Prostaglandin A2 (BioDeep_00000006014)

 

Secondary id: BioDeep_00000171539, BioDeep_00000227111, BioDeep_00000629503

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(5Z)-7-[(1R,2S)-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid

化学式: C20H30O4 (334.2144)
中文名称: 前列腺素 A2
谱图信息: 最多检出来源 Homo sapiens(plant) 27.27%

分子结构信息

SMILES: CCCCCC(C=CC1C=CC(=O)C1CC=CCCCC(=O)O)O
InChI: InChI=1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)/b7-4-,14-12+/t16-,17-,18+/m0/s1

描述信息

Produced by the seminal vesicles, prostaglandins are a group of lipid compounds that are derived enzymatically from fatty acids. Technically hormones, the prostanoid class of fatty acid derivatives is a subclass of eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent, able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signaling pathways. Prostaglandin A is a cyclopentenone and is an endogenous metabolite derived from arachidonic acid. It exhibits potent cellular anti-proliferative activity in vivo and in vitro. Excess PGA2 causes an accumulation in both S and G2/M, and a marked decrease in G1. There is also an increase in DNA content preceeding the G0/G1 peak (indicative of apoptotic body formation) mediated by changes in expression levels of Bax and Bcl-2.
Produced by the seminal vessicals: Prostaglandins are a group of lipid compounds that are derived enzymatically from fattyacids. Technically a hormone, the prostanoid class of fatty acid derivatives is a subclass of eicosanoids. Prostaglandin A is cyclopentenone and endogenous metabolite derived from arachidonic acid. Exhibits potent cellular anti-proliferative activity in vivo and in vitro. Excess PGA2 causes an accumulation in both S and G2/M, and a marked decrease in G1. As well there is an increase in DNA content preceeding the G0/G1 peak (indicative of apoptic body formation) mediated by changes in expression levels of Bax and Bcl-2.

同义名列表

24 个代谢物同义名

(5Z)-7-[(1R,2S)-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid; (Z)-7-((1R,2S)-2-((e)-(3S)-3-Hydroxyoct-1-enyl)-5-oxocyclopent-3-enyl)hept-5-enoic acid; 7-[2-(3-hydroxyoct-1-enyl)-5-oxocyclopent-3-en-1-yl]hept-5-enoic acid; 7-[2-(3-Hydroxy-1-octenyl)-5-oxo-3-cyclopenten-1-yl]-5-heptenoic acid; 15Α-hydroxy-9-oxo-cis-5,10,trans-13-prostatrienecarboxylic acid; (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5, 10,13-triene-1-Oic acid; (5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,10,13-trien-1-Oic acid; 15Α-hydroxy-9-oxo-cis-5,10,trans-13-prostatrienecarboxylate; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostatrienoic acid; 15Α-hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoic acid; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoic acid; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostatrienoate; 9-oxo-15S-hydroxy-prosta-5Z,10,13E-trien-1-oic acid; 15Α-hydroxy-9-oxo-cis-5,10,trans-13-prostatrienoate; 15(S)-Hydroxy-9-oxo-5-cis-10,13-trans-prostenoate; 15(S)-Prostaglandin a2; (15S)-Prostaglandin a2; (+)-Prostaglandin a2; PROSTAGLANDIN A2; 5,6-cis-PGA2; NSC 165561; (15S)-PGA2; Medullin; PGA2



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

52 个相关的代谢反应过程信息。

Reactome(5)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, BCL2, CASP3, CASP9, CCND1, CDK2, CDKN1A, DDIT3, MYC, PPARG, PTGS2
Peripheral membrane protein 2 AP1S2, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 11 ALB, BANP, BCL2, CASP3, CASP9, CCND1, CDK2, CDKN1A, DDIT3, MYC, PPARG
cytosol 12 ALB, AP1S2, AVP, BCL2, CASP3, CASP9, CCND1, CDK2, CDKN1A, DDIT3, GCLM, PPARG
dendrite 1 AVP
nuclear body 2 BANP, CDKN1A
centrosome 3 ALB, CCND1, CDK2
nucleoplasm 7 BANP, CASP3, CCND1, CDK2, CDKN1A, MYC, PPARG
RNA polymerase II transcription regulator complex 2 DDIT3, PPARG
Cell membrane 2 PTGER4, TNF
Cytoplasmic side 1 AP1S2
Multi-pass membrane protein 1 PTGER4
cell surface 2 EPO, TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ALB, AP1S2
Golgi membrane 1 AP1S2
lysosomal membrane 1 AP1S2
neuronal cell body 2 CASP3, TNF
endosome 1 CDK2
plasma membrane 4 KNG1, PTGER4, REN, TNF
Membrane 4 BCL2, MYC, PTGER4, REN
caveola 1 PTGS2
extracellular exosome 3 ALB, EPO, KNG1
endoplasmic reticulum 3 ALB, BCL2, PTGS2
extracellular space 6 ALB, AVP, EPO, KNG1, REN, TNF
perinuclear region of cytoplasm 2 CDKN1A, PPARG
bicellular tight junction 1 CCND1
mitochondrion 2 BCL2, CASP9
protein-containing complex 6 ALB, BCL2, CASP9, CDKN1A, MYC, PTGS2
intracellular membrane-bounded organelle 2 AP1S2, PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 4 ALB, AVP, EPO, REN
extracellular region 6 ALB, AVP, EPO, KNG1, REN, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
anchoring junction 1 ALB
transcription regulator complex 2 CDK2, DDIT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK2
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
nucleolus 2 CDKN1A, MYC
Early endosome 1 AP1S2
Membrane, clathrin-coated pit 1 AP1S2
apical part of cell 1 REN
clathrin-coated pit 1 AP1S2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
pore complex 1 BCL2
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 AVP
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 DDIT3
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 3 DDIT3, MYC, PPARG
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 KNG1
Nucleus, nucleolus 1 MYC
spindle pole 1 ALB
chromosome, telomeric region 1 CDK2
blood microparticle 2 ALB, KNG1
nuclear envelope 2 CDK2, MYC
Endomembrane system 1 AP1S2
Cytoplasmic vesicle membrane 1 AP1S2
Nucleus, nucleoplasm 1 MYC
cell body 1 EPO
myelin sheath 1 BCL2
trans-Golgi network membrane 1 AP1S2
secretory granule lumen 1 EPO
endoplasmic reticulum lumen 3 ALB, KNG1, PTGS2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 CDK2
platelet alpha granule lumen 2 ALB, KNG1
RNA polymerase II transcription repressor complex 1 MYC
neuronal dense core vesicle 1 AVP
apoptosome 1 CASP9
clathrin-coated endocytic vesicle membrane 1 AVP
Cajal body 1 CDK2
protein-DNA complex 1 DDIT3
death-inducing signaling complex 1 CASP3
AP-type membrane coat adaptor complex 1 AP1S2
membrane coat 1 AP1S2
Rough endoplasmic reticulum 1 MYC
AP-1 adaptor complex 1 AP1S2
condensed chromosome 1 CDK2
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK2, CDKN1A
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
Myc-Max complex 1 MYC
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA-p21 complex 1 CDKN1A
CHOP-C/EBP complex 1 DDIT3
CHOP-ATF3 complex 1 DDIT3
CHOP-ATF4 complex 1 DDIT3
cyclin A2-CDK2 complex 1 CDK2
cyclin D1-CDK6 complex 1 CCND1
cyclin A1-CDK2 complex 1 CDK2
glutamate-cysteine ligase complex 1 GCLM
ciliary transition fiber 1 ALB
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
nucleoplasmic reticulum 1 MYC


文献列表

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