Biotin amide (BioDeep_00000004788)
Secondary id: BioDeep_00001869578
human metabolite Endogenous
Metabolite Card
Formula: C10H17N3O2S (243.1041422)
Chinese Names:
Spectrum Hits:
Top Source Homo sapiens(viridiplantae) 14.07%
Molecular Structure
SMILES: C(CCC(=O)N)C[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2
InChI: InChI=1S/C10H17N3O2S/c11-8(14)4-2-1-3-7-9-6(5-16-7)12-10(15)13-9/h6-7,9H,1-5H2,(H2,11,14)(H2,12,13,15)/t6-,7-,9-/m0/s1
Description
The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927). Late-onset multiple carboxylase deficiency (MCD) with biotinidase deficiency is caused by mutation in the biotinidase gene. MCD is an autosomal recessive metabolic disorder characterized primarily by cutaneous and neurologic abnormalities. Symptoms result from the patients inability to reutilize biotin, a necessary nutrient. (OMIM 253260).
The enzyme biotinidase (EC-Number 3.5.1.12 ) is involved in the recycling of the vitamin biotin, cleaving D-biotinylamides and esters, in a reaction including biotin amide and water. (PMID 1719240, 171927)
Synonyms
7 synonym names
5-[(3AS,6R,6ar)-2-hydroxy-1H,3ah,4H,6H,6ah-thieno[3,4-D]imidazol-6-yl]pentanimidate; 5-[(3aR,4R,6aS)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamide; 5-[(3aR,4R,6aS)-2-oxo-hexahydrothieno[3,4-d]imidazolidin-4-yl]pentanamide; SCHEMBL8932330; Biotin amide; Biotinamide; Biotin amide
Cross Reference
15 cross reference id
- ChEBI: CHEBI:16615
- KEGG: C01893
- PubChem: 439597
- PubChem: 83831
- PubChem: 497
- HMDB: HMDB0001458
- Metlin: METLIN6255
- foodb: FDB022636
- chemspider: 388677
- CAS: 6929-42-6
- PMhub: MS000017387
- PubChem: 5006
- NIKKAJI: J2.734.777K
- RefMet: Biotin amide
- KNApSAcK: 16615
Classification Terms
Related Pathways
Reactome(0)
BioCyc(0)
PlantCyc(0)
Biological Process
0 related biological process reactions.
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 organism taxonomy source information
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
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- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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Literature Reference
- D Scott Wilbur, Donald K Hamlin, Ming-Kuan Chyan. Biotin reagents for antibody pretargeting. 7. Investigation of chemically inert biotinidase blocking functionalities for synthetic utility.
Bioconjugate chemistry.
2006 Nov; 17(6):1514-22. doi:
10.1021/bc060084m
. [PMID: 17105231] - Anna Bogusiewicz, Nell I Mock, Donald M Mock. A biotin-protein bond with stability in plasma.
Analytical biochemistry.
2005 Feb; 337(1):98-102. doi:
10.1016/j.ab.2004.10.023
. [PMID: 15649381] - Shiro Okumura, Tetsuyuki Akao, Satoko Yamashita, Tokio Ichimatsu, Kuniyo Inouye. Determination of Biotinylated Proteins as an Index for Purification of Plasma Membrane using Surface Plasmon Resonance-based Optical Biosensor.
Cytotechnology.
2005 Jan; 47(1-3):59-67. doi:
10.1007/s10616-005-3757-4
. [PMID: 19003045] - D S Wilbur, D K Hamlin, M K Chyan, B B Kegley, P M Pathare. Biotin reagents for antibody pretargeting. 5. Additional studies of biotin conjugate design to provide biotinidase stability.
Bioconjugate chemistry.
2001 Jul; 12(4):616-23. doi:
10.1021/bc0100096
. [PMID: 11459467] - A C Buck. Disorders of micturition in bacterial prostatitis.
Proceedings of the Royal Society of Medicine.
1975 Aug; 68(8):508-11. doi:
NULL
. [PMID: 681]