Pheophytin a (BioDeep_00000005956)

   

natural product


代谢物信息卡片


3,7,11,15-tetramethylhexadec-2-en-1-yl [3S-[3alpha(2E,7S*,11S*),4beta,21beta]]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionate

化学式: C55H74N4O5 (870.5659)
中文名称: 脱镁叶绿素 A
谱图信息: 最多检出来源 Viridiplantae(plant) 19.28%

分子结构信息

SMILES: C=CC1=C(C)C2=NC1=CC1=NC(=CC3=C(C)C4=C(O)C(C(=O)OC)C(=C5NC(=C2)C(C)C5CCC(=O)OCC=C(C)CCCC(C)CCCC(C)CCCC(C)C)C4=N3)C(CC)=C1C
InChI: InChI=1S/C55H72N4O5/c1-13-39-35(8)42-28-44-37(10)41(24-25-48(60)64-27-26-34(7)23-17-22-33(6)21-16-20-32(5)19-15-18-31(3)4)52(58-44)50-51(55(62)63-12)54(61)49-38(11)45(59-53(49)50)30-47-40(14-2)36(9)43(57-47)29-46(39)56-42/h13,26,28-33,37,41,51H,1,14-25,27H2,2-12H3/b34-26+,42-28-,43-29-,44-28-,45-30-,46-29-,47-30-,52-50-

描述信息

Pheophytin a is practically insoluble (in water) and an extremely strong acidic compound (based on its pKa). Pheophytin a can be found in a number of food items such as tea, wasabi, corn salad, and pigeon pea, which makes pheophytin a a potential biomarker for the consumption of these food products.

同义名列表

2 个代谢物同义名

3,7,11,15-tetramethylhexadec-2-en-1-yl [3S-[3alpha(2E,7S*,11S*),4beta,21beta]]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionate; Pheophytin a



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

127 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(127)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ARHGAP45, BFSP2, CAT, GLUL, HPGDS, PRKX, SPX, TYRP1
Peripheral membrane protein 3 BFSP2, HSD17B6, PLOD2
Endosome membrane 1 TYRP1
Endoplasmic reticulum membrane 2 CYP26A1, PLOD2
Nucleus 3 GLUL, MYB, PRKX
cytosol 7 ARHGAP45, CAT, GLUL, GSR, HPGDS, LIPE, MYB
nucleoplasm 5 ATP2B1, CD2, HPGDS, MYB, PRKX
RNA polymerase II transcription regulator complex 1 MYB
Cell membrane 5 ATP2B1, BFSP2, CD2, GLUL, LIPE
Lipid-anchor 1 GLUL
Cytoplasmic side 1 BFSP2
ruffle membrane 1 ARHGAP45
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 2 ATP2B1, MT-CYB
Synapse 1 ATP2B1
cell cortex 1 BFSP2
cell surface 1 CD2
glutamatergic synapse 1 ATP2B1
Golgi apparatus 2 ATRN, CD2
mitochondrial inner membrane 3 ATP5ME, CYP24A1, MT-CYB
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 GLUL, LIPE
Cytoplasmic vesicle, secretory vesicle 1 SPX
plasma membrane 6 ARHGAP45, ATP2B1, ATRN, BFSP2, CD2, GLUL
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ARHGAP45, ATP2B1, CAT, LIPE, MT-CYB, MYB
basolateral plasma membrane 1 ATP2B1
caveola 1 LIPE
extracellular exosome 6 ATP2B1, ATRN, CAT, GLUL, GSR, PLOD2
Lumenal side 2 HSD17B6, PLOD2
endoplasmic reticulum 3 GLUL, HSD17B6, PLOD2
extracellular space 2 ATRN, SPX
mitochondrion 6 ATP5ME, CAT, CYP24A1, GLUL, GSR, MT-CYB
protein-containing complex 2 CAT, CD2
intracellular membrane-bounded organelle 4 ATP2B1, CAT, HPGDS, HSD17B6
Microsome membrane 2 CYP26A1, HSD17B6
Single-pass type I membrane protein 3 ATRN, CD2, TYRP1
extracellular region 4 ARHGAP45, CAT, CD2, SPX
cytoplasmic side of plasma membrane 1 CD2
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 2 CAT, GSR
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 CD2, GSR
Melanosome membrane 1 TYRP1
cell-cell junction 1 CD2
Cell projection, ruffle membrane 1 ARHGAP45
Mitochondrion inner membrane 1 MT-CYB
Cytoplasm, cytoskeleton 1 BFSP2
focal adhesion 1 CAT
Peroxisome 1 CAT
intracellular vesicle 1 TYRP1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
intermediate filament 1 BFSP2
lateral plasma membrane 1 ATP2B1
cell projection 1 ATP2B1
cytoskeleton 1 BFSP2
Secreted, extracellular space 1 SPX
Cytoplasm, cell cortex 1 BFSP2
Basolateral cell membrane 1 ATP2B1
[Isoform 3]: Secreted 1 ATRN
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Melanosome 1 TYRP1
Presynaptic cell membrane 1 ATP2B1
cell body 1 GLUL
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
nuclear matrix 1 MYB
dense core granule 1 SPX
transport vesicle 1 SPX
rough endoplasmic reticulum membrane 1 PLOD2
azurophil granule lumen 1 ARHGAP45
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 TYRP1
respiratory chain complex III 1 MT-CYB
[Isoform 1]: Cell membrane 1 ATRN
Rough endoplasmic reticulum 1 PLOD2
proton-transporting ATP synthase complex 1 ATP5ME
glial cell projection 1 GLUL
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
catalase complex 1 CAT
photoreceptor ribbon synapse 1 ATP2B1


