N-Methylpyridinium (BioDeep_00000004981)

 

Secondary id: BioDeep_00001869197

human metabolite blood metabolite


代谢物信息卡片


1-Methylpyridinium mu-iodotetraiododimercurate (1-)

化学式: C6H8N+ (94.0657)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 70.11%

分子结构信息

SMILES: C[N+]1=CC=CC=C1
InChI: InChI=1S/C6H8N/c1-7-5-3-2-4-6-7/h2-6H,1H3/q+1

描述信息

同义名列表

7 个代谢物同义名

1-Methylpyridinium mu-iodotetraiododimercurate (1-); 1-Methylpyridinium dibromoiodate (1-); 1-Methylpyridinium chloride; 1-METHYLPYRIDINIUM IODIDE; 1-methylpyridin-1-ium; N-Methylpyridinium; 1-Methylpyridinium



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

36 个相关的代谢反应过程信息。

Reactome(36)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADIG, AKT1, ALB, BDNF, EGFR, HPGDS, MAPK8, NQO1
Endosome membrane 2 EGFR, SLC6A4
Endoplasmic reticulum membrane 2 CHRM3, EGFR
Nucleus 8 ADIG, AKT1, ALB, EGFR, GABPA, MAPK8, NQO1, TMEM53
cytosol 7 AKT1, ALB, ATP12A, HPGDS, MAPK8, NQO1, SST
dendrite 4 BDNF, CHRM3, HRH2, NQO1
centrosome 1 ALB
nucleoplasm 4 AKT1, GABPA, HPGDS, MAPK8
Cell membrane 6 AKT1, CHRM3, EGFR, HRH2, SLC6A4, TNF
lamellipodium 1 AKT1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 6 ATP12A, CHRM3, HRH2, SLC25A16, SLC6A4, UCP2
Synapse 5 CHRM3, HRH2, MAPK8, NQO1, SLC6A4
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 3 ADIPOQ, EGFR, TNF
glutamatergic synapse 2 AKT1, EGFR
Golgi apparatus 1 ALB
Golgi membrane 2 EGFR, INS
mitochondrial inner membrane 2 SLC25A16, UCP2
neuronal cell body 3 NQO1, SST, TNF
postsynapse 1 AKT1
presynaptic membrane 1 SLC6A4
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 1 NQO1
Presynapse 1 SLC6A4
endosome 1 EGFR
plasma membrane 7 AKT1, ATP12A, CHRM3, EGFR, HRH2, SLC6A4, TNF
Membrane 8 ADIG, AKT1, BDNF, EGFR, NQO1, SLC25A16, SLC6A4, TMEM53
apical plasma membrane 2 ATP12A, EGFR
axon 2 BDNF, MAPK8
basolateral plasma membrane 3 ATP12A, CHRM3, EGFR
extracellular exosome 1 ALB
endoplasmic reticulum 2 ADIPOQ, ALB
extracellular space 7 ADIPOQ, ALB, BDNF, EGFR, INS, SST, TNF
perinuclear region of cytoplasm 2 BDNF, EGFR
mitochondrion 2 SLC25A16, UCP2
protein-containing complex 3 AKT1, ALB, EGFR
intracellular membrane-bounded organelle 1 HPGDS
Single-pass type I membrane protein 1 EGFR
Secreted 6 ADIG, ADIPOQ, ALB, BDNF, INS, SST
extracellular region 7 ADIG, ADIPOQ, ALB, BDNF, INS, SST, TNF
Single-pass membrane protein 2 ADIG, TMEM53
anchoring junction 1 ALB
Nucleus membrane 1 TMEM53
nuclear membrane 2 EGFR, TMEM53
external side of plasma membrane 1 TNF
actin cytoskeleton 1 ATP12A
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 2 CHRM3, SLC6A4
Apical cell membrane 1 ATP12A
Mitochondrion inner membrane 2 SLC25A16, UCP2
Membrane raft 3 EGFR, SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 2 EGFR, SLC6A4
spindle 1 AKT1
GABA-ergic synapse 1 SST
collagen trimer 1 ADIPOQ
intracellular vesicle 1 EGFR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ADIPOQ
lateral plasma membrane 1 CHRM3
Nucleus outer membrane 1 TMEM53
nuclear outer membrane 1 TMEM53
Postsynaptic cell membrane 1 CHRM3
receptor complex 1 EGFR
Cell projection, neuron projection 1 SLC6A4
neuron projection 1 SLC6A4
ciliary basal body 2 AKT1, ALB
chromatin 1 GABPA
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 CHRM3
Endomembrane system 2 SLC6A4, TMEM53
endosome lumen 1 INS
Lipid droplet 1 ADIG
basal plasma membrane 2 CHRM3, EGFR
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, BDNF, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
clathrin-coated endocytic vesicle membrane 1 EGFR
basal dendrite 1 MAPK8
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
potassium:proton exchanging ATPase complex 1 ATP12A
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
serotonergic synapse 1 SLC6A4
