allysine (BioDeep_00000604946)
Main id: BioDeep_00000004077
代谢物信息卡片
allysine
化学式: C6H11NO3 (145.0739)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC=O)CC(C(=O)O)N
InChI: InChI=1S/C6H11NO3/c7-5(6(9)10)3-1-2-4-8/h4-5H,1-3,7H2,(H,9,10)
描述信息
An alpha-amino acid consisting of lysine having an oxo group in place of the side-chain amino group.
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:17027
- ChEBI: CHEBI:17917
- KEGG: C04076
- PubChem: 160603
- Metlin: METLIN6118
- DrugBank: DB02571
- CAS: 6665-12-9
- MetaboLights: MTBLC17027
- PubChem: 6771
- 3DMET: B00675
- NIKKAJI: J1.136.598A
- RefMet: Allysine
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dietmar Funck, Malte Sinn, Giuseppe Forlani, Jörg S Hartig. Guanidine production by plant homoarginine-6-hydroxylases.
eLife.
2024 Apr; 12(?):. doi:
10.7554/elife.91458. [PMID: 38619227] - João Leandro, Tetyana Dodatko, Robert J DeVita, Hongjie Chen, Brandon Stauffer, Chunli Yu, Sander M Houten. Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.
Journal of inherited metabolic disease.
2020 11; 43(6):1154-1164. doi:
10.1002/jimd.12276. [PMID: 32567100] - Juliette Bouchereau, Manuel Schiff. Inherited Disorders of Lysine Metabolism: A Review.
The Journal of nutrition.
2020 10; 150(Suppl 1):2556S-2560S. doi:
10.1093/jn/nxaa112. [PMID: 33000154] - Mario Estévez, Patricia Padilla, Leila Carvalho, Lourdes Martín, Ana Carrapiso, Josué Delgado. Malondialdehyde interferes with the formation and detection of primary carbonyls in oxidized proteins.
Redox biology.
2019 09; 26(?):101277. doi:
10.1016/j.redox.2019.101277. [PMID: 31352127] - Jiao Xue, Junjuan Wang, Pan Gong, Minhang Wu, Wenshuang Yang, Shiju Jiang, Ye Wu, Yuwu Jiang, Yuehua Zhang, Tatiana Yuzyuk, Hong Li, Zhixian Yang. Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy.
Scientific reports.
2019 08; 9(1):11371. doi:
10.1038/s41598-019-47882-2. [PMID: 31388081] - Charles R Evans, Alla Karnovsky, Michael A Puskarich, George Michailidis, Alan E Jones, Kathleen A Stringer. Untargeted Metabolomics Differentiates l-Carnitine Treated Septic Shock 1-Year Survivors and Nonsurvivors.
Journal of proteome research.
2019 05; 18(5):2004-2011. doi:
10.1021/acs.jproteome.8b00774. [PMID: 30895797] - Amal Al Teneiji, Theodora U J Bruun, Dawn Cordeiro, Jaina Patel, Michal Inbar-Feigenberg, Shelly Weiss, Eduard Struys, Saadet Mercimek-Mahmutoglu. Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy.
Metabolic brain disease.
2017 04; 32(2):443-451. doi:
10.1007/s11011-016-9933-8. [PMID: 27882480] - Zhipeng A Wang, Yu Zeng, Yadagiri Kurra, Xin Wang, Jeffery M Tharp, Erol C Vatansever, Willie W Hsu, Susie Dai, Xinqiang Fang, Wenshe R Liu. A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation.
Angewandte Chemie (International ed. in English).
2017 01; 56(1):212-216. doi:
10.1002/anie.201609452. [PMID: 27910233] - Izabella Agostinho Pena, Lygia Azevedo Marques, Ângelo B A Laranjeira, José A Yunes, Marcos N Eberlin, Alex MacKenzie, Paulo Arruda. Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE).
Biochimica et biophysica acta. Molecular basis of disease.
2017 01; 1863(1):121-128. doi:
10.1016/j.bbadis.2016.09.006. [PMID: 27615426] - Mariana Utrera, David Morcuende, Mario Estévez. Temperature of frozen storage affects the nature and consequences of protein oxidation in beef patties.
Meat science.
