Effects in Cultured Human Endothelial Cells Through Their Elongation Products. Molecular nutrition & food research. 2020 10; 64(20):e2000382. doi: 10.1002/mnfr.202000382. [PMID: 32898315]
Takahisa Mori, Kazuhiro Yoshioka, Yuhei Tanno, Shigen Kasakura. Association of Serum Fatty Acids at Admission with the Age of Onset of Intracerebral Hemorrhage. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102903. [PMID: 32977415]
Ekaterina Novichkova, Katya Chumin, Noy Eretz-Kdosha, Sammy Boussiba, Jacob Gopas, Guy Cohen, Inna Khozin-Goldberg. DGLA from the Microalga Lobosphaera Incsa P127 Modulates Inflammatory Response, Inhibits iNOS Expression and Alleviates NO Secretion in RAW264.7 Murine Macrophages. Nutrients. 2020 Sep; 12(9):. doi: 10.3390/nu12092892. [PMID: 32971852]
Souha Hammouda, Imen Ghzaiel, Wided Khamlaoui, Sonia Hammami, Samia Younes Mhenni, Slim Samet, Mohamed Hammami, Amira Zarrouk. Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population. Prostaglandins, leukotrienes, and essential fatty acids. 2020 09; 160(?):102159. doi: 10.1016/j.plefa.2020.102159. [PMID: 32682282]
Marcos A Perez, Leslie Magtanong, Scott J Dixon, Jennifer L Watts. Dietary Lipids Induce Ferroptosis in Caenorhabditiselegans and Human Cancer Cells. Developmental cell. 2020 08; 54(4):447-454.e4. doi: 10.1016/j.devcel.2020.06.019. [PMID: 32652074]
Takahisa Mori, Kazuhiro Yoshioka, Yuhei Tanno, Shigen Kasakura. Association of Serum Fatty Acids at Admission with the Age of Onset of Acute Ischemic Stroke. Nutrients. 2020 Aug; 12(8):. doi: 10.3390/nu12082411. [PMID: 32806540]
Hugo F Olivares-Rubio, J J Espinosa-Aguirre. Role of epoxyeicosatrienoic acids in the lung. Prostaglandins & other lipid mediators. 2020 08; 149(?):106451. doi: 10.1016/j.prostaglandins.2020.106451. [PMID: 32294527]
Kodai Ishihara, Kazuhiro P Izawa, Masahiro Kitamura, Takayuki Shimogai, Yuji Kanejima, Tomoyuki Morisawa, Ikki Shimizu. Serum concentration of dihomo-γ-linolenic acid is associated with cognitive function and mild cognitive impairment in coronary artery disease patients. Prostaglandins, leukotrienes, and essential fatty acids. 2020 07; 158(?):102038. doi: 10.1016/j.plefa.2019.102038. [PMID: 31767440]
John D Imig, Wojciech K Jankiewicz, Abdul H Khan. Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture. Hypertension (Dallas, Tex. : 1979). 2020 07; 76(1):3-15. doi: 10.1161/hypertensionaha.120.13898. [PMID: 32475311]
Cuiping Zhang, Zuojian Hu, Ke Wang, Lujie Yang, Yue Li, Hartmut Schlüter, Pengyuan Yang, Jiaxu Hong, Hongxiu Yu. Lipidomic profiling of virus infection identifies mediators that resolve herpes simplex virus-induced corneal inflammatory lesions. The Analyst. 2020 Jun; 145(11):3967-3976. doi: 10.1039/d0an00263a. [PMID: 32319474]
Ming-Xiao Wang, Li-Jun Wang, Yu Xiao, Dan-Dan Zhang, Xin-Peng Duan, Wen-Hui Wang. Epoxyeicosatrienoic acid metabolites inhibit Kir4.1/Kir5.1 in the distal convoluted tubule. American journal of physiology. Renal physiology. 2020 06; 318(6):F1369-F1376. doi: 10.1152/ajprenal.00018.2020. [PMID: 32308018]
