Difructose anhydride III (BioDeep_00000005513)

Main id: BioDeep_00000178269

Secondary id: BioDeep_00001870842


代谢物信息卡片


bis-beta-D-fructofuranose 1,2:2,3-dianhydride

化学式: C12H20O10 (324.1056)
中文名称: 二果糖酐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C2(C(C(C(O2)CO)O)O)OC3C(C(OC3(O1)CO)CO)O
InChI: InChI=1S/C12H20O10/c13-1-5-7(16)9(18)12(21-5)4-19-11(3-15)10(22-12)8(17)6(2-14)20-11/h5-10,13-18H,1-4H2/t5-,6-,7-,8-,9+,10+,11-,12+/m1/s1



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 BGLAP, GAPDH, MARVELD1, MYLK, S100G, SLC11A2
Golgi apparatus, trans-Golgi network membrane 1 SLC11A2
Endosome membrane 3 SLC11A2, TF, TFRC
Nucleus 3 GAPDH, MARVELD1, SLC11A2
cytosol 2 GAPDH, MYLK
dendrite 1 BGLAP
trans-Golgi network 1 SLC11A2
Cell membrane 5 CLDN1, F11R, MARVELD1, SLC11A2, TFRC
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Early endosome membrane 1 SLC11A2
Multi-pass membrane protein 3 CLDN1, MARVELD1, SLC11A2
Synapse 1 MYLK
cell junction 1 F11R
cell surface 3 SLC11A2, TF, TFRC
glutamatergic synapse 1 TFRC
Golgi apparatus 1 SLC11A2
Golgi membrane 1 INS
lysosomal membrane 1 SLC11A2
Cytoplasm, cytosol 1 GAPDH
Lysosome 1 SLC11A2
endosome 1 TFRC
plasma membrane 9 CLDN1, F11R, GAPDH, GCG, MARVELD1, MYLK, SLC11A2, TF, TFRC
Membrane 5 CLDN1, GAPDH, MARVELD1, SLC11A2, TFRC
apical plasma membrane 4 CLDN1, S100G, SLC11A2, TF
basolateral plasma membrane 3 CLDN1, S100G, TFRC
extracellular exosome 4 F11R, GAPDH, TF, TFRC
Lysosome membrane 1 SLC11A2
extracellular space 8 BGLAP, GCG, INS, PTH, PYY, S100G, TF, TFRC
perinuclear region of cytoplasm 4 GAPDH, SLC11A2, TF, TFRC
Cell junction, tight junction 2 CLDN1, F11R
bicellular tight junction 2 CLDN1, F11R
mitochondrion 1 SLC11A2
protein-containing complex 2 CLDN1, F11R
intracellular membrane-bounded organelle 2 GAPDH, TFRC
Single-pass type I membrane protein 1 F11R
Secreted 4 BGLAP, GCG, INS, TF
extracellular region 7 BGLAP, GCG, INS, PTH, PYY, TF, TFRC
Mitochondrion outer membrane 1 SLC11A2
mitochondrial outer membrane 1 SLC11A2
basal part of cell 2 SLC11A2, TF
nuclear membrane 1 GAPDH
external side of plasma membrane 1 TFRC
Extracellular vesicle 2 SLC11A2, TFRC
actin cytoskeleton 1 MYLK
perikaryon 1 BGLAP
cytoplasmic vesicle 3 SLC11A2, TF, TFRC
microtubule cytoskeleton 1 GAPDH
Early endosome 3 SLC11A2, TF, TFRC
apical part of cell 1 SLC11A2
cell-cell junction 1 F11R
clathrin-coated pit 2 TF, TFRC
recycling endosome 3 SLC11A2, TF, TFRC
Single-pass type II membrane protein 1 TFRC
vesicle 3 BGLAP, GAPDH, TF
Apical cell membrane 1 SLC11A2
Cell projection, lamellipodium 1 MYLK
Cytoplasm, perinuclear region 1 GAPDH
Cytoplasm, cytoskeleton 2 GAPDH, MARVELD1
lateral plasma membrane 1 CLDN1
Late endosome 2 SLC11A2, TF
Late endosome membrane 1 SLC11A2
cytoskeleton 2 GAPDH, MARVELD1
brush border membrane 1 SLC11A2
blood microparticle 2 TF, TFRC
Basolateral cell membrane 1 CLDN1
Recycling endosome membrane 2 SLC11A2, TFRC
endosome lumen 1 INS
Lipid droplet 1 GAPDH
Melanosome 1 TFRC
stress fiber 1 MYLK
basal plasma membrane 1 TF
secretory granule lumen 3 GCG, INS, TF
HFE-transferrin receptor complex 2 TF, TFRC
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 4 BGLAP, GCG, INS, TF
endocytic vesicle 1 TF
transport vesicle 1 INS
tight junction 2 CLDN1, F11R
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 2 TF, TFRC
Vacuole 1 SLC11A2
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
ribonucleoprotein complex 1 GAPDH
GAIT complex 1 GAPDH
postsynaptic recycling endosome membrane 1 TFRC
[Isoform 3]: Cell membrane 1 SLC11A2
vesicle coat 1 TF
[Glucagon-like peptide 1]: Secreted 1 GCG
[Transferrin receptor protein 1, serum form]: Secreted 1 TFRC
Extracellular vesicle membrane 1 SLC11A2
[Isoform 1]: Early endosome membrane 1 SLC11A2
[Isoform 2]: Late endosome membrane 1 SLC11A2
paraferritin complex 1 SLC11A2
dense body 1 TF


