1H-Indol-3-amine (BioDeep_00000004764)
Secondary id: BioDeep_00001869484
human metabolite blood metabolite natural product
代谢物信息卡片
化学式: C8H8N2 (132.0687)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 14.38%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=CN2)N
InChI: InChI=1S/C8H8N2/c9-7-5-10-8-4-2-1-3-6(7)8/h1-5,10H,9H2
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:28626
- KEGG: C01819
- PubChem: 230280
- HMDB: HMDB0244887
- Metlin: METLIN65657
- chemspider: 200560
- CAS: 56480-48-9
- PMhub: MS000017356
- PubChem: 4943
- NIKKAJI: J83.297I
- KNApSAcK: 28626
- LOTUS: LTS0038880
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
10 个相关的物种来源信息
- 4206 - Adoxaceae: LTS0038880
- 2759 - Eukaryota: LTS0038880
- 9606 - Homo sapiens: -
- 3398 - Magnoliopsida: LTS0038880
- 4201 - Sambucus: LTS0038880
- 57203 - Sambucus adnata: 10.1248/CPB.59.1396
- 57203 - Sambucus adnata: LTS0038880
- 35493 - Streptophyta: LTS0038880
- 58023 - Tracheophyta: LTS0038880
- 33090 - Viridiplantae: LTS0038880
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Giuseppe Mannino, Carlo Pernici, Graziella Serio, Carla Gentile, Cinzia M Bertea. Melatonin and Phytomelatonin: Chemistry, Biosynthesis, Metabolism, Distribution and Bioactivity in Plants and Animals-An Overview.
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2018 10; 20(5):577-586. doi:
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Neuroscience.
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The Journal of clinical investigation.
2012 Aug; 122(8):2940-54. doi:
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Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.
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European journal of immunology.
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Psychosomatics.
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Kidney international.
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Experimental gerontology.
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Clinical and vaccine immunology : CVI.
2012 Mar; 19(3):436-42. doi:
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Journal of Alzheimer's disease : JAD.
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PloS one.
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PloS one.
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Archives of physiology and biochemistry.
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Journal of neuroinflammation.
2011 Nov; 8(?):151. doi:
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The FEBS journal.
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Journal of pineal research.
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Gan to kagaku ryoho. Cancer & chemotherapy.
2011 Nov; 38(12):1927-9. doi:
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Immunity & ageing : I & A.
2011 Oct; 8(?):9. doi:
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The Journal of biological chemistry.
2011 Oct; 286(40):34800-8. doi:
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European heart journal.
2011 Oct; 32(20):2573-84. doi:
10.1093/eurheartj/ehq501
. [PMID: 21285075] - Renske A de Jong, Hans W Nijman, H Marike Boezen, Marcel Volmer, Klaske A Ten Hoor, Jasper Krijnen, Ate G J van der Zee, Harry Hollema, Ido P Kema. Serum tryptophan and kynurenine concentrations as parameters for indoleamine 2,3-dioxygenase activity in patients with endometrial, ovarian, and vulvar cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2011 Oct; 21(7):1320-7. doi:
10.1097/igc.0b013e31822017fb
. [PMID: 21720257] - Stephanie W Watts, Samantha Shaw, Robert Burnett, Anne M Dorrance. Indoleamine 2,3-diooxygenase in periaortic fat: mechanisms of inhibition of contraction.
American journal of physiology. Heart and circulatory physiology.
2011 Oct; 301(4):H1236-47. doi:
10.1152/ajpheart.00384.2011
. [PMID: 21841011] - Chantal Mengus, Clémentine Le Magnen, Emanuele Trella, Kawa Yousef, Lukas Bubendorf, Maurizio Provenzano, Alexander Bachmann, Michael Heberer, Giulio C Spagnoli, Stephen Wyler. Elevated levels of circulating IL-7 and IL-15 in patients with early stage prostate cancer.
Journal of translational medicine.
2011 Sep; 9(?):162. doi:
10.1186/1479-5876-9-162
. [PMID: 21943235] - Kenji Nakajima, Tomoya Yamashita, Tomoyuki Kita, Masafumi Takeda, Naoto Sasaki, Kazuyuki Kasahara, Masakazu Shinohara, Yoshiyuki Rikitake, Tatsuro Ishida, Mitsuhiro Yokoyama, Ken-ichi Hirata. Orally administered eicosapentaenoic acid induces rapid regression of atherosclerosis via modulating the phenotype of dendritic cells in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Sep; 31(9):1963-72. doi:
10.1161/atvbaha.111.229443
. [PMID: 21817104] - Yuzo Suzuki, Takafumi Suda, Koushi Yokomura, Masako Suzuki, Michio Fujie, Kazuki Furuhashi, Dai Hahimoto, Noriyuki Enomto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Yutaka Nakano, Hirotoshi Nakamura, Kingo Chida. Serum activity of indoleamine 2,3-dioxygenase predicts prognosis of community-acquired pneumonia.