2014 Mar; 96(3):1250-7. doi:
10.1016/j.meatsci.2013.10.032. [PMID: 24334047] - Isaac Ferrer-López, Pedro Ruiz-Sala, Begoña Merinero, Celia Pérez-Cerdá, Magdalena Ugarte. Determination of urinary alpha-aminoadipic semialdehyde by LC-MS/MS in patients with congenital metabolic diseases.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 944(?):141-3. doi:
10.1016/j.jchromb.2013.10.032. [PMID: 24316525] - Eduard Alexander Struys, Benjamin Nota, Abdellatif Bakkali, Saad Al Shahwan, Gajja Sophi Salomons, Brahim Tabarki. Pyridoxine-dependent epilepsy with elevated urinary α-amino adipic semialdehyde in molybdenum cofactor deficiency.
Pediatrics.
2012 Dec; 130(6):e1716-9. doi:
10.1542/peds.2012-1094. [PMID: 23147983] - M Utrera, M Armenteros, S Ventanas, F Solano, M Estévez. Pre-freezing raw hams affects quality traits in cooked hams: potential influence of protein oxidation.
Meat science.
2012 Dec; 92(4):596-603. doi:
10.1016/j.meatsci.2012.06.005. [PMID: 22748310] - Els Vossen, Mariana Utrera, Stefaan De Smet, David Morcuende, Mario Estévez. Dog rose (Rosa canina L.) as a functional ingredient in porcine frankfurters without added sodium ascorbate and sodium nitrite.
Meat science.
2012 Dec; 92(4):451-7. doi:
10.1016/j.meatsci.2012.05.010. [PMID: 22698996] - Clara D M van Karnebeek, Hans Hartmann, Sravan Jaggumantri, Levinus A Bok, Barb Cheng, Mary Connolly, Curtis R Coughlin, Anibh M Das, Sidney M Gospe, Cornelis Jakobs, Johanna H van der Lee, Saadet Mercimek-Mahmutoglu, Uta Meyer, Eduard Struys, Graham Sinclair, Johan Van Hove, Jean-Paul Collet, Barbara R Plecko, Sylvia Stockler. Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Molecular genetics and metabolism.
2012 Nov; 107(3):335-44. doi:
10.1016/j.ymgme.2012.09.006. [PMID: 23022070] - Philippa B Mills, Emma J Footitt, Serkan Ceyhan, Paula J Waters, Cornelis Jakobs, Peter T Clayton, Eduard A Struys. Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.
Journal of inherited metabolic disease.
2012 Nov; 35(6):1031-6. doi:
10.1007/s10545-012-9466-1. [PMID: 22403017] - Abdulaziz S Al-Saman, Tamer M Rizk. A case of extreme prematurity and delayed diagnosis of pyridoxine-dependent epilepsy.
Neurosciences (Riyadh, Saudi Arabia).
2012 Oct; 17(4):371-3. doi:
NULL. [PMID: 23022904] - Eduard A Struys, Levinus A Bok, Dina Emal, Saskia Houterman, Michel A Willemsen, Cornelis Jakobs. The measurement of urinary Δ¹-piperideine-6-carboxylate, the alter ego of α-aminoadipic semialdehyde, in Antiquitin deficiency.
Journal of inherited metabolic disease.
2012 Sep; 35(5):909-16. doi:
10.1007/s10545-011-9443-0. [PMID: 22249334] - Majid Alfadhel, Sandra Sirrs, Paula J Waters, András Szeitz, Eduard Struys, Marion Coulter-Mackie, Sylvia Stockler-Ipsiroglu. Variability of phenotype in two sisters with pyridoxine dependent epilepsy.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
2012 Jul; 39(4):516-9. doi:
10.1017/s0317167100014050. [PMID: 22728861] - Chad Brocker, Miriam Cantore, Paola Failli, Vasilis Vasiliou. Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity.
Chemico-biological interactions.
2011 May; 191(1-3):269-77. doi:
10.1016/j.cbi.2011.02.016. [PMID: 21338592] - Sven W Sauer, Silvana Opp, Georg F Hoffmann, David M Koeller, Jürgen G Okun, Stefan Kölker. Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I.