Mercè Pallàs, Santiago Vázquez, Coral Sanfeliu, Carles Galdeano, Christian Griñán-Ferré. Soluble Epoxide Hydrolase Inhibition to Face Neuroinflammation in Parkinson's Disease: A New Therapeutic Strategy. Biomolecules. 2020 05; 10(5):. doi: 10.3390/biom10050703. [PMID: 32369955]
Susan Sergeant, Brian Hallmark, Rasika A Mathias, Tammy L Mustin, Priscilla Ivester, Maggie L Bohannon, Ingo Ruczinski, Laurel Johnstone, Michael C Seeds, Floyd H Chilton. Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils. The American journal of clinical nutrition. 2020 05; 111(5):1068-1078. doi: 10.1093/ajcn/nqaa023. [PMID: 32167131]
Frédérique Pédrono, Nathalie Boulier-Monthéan, Françoise Boissel, Jordane Ossemond, Roselyne Viel, Alain Fautrel, Justine Marchix, Didier Dupont. Sciadonic acid derived from pine nuts as a food component to reduce plasma triglycerides by inhibiting the rat hepatic Δ9-desaturase. Scientific reports. 2020 04; 10(1):6223. doi: 10.1038/s41598-020-63301-3. [PMID: 32277113]
Marco Rahm, Juliane Merl-Pham, Jerzy Adamski, Stefanie M Hauck. Time-resolved phosphoproteomic analysis elucidates hepatic 11,12-Epoxyeicosatrienoic acid signaling pathways. Prostaglandins & other lipid mediators. 2020 02; 146(?):106387. doi: 10.1016/j.prostaglandins.2019.106387. [PMID: 31669255]
Walter Adams, Rudra Bhowmick, Elsa N Bou Ghanem, Kristin Wade, Mikhail Shchepetov, Jeffrey N Weiser, Beth A McCormick, Rodney K Tweten, John M Leong. Pneumolysin Induces 12-Lipoxygenase-Dependent Neutrophil Migration during Streptococcus pneumoniae Infection. Journal of immunology (Baltimore, Md. : 1950). 2020 01; 204(1):101-111. doi: 10.4049/jimmunol.1800748. [PMID: 31776202]
Carolina Shene, Paris Paredes, Daniela Vergara, Allison Leyton, Marcelo Garcés, Liset Flores, Mónica Rubilar, Mariela Bustamante, Roberto Armenta. Antarctic thraustochytrids: Producers of long-chain omega-3 polyunsaturated fatty acids. MicrobiologyOpen. 2020 01; 9(1):e00950. doi: 10.1002/mbo3.950. [PMID: 31637873]
Dariusz Kotlega, Agnieszka Zembron-Lacny, Barbara Morawin, Monika Golab-Janowska, Przemyslaw Nowacki, Malgorzata Szczuko. Free Fatty Acids and Their Inflammatory Derivatives Affect BDNF in Stroke Patients. Mediators of inflammation. 2020; 2020(?):6676247. doi: 10.1155/2020/6676247. [PMID: 33343231]
Yi-Min Kuo, Pei-Chien Hsu, Chia-Chi Hung, Ya-Yu Hu, Yu-Jie Huang, Yu-Ling Gan, Chun-Hua Lin, Feng-Shiun Shie, Wen-Kuei Chang, Lung-Sen Kao, Mei-Yung Tsou, Yi-Hsuan Lee. Soluble Epoxide Hydrolase Inhibition Attenuates Excitotoxicity Involving 14,15-Epoxyeicosatrienoic Acid-Mediated Astrocytic Survival and Plasticity to Preserve Glutamate Homeostasis. Molecular neurobiology. 2019 Dec; 56(12):8451-8474. doi: 10.1007/s12035-019-01669-8. [PMID: 31257558]
Boye L Jensen. Protection against acute kidney injury is afforded by a 14,15-epoxy-eicosatrienoic acid (EET) analog-A potential druggable pathway. Acta physiologica (Oxford, England). 2019 10; 227(2):e13330. doi: 10.1111/apha.13330. [PMID: 31177630]