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jacob Schade Engbjerg, Vincenzo Costanzo, Donato Sardella, Luca Bordoni, Steen Jakobsen, Luciano D'Apolito, Jørgen Frøkiær, Francesco Trepiccione, Giovambattista Capasso, Sebastian Frische. The Probe for Renal Organic Cation Secretion (4-Dimethylaminostyryl)-N-Methylpyridinium (ASP+)) Shows Amplified Fluorescence by Binding to Albumin and Is Accumulated In Vivo. Molecular imaging. 2022; 2022(?):7908357. doi: 10.1155/2022/7908357. [PMID: 35418808]
  • Letizia Bresciani, Michele Tassotti, Alice Rosi, Daniela Martini, Monica Antonini, Alessandra Dei Cas, Riccardo Bonadonna, Furio Brighenti, Daniele Del Rio, Pedro Mena. Absorption, Pharmacokinetics, and Urinary Excretion of Pyridines After Consumption of Coffee and Cocoa-Based Products Containing Coffee in a Repeated Dose, Crossover Human Intervention Study. Molecular nutrition & food research. 2020 09; 64(18):e2000489. doi: 10.1002/mnfr.202000489. [PMID: 32776430]
  • Agnieszka Zakrzewska, Malgorzata Szafarz, Kamil Kus, Agnieszka Kij, Anna Gonciarz, Maria Walczak. QUANTIFICATION AND PHARMACOKINETICS OF 1 -METHYLPYRIDINIUM AND 1,4-DIMETHYLPYRIDINIUM IN RATS BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY. TISSUE DISTRIBUTION OF 1,4-DIMETHYLPYRIDINIUM IN RATS. Acta poloniae pharmaceutica. 2016 Sep; 73(5):1111-1121. doi: . [PMID: 29638051]
  • Kathryn M Docherty, Steven W Aiello, Barbara K Buehler, Stuart E Jones, Blair R Szymczyna, Katherine A Walker. Ionic liquid biodegradability depends on specific wastewater microbial consortia. Chemosphere. 2015 Oct; 136(?):160-6. doi: 10.1016/j.chemosphere.2015.05.016. [PMID: 25985304]
  • T Bakuradze, R Lang, T Hofmann, G Eisenbrand, D Schipp, J Galan, E Richling. Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomized controlled trial. European journal of nutrition. 2015 Feb; 54(1):149-56. doi: 10.1007/s00394-014-0696-x. [PMID: 24740588]
  • Paola Galletti, Danilo Malferrari, Chiara Samorì, Giorgio Sartor, Emilio Tagliavini. Effects of ionic liquids on membrane fusion and lipid aggregation of egg-PC liposomes. Colloids and surfaces. B, Biointerfaces. 2015 Jan; 125(?):142-50. doi: 10.1016/j.colsurfb.2014.11.021. [PMID: 25483843]
  • J Walker, B Rohm, R Lang, M W Pariza, T Hofmann, V Somoza. Identification of coffee components that stimulate dopamine release from pheochromocytoma cells (PC-12). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Feb; 50(2):390-8. doi: 10.1016/j.fct.2011.09.041. [PMID: 22019894]
  • Roman Lang, Anika Wahl, Timo Stark, Thomas Hofmann. Urinary N-methylpyridinium and trigonelline as candidate dietary biomarkers of coffee consumption. Molecular nutrition & food research. 2011 Nov; 55(11):1613-23. doi: 10.1002/mnfr.201000656. [PMID: 21618426]
  • Christine Kotyczka, Ute Boettler, Roman Lang, Herbert Stiebitz, Gerhard Bytof, Ingo Lantz, Thomas Hofmann, Doris Marko, Veronika Somoza. Dark roast coffee is more effective than light roast coffee in reducing body weight, and in restoring red blood cell vitamin E and glutathione concentrations in healthy volunteers. Molecular nutrition & food research. 2011 Oct; 55(10):1582-6. doi: 10.1002/mnfr.201100248. [PMID: 21809439]
  • Ute Boettler, Katharina Sommerfeld, Nadine Volz, Gudrun Pahlke, Nicole Teller, Veronika Somoza, Roman Lang, Thomas Hofmann, Doris Marko. Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression. The Journal of nutritional biochemistry. 2011 May; 22(5):426-40. doi: 10.1016/j.jnutbio.2010.03.011. [PMID: 20655719]
  • Tamara Bakuradze, Roman Lang, Thomas Hofmann, Herbert Stiebitz, Gerhard Bytof, Ingo Lantz, Matthias Baum, Gerhard Eisenbrand, Christine Janzowski. Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines. Molecular nutrition & food research. 2010 Dec; 54(12):1734-43. doi: 10.1002/mnfr.201000147. [PMID: 20589861]
  • Malte Rubach, Roman Lang, Carola Skupin, Thomas Hofmann, Veronika Somoza. Activity-guided fractionation to characterize a coffee beverage that effectively down-regulates mechanisms of gastric acid secretion as compared to regular coffee. Journal of agricultural and food chemistry. 2010 Apr; 58(7):4153-61. doi: 10.1021/jf904493f. [PMID: 20235536]