文献列表

  • Dong Geun Lee, Shota Hori, Ohji Kohmoto, Shinri Kitta, Ryo Yoshida, Yasutake Tanaka, Hidehisa Shimizu, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Satoru Fukiya, Atsushi Yokota, Satoshi Ishizuka. Ingestion of difructose anhydride III partially suppresses the deconjugation and 7α-dehydroxylation of bile acids in rats fed with a cholic acid-supplemented diet. Bioscience, biotechnology, and biochemistry. 2019 Jul; 83(7):1329-1335. doi: 10.1080/09168451.2019.1597617. [PMID: 30912732]
  • Ayami Maetani, Masayuki Ohtani, Kaoru Hatate, Kotaro Matsumoto, Norio Yamagishi. Effect of dietary difructose anhydride III supplementation on bone mineral density and calcium metabolism in late-lactation dairy cows. The Journal of veterinary medical science. 2018 Jul; 80(7):1061-1067. doi: 10.1292/jvms.17-0614. [PMID: 29760322]
  • Katsuki Toda, Seiichi Uno, Emiko Kokushi, Ayaka Shiiba, Hiroshi Hasunuma, Daisaku Matsumoto, Masayuki Ohtani, Osamu Yamato, Urara Shinya, Missaka Wijayagunawardane, Johanna Fink-Gremmels, Masayasu Taniguchi, Mitsuhiro Takagi. Fructo-Oligosaccharide (DFA III) Feed Supplementation for Mitigation of Mycotoxin Exposure in Cattle-Clinical Evaluation by a Urinary Zearalenone Monitoring System. Toxins. 2018 06; 10(6):. doi: 10.3390/toxins10060223. [PMID: 29857569]
  • A Htun, T Sato, N Fukuma, M Hanada. Effects of difructose anhydride III on serum immunoglobulin G concentration and health status of newborn Holstein calves during the preweaning period. Journal of dairy science. 2018 Apr; 101(4):3226-3232. doi: 10.3168/jds.2017-13541. [PMID: 29428752]
  • Tohru Hira, Kurumi Yanagihara, Toshiki Koga, Keisuke Takahashi, Taizo Nagura, Hirokatsu Uchino, Hiroshi Hara. Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet. Bioscience, biotechnology, and biochemistry. 2017 Nov; 81(11):2186-2194. doi: 10.1080/09168451.2017.1373591. [PMID: 28950751]
  • A Htun, T Sato, M Hanada. Effect of difructose anhydride III supplementation on passive immunoglobulin G transfer and serum immunoglobulin G concentration in newborn Holstein calves fed pooled colostrum. Journal of dairy science. 2016 Jul; 99(7):5701-5706. doi: 10.3168/jds.2015-10716. [PMID: 27157573]
  • M Teramura, S Wynn, M Reshalaitihan, W Kyuno, T Sato, M Ohtani, C Kawashima, M Hanada. Supplementation with difructose anhydride III promotes passive calcium absorption in the small intestine immediately after calving in dairy cows. Journal of dairy science. 2015 Dec; 98(12):8688-97. doi: 10.3168/jds.2015-9576. [PMID: 26454295]
  • T Sato, M Hanada, M Ohtani, T Nakai, M Teramura, H Sadoya, T Takahashi, A Hongo. Short communication: effect of difructose anhydride III on serum immunoglobulin G concentration in newborn calves. Journal of dairy science. 2012 Sep; 95(9):5336-5339. doi: 10.3168/jds.2011-4989. [PMID: 22916939]
  • Hiroto Kikuchi, Masanao Inoue, Hidetoshi Saito, Hiroaki Sakurai, Tsutomu Aritsuka, Fusao Tomita, Atsushi Yokota. Industrial production of difructose anhydride III (DFA III) from crude inulin extracted from chicory roots using Arthrobacter sp. H65-7 fructosyltransferase. Journal of bioscience and bioengineering. 2009 Mar; 107(3):262-5. doi: 10.1016/j.jbiosc.2008.11.013. [PMID: 19269589]
  • Kyoko Tomita, Takuya Shiomi, Yasuhide Okuhara, Akiko Tamura, Norihiro Shigematsu, Hiroshi Hara. Ingestion of difructose anhydride III enhances absorption and retention of calcium in healthy men. Bioscience, biotechnology, and biochemistry. 2007 Mar; 71(3):681-7. doi: 10.1271/bbb.60465. [PMID: 17341829]
  • Kazuki Shiga, Megumi Nishimukai, Fusao Tomita, Hiroshi Hara. Ingestion of difructose anhydride III, a non-digestible disaccharide, improves postgastrectomy osteopenia in rats. Scandinavian journal of gastroenterology. 2006 Oct; 41(10):1165-73. doi: 10.1080/00365520600575753. [PMID: 16990201]
  • Akiko Tamura, Megumi Nishimukai, Norihiro Shigematsu, Hiroshi Hara. Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats. The British journal of nutrition. 2006 Sep; 96(3):442-9. doi: . [PMID: 16925848]