The Journal of infection.
2011 Sep; 63(3):215-22. doi:
10.1016/j.jinf.2011.07.003
. [PMID: 21784100] - An Kang, Haiping Hao, Xiao Zheng, Yan Liang, Yuan Xie, Tong Xie, Chen Dai, Qijin Zhao, Xiaolan Wu, Lin Xie, Guangji Wang. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy.
Journal of neuroinflammation.
2011 Aug; 8(?):100. doi:
10.1186/1742-2094-8-100
. [PMID: 21843370] - Luiz Gustavo A Chuffa, Fábio R F Seiva, Wagner José Fávaro, Giovana R Teixeira, João P A Amorim, Leonardo O Mendes, Beatriz A Fioruci, Patrícia Fernanda F Pinheiro, Ana Angélica H Fernandes, Janete A A Franci, Flávia K Delella, Marcelo Martinez, Francisco E Martinez. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation.
Reproductive biology and endocrinology : RB&E.
2011 Aug; 9(?):108. doi:
10.1186/1477-7827-9-108
. [PMID: 21810236] - Xin Fu, Marcus A Lawson, Keith W Kelley, Robert Dantzer. HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner.
Journal of neuroinflammation.
2011 Aug; 8(?):88. doi:
10.1186/1742-2094-8-88
. [PMID: 21810259] - Luiz Gustavo A Chuffa, João P A Amorim, Giovana R Teixeira, Leonardo O Mendes, Beatriz A Fioruci, Patrícia F F Pinheiro, Fábio R F Seiva, Ethel L B Novelli, Wilson de Mello Júnior, Marcelo Martinez, Camila C D Almeida-Francia, Francisco E Martinez. Long-term exogenous melatonin treatment modulates overall feed efficiency and protects ovarian tissue against injuries caused by ethanol-induced oxidative stress in adult UChB rats.
Alcoholism, clinical and experimental research.
2011 Aug; 35(8):1498-508. doi:
10.1111/j.1530-0277.2011.01486.x
. [PMID: 21438888] - Shixiu Qiu, Zhengfeng Fang, De Wu, Yan Lin, Lianqiang Che. Tryptophan supplements promote pregnancy success in mice challenged with pseudorabies virus (PRV) by regulating the expression of systemic cytokines, immunoglobulins, PRV-specific protein profiles, and toll-like receptors.
Journal of medicinal food.
2011 Jul; 14(7-8):857-65. doi:
10.1089/jmf.2010.1146
. [PMID: 21663516] - Debra E Lyon, Jeanne M Walter, Angela R Starkweather, Christine M Schubert, Nancy L McCain. Tryptophan degradation in women with breast cancer: a pilot study.
BMC research notes.
2011 May; 4(?):156. doi:
10.1186/1756-0500-4-156
. [PMID: 21615916] - Xiao-Su Zhao, Kai-Yan Liu, Dai-Hong Liu, Lan-Ping Xu, Huan Chen, Xiao-Jun Huang. Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT.
Clinical transplantation.
2011 May; 25(3):E304-11. doi:
10.1111/j.1399-0012.2011.01416.x
. [PMID: 21355883] - Katharina Kurz, Manfred Herold, Christiana Winkler, Werner Klotz, Elisabeth Russe, Dietmar Fuchs. Effects of adalimumab therapy on disease activity and interferon-γ-mediated biochemical pathways in patients with rheumatoid arthritis.
Autoimmunity.
2011 May; 44(3):235-42. doi:
10.3109/08916934.2010.528476
. [PMID: 21434757] - Erika Cecon, Regina P Markus. Relevance of the chronobiological and non-chronobiological actions of melatonin for enhancing therapeutic efficacy in neurodegenerative disorders.
Recent patents on endocrine, metabolic & immune drug discovery.
2011 May; 5(2):91-9. doi:
10.2174/187221411799015381
. [PMID: 22074584] - J Jylhävä, A Haarala, M Kähönen, T Lehtimäki, A Jula, L Moilanen, Y A Kesäniemi, M S Nieminen, M Hurme. Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey.