Uwe Hoff, Gordana Bubalo, Mandy Fechner, Maximilian Blum, Ye Zhu, Andreas Pohlmann, Jan Hentschel, Karen Arakelyan, Erdmann Seeliger, Bert Flemming, Dennis Gürgen, Michael Rothe, Thoralf Niendorf, Vijaya L Manthati, John R Falck, Michael Haase, Wolf-Hagen Schunck, Duska Dragun. A synthetic epoxyeicosatrienoic acid analogue prevents the initiation of ischemic acute kidney injury. Acta physiologica (Oxford, England). 2019 10; 227(2):e13297. doi: 10.1111/apha.13297. [PMID: 31077555]
Margaret L Ong, Robert S Venick, Stephen B Shew, James C Y Dunn, Laurie Reyen, Tristan Grogan, Kara L Calkins. Intravenous Fish Oil and Serum Fatty Acid Profiles in Pediatric Patients With Intestinal Failure-Associated Liver Disease. JPEN. Journal of parenteral and enteral nutrition. 2019 08; 43(6):717-725. doi: 10.1002/jpen.1532. [PMID: 30900274]
Prabha Tiwari, Takahiro Nagatake, So-Ichiro Hirata, Kento Sawane, Azusa Saika, Yuki Shibata, Sakiko Morimoto, Tetsuya Honda, Jun Adachi, Yuichi Abe, Junko Isoyama, Takeshi Tomonaga, Hiroshi Kiyono, Kenji Kabashima, Jun Kunisawa. Dietary coconut oil ameliorates skin contact hypersensitivity through mead acid production in mice. Allergy. 2019 08; 74(8):1522-1532. doi: 10.1111/all.13762. [PMID: 30843234]
Leah Gramlich, Carol Ireton-Jones, John M Miles, Maya Morrison, Alessandro Pontes-Arruda. Essential Fatty Acid Requirements and Intravenous Lipid Emulsions. JPEN. Journal of parenteral and enteral nutrition. 2019 08; 43(6):697-707. doi: 10.1002/jpen.1537. [PMID: 30908685]
Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Sakda Khoomrung, Chanikul Chutrakul, Kobkul Laoteng. Reengineering lipid biosynthetic pathways of Aspergillus oryzae for enhanced production of γ-linolenic acid and dihomo-γ-linolenic acid. Gene. 2019 Jul; 706(?):106-114. doi: 10.1016/j.gene.2019.04.074. [PMID: 31039437]
Marco Raffaele, Lars Bellner, Shailendra P Singh, Gaia Favero, Rita Rezzani, Luigi Fabrizio Rodella, John R Falck, Nader G Abraham, Luca Vanella. Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial signaling. Experimental cell research. 2019 07; 380(2):180-187. doi: 10.1016/j.yexcr.2019.04.029. [PMID: 31039348]
Benjamin Gollasch, Inci Dogan, Michael Rothe, Maik Gollasch, Friedrich C Luft. Maximal exercise and plasma cytochrome P450 and lipoxygenase mediators: a lipidomics study. Physiological reports. 2019 07; 7(13):e14165. doi: 10.14814/phy2.14165. [PMID: 31304687]
Parker N Hyde, Teryn N Sapper, Christopher D Crabtree, Richard A LaFountain, Madison L Bowling, Alex Buga, Brandon Fell, Fionn T McSwiney, Ryan M Dickerson, Vincent J Miller, Debbie Scandling, Orlando P Simonetti, Stephen D Phinney, William J Kraemer, Sarah A King, Ronald M Krauss, Jeff S Volek. Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI insight. 2019 06; 4(12):. doi: 10.1172/jci.insight.128308. [PMID: 31217353]
Giovanni Brotzu, Anna Maria Fadda, Maria Letizia Manca, Thomas Manca, Francesca Marongiu, Monica Campisi, Francesca Consolaro. A liposome-based formulation containing equol, dihomo-γ-linolenic acid and propionyl-l-carnitine to prevent and treat hair loss: A prospective investigation. Dermatologic therapy. 2019 01; 32(1):e12778. doi: 10.1111/dth.12778. [PMID: 30371981]