  • Kazuki Shiga, Megumi Nishimukai, Fusao Tomita, Hiroshi Hara. Ingestion of difructose anhydride III, a non-digestible disaccharide, prevents gastrectomy-induced iron malabsorption and anemia in rats. Nutrition (Burbank, Los Angeles County, Calif.). 2006 Jul; 22(7-8):786-93. doi: 10.1016/j.nut.2005.12.013. [PMID: 16815493]
  • Rieko Mitamura, Hiroshi Hara. Ingestion of difructose anhydride III partially restores calcium absorption impaired by vitamin D and estrogen deficiency in rats. European journal of nutrition. 2006 Jun; 45(4):242-9. doi: 10.1007/s00394-006-0592-0. [PMID: 16477367]
  • Akiko Tamura, Hadzuki Nino, Tomoko Minobe, Violeta G Raneva, Norihiro Shigematsu, Hiroshi Hara, Taro Kishida, Kiyoshi Ebihara. Difructose anhydride III does not contribute to body energy accumulation in rats. Bioscience, biotechnology, and biochemistry. 2006 Jun; 70(6):1416-22. doi: 10.1271/bbb.50666. [PMID: 16794322]
  • Kimiko Minamida, Chikako Asakawa, I Nengah Sujaya, Maki Kaneko, Ayumi Abe, Teruo Sone, Hiroshi Hara, Kozo Asano, Fusao Tomita. Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans. Journal of bioscience and bioengineering. 2006 Feb; 101(2):149-56. doi: 10.1263/jbb.101.149. [PMID: 16569611]
  • Kimiko Minamida, Midori Ohashi, Hiroshi Hara, Kozo Asano, Fusao Tomita. Effects of ingestion of difructose anhydride III (DFA III) and the DFA III-assimilating bacterium Ruminococcus productus on rat intestine. Bioscience, biotechnology, and biochemistry. 2006 Feb; 70(2):332-9. doi: 10.1271/bbb.70.332. [PMID: 16495647]
  • Rieko Mitamura, Hiroshi Hara. Prolonged feeding of difructose anhydride III increases strength and mineral concentrations of the femur in ovariectomized rats. The British journal of nutrition. 2005 Aug; 94(2):268-74. doi: 10.1079/bjn20051483. [PMID: 16115362]
  • Kimiko Minamida, Maki Kaneko, Midori Ohashi, I Nengah Sujaya, Teruo Sone, Masaru Wada, Atsushi Yokota, Hiroshi Hara, Kozo Asano, Fusao Tomita. Effects of difructose anhydride III (DFA III) administration on bile acids and growth of DFA III-assimilating bacterium Ruminococcus productus on rat intestine. Journal of bioscience and bioengineering. 2005 Jun; 99(6):548-54. doi: 10.1263/jbb.99.548. [PMID: 16233830]
  • Akiko Tamura, Takuya Shiomi, Noriko Tamaki, Norihiro Shigematsu, Fusao Tomita, Hiroshi Hara. Comparative effect of repeated ingestion of difructose anhydride III and palatinose on the induction of gastrointestinal symptoms in humans. Bioscience, biotechnology, and biochemistry. 2004 Sep; 68(9):1882-7. doi: 10.1271/bbb.68.1882. [PMID: 15388963]
  • Norihiro Shigematsu, Yasuhide Okuhara, Takuya Shiomi, Fusao Tomita, Hiroshi Hara. Effect of difructose anhydride III on calcium absorption in humans. Bioscience, biotechnology, and biochemistry. 2004 May; 68(5):1011-6. doi: 10.1271/bbb.68.1011. [PMID: 15170103]
  • Akiko Tamura, Takuya Shiomi, Norihiro Shigematsu, Fusao Tomita, Hiroshi Hara. Evidence suggesting that difructose anhydride III is an indigestible and low fermentable sugar during the early stages after ingestion in humans. Journal of nutritional science and vitaminology. 2003 Dec; 49(6):422-7. doi: 10.3177/jnsv.49.422. [PMID: 14974733]
  • Kaosar Afsana, Kazuki Shiga, Satoshi Ishizuka, Hiroshi Hara. Ingestion of an indigestible saccharide, difructose anhydride III, partially prevents the tannic acid-induced suppression of iron absorption in rats. The Journal of nutrition. 2003 Nov; 133(11):3553-60. doi: 10.1093/jn/133.11.3553. [PMID: 14608073]
  • H Prosl, A Tamer. [Parasitic fauna of the rhesus monkey (Macaca mulatta) and of the (Macaca irus)]. Zentralblatt fur Veterinarmedizin. Reihe B. Journal of veterinary medicine. Series B. 1979 Nov; 26(9):696-709. doi: NULL. [PMID: 119389]
  • M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study. Cancer treatment reports. 1979 Sep; 63(9-10):1663-7. doi: . [PMID: 91435]