Clinical and experimental immunology.
2011 May; 164(2):211-7. doi:
10.1111/j.1365-2249.2011.04354.x
. [PMID: 21391986] - Katherine A Jackman, Vanessa H Brait, Yutang Wang, Ghassan J Maghzal, Helen J Ball, Gavin McKenzie, T Michael De Silva, Roland Stocker, Christopher G Sobey. Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 May; 383(5):471-81. doi:
10.1007/s00210-011-0611-4
. [PMID: 21359968] - Michael Maes. Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression.
Progress in neuro-psychopharmacology & biological psychiatry.
2011 Apr; 35(3):664-75. doi:
10.1016/j.pnpbp.2010.06.014
. [PMID: 20599581] - M Maes, B E Leonard, A M Myint, M Kubera, R Verkerk. The new '5-HT' hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression.
Progress in neuro-psychopharmacology & biological psychiatry.
2011 Apr; 35(3):702-21. doi:
10.1016/j.pnpbp.2010.12.017
. [PMID: 21185346] - Madeleine Ingelsten, Alex Karlsson-Parra, Anna Björnson Granqvist, Johan Mölne, Michael Olausson, Börje Haraldsson, Jenny Nyström. Postischemic inflammatory response in an auxiliary liver graft predicts renal graft outcome in sensitized patients.
Transplantation.
2011 Apr; 91(8):888-94. doi:
10.1097/tp.0b013e3182100f19
. [PMID: 21494202] - Valentina Durastanti, Alessandra Lugaresi, Placido Bramanti, Mariapia Amato, Paolo Bellantonio, Giovanna De Luca, Orietta Picconi, Roberta Fantozzi, Laura Locatelli, Annalisa Solda', Edoardo Sessa, Rocco Totaro, Silvia Marino, Valentina Zipoli, Marino Zorzon, Enrico Millefiorini. Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients.
Journal of translational medicine.
2011 Apr; 9(?):42. doi:
10.1186/1479-5876-9-42
. [PMID: 21501517] - Marcel Jenny, Angela Wondrak, Elissaveta Zvetkova, Nguyen Thi Ngoc Tram, Phan Thi Phi Phi, Harald Schennach, Zoran Culig, Florian Ueberall, Dietmar Fuchs. Crinum latifolium leave extracts suppress immune activation cascades in peripheral blood mononuclear cells and proliferation of prostate tumor cells.
Scientia pharmaceutica.
2011 Apr; 79(2):323-35. doi:
10.3797/scipharm.1011-13
. [PMID: 21773069] - Tuula K Outinen, Satu M Mäkelä, Ilpo O Ala-Houhala, Heini S A Huhtala, Mikko Hurme, Daniel H Libraty, Simo S Oja, Ilkka H Pörsti, Jaana T Syrjänen, Antti Vaheri, Jukka T Mustonen. High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica.
Journal of medical virology.
2011 Apr; 83(4):731-7. doi:
10.1002/jmv.22018
. [PMID: 21328391] - Xiong B Wang, Zhong Z Fan, Doina Anton, Annika V Vollenhoven, Zhen H Ni, Xiao F Chen, Ann K Lefvert. CTLA4 is expressed on mature dendritic cells derived from human monocytes and influences their maturation and antigen presentation.
BMC immunology.
2011 Mar; 12(?):21. doi:
10.1186/1471-2172-12-21
. [PMID: 21414236] - Rikke Bæk Sørensen, Tania Køllgaard, Rikke Sick Andersen, Joost Huibert van den Berg, Inge Marie Svane, Per thor Straten, Mads Hald Andersen. Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2.
Cancer research.
2011 Mar; 71(6):2038-44. doi:
10.1158/0008-5472.can-10-3403
. [PMID: 21406395] - Theodoros Eleftheriadis, Vassilios Liakopoulos, Georgia Antoniadi, Ioannis Stefanidis, Grammati Galaktidou. Indoleamine 2,3-dioxygenase is increased in hemodialysis patients and affects immune response to hepatitis B vaccination.
Vaccine.
2011 Mar; 29(12):2242-7. doi:
10.1016/j.vaccine.2011.01.051
. [PMID: 21292009] - Naveen Kumar Singhal, Garima Srivastava, Devendra Kumar Patel, Swatantra Kumar Jain, Mahendra Pratap Singh. Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson's disease phenotype in the mouse.