Brain : a journal of neurology.
2011 Jan; 134(Pt 1):157-70. doi:
10.1093/brain/awq269. [PMID: 20923787] - Abdul Jaleel, Gregory C Henderson, Benjamin J Madden, Katherine A Klaus, Dawn M Morse, Srinivas Gopala, K Sreekumaran Nair. Identification of de novo synthesized and relatively older proteins: accelerated oxidative damage to de novo synthesized apolipoprotein A-1 in type 1 diabetes.
Diabetes.
2010 Oct; 59(10):2366-74. doi:
10.2337/db10-0371. [PMID: 20622162] - Philippa B Mills, Emma J Footitt, Kevin A Mills, Karin Tuschl, Sarah Aylett, Sophia Varadkar, Cheryl Hemingway, Neil Marlow, Janet Rennie, Peter Baxter, Olivier Dulac, Rima Nabbout, William J Craigen, Bernhard Schmitt, François Feillet, Ernst Christensen, Pascale De Lonlay, Mike G Pike, M Imelda Hughes, Eduard A Struys, Cornelis Jakobs, Sameer M Zuberi, Peter T Clayton. Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency).
Brain : a journal of neurology.
2010 Jul; 133(Pt 7):2148-59. doi:
10.1093/brain/awq143. [PMID: 20554659] - Xingjun Fan, Jianye Zhang, Mathilde Theves, Christopher Strauch, Ina Nemet, Xiaoqin Liu, Juan Qian, Frank J Giblin, Vincent M Monnier. Mechanism of lysine oxidation in human lens crystallins during aging and in diabetes.
The Journal of biological chemistry.
2009 Dec; 284(50):34618-27. doi:
10.1074/jbc.m109.032094. [PMID: 19854833] - Katerina Sadilkova, Sidney M Gospe, Si Houn Hahn. Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
Journal of neuroscience methods.
2009 Oct; 184(1):136-41. doi:
10.1016/j.jneumeth.2009.07.019. [PMID: 19631689] - Mario Estévez, Velimatti Ollilainen, Marina Heinonen. Analysis of protein oxidation markers alpha-aminoadipic and gamma-glutamic semialdehydes in food proteins using liquid chromatography (LC)-electrospray ionization (ESI)-multistage tandem mass spectrometry (MS).
Journal of agricultural and food chemistry.
2009 May; 57(9):3901-10. doi:
10.1021/jf804017p. [PMID: 19326863] - David R Sell, Christopher M Strauch, Wei Shen, Vincent M Monnier. Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.
Annals of the New York Academy of Sciences.
2008 Apr; 1126(?):205-9. doi:
10.1196/annals.1433.065. [PMID: 18448817] - Mitsugu Akagawa, Daisuke Sasaki, Yoshihisa Ishii, Yayoi Kurota, Mari Yotsu-Yamashita, Koji Uchida, Kyozo Suyama. New method for the quantitative determination of major protein carbonyls, alpha-aminoadipic and gamma-glutamic semialdehydes: investigation of the formation mechanism and chemical nature in vitro and in vivo.
Chemical research in toxicology.
2006 Aug; 19(8):1059-65. doi:
10.1021/tx060026p. [PMID: 16918245] - R Pulido, A Jiménez-Escrig, L Orensanz, F Saura-Calixto, A Jiménez-Escrig. Study of plasma antioxidant status in Alzheimer's disease.
European journal of neurology.
2005 Jul; 12(7):531-5. doi:
10.1111/j.1468-1331.2005.01000.x. [PMID: 15958093] - Mitsugu Akagawa, Daisuke Sasaki, Yayoi Kurota, Kyozo Suyama. Formation of alpha-aminoadipic and gamma-glutamic semialdehydes in proteins by the maillard reaction.
Annals of the New York Academy of Sciences.
2005 Jun; 1043(?):129-34. doi:
10.1196/annals.1333.016. [PMID: 16037231] - J F Young, L O Dragsted, B Daneshvar, S T Lauridsen, M Hansen, B Sandström. The effect of grape-skin extract on oxidative status.
The British journal of nutrition.
2000 Oct; 84(4):505-13. doi:
10.1017/s0007114500001811. [PMID: 11103221]
