TRX-0237 (BioDeep_00001869846)

Main id: BioDeep_00000005937

 


代谢物信息卡片


Leucomethylene blue

化学式: C16H19N3S (285.13)
中文名称: 還原亞甲藍
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)C1=CC2=C(C=C1)NC3=C(S2)C=C(C=C3)N(C)C
InChI: InChI=1S/C16H19N3S/c1-18(2)11-5-7-13-15(9-11)20-16-10-12(19(3)4)6-8-14(16)17-13/h5-10,17H,1-4H3

描述信息

A member of the class of phenothiazines that is 10H-phenothiazine in which the ring hydrogens at positions 3 and 7 have been replaced by dimethylamino groups.
C26170 - Protective Agent > C1509 - Neuroprotective Agent

同义名列表

3 个代谢物同义名

Leucomethylene blue; TRX-0237; Leucomethylene blue



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ALB, BLVRB, CHAT, GRIN1, MAPT, SNCA, TARDBP, XDH
Peripheral membrane protein 1 MAPT
Endoplasmic reticulum membrane 2 GRIN1, GRIN2A
Nucleus 6 ALB, CHAT, GABPA, MAPT, SNCA, TARDBP
cytosol 8 ALB, BLVRB, CHAT, GSR, MAPT, MB, SNCA, XDH
dendrite 2 GRIN1, MAPT
centrosome 1 ALB
nucleoplasm 4 BLVRB, FAM20C, GABPA, TARDBP
Cell membrane 4 GRIN1, GRIN2A, LSR, MAPT
Cytoplasmic side 1 MAPT
Cell projection, axon 2 MAPT, SNCA
Multi-pass membrane protein 2 GRIN1, GRIN2A
Golgi apparatus membrane 1 FAM20C
Synapse 4 CHAT, GRIN1, GRIN2A, SNCA
cell cortex 1 SNCA
cell junction 1 LSR
cell surface 2 GRIN1, GRIN2A
glutamatergic synapse 1 GRIN2A
Golgi apparatus 2 ALB, FAM20C
Golgi membrane 2 FAM20C, INS
growth cone 2 MAPT, SNCA
neuronal cell body 2 MAPT, SNCA
postsynapse 1 SNCA
presynaptic membrane 1 GRIN2A
synaptic vesicle 2 GRIN1, GRIN2A
Cytoplasm, cytosol 1 MAPT
Lysosome 1 SNCA
plasma membrane 6 BLVRB, GRIN1, GRIN2A, LSR, MAPT, SNCA
synaptic vesicle membrane 1 SNCA
terminal bouton 1 GRIN1
Membrane 4 GRIN1, GRIN2A, LSR, SNCA
axon 2 MAPT, SNCA
extracellular exosome 6 ALB, BLVRB, FAM20C, GSR, LSR, MB
endoplasmic reticulum 3 ALB, FAM20C, GRIN2A
extracellular space 5 ALB, FAM20C, INS, SNCA, XDH
perinuclear region of cytoplasm 1 SNCA
Cell junction, tight junction 1 LSR
bicellular tight junction 1 LSR
mitochondrion 4 GSR, MAPT, SNCA, TARDBP
protein-containing complex 2 ALB, SNCA
intracellular membrane-bounded organelle 1 BLVRB
postsynaptic density 2 GRIN1, GRIN2A
Single-pass type I membrane protein 1 LSR
Secreted 5 ALB, FAM20C, INS, MAPT, SNCA
extracellular region 4 ALB, INS, MAPT, SNCA
excitatory synapse 1 GRIN1
mitochondrial matrix 1 GSR
anchoring junction 1 ALB
external side of plasma membrane 1 GSR
chylomicron 1 LSR
low-density lipoprotein particle 1 LSR
very-low-density lipoprotein particle 1 LSR
actin cytoskeleton 1 SNCA
dendritic spine 3 GRIN1, GRIN2A, MAPT
microtubule cytoskeleton 1 MAPT
axon cytoplasm 1 MAPT
sarcoplasm 1 MB
Single-pass type II membrane protein 1 FAM20C
postsynaptic membrane 2 GRIN1, GRIN2A
Membrane raft 1 MAPT
Cytoplasm, cytoskeleton 1 MAPT
microtubule 1 MAPT
axolemma 1 MAPT
Peroxisome 1 XDH
sarcoplasmic reticulum 1 XDH
Cell projection, dendritic spine 1 GRIN2A
nuclear speck 2 MAPT, TARDBP
Postsynaptic cell membrane 2 GRIN1, GRIN2A
neuron projection 4 CHAT, GRIN1, GRIN2A, MAPT
ciliary basal body 1 ALB
chromatin 2 GABPA, TARDBP
supramolecular fiber 1 SNCA
centriole 1 ALB
cytoplasmic ribonucleoprotein granule 1 MAPT
spindle pole 1 ALB
blood microparticle 1 ALB
Endomembrane system 1 LSR
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 GRIN2A
Cell projection, dendrite 1 MAPT
Cytoplasm, Stress granule 1 TARDBP
cytoplasmic stress granule 1 TARDBP
cell body 1 MAPT
Synaptic cell membrane 1 GRIN1
synaptic membrane 2 GRIN1, GRIN2A
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, FAM20C, INS
platelet alpha granule lumen 1 ALB
axon terminus 1 SNCA
transport vesicle 1 INS
tight junction 1 LSR
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 2 GRIN1, GRIN2A
perichromatin fibrils 1 TARDBP
synaptic cleft 1 GRIN1
NMDA selective glutamate receptor complex 2 GRIN1, GRIN2A
intracellular non-membrane-bounded organelle 1 TARDBP
tricellular tight junction 1 LSR
somatodendritic compartment 1 MAPT
nuclear periphery 1 MAPT
glial cell projection 1 MAPT
Cytoplasm, sarcoplasm 1 MB
inclusion body 1 SNCA
neurofibrillary tangle 1 MAPT
main axon 1 MAPT
tubulin complex 1 MAPT
ciliary transition fiber 1 ALB
interchromatin granule 1 TARDBP