Marcus O D Sjödin, Antonio Checa, Mingxing Yang, Sven-Erik Dahlén, Åsa M Wheelock, Anders Eklund, Johan Grunewald, Craig E Wheelock. Soluble epoxide hydrolase derived lipid mediators are elevated in bronchoalveolar lavage fluid from patients with sarcoidosis: a cross-sectional study. Respiratory research. 2018 Dec; 19(1):236. doi: 10.1186/s12931-018-0939-0. [PMID: 30509266]
Ann M Gregus, Matthew W Buczynski, Darren S Dumlao, Paul C Norris, Ganesha Rai, Anton Simeonov, David J Maloney, Ajit Jadhav, Qinghao Xu, Spencer C Wei, Bethany L Fitzsimmons, Edward A Dennis, Tony L Yaksh. Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. doi: 10.1097/j.pain.0000000000001373. [PMID: 30130298]
Sara Bonafini, Alice Giontella, Angela Tagetti, Denise Marcon, Martina Montagnana, Marco Benati, Rossella Gaudino, Paolo Cavarzere, Mirjam Karber, Michael Rothe, Pietro Minuz, Franco Antonazzi, Claudio Maffeis, Wolf Hagen Schunck, Cristiano Fava. Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children. Nutrients. 2018 Nov; 10(11):. doi: 10.3390/nu10111689. [PMID: 30400671]
Maxwell Zeigler, Dale Whittington, Nona Sotoodehnia, Rozenn N Lemaitre, Rheem A Totah. A sensitive and improved throughput UPLC-MS/MS quantitation method of total cytochrome P450 mediated arachidonic acid metabolites that can separate regio-isomers and cis/trans-EETs from human plasma. Chemistry and physics of lipids. 2018 11; 216(?):162-170. doi: 10.1016/j.chemphyslip.2018.09.004. [PMID: 30201384]
Tomoharu Mizukami, Kazutaka Ikeda, Yuta Shimanaka, Katsunari Korogi, Chunyu Zhou, Hiroshi Takase, Hitomi Tsuiji, Nozomu Kono, Takao Kohno, Hiroyuki Arai, Makoto Arita, Mitsuharu Hattori. Reelin deficiency leads to aberrant lipid composition in mouse brain. Biochemical and biophysical research communications. 2018 10; 505(1):81-86. doi: 10.1016/j.bbrc.2018.09.089. [PMID: 30241938]
Yuya Tsurutani, Kosuke Inoue, Chiho Sugisawa, Jun Saito, Masao Omura, Tetsuo Nishikawa. Increased Serum Dihomo-γ-linolenic Acid Levels Are Associated with Obesity, Body Fat Accumulation, and Insulin Resistance in Japanese Patients with Type 2 Diabetes. Internal medicine (Tokyo, Japan). 2018 Oct; 57(20):2929-2935. doi: 10.2169/internalmedicine.0816-18. [PMID: 29877283]
Eduardo Villamor, Luis A Villar, Anyela Lozano-Parra, Víctor M Herrera, Oscar F Herrán. Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome. The British journal of nutrition. 2018 10; 120(7):787-796. doi: 10.1017/s0007114518002039. [PMID: 30105961]
Lai Wang, Gan Luo, Long-Fei Zhang, Hui-Xia Geng. Neuroprotective effects of epoxyeicosatrienoic acids. Prostaglandins & other lipid mediators. 2018 09; 138(?):9-14. doi: 10.1016/j.prostaglandins.2018.07.002. [PMID: 30031209]
Lu Liu, Nitin Puri, Marco Raffaele, Joseph Schragenheim, Shailendra P Singh, J Alyce Bradbury, Lars Bellner, Luca Vanella, Darryl C Zeldin, Jian Cao, Nader G Abraham. Ablation of soluble epoxide hydrolase reprogram white fat to beige-like fat through an increase in mitochondrial integrity, HO-1-adiponectin in vitro and in vivo. Prostaglandins & other lipid mediators. 2018 09; 138(?):1-8. doi: 10.1016/j.prostaglandins.2018.07.004. [PMID: 30041041]
Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
Junko Yamaguchi, Kosaku Kinoshita, Shingo Ihara, Makoto Furukawa, Atsushi Sakurai. The Clinical Significance of Low Serum Arachidonic Acid in Sepsis Patients with Hypoalbuminemia. Internal medicine (Tokyo, Japan). 2018 Jul; 57(13):1833-1840. doi: 10.2169/internalmedicine.9124-17. [PMID: 29491308]
Joseph Schragenheim, Lars Bellner, Jian Cao, Shailendra P Singh, David Bamshad, John A McClung, Omri Maayan, Aliza Meissner, Ilana Grant, Charles T Stier, Nader G Abraham. EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter. Prostaglandins & other lipid mediators. 2018 07; 137(?):30-39. doi: 10.1016/j.prostaglandins.2018.05.008. [PMID: 29787809]
Yi-Er Qiu, Jun Qin, Yang Luo, Shao-Lan Qin, Yi-Fei Mu, Ran Cun, Hou-Li Jiang, Jian-Jun Chen, Min-Hao Yu, Ming Zhong. Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression. Prostaglandins & other lipid mediators. 2018 05; 136(?):9-14. doi: 10.1016/j.prostaglandins.2018.03.004. [PMID: 29580941]
Pinming Liu, Shaoling Zhang, Jingwei Gao, Ying Lin, Guangzi Shi, Wanbing He, Rhian M Touyz, Li Yan, Hui Huang. Downregulated Serum 14, 15-Epoxyeicosatrienoic Acid Is Associated With Abdominal Aortic Calcification in Patients With Primary Aldosteronism. Hypertension (Dallas, Tex. : 1979). 2018 04; 71(4):592-598. doi: 10.1161/hypertensionaha.117.10644. [PMID: 29440332]
Yi Xu, Xiaoyu Yang, Tao Wang, Liu Yang, Yu-Ying He, Keith Miskimins, Steven Y Qian. Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-γ-linolenic acid peroxidation dependent mechanism. BMC cancer. 2018 03; 18(1):330. doi: 10.1186/s12885-018-4250-8. [PMID: 29587668]
Jyrki K Virtanen, Jason H Y Wu, Sari Voutilainen, Jaakko Mursu, Tomi-Pekka Tuomainen. Serum n-6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study. The American journal of clinical nutrition. 2018 03; 107(3):427-435. doi: 10.1093/ajcn/nqx063. [PMID: 29566193]
Yuan Guo, Fei Luo, Xv Zhang, Jingyuan Chen, Li Shen, Yi Zhu, Danyan Xu. TPPU enhanced exercise-induced epoxyeicosatrienoic acid concentrations to exert cardioprotection in mice after myocardial infarction. Journal of cellular and molecular medicine. 2018 03; 22(3):1489-1500. doi: 10.1111/jcmm.13412. [PMID: 29265525]
Tsitsi Chimhashu, Linda Malan, Jeannine Baumgartner, Paul J van Jaarsveld, Valeria Galetti, Diego Moretti, Cornelius M Smuts, Michael B Zimmermann. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children. The British journal of nutrition. 2018 03; 119(6):610-619. doi: 10.1017/s000711451700366x. [PMID: 29352828]
Marija Knez, Elad Tako, Raymond P Glahn, Nikolai Kolba, Emma de Courcy-Ireland, James C R Stangoulis. Linoleic Acid:Dihomo-γ-Linolenic Acid Ratio Predicts the Efficacy of Zn-Biofortified Wheat in Chicken (Gallus gallus). Journal of agricultural and food chemistry. 2018 Feb; 66(6):1394-1400. doi: 10.1021/acs.jafc.7b04905. [PMID: 29359556]
