Neurosporene (BioDeep_00000005818)

 

Secondary id: BioDeep_00000638803

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(6E,8E,10E,12E,14E,16E,18E,20E,22E,26E)-2,6,10,14,19,23,27,31-Octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,26,30-dodecaene

化学式: C40H58 (538.4538)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(plant) 8.69%

分子结构信息

SMILES: CC(=CCCC(=CCCC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC=C(C)CCC=C(C)C)C)C)C)C
InChI: InChI=1S/C40H58/c1-33(2)19-13-23-37(7)27-17-31-39(9)29-15-25-35(5)21-11-12-22-36(6)26-16-30-40(10)32-18-28-38(8)24-14-20-34(3)4/h11-12,15-17,19-22,25-31H,13-14,18,23-24,32H2,1-10H3/b12-11+,25-15+,26-16+,31-17+,35-21+,36-22+,37-27+,38-28+,39-29+,40-30+

描述信息

Neurosporene, also known as all-trans-neurosporene or 7,8-dihydro-ψ,ψ-carotene, is a member of the class of compounds known as carotenes. Carotenes are a type of unsaturated hydrocarbons containing eight consecutive isoprene units. They are characterized by the presence of two end-groups (mostly cyclohexene rings, but also cyclopentene rings or acyclic groups) linked by a long branched alkyl chain. Carotenes belonging form a subgroup of the carotenoids family. Thus, neurosporene is considered to be an isoprenoid lipid molecule. Neurosporene can be found in a number of food items such as chicory, poppy, silver linden, and towel gourd, which makes neurosporene a potential biomarker for the consumption of these food products. Neurosporene can be found primarily in blood and breast milk. Neurosporene is a carotenoid pigment. It is an intermediate in the biosynthesis of lycopene and a variety of bacterial carotenoids .
Neurosporene is a triterpenoid carotenoid identified in human plasma, (PMID: 1416048), serum (PMID: 1416048), milk (PMID: 9164160), and tissues of the human eye (PMID: 11180970).
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids

同义名列表

10 个代谢物同义名

(6E,8E,10E,12E,14E,16E,18E,20E,22E,26E)-2,6,10,14,19,23,27,31-Octamethyldotriaconta-2,6,8,10,12,14,16,18,20,22,26,30-dodecaene; (9Z,7Z,9Z)-7,8-Dihydrolycopene; 7,8-Dihydro-psi,psi-carotene; 7,8-Dihydro-ψ,ψ-carotene; 1,2-Dihydroneurosporene; all-trans neurosporene; all-trans-Neurosporene; Neurosporene; Neurosporin; all-trans-Neurosporene



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(6)

PlantCyc(2)

代谢反应

304 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(13)

WikiPathways(0)

Plant Reactome(228)

INOH(0)

PlantCyc(63)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

110 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 CAT, GGPS1
Peripheral membrane protein 1 PLOD2
Endoplasmic reticulum membrane 2 PLOD1, PLOD2
Mitochondrion membrane 1 TSPO
cytosol 3 CAT, GGPS1, TSPO
mitochondrial membrane 1 TSPO
phagocytic vesicle 1 STX8
trans-Golgi network 1 STX8
nucleoplasm 1 GGPS1
Multi-pass membrane protein 2 MT-CYB, TSPO
mitochondrial inner membrane 1 MT-CYB
endosome 1 STX8
plasma membrane 1 STX8
Membrane 4 CAT, MT-CYB, STX8, TSPO
extracellular exosome 4 CAT, PLOD1, PLOD2, TSPO
Lumenal side 1 PLOD2
endoplasmic reticulum 4 PLOD1, PLOD2, STX8, TSPO
perinuclear region of cytoplasm 2 GGPS1, STX8
mitochondrion 3 CAT, MT-CYB, TSPO
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, TSPO
extracellular region 1 CAT
Single-pass membrane protein 1 STX8
mitochondrial outer membrane 1 TSPO
mitochondrial matrix 1 CAT
Z disc 1 GGPS1
Early endosome 1 STX8
recycling endosome 1 STX8
vesicle 1 STX8
Cytoplasm, perinuclear region 1 GGPS1
Mitochondrion inner membrane 1 MT-CYB
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Late endosome 1 STX8
Endomembrane system 1 STX8
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
SNARE complex 1 STX8
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
rough endoplasmic reticulum membrane 2 PLOD1, PLOD2
Single-pass type IV membrane protein 1 STX8
respiratory chain complex III 1 MT-CYB
Rough endoplasmic reticulum 1 PLOD2
catalase complex 1 CAT
catalytic complex 1 PLOD1


