Actinorhodin (BioDeep_00000006284)

   

natural product


代谢物信息卡片


Actinorhodin

化学式: C32H26O14 (634.1322496)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 6.67%

分子结构信息

SMILES: CC1C2=C(CC(O1)CC(=O)O)C(=O)C3=C(C2=O)C(=O)C(=CC3=O)C4=CC(=C5C(=C4O)C(=C6C(OC(CC6=C5O)CC(=O)O)C)O)O
InChI: InChI=1S/C32H26O14/c1-9-21-15(3-11(45-9)5-19(35)36)29(41)23-17(33)7-13(27(39)25(23)31(21)43)14-8-18(34)24-26(28(14)40)32(44)22-10(2)46-12(6-20(37)38)4-16(22)30(24)42/h7-12,33,39,41,43H,3-6H2,1-2H3,(H,35,36)(H,37,38)/t9-,10-,11+,12+/m1/s1

描述信息

A member of the class of benzoisochromanequinone that is produced by Streptomyces coelicolor A3(2) and exhibits antibiotic activity.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents

同义名列表

2 个代谢物同义名

Actinorhodin; FT-0775158



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

669 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaocao Liu, Guosong Zheng, Gang Wang, Weihong Jiang, Lei Li, Yinhua Lu. Overexpression of the diguanylate cyclase CdgD blocks developmental transitions and antibiotic biosynthesis in Streptomyces coelicolor. Science China. Life sciences. 2019 Nov; 62(11):1492-1505. doi: 10.1007/s11427-019-9549-8. [PMID: 31228045]
  • Jingman Wang, Anrui Lu, Jiakun Liu, Weiren Huang, Jin Wang, Zhiming Cai, Guoping Zhao. iCatch: a new strategy for capturing large DNA fragments using homing endonucleases. Acta biochimica et biophysica Sinica. 2019 Jan; 51(1):97-103. doi: 10.1093/abbs/gmy139. [PMID: 30452545]
  • Shanshan Li, Junyang Wang, Wensheng Xiang, Keqian Yang, Zilong Li, Weishan Wang. An Autoregulated Fine-Tuning Strategy for Titer Improvement of Secondary Metabolites Using Native Promoters in Streptomyces. ACS synthetic biology. 2018 02; 7(2):522-530. doi: 10.1021/acssynbio.7b00318. [PMID: 29087698]
  • Roberto Scaffaro, Francesco Lopresti, Alberto Sutera, Luigi Botta, Rosa Maria Fontana, Giuseppe Gallo. Plasma modified PLA electrospun membranes for actinorhodin production intensification in Streptomyces coelicolor immobilized-cell cultivations. Colloids and surfaces. B, Biointerfaces. 2017 Sep; 157(?):233-241. doi: 10.1016/j.colsurfb.2017.05.060. [PMID: 28599184]
  • Tatsuya Nishiyama, Yoshiteru Hashimoto, Hitoshi Kusakabe, Takuto Kumano, Michihiko Kobayashi. Natural low-molecular mass organic compounds with oxidase activity as organocatalysts. Proceedings of the National Academy of Sciences of the United States of America. 2014 Dec; 111(48):17152-7. doi: 10.1073/pnas.1417941111. [PMID: 25411318]
  • Jia-Kun Liu, Wei-Hua Chen, Shuang-Xi Ren, Guo-Ping Zhao, Jin Wang. iBrick: a new standard for iterative assembly of biological parts with homing endonucleases. PloS one. 2014; 9(10):e110852. doi: 10.1371/journal.pone.0110852. [PMID: 25329380]
  • Pengfei Xie, Ana Zeng, Xiaoting Lv, Qiuxiang Cheng, Zhongjun Qin. A putative transglycosylase encoded by SCO4132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor. Acta biochimica et biophysica Sinica. 2013 Apr; 45(4):296-302. doi: 10.1093/abbs/gmt012. [PMID: 23403510]
  • Zhenyu Yu, Hong Zhu, Fujun Dang, Weiwen Zhang, Zhongjun Qin, Sheng Yang, Huarong Tan, Yinhua Lu, Weihong Jiang. Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. Molecular microbiology. 2012 Aug; 85(3):535-56. doi: 10.1111/j.1365-2958.2012.08126.x. [PMID: 22676800]
  • Min Zhou, Xinyun Jing, Pengfei Xie, Weihua Chen, Tao Wang, Haiyang Xia, Zhongjun Qin. Sequential deletion of all the polyketide synthase and nonribosomal peptide synthetase biosynthetic gene clusters and a 900-kb subtelomeric sequence of the linear chromosome of Streptomyces coelicolor. FEMS microbiology letters. 2012 Aug; 333(2):169-79. doi: 10.1111/j.1574-6968.2012.02609.x. [PMID: 22670631]
  • Sylvain Lerat, Martin Forest, Annie Lauzier, Gilles Grondin, Serge Lacelle, Carole Beaulieu. Potato suberin induces differentiation and secondary metabolism in the genus Streptomyces. Microbes and environments. 2012; 27(1):36-42. doi: 10.1264/jsme2.me11282. [PMID: 22129602]
