Allosamidin (BioDeep_00000005796)

   

Volatile Flavor Compounds


代谢物信息卡片


Allosamidine

化学式: C25H42N4O14 (622.2697392)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1OC2C(OC(C(C2O)NC(=O)C)OC3C(C4C(C3O)N=C(O4)N(C)C)CO)CO)CO)O)O
InChI: InChI=1S/C25H42N4O14/c1-8(33)26-14-17(36)16(35)11(6-31)39-23(14)42-22-12(7-32)40-24(15(19(22)38)27-9(2)34)41-21-10(5-30)20-13(18(21)37)28-25(43-20)29(3)4/h10-24,30-32,35-38H,5-7H2,1-4H3,(H,26,33)(H,27,34)/t10-,11+,12+,13+,14+,15+,16+,17-,18+,19-,20-,21+,22+,23-,24-/m0/s1

描述信息

D010575 - Pesticides > D007306 - Insecticides
D004791 - Enzyme Inhibitors
D016573 - Agrochemicals

同义名列表

4 个代谢物同义名

Allosamidine; CHEMBL318258; Allosamidin; Allosamidine



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Naoyuki Umemoto, Yuka Kanda, Takayuki Ohnuma, Takuo Osawa, Tomoyuki Numata, Shohei Sakuda, Toki Taira, Tamo Fukamizo. Crystal structures and inhibitor binding properties of plant class V chitinases: the cycad enzyme exhibits unique structural and functional features. The Plant journal : for cell and molecular biology. 2015 Apr; 82(1):54-66. doi: 10.1111/tpj.12785. [PMID: 25652217]
  • Shiro Kitamoto, Kensuke Egashira, Toshihiro Ichiki, Xinbing Han, Sara McCurdy, Shohei Sakuda, Kenji Sunagawa, William A Boisvert. Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice. The American journal of pathology. 2013 Jul; 183(1):313-25. doi: 10.1016/j.ajpath.2013.04.003. [PMID: 23685110]
  • Rumdeep K Grewal, Sumanti Gupta, Sampa Das. Xanthomonas oryzae pv oryzae triggers immediate transcriptomic modulations in rice. BMC genomics. 2012 Jan; 13(?):49. doi: 10.1186/1471-2164-13-49. [PMID: 22289642]
  • Jianling Liu, Mengmeng Liu, Yao Yao, Jinan Wang, Yan Li, Guohui Li, Yonghua Wang. Identification of novel potential β-N-acetyl-D-hexosaminidase inhibitors by virtual screening, molecular dynamics simulation and MM-PBSA calculations. International journal of molecular sciences. 2012; 13(4):4545-4563. doi: 10.3390/ijms13044545. [PMID: 22605995]
  • Erico A R Vasconcelos, Celso G Santana, Claudia V Godoy, Claudine D S Seixas, Marilia S Silva, Leonora R S Moreira, Osmundo B Oliveira-Neto, Daniel Price, Elaine Fitches, Edivaldo X F Filho, Angela Mehta, John A Gatehouse, Maria F Grossi-De-Sa. A new chitinase-like xylanase inhibitor protein (XIP) from coffee (Coffea arabica) affects Soybean Asian rust (Phakopsora pachyrhizi) spore germination. BMC biotechnology. 2011 Feb; 11(?):14. doi: 10.1186/1472-6750-11-14. [PMID: 21299880]
  • Alexander W Schüttelkopf, Ludovic Gros, David E Blair, Julie A Frearson, Daan M F van Aalten, Ian H Gilbert. Acetazolamide-based fungal chitinase inhibitors. Bioorganic & medicinal chemistry. 2010 Dec; 18(23):8334-40. doi: 10.1016/j.bmc.2010.09.062. [PMID: 21044846]
  • Toki Taira, Maho Fujiwara, Nicole Dennhart, Hiroko Hayashi, Shoko Onaga, Takayuki Ohnuma, Thomas Letzel, Shohei Sakuda, Tamo Fukamizo. Transglycosylation reaction catalyzed by a class V chitinase from cycad, Cycas revoluta: a study involving site-directed mutagenesis, HPLC, and real-time ESI-MS. Biochimica et biophysica acta. 2010 Apr; 1804(4):668-75. doi: 10.1016/j.bbapap.2009.10.015. [PMID: 19879383]
  • Yasuhiro Takenaka, Sachiko Nakano, Masahiro Tamoi, Shohei Sakuda, Tamo Fukamizo. Chitinase gene expression in response to environmental stresses in Arabidopsis thaliana: chitinase inhibitor allosamidin enhances stress tolerance. Bioscience, biotechnology, and biochemistry. 2009 May; 73(5):1066-71. doi: 10.1271/bbb.80837. [PMID: 19420714]
  • Julia Kzhyshkowska, Alexei Gratchev, Sergij Goerdt. Human chitinases and chitinase-like proteins as indicators for inflammation and cancer. Biomarker insights. 2007 May; 2(?):128-46. doi: 10.1177/117727190700200023. [PMID: 19662198]
  • Ramon Hurtado-Guerrero, Daan M F van Aalten. Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors. Chemistry & biology. 2007 May; 14(5):589-99. doi: 10.1016/j.chembiol.2007.03.015. [PMID: 17524989]
  • Sonja S Klemsdal, Jihong Liu Clarke, Ingunn A Hoell, Vincent G H Eijsink, May-Bente Brurberg. Molecular cloning, characterization, and expression studies of a novel chitinase gene (ech30) from the mycoparasite Trichoderma atroviride strain P1. FEMS microbiology letters. 2006 Mar; 256(2):282-9. doi: 10.1111/j.1574-6968.2006.00132.x. [PMID: 16499618]