  • Roman Lang, Anika Wahl, Thomas Skurk, Erkan Firat Yagar, Ludger Schmiech, Rudolf Eggers, Hans Hauner, Thomas Hofmann. Development of a hydrophilic liquid interaction chromatography-high-performance liquid chromatography-tandem mass spectrometry based stable isotope dilution analysis and pharmacokinetic studies on bioactive pyridines in human plasma and urine after coffee consumption. Analytical chemistry. 2010 Feb; 82(4):1486-97. doi: 10.1021/ac902616k. [PMID: 20073472]
  • Angélique Durand Dal-Maso, Jérôme Dellacasagrande, Frédéric Legendre, Gérard Tiraby, Casimir Blonski, Pascal Hoffmann. Synthesis and evaluation of new phosphonolipid compounds for gene delivery. European journal of medicinal chemistry. 2008 Aug; 43(8):1758-66. doi: 10.1016/j.ejmech.2007.11.002. [PMID: 18096273]
  • Wolfgang W Huber, Wolfram Parzefall. Modification of N-acetyltransferases and glutathione S-transferases by coffee components: possible relevance for cancer risk. Methods in enzymology. 2005; 401(?):307-41. doi: 10.1016/s0076-6879(05)01020-7. [PMID: 16399395]
  • Daisuke Harada, Makoto Anraku, Hikaru Fukuda, Shinsaku Naito, Kumiko Harada, Ayaka Suenaga, Masaki Otagiri. Kinetic studies of covalent binding between N-acetyl-L-cysteine and human serum albumin through a mixed-disulfide using an N-methylpyridinium polymer-based column. Drug metabolism and pharmacokinetics. 2004 Aug; 19(4):297-302. doi: 10.2133/dmpk.19.297. [PMID: 15499198]
  • Veronika Somoza, Michael Lindenmeier, Elisabeth Wenzel, Oliver Frank, Helmut F Erbersdobler, Thomas Hofmann. Activity-guided identification of a chemopreventive compound in coffee beverage using in vitro and in vivo techniques. Journal of agricultural and food chemistry. 2003 Nov; 51(23):6861-9. doi: 10.1021/jf034750e. [PMID: 14582987]
  • Wolfgang Wrasidlo, Gerhard Gaedicke, Rodney Kiplin Guy, Johanne Renaud, Emmanuel Pitsinos, Kyriaco C Nicolaou, Ralph A Reisfeld, Holger N Lode. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjugate chemistry. 2002 Sep; 13(5):1093-9. doi: 10.1021/bc0200226. [PMID: 12236791]
  • H Watanabe, K Yamasaki, U Kragh-Hansen, S Tanase, K Harada, A Suenaga, M Otagiri. In vitro and in vivo properties of recombinant human serum albumin from Pichia pastoris purified by a method of short processing time. Pharmaceutical research. 2001 Dec; 18(12):1775-81. doi: 10.1023/a:1013391001141. [PMID: 11785700]
  • K Harada, S Uda, M Nakayama, A Sugii. High performance liquid chromatography of 99mTc labeled human serum albumin using an N-methylpyridinium polymer column. Chemical & pharmaceutical bulletin. 1992 Mar; 40(3):697-700. doi: 10.1248/cpb.40.697. [PMID: 1611681]
  • K Nishimura, K Harada, S Masuda, A Sugii. High-performance liquid chromatography of serum albumins on an N-methylpyridinium polymer-based column. Journal of chromatography. 1990 Jan; 525(1):176-82. doi: 10.1016/s0378-4347(00)83391-5. [PMID: 2338438]
  • L A Damani, M S Shaker, P A Crooks, C S Godin, C Nwosu. N-methylation and quaternization of pyridine in vitro by rabbit lung, liver and kidney N-methyltransferases: an S-adenosyl-L-methionine-dependent reaction. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Jul; 16(7):645-50. doi: 10.3109/00498258609043554. [PMID: 3751119]
  • P Masson, A Privat de Garilhe, P Burnat. [Multiple molecular forms of human plasma butyrylcholinesterase. II.-Study of the C1, C3 and C4 components by means of affinity electrophoresis (author's transl)]. Biochimica et biophysica acta. 1982 Mar; 701(3):269-84. doi: 10.1016/0167-4838(82)90230-8. [PMID: 7066331]
  • H MCKENNIS, E R BOWMAN, A HORVATH, J P BEDERKA. METABOLIC RELEASE OF METHYL GROUPS FROM A SERIES OF N-METHYLPYRIDINIUM COMPOUNDS. Nature. 1964 May; 202(?):699-700. doi: 10.1038/202699a0. [PMID: 14190039]
  • F BERGLUND, C E ELWIN, A SUNDWALL. Studies on the renal elimination of N-methylpyridinium-2-aldoxime. Biochemical pharmacology. 1962 Apr; 11(?):383-8. doi: 10.1016/0006-2952(62)90060-6. [PMID: 13867725]