文献列表

  • Helen Shiells, Bjoern O Schelter, Peter Bentham, Thomas C Baddeley, Christopher M Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic, Roger T Staff, Alison D Murray, Luc Bracoud, Damon J Wischik, Gernot Riedel, Serge Gauthier, Jianping Jia, Hans J Moebius, Jiri Hardlund, Christopher M Kipps, Karin Kook, John M D Storey, Charles R Harrington, Claude M Wischik. Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia. Journal of Alzheimer's disease : JAD. 2020; 75(2):501-519. doi: 10.3233/jad-191173. [PMID: 32280089]
  • Naser Sabaghnia, Mohsen Janmohammadi, Maryam Dalili, Ziba Karimi, Sadegh Rostamnia. Euphorbia leaf extract-assisted sustainable synthesis of Au NPs supported on exfoliated GO for superior activity on water purification: reduction of 4-NP and MB. Environmental science and pollution research international. 2019 Apr; 26(12):11719-11729. doi: 10.1007/s11356-019-04437-2. [PMID: 30806928]
  • Wei-Feng Gui, Shuo Xu, Zhi-Sheng Dang, Yu-Min Zhao. In Vitro and in Vivo Effect of MAPK Signal Transduction Pathway Inhibitors on Echinococcus multilocularis. The Journal of parasitology. 2019 02; 105(1):146-154. doi: 10.1645/18-121. [PMID: 30807708]
  • Bjoern O Schelter, Helen Shiells, Thomas C Baddeley, Christopher M Rubino, Harish Ganesan, Jeffrey Hammel, Vesna Vuksanovic, Roger T Staff, Alison D Murray, Luc Bracoud, Gernot Riedel, Serge Gauthier, Jianping Jia, Peter Bentham, Karin Kook, John M D Storey, Charles R Harrington, Claude M Wischik. Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2019; 72(3):931-946. doi: 10.3233/jad-190772. [PMID: 31658058]
  • Xuyin Zhang, Luoqi Jia, Xiang Tao, Jingxin Ding, Keqin Hua. Intraoperative nerve staining in nerve-sparing radical hysterectomy: a pilot study. Archives of gynecology and obstetrics. 2017 Mar; 295(3):737-741. doi: 10.1007/s00404-016-4284-6. [PMID: 28084524]
  • Khan Behlol Ayaz Ahmed, Swetha Subramanian, Aravind Sivasubramanian, Ganapathy Veerappan, Anbazhagan Veerappan. Preparation of gold nanoparticles using Salicornia brachiata plant extract and evaluation of catalytic and antibacterial activity. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2014 Sep; 130(?):54-8. doi: 10.1016/j.saa.2014.03.070. [PMID: 24762573]
  • Hiromi Sakai, Bing Li, Wei Lee Lim, Yumika Iga. Red blood cells donate electrons to methylene blue mediated chemical reduction of methemoglobin compartmentalized in liposomes in blood. Bioconjugate chemistry. 2014 Jul; 25(7):1301-10. doi: 10.1021/bc500153x. [PMID: 24877769]
  • Holger Borwitzky, Walter E Haefeli, Jürgen Burhenne. Analysis of methylene blue in human urine by capillary electrophoresis. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Nov; 826(1-2):244-51. doi: 10.1016/j.jchromb.2005.09.013. [PMID: 16182616]
  • Norman F Gaudette, Jon W Lodge. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine and B6C3F1 mouse urine. Journal of analytical toxicology. 2005 Jan; 29(1):28-33. doi: 10.1093/jat/29.1.28. [PMID: 15808010]
  • S C Salaris, C F Babbs, W D Voorhees. Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury. Biochemical pharmacology. 1991 Jul; 42(3):499-506. doi: 10.1016/0006-2952(91)90311-r. [PMID: 1650213]
  • N Ohishi, H Ohkawa, A Miike, T Tatano, K Yagi. A new assay method for lipid peroxides using a methylene blue derivative. Biochemistry international. 1985 Feb; 10(2):205-11. doi: ". [PMID: 3994732]
  • A S Deshmukh, N K Bansal, K A Kropp. Use of methylene blue in suspected colovesical fistula. The Journal of urology. 1977 Nov; 118(5):819-20. doi: 10.1016/s0022-5347(17)58206-3. [PMID: 72169]