L-3-Aminodihydro-2(3H)-furanone (BioDeep_00000005035)

 

Secondary id: BioDeep_00001868997

human metabolite Endogenous


代谢物信息卡片


Homoserine lactone hydrochloride, (S)-isomer

化学式: C4H7NO2 (101.0477)
中文名称: 高丝氨酸内酯
谱图信息: 最多检出来源 Homo sapiens(plant) 5.51%

分子结构信息

SMILES: C1COC(=O)C1N
InChI: InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2

描述信息

L-3-Aminodihydro-2(3H)-furanone is found in pulses. L-3-Aminodihydro-2(3H)-furanone is a constituent of pea Pisum sativum seedlings
Constituent of pea Pisum sativum seedlings. L-3-Aminodihydro-2(3H)-furanone is found in pulses and common pea.

同义名列表

14 个代谢物同义名

Homoserine lactone hydrochloride, (S)-isomer; alpha-Amino-gamma-butyrolactone; L-3-Aminodihydro-2(3H)-furanone; Homoserine lactone hydrobromide; Homoserine lactone, (S)-isomer; a-Amino-g-butyrolactone; Α-amino-γ-butyrolactone; 2-Aminobutan-4-olide; 3-aminooxolan-2-one; homoserine lactone; HSLS; Hsl; Homoserine lactone; Homoserine lactone