  • Tao Zheng, Morgan Rabach, Ning Yuan Chen, Lesley Rabach, Xiaoxia Hu, Jack A Elias, Zhou Zhu. Molecular cloning and functional characterization of mouse chitotriosidase. Gene. 2005 Aug; 357(1):37-46. doi: 10.1016/j.gene.2005.05.006. [PMID: 16005164]
  • Myungjo You, Xuenan Xuan, Naotoshi Tsuji, Tsugihiko Kamio, DeMar Taylor, Naoyoshi Suzuki, Kozo Fujisaki. Identification and molecular characterization of a chitinase from the hard tick Haemaphysalis longicornis. The Journal of biological chemistry. 2003 Mar; 278(10):8556-63. doi: 10.1074/jbc.m206831200. [PMID: 12502707]
  • Douglas R Houston, Ian Eggleston, Bjørnar Synstad, Vincent G H Eijsink, Daan M F van Aalten. The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate. The Biochemical journal. 2002 Nov; 368(Pt 1):23-7. doi: 10.1042/bj20021034. [PMID: 12323074]
  • Antje Germer, Martin G Peter, Erich Kleinpeter. Solution-state conformational study of the hevamine inhibitor allosamidin and six potential inhibitor analogues by NMR spectroscopy and molecular modeling. The Journal of organic chemistry. 2002 Sep; 67(18):6328-38. doi: 10.1021/jo0163703. [PMID: 12201750]
  • Antje Germer, Sabrina Klod, Martin G Peter, Erich Kleinpeter. NMR spectroscopic and theoretical study of the complexation of the inhibitor allosamidin in the binding pocket of the plant chitinase hevamine. Journal of molecular modeling. 2002 Aug; 8(8):231-6. doi: 10.1007/s00894-002-0091-z. [PMID: 12324799]
  • Fabrizia Fusetti, Holger von Moeller, Douglas Houston, Henriette J Rozeboom, Bauke W Dijkstra, Rolf G Boot, Johannes M F G Aerts, Daan M F van Aalten. Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. The Journal of biological chemistry. 2002 Jul; 277(28):25537-44. doi: 10.1074/jbc.m201636200. [PMID: 11960986]
  • W De Boer, P J Klein Gunnewiek, G A Kowalchuk, J A Van Veen. Growth of chitinolytic dune soil beta-subclass Proteobacteria in response to invading fungal hyphae. Applied and environmental microbiology. 2001 Aug; 67(8):3358-62. doi: 10.1128/aem.67.8.3358-3362.2001. [PMID: 11472904]
  • D M van Aalten, D Komander, B Synstad, S Gåseidnes, M G Peter, V G Eijsink. Structural insights into the catalytic mechanism of a family 18 exo-chitinase. Proceedings of the National Academy of Sciences of the United States of America. 2001 Jul; 98(16):8979-84. doi: 10.1073/pnas.151103798. [PMID: 11481469]
  • E Bokma, T Barends, A C Terwissch van Scheltingab, B W Dijkstr, J J Beintema. Enzyme kinetics of hevamine, a chitinase from the rubber tree Hevea brasiliensis. FEBS letters. 2000 Jul; 478(1-2):119-22. doi: 10.1016/s0014-5793(00)01833-0. [PMID: 10922481]
  • Takeshi Watanabe, Ryo Kanai, Tomokazu Kawase, Toshiaki Tanabe, Masaru Mitsutomi, Shohei Sakuda, Kiyotaka Miyashita. Family 19 chitinases of Streptomyces species: characterization and distribution. Microbiology (Reading, England). 1999 Dec; 145 ( Pt 12)(?):3353-3363. doi: 10.1099/00221287-145-12-3353. [PMID: 10627034]
  • Bernard Overdijk, Gé J Van Steijn, Frank C Odds. Distribution of chitinase in guinea pig tissues and increases in levels of this enzyme after systemic infection with Aspergillus fumigatus. Microbiology (Reading, England). 1999 Jan; 145 ( Pt 1)(?):259-269. doi: 10.1099/13500872-145-1-259. [PMID: 10206706]
  • A Hodge, G W Gooday, I J Alexander. Inhibition of chitinolytic activities from tree species and associated fungi. Phytochemistry. 1996 Jan; 41(1):77-84. doi: 10.1016/0031-9422(95)00571-4. [PMID: 8588878]
  • A C Terwisscha van Scheltinga, S Armand, K H Kalk, A Isogai, B Henrissat, B W Dijkstra. Stereochemistry of chitin hydrolysis by a plant chitinase/lysozyme and X-ray structure of a complex with allosamidin: evidence for substrate assisted catalysis. Biochemistry. 1995 Dec; 34(48):15619-23. doi: 10.1021/bi00048a003. [PMID: 7495789]
  • G M Escott, D J Adams. Chitinase activity in human serum and leukocytes. Infection and immunity. 1995 Dec; 63(12):4770-3. doi: 10.1128/iai.63.12.4770-4773.1995. [PMID: 7591134]
  • C E Semino, P W Robbins. Synthesis of 'Nod'-like chitin oligosaccharides by the Xenopus developmental protein DG42. Proceedings of the National Academy of Sciences of the United States of America. 1995 Apr; 92(8):3498-501. doi: 10.1073/pnas.92.8.3498. [PMID: 7724589]
  • E Cabib, A Sburlati, B Bowers, S J Silverman. Chitin synthase 1, an auxiliary enzyme for chitin synthesis in Saccharomyces cerevisiae. The Journal of cell biology. 1989 May; 108(5):1665-72. doi: 10.1083/jcb.108.5.1665. [PMID: 2523889]