Jing Luo, Jian-Feng Yao, Xiao-Fei Deng, Xiao-Dan Zheng, Min Jia, Yue-Qin Wang, Yan Huang, Jian-Hua Zhu. 14, 15-EET induces breast cancer cell EMT and cisplatin resistance by up-regulating integrin αvβ3 and activating FAK/PI3K/AKT signaling. Journal of experimental & clinical cancer research : CR. 2018 Feb; 37(1):23. doi: 10.1186/s13046-018-0694-6. [PMID: 29426357]
Yuri Hayashi, Ayano Shimamura, Tomoko Ishikawa, Yoko Fujiwara, Ikuyo Ichi. FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion. Biochemical and biophysical research communications. 2018 02; 496(2):549-555. doi: 10.1016/j.bbrc.2018.01.064. [PMID: 29353041]
Frédérique Pédrono, Nathalie Boulier-Monthéan, Françoise Boissel, Jordane Ossemond, Françoise Lohézic-Le Dévéhat. The Hypotriglyceridemic Effect of Sciadonic Acid is Mediated by the Inhibition of Δ9-Desaturase Expression and Activity. Molecular nutrition & food research. 2018 02; 62(4):. doi: 10.1002/mnfr.201700567. [PMID: 29272066]
Fernando Elijovich, Ginger L Milne, Nancy J Brown, Michal Laniado-Schwartzman, Cheryl L Laffer. Two Pools of Epoxyeicosatrienoic Acids in Humans: Alterations in Salt-Sensitive Normotensive Subjects. Hypertension (Dallas, Tex. : 1979). 2018 02; 71(2):346-355. doi: 10.1161/hypertensionaha.117.10392. [PMID: 29279315]
Jung-Ung An, Yong-Seok Song, Kyoung-Rok Kim, Yoon-Joo Ko, Do-Young Yoon, Deok-Kun Oh. Biotransformation of polyunsaturated fatty acids to bioactive hepoxilins and trioxilins by microbial enzymes. Nature communications. 2018 01; 9(1):128. doi: 10.1038/s41467-017-02543-8. [PMID: 29317615]
Heejin Kim, Nakyung Choi, Hak-Ryul Kim, Junsoo Lee, In-Hwan Kim. Preparation of High Purity Δ5-Olefinic Acids from Pine Nut Oil via Repeated Lipase-Catalyzed Esterification. Journal of oleo science. 2018; 67(11):1435-1442. doi: 10.5650/jos.ess18136. [PMID: 30404964]
Emma Kjellberg, Josefine Roswall, Stefan Bergman, Birgitta Strandvik, Jovanna Dahlgren. Serum n-6 and n-9 Fatty Acids Correlate With Serum IGF-1 and Growth Up to 4 Months of Age in Healthy Infants. Journal of pediatric gastroenterology and nutrition. 2018 01; 66(1):141-146. doi: 10.1097/mpg.0000000000001691. [PMID: 28753183]
Xiaoyan Huang, Yuguang Wang, Yi Wang, Liang Yang, Jia Wang, Yue Gao. Ophiopogonin D Reduces Myocardial Ischemia-Reperfusion Injury via Upregulating CYP2J3/EETs in Rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 49(4):1646-1658. doi: 10.1159/000493500. [PMID: 30227401]
Qi Zhang, Xiang Wang, Guifang Yan, Juan Lei, Yu Zhou, Lei Wu, Ting Wang, Xiao Zhang, Duyun Ye, Yongsheng Li. Anti- Versus Pro-Inflammatory Metabololipidome Upon Cupping Treatment. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 45(4):1377-1389. doi: 10.1159/000487563. [PMID: 29462800]
Mohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed, Mohamed Abid, Kamel Jamoussi, Mohamed Hammami. Role of disturbed fatty acids metabolism in the pathophysiology of diabetic erectile dysfunction. Lipids in health and disease. 2017 Dec; 16(1):241. doi: 10.1186/s12944-017-0637-9. [PMID: 29233142]