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CASP3, CASP7, CFTR, ELANE, GPER1, NFKB1, PFDN5, XBP1
Peripheral membrane protein 3 HSD17B6, PON2, XBP1
Endosome membrane 1 CFTR
Endoplasmic reticulum membrane 8 CALU, CFTR, GPER1, PIGX, PIGZ, PON1, PON3, XBP1
Mitochondrion membrane 1 GPER1
Nucleus 7 CASP3, CASP7, CFTR, GPER1, NFKB1, PFDN5, XBP1
cytosol 8 CASP3, CASP7, CFTR, ELANE, GPER1, NFKB1, PFDN5, XBP1
dendrite 1 GPER1
mitochondrial membrane 1 GPER1
phagocytic vesicle 1 ELANE
trans-Golgi network 1 GPER1
nucleoplasm 5 CASP3, CASP7, GPER1, NFKB1, XBP1
RNA polymerase II transcription regulator complex 1 XBP1
Cell membrane 2 CFTR, TNF
Cell projection, axon 1 GPER1
Early endosome membrane 2 CFTR, HSD17B6
Multi-pass membrane protein 3 CFTR, GPER1, PIGZ
Golgi apparatus membrane 1 GPER1
cell surface 3 CFTR, ELANE, TNF
dendritic shaft 1 GPER1
glutamatergic synapse 1 CASP3
Golgi apparatus 2 CALU, GPER1
Golgi membrane 1 GPER1
lysosomal membrane 1 CFTR
neuronal cell body 2 CASP3, TNF
presynaptic membrane 1 GPER1
Cytoplasm, cytosol 1 CASP7
plasma membrane 5 CFTR, GCG, GPER1, PON2, TNF
presynaptic active zone 1 GPER1
Membrane 5 CALU, CFTR, GPER1, PON2, XBP1
apical plasma membrane 1 CFTR
axon 1 GPER1
extracellular exosome 4 ELANE, LYZ, PON1, PON3
Lumenal side 1 HSD17B6
endoplasmic reticulum 5 CALU, GPER1, HSD17B6, PIGZ, XBP1
extracellular space 8 CASP7, CXCL8, ELANE, GCG, LYZ, PON1, PON3, TNF
perinuclear region of cytoplasm 1 GPER1
mitochondrion 1 NFKB1
protein-containing complex 1 CFTR
intracellular membrane-bounded organelle 2 GPER1, HSD17B6
Microsome membrane 1 HSD17B6
postsynaptic density 2 CASP3, GPER1
Single-pass type I membrane protein 1 PIGX
Secreted 3 CALU, CXCL8, GCG
extracellular region 10 CALU, CXCL8, ELANE, GCG, LYZ, NFKB1, PON1, PON2, PON3, TNF
Single-pass membrane protein 1 PIGX
hippocampal mossy fiber to CA3 synapse 1 GPER1
transcription regulator complex 1 NFKB1
external side of plasma membrane 1 TNF
high-density lipoprotein particle 1 PON1
nucleolus 1 GPER1
Early endosome 2 CFTR, GPER1
recycling endosome 3 CFTR, GPER1, TNF
Single-pass type II membrane protein 2 TNF, XBP1
Apical cell membrane 1 CFTR
Membrane raft 1 TNF
collagen-containing extracellular matrix 1 ELANE
secretory granule 1 ELANE
chromatin 1 NFKB1
phagocytic cup 1 TNF
Secreted, extracellular space 2 CASP7, PON3
blood microparticle 1 PON1
nuclear envelope 1 GPER1
Recycling endosome membrane 1 CFTR
chloride channel complex 1 CFTR
Cytoplasmic vesicle membrane 1 GPER1
Cell projection, dendrite 1 GPER1
Melanosome 1 CALU
Golgi-associated vesicle membrane 1 CFTR
intermediate filament cytoskeleton 1 PFDN5
secretory granule lumen 2 GCG, NFKB1
endoplasmic reticulum lumen 2 CALU, GCG
transcription repressor complex 1 ELANE
axon terminus 1 GPER1
specific granule lumen 3 ELANE, LYZ, NFKB1
tertiary granule lumen 1 LYZ
azurophil granule lumen 2 ELANE, LYZ
clathrin-coated endocytic vesicle membrane 1 CFTR
Sarcoplasmic reticulum lumen 1 CALU
[Isoform 2]: Nucleus 1 XBP1
[Isoform 1]: Nucleus 1 XBP1
prefoldin complex 1 PFDN5
death-inducing signaling complex 1 CASP3
keratin filament 1 GPER1
Cytoplasmic vesicle, phagosome 1 ELANE
dendritic spine head 1 GPER1
Cell projection, dendritic spine membrane 1 GPER1
dendritic spine membrane 1 GPER1
spherical high-density lipoprotein particle 1 PON1
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[X-box-binding protein 1, cytoplasmic form]: Cytoplasm 1 XBP1
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yongming Duan, Min Han, Maja Grimm, Jessica Ponath, Michael Reichelt, Axel Mithöfer, Adam Schikora. Combination of bacterial N-acyl homoserine lactones primes Arabidopsis defenses via jasmonate metabolism. Plant physiology. 2023 Jan; ?(?):. doi: 10.1093/plphys/kiad017. [PMID: 36649188]
  • Abhishek Shrestha, Casandra Hernández-Reyes, Maja Grimm, Johannes Krumwiede, Elke Stein, Sebastian T Schenk, Adam Schikora. AHL-Priming Protein 1 mediates N-3-oxo-tetradecanoyl-homoserine lactone priming in Arabidopsis. BMC biology. 2022 12; 20(1):268. doi: 10.1186/s12915-022-01464-3. [PMID: 36464707]
  • Xiang-Yu Cao, Qian Zhao, Ya-Na Sun, Ming-Xiang Yu, Fang Liu, Zhe Zhang, Zhen-Hua Jia, Shui-Shan Song. Cellular messengers involved in the inhibition of the Arabidopsis primary root growth by bacterial quorum-sensing signal N-decanoyl-L-homoserine lactone. BMC plant biology. 2022 Oct; 22(1):488. doi: 10.1186/s12870-022-03865-6. [PMID: 36229795]