文献列表

  • Alexey A Zabelin, Anton M Khristin, Vyacheslav B Kovalev, Ravil A Khatypov, Anatoly Ya Shkuropatov. Primary charge separation in native and plant pheophytin a-modified reaction centers of Chloroflexus aurantiacus: Ultrafast transient absorption measurements at low temperature. Biochimica et biophysica acta. Bioenergetics. 2023 Apr; 1864(3):148976. doi: 10.1016/j.bbabio.2023.148976. [PMID: 37061174]
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  • Hamdoon A Mohammed, Mohsen S Al-Omar, Mahmoud Zaki El-Readi, Ahmad H Alhowail, Maha A Aldubayan, Ahmed A H Abdellatif. Formulation of Ethyl Cellulose Microparticles Incorporated Pheophytin A Isolated from Suaeda vermiculata for Antioxidant and Cytotoxic Activities. Molecules (Basel, Switzerland). 2019 Apr; 24(8):. doi: 10.3390/molecules24081501. [PMID: 30999569]
  • Ying Chen, Yousuke Shimoda, Makio Yokono, Hisashi Ito, Ayumi Tanaka. Mg-dechelatase is involved in the formation of photosystem II but not in chlorophyll degradation in Chlamydomonas reinhardtii. The Plant journal : for cell and molecular biology. 2019 03; 97(6):1022-1031. doi: 10.1111/tpj.14174. [PMID: 30471153]
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  • Petrina Kapewangolo, Martha Kandawa-Schulz, Debra Meyer. Anti-HIV Activity of Ocimum labiatum Extract and Isolated Pheophytin-a. Molecules (Basel, Switzerland). 2017 Nov; 22(11):. doi: 10.3390/molecules22111763. [PMID: 29113139]
  • Myoung-Yun Pyo, Bo-kyung Park, Jeong June Choi, Mihi Yang, Hyun Ok Yang, Jin Wook Cha, Jin-Cheol Kim, In Seon Kim, Hyang Burm Lee, Mirim Jin. Pheophytin a and chlorophyll a identified from environmentally friendly cultivation of green pepper enhance interleukin-2 and interferon-γ in Peyer's patches ex vivo. Biological & pharmaceutical bulletin. 2013; 36(11):1747-53. doi: 10.1248/bpb.b13-00302. [PMID: 24189419]
  • Ramón Aparicio-Ruiz, María Roca, Beatriz Gandul-Rojas. Mathematical model to predict the formation of pyropheophytin a in virgin olive oil during storage. Journal of agricultural and food chemistry. 2012 Jul; 60(28):7040-9. doi: 10.1021/jf3010965. [PMID: 22708655]
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  • Silvia Schelbert, Sylvain Aubry, Bo Burla, Birgit Agne, Felix Kessler, Karin Krupinska, Stefan Hörtensteiner. Pheophytin pheophorbide hydrolase (pheophytinase) is involved in chlorophyll breakdown during leaf senescence in Arabidopsis. The Plant cell. 2009 Mar; 21(3):767-85. doi: 10.1105/tpc.108.064089. [PMID: 19304936]
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