Salutaridine (BioDeep_00000000497)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(1S,9R)-3-hydroxy-4,13-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10,13-pentaen-12-one

化学式: C19H21NO4 (327.1471)
中文名称: 清风藤碱
谱图信息: 最多检出来源 Homo sapiens(plant) 15.37%

分子结构信息

SMILES: CN1CCC23C=C(C(=O)C=C2C1CC4=C3C(=C(C=C4)OC)O)OC
InChI: InChI=1S/C19H21NO4/c1-20-7-6-19-10-16(24-3)14(21)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9-10,13,22H,6-8H2,1-3H3

描述信息

Salutaridine is a morphinane alkaloid from the opium poppy, in which the 5,6,8,14-tetradehydromorphinan-7-one skeleton is substituted at position 4 by a hydroxyl group, positions 3 and 6 by methoxy groups and position N17 by a methyl group. An intermediate in the biosynthesis of narcotic analgesics such as morphine and codeine. It has a role as a metabolite and an anti-HBV agent. It is a conjugate base of a salutaridinium(1+). It derives from a hydride of a morphinan.
Salutaridine is a natural product found in Sarcocapnos saetabensis, Platycapnos saxicola, and other organisms with data available.
A morphinane alkaloid from the opium poppy, in which the 5,6,8,14-tetradehydromorphinan-7-one skeleton is substituted at position 4 by a hydroxyl group, positions 3 and 6 by methoxy groups and position N17 by a methyl group. An intermediate in the biosynthesis of narcotic analgesics such as morphine and codeine.
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids

同义名列表

18 个代谢物同义名

(1S,9R)-3-hydroxy-4,13-dimethoxy-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5,10,13-pentaen-12-one; Morphinan-7-one, 5,6,8,14-tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-; 5,6,8,14-Tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-morphinan-7-one; 4-Hydroxy-3,6-dimethoxy-17-methyl-5,6,8,14-tetradehydromorphinan-7-one; salutaridine, (9alpha,13alpha)-isomer; GVTRUVGBZQJVTF-YJYMSZOUSA-N; salutaridine, (+-)-isomer; SALUTARIDINE, (+)-; SALUTARIDINE [MI]; (+)-salutaridine; UNII-7X10PRH74D; salutaridine; SALUTARIDIN; Floripavine; sinoacutine; 7X10PRH74D; 5,6,8,14-Tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-morphinan-7- one; Salutaridine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

147 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, ARG1, CBR1, EGFR, MAPK8, PIK3CA, PTGS2, PTPN11, SOS1, VEGFA
Peripheral membrane protein 3 CYP1B1, GORASP1, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 CYP1B1, EGFR, PTGS2
Nucleus 7 AIMP2, ARG1, EGFR, JUN, MAPK8, PTPN11, VEGFA
cytosol 7 AIMP2, ARG1, CBR1, MAPK8, PIK3CA, PTPN11, SOS1
dendrite 1 OPRM1
nucleoplasm 3 JUN, MAPK8, PTPN11
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 3 EGFR, OPRM1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Cell projection, axon 1 OPRM1
Cytoplasmic granule 1 ARG1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 MT-CYB, OPRM1
Golgi apparatus membrane 1 GORASP1
Synapse 2 MAPK8, OPRM1
cell junction 1 EGFR
cell surface 3 EGFR, TNF, VEGFA
glutamatergic synapse 2 EGFR, SOS1
Golgi apparatus 3 GORASP1, OPRM1, VEGFA
Golgi membrane 2 EGFR, GORASP1
mitochondrial inner membrane 1 MT-CYB
neuronal cell body 2 SOS1, TNF
Cytoplasm, cytosol 1 AIMP2
endosome 2 EGFR, OPRM1
plasma membrane 5 EGFR, OPRM1, PIK3CA, SOS1, TNF
Membrane 6 AIMP2, CYP1B1, EGFR, MT-CYB, OPRM1, VEGFA
apical plasma membrane 1 EGFR
axon 3 CCK, MAPK8, OPRM1
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 2 CBR1, VWF
endoplasmic reticulum 4 OPRM1, PTGS2, VEGFA, VWF
extracellular space 8 ARG1, CCK, EGFR, IL17A, IL6, TNF, VEGFA, VWF
perinuclear region of cytoplasm 2 EGFR, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 CYP1B1, MT-CYB, PTPN11
protein-containing complex 3 EGFR, PTGS2, PTPN11
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 2 CYP1B1, PTGS2
postsynaptic density 1 SOS1
Single-pass type I membrane protein 1 EGFR
Secreted 5 CCK, IL17A, IL6, VEGFA, VWF
extracellular region 7 ARG1, CCK, IL17A, IL6, TNF, VEGFA, VWF
transcription regulator complex 1 JUN
nuclear membrane 1 EGFR
external side of plasma membrane 2 IL17A, TNF
Extracellular vesicle 1 CBR1
Secreted, extracellular space, extracellular matrix 2 VEGFA, VWF
perikaryon 1 OPRM1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 MT-CYB
Membrane raft 2 EGFR, TNF
focal adhesion 1 EGFR
cis-Golgi network 1 GORASP1
extracellular matrix 2 VEGFA, VWF
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 VWF
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 EGFR
neuron projection 2 OPRM1, PTGS2
chromatin 1 JUN
phagocytic cup 1 TNF
nuclear chromosome 1 JUN
Cell projection, dendrite 1 OPRM1
euchromatin 1 JUN
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
platelet alpha granule 1 VWF
endoplasmic reticulum lumen 2 IL6, PTGS2
platelet alpha granule lumen 2 VEGFA, VWF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 ARG1
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
clathrin-coated endocytic vesicle membrane 1 EGFR
respiratory chain complex III 1 MT-CYB
basal dendrite 1 MAPK8
nucleosome 1 SOS1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 JUN
GTPase complex 1 SOS1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Weibel-Palade body 1 VWF
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform 12]: Cytoplasm 1 OPRM1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Neda Safa, Tomaž Trobec, Darren C Holland, Blazej Slazak, Erik Jacobsson, Jeffrey A Hawkes, Robert Frangež, Kristina Sepčić, Ulf Göransson, Lindon W K Moodie, Luke P Robertson. Spatial Distribution and Stability of Cholinesterase Inhibitory Protoberberine Alkaloids from Papaver setiferum. Journal of natural products. 2022 01; 85(1):215-224. doi: 10.1021/acs.jnatprod.1c00980. [PMID: 34910498]
  • Liyuan Zhu, Jiahua Mei, Chaorui Peng, Yuancui Zhao, Yunkuan Liu, Lili Cui, Kun Zhang, Yunshu Ma. Pharmacokinetics, tissue distribution, plasma protein binding rate and excretion of sinoacutine following intravenous administration in female and male Sprague-Dawley rats. Xenobiotica; the fate of foreign compounds in biological systems. 2022 Jan; 52(1):91-98. doi: 10.1080/00498254.2022.2036390. [PMID: 35099357]
  • Yuancui Zhao, Lili Cui, Xing Xin Yang, Xingqian Sun, Yunkuan Liu, Zixian Yang, Liyuan Zhu, Chaorui Peng, Danye Li, Junfei Cai, Yunshu Ma. Sinoacutine inhibits inflammatory responses to attenuates acute lung injury by regulating NF-κB and JNK signaling pathways. BMC complementary medicine and therapies. 2021 Nov; 21(1):284. doi: 10.1186/s12906-021-03458-0. [PMID: 34801005]
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