文献列表

  • Jessica L Cooperstone, Robin A Ralston, Ken M Riedl, Thomas C Haufe, Ralf M Schweiggert, Samantha A King, Cynthia D Timmers, David M Francis, Gregory B Lesinski, Steven K Clinton, Steven J Schwartz. Enhanced bioavailability of lycopene when consumed as cis-isomers from tangerine compared to red tomato juice, a randomized, cross-over clinical trial. Molecular nutrition & food research. 2015 Apr; 59(4):658-69. doi: 10.1002/mnfr.201400658. [PMID: 25620547]
  • Elio Fantini, Giulia Falcone, Sarah Frusciante, Leonardo Giliberto, Giovanni Giuliano. Dissection of tomato lycopene biosynthesis through virus-induced gene silencing. Plant physiology. 2013 Oct; 163(2):986-98. doi: 10.1104/pp.113.224733. [PMID: 24014574]
  • P Shalem Raj, E V V Ramaprasad, S Vaseef, Ch Sasikala, Ch V Ramana. Rhodobacter viridis sp. nov., a phototrophic bacterium isolated from mud of a stream. International journal of systematic and evolutionary microbiology. 2013 Jan; 63(Pt 1):181-186. doi: 10.1099/ijs.0.038471-0. [PMID: 22389279]
  • LingLin Wan, Juan Han, Min Sang, AiFen Li, Hong Wu, ShunJi Yin, ChengWu Zhang. De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels. PloS one. 2012; 7(4):e35142. doi: 10.1371/journal.pone.0035142. [PMID: 22536352]
  • Michael Wormit, Philipp H P Harbach, Jan M Mewes, Sergiu Amarie, Josef Wachtveitl, Andreas Dreuw. Excitation energy transfer and carotenoid radical cation formation in light harvesting complexes - a theoretical perspective. Biochimica et biophysica acta. 2009 Jun; 1787(6):738-46. doi: 10.1016/j.bbabio.2009.01.021. [PMID: 19366605]
  • Lee Gyan Kwa, Dominik Wegmann, Britta Brügger, Felix T Wieland, Gerhard Wanner, Paula Braun. Mutation of a single residue, beta-glutamate-20, alters protein-lipid interactions of light harvesting complex II. Molecular microbiology. 2008 Jan; 67(1):63-77. doi: 10.1111/j.1365-2958.2007.06017.x. [PMID: 18034796]
  • Yuan Liu, Yongqiang Wu, Chunhe Xu. Elimination of polarity in the carotenoid terminus promotes the exposure of B850-binding sites (Tyr 44, 45) and ANS-mediated energy transfer in LH2 complexes of Rhodobacter sphaeroides. Biochemical and biophysical research communications. 2004 Dec; 325(2):600-4. doi: 10.1016/j.bbrc.2004.10.067. [PMID: 15530435]
  • L Tao, S Picataggio, P E Rouvière, Q Cheng. Asymmetrically acting lycopene beta-cyclases (CrtLm) from non-photosynthetic bacteria. Molecular genetics and genomics : MGG. 2004 Mar; 271(2):180-8. doi: 10.1007/s00438-003-0969-1. [PMID: 14740205]
  • Liu Yuan, Zhang Wei, Wu Yongqiang, Xu Chunhe. Acquirement and characterization of a carotenoid mutant (GM309) of Rhodobacter sphaeroides 601. Science in China. Series C, Life sciences. 2004 Feb; 47(1):52-8. doi: 10.1360/02yc0254. [PMID: 15382676]
  • Frederick Khachik, Lorena Carvalho, Paul S Bernstein, Garth J Muir, Da-You Zhao, Nikita B Katz. Chemistry, distribution, and metabolism of tomato carotenoids and their impact on human health. Experimental biology and medicine (Maywood, N.J.). 2002 Nov; 227(10):845-51. doi: 10.1177/153537020222701002. [PMID: 12424324]
  • Nancy A Eckardt. Tangerine dreams: cloning of carotenoid isomerase from Arabidopsis and tomato. The Plant cell. 2002 Feb; 14(2):289-92. doi: 10.1105/tpc.140210. [PMID: 11884674]
  • J Harada, K V Nagashima, S Takaichi, N Misawa, K Matsuura, K Shimada. Phytoene desaturase, CrtI, of the purple photosynthetic bacterium, Rubrivivax gelatinosus, produces both neurosporene and lycopene. Plant & cell physiology. 2001 Oct; 42(10):1112-8. doi: 10.1093/pcp/pce140. [PMID: 11673627]
  • S Takaichi, G Sandmann, G Schnurr, Y Satomi, A Suzuki, N Misawa. The carotenoid 7,8-dihydro-psi end group can be cyclized by the lycopene cyclases from the bacterium Erwinia uredovora and the higher plant Capsicum annuum. European journal of biochemistry. 1996 Oct; 241(1):291-6. doi: 10.1111/j.1432-1033.1996.0291t.x. [PMID: 8898919]
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