  • Yonghong Wang, Xiangling Fang, Fengqiu An, Guohong Wang, Xing Zhang. Improvement of antibiotic activity of Xenorhabdus bovienii by medium optimization using response surface methodology. Microbial cell factories. 2011 Nov; 10(?):98. doi: 10.1186/1475-2859-10-98. [PMID: 22082189]
  • Weihua Chen, Zhongjun Qin. Development of a gene cloning system in a fast-growing and moderately thermophilic Streptomyces species and heterologous expression of Streptomyces antibiotic biosynthetic gene clusters. BMC microbiology. 2011 Oct; 11(?):243. doi: 10.1186/1471-2180-11-243. [PMID: 22032628]
  • Zhiqun Lu, Pengfei Xie, Zhongjun Qin. Promotion of markerless deletion of the actinorhodin biosynthetic gene cluster in Streptomyces coelicolor. Acta biochimica et biophysica Sinica. 2010 Oct; 42(10):717-21. doi: 10.1093/abbs/gmq080. [PMID: 20810535]
  • Ludmila V Roze, Anindya Chanda, Maris Laivenieks, Randolph M Beaudry, Katherine A Artymovich, Anna V Koptina, Deena W Awad, Dina Valeeva, Arthur D Jones, John E Linz. Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism. BMC biochemistry. 2010 Aug; 11(?):33. doi: 10.1186/1471-2091-11-33. [PMID: 20735852]
  • Xinxuan Wang, Lili Huang, Zhensheng Kang, Heinrich Buchenauer, Xiaoning Gao. Optimization of the fermentation process of actinomycete strain hhs.015. Journal of biomedicine & biotechnology. 2010; 2010(?):141876. doi: 10.1155/2010/141876. [PMID: 20508842]
  • Pengfei Xie, Ana Zeng, Zhongjun Qin. cmdABCDEF, a cluster of genes encoding membrane proteins for differentiation and antibiotic production in Streptomyces coelicolor A3(2). BMC microbiology. 2009 Aug; 9(?):157. doi: 10.1186/1471-2180-9-157. [PMID: 19650935]
  • Dan Shu, Lei Chen, Weihua Wang, Zhenyu Yu, Cong Ren, Weiwen Zhang, Sheng Yang, Yinhua Lu, Weihong Jiang. afsQ1-Q2-sigQ is a pleiotropic but conditionally required signal transduction system for both secondary metabolism and morphological development in Streptomyces coelicolor. Applied microbiology and biotechnology. 2009 Jan; 81(6):1149-60. doi: 10.1007/s00253-008-1738-1. [PMID: 18949475]
  • Ming Li, Tae-Jong Kim, Hyung-Jin Kwon, Joo-Won Suh. Effects of extracellular ATP on the physiology of Streptomyces coelicolor A3(2). FEMS microbiology letters. 2008 Sep; 286(1):24-31. doi: 10.1111/j.1574-6968.2008.01248.x. [PMID: 18565122]
  • Lei Chen, Yinhua Lu, Jun Chen, Weiwen Zhang, Dan Shu, Zhongjun Qin, Sheng Yang, Weihong Jiang. Characterization of a negative regulator AveI for avermectin biosynthesis in Streptomyces avermitilis NRRL8165. Applied microbiology and biotechnology. 2008 Aug; 80(2):277-86. doi: 10.1007/s00253-008-1545-8. [PMID: 18560830]
  • Yinhua Lu, Weihua Wang, Dan Shu, Weiwen Zhang, Lei Chen, Zhongjun Qin, Sheng Yang, Weihong Jiang. Characterization of a novel two-component regulatory system involved in the regulation of both actinorhodin and a type I polyketide in Streptomyces coelicolor. Applied microbiology and biotechnology. 2007 Dec; 77(3):625-35. doi: 10.1007/s00253-007-1184-5. [PMID: 17899070]
  • Ikuro Abe, Yoriko Utsumi, Satoshi Oguro, Hiroyuki Morita, Yukie Sano, Hiroshi Noguchi. A plant type III polyketide synthase that produces pentaketide chromone. Journal of the American Chemical Society. 2005 Feb; 127(5):1362-3. doi: 10.1021/ja0431206. [PMID: 15686354]
  • Haifeng Hu, Qin Zhang, Kozo Ochi. Activation of antibiotic biosynthesis by specified mutations in the rpoB gene (encoding the RNA polymerase beta subunit) of Streptomyces lividans. Journal of bacteriology. 2002 Jul; 184(14):3984-91. doi: 10.1128/jb.184.14.3984-3991.2002. [PMID: 12081971]
  • C J Bruton, E P Guthrie, K F Chater. Phage vectors that allow monitoring of transcription of secondary metabolism genes in Streptomyces. Bio/technology (Nature Publishing Company). 1991 Jul; 9(7):652-6. doi: 10.1038/nbt0791-652. [PMID: 1367661]
  • E Strauch, E Takano, H A Baylis, M J Bibb. The stringent response in Streptomyces coelicolor A3(2). Molecular microbiology. 1991 Feb; 5(2):289-98. doi: 10.1111/j.1365-2958.1991.tb02109.x. [PMID: 1710311]