Journal of pineal research.
2011 Mar; 50(2):97-109. doi:
10.1111/j.1600-079x.2010.00819.x
. [PMID: 20964710] - L G A Chuffa, J P A Amorim, G R Teixeira, L O Mendes, B A Fioruci, P F F Pinheiro, F R F Seiva, E L B Novelli, W Mello Júnior, M Martinez, F E Martinez. Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2011 Mar; 44(3):217-23. doi:
10.1590/s0100-879x2011007500018
. [PMID: 21344135] - Kyoung Ja Kwon, Jung Nam Kim, Min Kyeong Kim, Jongmin Lee, Louis J Ignarro, Hee-Jin Kim, Chan Young Shin, Seol-Heui Han. Melatonin synergistically increases resveratrol-induced heme oxygenase-1 expression through the inhibition of ubiquitin-dependent proteasome pathway: a possible role in neuroprotection.
Journal of pineal research.
2011 Mar; 50(2):110-23. doi:
10.1111/j.1600-079x.2010.00820.x
. [PMID: 21073519] - Barbara Sperner-Unterweger, Gabriele Neurauter, Martin Klieber, Katharina Kurz, Verena Meraner, Alain Zeimet, Dietmar Fuchs. Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers.
Immunobiology.
2011 Mar; 216(3):296-301. doi:
10.1016/j.imbio.2010.07.010
. [PMID: 20822828] - J Drobnik, D Slotwinska, S Olczak, D Tosik, A Pieniazek, K Matczak, A Koceva-Chyla, A Szczepanowska. Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2011 Feb; 62(1):29-35. doi:
"
. [PMID: 21451207] - Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.
Lipids in health and disease.
2011 Jan; 10(?):16. doi:
10.1186/1476-511x-10-16
. [PMID: 21247506] - Jennifer M Babik, Deborah Cohan, Alexander Monto, Dennis J Hartigan-O'Connor, Joseph M McCune. The human fetal immune response to hepatitis C virus exposure in utero.
The Journal of infectious diseases.
2011 Jan; 203(2):196-206. doi:
10.1093/infdis/jiq044
. [PMID: 21288819] - Anne-Laure Dinel, Caroline André, Agnès Aubert, Guillaume Ferreira, Sophie Layé, Nathalie Castanon. Cognitive and emotional alterations are related to hippocampal inflammation in a mouse model of metabolic syndrome.
PloS one.
2011; 6(9):e24325. doi:
10.1371/journal.pone.0024325
. [PMID: 21949705] - Yohei Miyagi, Masahiko Higashiyama, Akira Gochi, Makoto Akaike, Takashi Ishikawa, Takeshi Miura, Nobuhiro Saruki, Etsuro Bando, Hideki Kimura, Fumio Imamura, Masatoshi Moriyama, Ichiro Ikeda, Akihiko Chiba, Fumihiro Oshita, Akira Imaizumi, Hiroshi Yamamoto, Hiroshi Miyano, Katsuhisa Horimoto, Osamu Tochikubo, Toru Mitsushima, Minoru Yamakado, Naoyuki Okamoto. Plasma free amino acid profiling of five types of cancer patients and its application for early detection.
PloS one.
2011; 6(9):e24143. doi:
10.1371/journal.pone.0024143
. [PMID: 21915291] - Daniel Louis Albert van den Hove, Daniel Van den Hove, Sissi Brigitte Jakob, Karla-Gerlinde Schraut, Gunter Kenis, Angelika Gertrud Schmitt, Susanne Kneitz, Claus-Jürgen Scholz, Valentina Wiescholleck, Gabriela Ortega, Jos Prickaerts, Harry Steinbusch, Klaus-Peter Lesch. Differential effects of prenatal stress in 5-Htt deficient mice: towards molecular mechanisms of gene × environment interactions.
PloS one.
2011; 6(8):e22715. doi:
10.1371/journal.pone.0022715
. [PMID: 21857948] - Christabelle J Darcy, Joshua S Davis, Tonia Woodberry, Yvette R McNeil, Dianne P Stephens, Tsin W Yeo, Nicholas M Anstey. An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.
PloS one.
2011; 6(6):e21185. doi:
10.1371/journal.pone.0021185
. [PMID: 21731667] - . [Oxidative stress and possibilities of its correction by melatonin].
Klinicheskaia meditsina.
2011; 89(5):21-5. doi:
. [PMID: 22242261]