Leucomethylene blue (BioDeep_00000005937)
Secondary id: BioDeep_00001869846
human metabolite blood metabolite natural product
代谢物信息卡片
化学式: C16H19N3S (285.13)
中文名称: 還原亞甲藍
谱图信息:
最多检出来源 Viridiplantae(plant) 63.64%
分子结构信息
SMILES: CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C
InChI: InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3
描述信息
C26170 - Protective Agent > C1509 - Neuroprotective Agent
同义名列表
12 个代谢物同义名
N3,N3,N7,N7-tetramethyl-10H-phenothiazine-3,7-diamine; Leucomethylene blue (Reduced Methylene Blue); Hydromethylthionine mesylate; Reduced methylene blue; Leuco-methylthioninium; Hydromethylthionine; Leucomethylene blue; Leukomethylene blue; LMTX Compound; Panatone; TRX-0237; Leucomethylene blue
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:134180
- KEGG: C05721
- PubChem: 164695
- HMDB: HMDB0254034
- Metlin: METLIN1223
- ChEMBL: CHEMBL549963
- chemspider: 144378
- CAS: 613-11-6
- PMhub: MS000018850
- PubChem: 8026
- KNApSAcK: 134180
- LOTUS: LTS0018247
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 7458 - Apidae: LTS0018247
- 7459 - Apis: LTS0018247
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 7461 - Apis cerana: LTS0018247
- 6656 - Arthropoda: LTS0018247
- 2759 - Eukaryota: LTS0018247
- 9606 - Homo sapiens: -
- 50557 - Insecta: LTS0018247
- 33208 - Metazoa: LTS0018247
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Helen Shiells, Bjoern O Schelter, Peter Bentham, Thomas C Baddeley, Christopher M Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic, Roger T Staff, Alison D Murray, Luc Bracoud, Damon J Wischik, Gernot Riedel, Serge Gauthier, Jianping Jia, Hans J Moebius, Jiri Hardlund, Christopher M Kipps, Karin Kook, John M D Storey, Charles R Harrington, Claude M Wischik. Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia.
Journal of Alzheimer's disease : JAD.
2020; 75(2):501-519. doi:
10.3233/jad-191173. [PMID: 32280089] - Naser Sabaghnia, Mohsen Janmohammadi, Maryam Dalili, Ziba Karimi, Sadegh Rostamnia. Euphorbia leaf extract-assisted sustainable synthesis of Au NPs supported on exfoliated GO for superior activity on water purification: reduction of 4-NP and MB.
Environmental science and pollution research international.
2019 Apr; 26(12):11719-11729. doi:
10.1007/s11356-019-04437-2. [PMID: 30806928] - Wei-Feng Gui, Shuo Xu, Zhi-Sheng Dang, Yu-Min Zhao. In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis.
The Journal of parasitology.
2019 02; 105(1):146-154. doi:
10.1645/18-121. [PMID: 30807708] - Bjoern O Schelter, Helen Shiells, Thomas C Baddeley, Christopher M Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic, Roger T Staff, Alison D Murray, Luc Bracoud, Gernot Riedel, Serge Gauthier, Jianping Jia, Peter Bentham, Karin Kook, John M D Storey, Charles R Harrington, Claude M Wischik. Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease.
Journal of Alzheimer's disease : JAD.
2019; 72(3):931-946. doi:
10.3233/jad-190772. [PMID: 31658058] - Xuyin Zhang, Luoqi Jia, Xiang Tao, Jingxin Ding, Keqin Hua. Intraoperative nerve staining in nerve-sparing radical hysterectomy: a pilot study.
Archives of gynecology and obstetrics.
2017 Mar; 295(3):737-741. doi:
10.1007/s00404-016-4284-6. [PMID: 28084524] - Khan Behlol Ayaz Ahmed, Swetha Subramanian, Aravind Sivasubramanian, Ganapathy Veerappan, Anbazhagan Veerappan. Preparation of gold nanoparticles using Salicornia brachiata plant extract and evaluation of catalytic and antibacterial activity.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Sep; 130(?):54-8. doi:
10.1016/j.saa.2014.03.070. [PMID: 24762573] - Hiromi Sakai, Bing Li, Wei Lee Lim, Yumika Iga. Red blood cells donate electrons to methylene blue mediated chemical reduction of methemoglobin compartmentalized in liposomes in blood.
Bioconjugate chemistry.
2014 Jul; 25(7):1301-10. doi:
10.1021/bc500153x. [PMID: 24877769] - Holger Borwitzky, Walter E Haefeli, Jürgen Burhenne. Analysis of methylene blue in human urine by capillary electrophoresis.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Nov; 826(1-2):244-51. doi:
10.1016/j.jchromb.2005.09.013. [PMID: 16182616] - Norman F Gaudette, Jon W Lodge. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and B6C3F1 mouse urine.
Journal of analytical toxicology.
2005 Jan; 29(1):28-33. doi:
10.1093/jat/29.1.28. [PMID: 15808010] - S C Salaris, C F Babbs, W D Voorhees. Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury.
Biochemical pharmacology.
1991 Jul; 42(3):499-506. doi:
10.1016/0006-2952(91)90311-r. [PMID: 1650213] - N Ohishi, H Ohkawa, A Miike, T Tatano, K Yagi. A new assay method for lipid peroxides using a methylene blue derivative.
Biochemistry international.
1985 Feb; 10(2):205-11. doi:
". [PMID: 3994732] - A S Deshmukh, N K Bansal, K A Kropp. Use of methylene blue in suspected colovesical fistula.
The Journal of urology.
1977 Nov; 118(5):819-20. doi:
10.1016/s0022-5347(17)58206-3. [PMID: 72169]