  • Min Zhu, Yusheng Yang, Meizhen Wang, Xiaoxiao Li, Ruifang Han, Qianqian Chen, Dongsheng Shen, Jiali Shentu. A deep insight into the suppression mechanism of Sedum alfredii root exudates on Pseudomonas aeruginosa based on quorum sensing. Ecotoxicology and environmental safety. 2021 Jul; 217(?):112240. doi: 10.1016/j.ecoenv.2021.112240. [PMID: 33901783]
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  • Xiaohua Du, Renyan Huang, Zhuo Zhang, Deyong Zhang, Ju'e Cheng, Peijie Tian, Yanqi Wang, Zhongying Zhai, Lijie Chen, Xiaoting Kong, Yong Liu, Pin Su. Rhodopseudomonas palustris Quorum Sensing Molecule pC-HSL Induces Systemic Resistance to TMV Infection via Upregulation of NbSIPK/NbWIPK Expressions in Nicotiana benthamiana. Phytopathology. 2021 Mar; 111(3):500-508. doi: 10.1094/phyto-05-20-0177-r. [PMID: 32876530]
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  • Miguel Medina Munoz, Noah Spencer, Shinichiro Enomoto, Colin Dale, Rita V M Rio. Quorum sensing sets the stage for the establishment and vertical transmission of Sodalis praecaptivus in tsetse flies. PLoS genetics. 2020 08; 16(8):e1008992. doi: 10.1371/journal.pgen.1008992. [PMID: 32797092]
  • Xiaofei Qin, Ganesh Kumar Thota, Ratna Singh, Rengarajan Balamurugan, Francisco M Goycoolea. Synthetic homoserine lactone analogues as antagonists of bacterial quorum sensing. Bioorganic chemistry. 2020 05; 98(?):103698. doi: 10.1016/j.bioorg.2020.103698. [PMID: 32217369]
  • Xiyi Zhuang, An Zhang, Weihua Chu. Anti-quorum sensing activity of Forsythia suspense extract against Chromobacterium violaceum by targeting CviR receptor. International microbiology : the official journal of the Spanish Society for Microbiology. 2020 May; 23(2):215-224. doi: 10.1007/s10123-019-00091-3. [PMID: 31342213]
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  • Fang Liu, Qian Zhao, Zhenhua Jia, Cong Song, Yali Huang, Hong Ma, Shuishan Song. N-3-oxo-octanoyl-homoserine lactone-mediated priming of resistance to Pseudomonas syringae requires the salicylic acid signaling pathway in Arabidopsis thaliana. BMC plant biology. 2020 Jan; 20(1):38. doi: 10.1186/s12870-019-2228-6. [PMID: 31992205]
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  • Olena V Moshynets, Lidia M Babenko, Sergiy P Rogalsky, Olga S Iungin, Jessica Foster, Iryna V Kosakivska, Geert Potters, Andrew J Spiers. Priming winter wheat seeds with the bacterial quorum sensing signal N-hexanoyl-L-homoserine lactone (C6-HSL) shows potential to improve plant growth and seed yield. PloS one. 2019; 14(2):e0209460. doi: 10.1371/journal.pone.0209460. [PMID: 30802259]
  • Yulia V Zaitseva, Olga A Koksharova, Valentina A Lipasova, Vladimir A Plyuta, Ilya V Demidyuk, Leonid S Chernin, Inessa A Khmel. SprI/SprR Quorum Sensing System of Serratia proteamaculans 94. BioMed research international. 2019; 2019(?):3865780. doi: 10.1155/2019/3865780. [PMID: 31915691]
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  • Ana Zúñiga, Francisco de la Fuente, Fernán Federici, Corinne Lionne, Jérome Bônnet, Victor de Lorenzo, Bernardo González. An Engineered Device for Indoleacetic Acid Production under Quorum Sensing Signals Enables Cupriavidus pinatubonensis JMP134 To Stimulate Plant Growth. ACS synthetic biology. 2018 06; 7(6):1519-1527. doi: 10.1021/acssynbio.8b00002. [PMID: 29746094]
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  • Johannes Arp, Sebastian Götze, Ruchira Mukherji, Derek J Mattern, María García-Altares, Martin Klapper, Debra A Brock, Axel A Brakhage, Joan E Strassmann, David C Queller, Bettina Bardl, Karsten Willing, Gundela Peschel, Pierre Stallforth. Synergistic activity of cosecreted natural products from amoebae-associated bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2018 04; 115(15):3758-3763. doi: 10.1073/pnas.1721790115. [PMID: 29592954]
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  • Katharina Buddrus-Schiemann, Martin Rieger, Marlene Mühlbauer, Maria Vittoria Barbarossa, Christina Kuttler, Burkhard A Hense, Michael Rothballer, Jenny Uhl, Juliano R Fonseca, Philippe Schmitt-Kopplin, Michael Schmid, Anton Hartmann. Analysis of N-acylhomoserine lactone dynamics in continuous cultures of Pseudomonas putida IsoF by use of ELISA and UHPLC/qTOF-MS-derived measurements and mathematical models. Analytical and bioanalytical chemistry. 2014 Oct; 406(25):6373-83. doi: 10.1007/s00216-014-8063-6. [PMID: 25116602]
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