Bing-Qing Deng, Ying Luo, Xin Kang, Chang-Bin Li, Christophe Morisseau, Jun Yang, Kin Sing Stephen Lee, Jian Huang, Da-Yong Hu, Ming-Yu Wu, Ai Peng, Bruce D Hammock, Jun-Yan Liu. Epoxide metabolites of arachidonate and docosahexaenoate function conversely in acute kidney injury involved in GSK3β signaling. Proceedings of the National Academy of Sciences of the United States of America. 2017 11; 114(47):12608-12613. doi: 10.1073/pnas.1705615114. [PMID: 29109264]
Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand. Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids. Archives of toxicology. 2017 Nov; 91(11):3571-3585. doi: 10.1007/s00204-017-2060-4. [PMID: 28975360]
Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah. Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo. Free radical biology & medicine. 2017 11; 112(?):131-140. doi: 10.1016/j.freeradbiomed.2017.07.015. [PMID: 28734877]
William B Campbell, John D Imig, James M Schmitz, John R Falck. Orally Active Epoxyeicosatrienoic Acid Analogs. Journal of cardiovascular pharmacology. 2017 Oct; 70(4):211-224. doi: 10.1097/fjc.0000000000000523. [PMID: 28937442]
Julia M Santos, Jung-A Park, Aby Joiakim, David A Putt, Robert N Taylor, Hyesook Kim. The role of soluble epoxide hydrolase in preeclampsia. Medical hypotheses. 2017 Oct; 108(?):81-85. doi: 10.1016/j.mehy.2017.07.033. [PMID: 29055406]
Masaru Hiki, Tetsuro Miyazaki, Kazunori Shimada, Yurina Sugita, Megumi Shimizu, Tatsuro Aikawa, Shohei Ouchi, Tomoyuki Shiozawa, Kiyoshi Takasu, Shuhei Takahashi, Atsutoshi Takagi, Katsumi Miyauchi, Hiroyuki Daida. Significance of Serum Polyunsaturated Fatty Acid Level Imbalance in Patients with Acute Venous Thromboembolism. Journal of atherosclerosis and thrombosis. 2017 Oct; 24(10):1016-1022. doi: 10.5551/jat.37424. [PMID: 28344195]
Megumi Haruna, Mie Shiraishi, Masayo Matsuzaki, Yuko Yatsuki, SeonAe Yeo. Effect of tailored dietary guidance for pregnant women on nutritional status: A double-cohort study. Maternal & child nutrition. 2017 10; 13(4):. doi: 10.1111/mcn.12391. [PMID: 27896937]
Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu. Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells. Biochimica et biophysica acta. Biomembranes. 2017 Oct; 1859(10):1967-1973. doi: 10.1016/j.bbamem.2017.07.001. [PMID: 28688796]
Jennifer Yeung, Michael Holinstat. Who is the real 12-HETrE?. Prostaglandins & other lipid mediators. 2017 09; 132(?):25-30. doi: 10.1016/j.prostaglandins.2017.02.005. [PMID: 28259546]
Xuehong Liu, Zu-Yuan Qian, Fuchun Xie, Wei Fan, Jonathan W Nelson, Xiangshu Xiao, Sanjiv Kaul, Anthony P Barnes, Nabil J Alkayed. Functional screening for G protein-coupled receptor targets of 14,15-epoxyeicosatrienoic acid. Prostaglandins & other lipid mediators. 2017 09; 132(?):31-40. doi: 10.1016/j.prostaglandins.2016.09.002. [PMID: 27649858]
Sha Lei, Fengjie Huang, Aihua Zhao, Tianlu Chen, Wenlian Chen, Guoxiang Xie, Xiaojiao Zheng, Yunjing Zhang, Haoyong Yu, Pin Zhang, Cynthia Rajani, Yuqian Bao, Weiping Jia, Wei Jia. The ratio of dihomo-γ-linolenic acid to deoxycholic acid species is a potential biomarker for the metabolic abnormalities in obesity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 09; 31(9):3904-3912. doi: 10.1096/fj.201700055r. [PMID: 28490483]