ETHYLENE GLYCOL (BioDeep_00000004679)

 

Secondary id: BioDeep_00000014744, BioDeep_00000868854, BioDeep_00001867629

PANOMIX_OTCML-2023


代谢物信息卡片


L-Menthyl 1,2-propylene glycol carbonate

化学式: C2H6O2 (62.0368)
中文名称: 乙二醇, 1,2-乙二醇
谱图信息: 最多检出来源 Homo sapiens(blood) 44.02%

分子结构信息

SMILES: C(CO)O
InChI: InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

描述信息

It is used as a food additive .
A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AD - Osmotically acting laxatives

同义名列表

6 个代谢物同义名

L-Menthyl 1,2-propylene glycol carbonate; ETHYLENE GLYCOL; Ethane-1,2-diol; 1,2-Ethanediol; Ethylene glycol; 1,2-Ethanediol



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

17 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(15)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ALB, ANG, AXIN2, CASP3, CAT, HPGDS, PMP2
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 SPP1
Nucleus 6 ACHE, ALB, ANG, AXIN2, CASP3, PMP2
cytosol 11 ALB, ANG, AVP, AXIN2, CASP3, CAT, GSR, HPGDS, LIPE, MB, PMP2
dendrite 1 AVP
centrosome 2 ALB, AXIN2
nucleoplasm 3 ATP2B1, CASP3, HPGDS
Cell membrane 5 ACHE, ATP2B1, LIPE, SPP1, TNF
Multi-pass membrane protein 2 ATP2B1, SPP1
Synapse 2 ACHE, ATP2B1
cell surface 2 ACHE, TNF
glutamatergic synapse 2 ATP2B1, CASP3
Golgi apparatus 4 ACHE, ALB, ATRN, SPP1
Golgi membrane 1 INS
growth cone 1 ANG
neuromuscular junction 1 ACHE
neuronal cell body 3 ANG, CASP3, TNF
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 LIPE
plasma membrane 6 ACHE, ATP2B1, ATRN, AXIN2, SPP1, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ACHE, ATP2B1, CAT, LIPE
basolateral plasma membrane 1 ATP2B1
caveola 1 LIPE
extracellular exosome 9 ALB, ATP2B1, ATRN, CAT, GSR, LYZ, MB, PMP2, SPP1
endoplasmic reticulum 1 ALB
extracellular space 11 ACHE, ALB, ANG, ATRN, AVP, CCL2, IL6, INS, LYZ, SPP1, TNF
perinuclear region of cytoplasm 2 ACHE, SPP1
mitochondrion 2 CAT, GSR
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 ATP2B1, CAT, HPGDS
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ATRN
Secreted 8 ACHE, ALB, ANG, AVP, CCL2, IL6, INS, SPP1
extracellular region 11 ACHE, ALB, ANG, AVP, CAT, CCL2, IL6, INS, LYZ, SPP1, TNF
[Isoform 2]: Secreted 1 ATRN
mitochondrial matrix 2 CAT, GSR
Extracellular side 1 ACHE
anchoring junction 1 ALB
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 GSR, TNF
actin cytoskeleton 1 ANG
beta-catenin destruction complex 1 AXIN2
nucleolus 1 ANG
sarcoplasm 1 MB
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 1 CAT
basement membrane 2 ACHE, ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 AVP
lateral plasma membrane 1 ATP2B1
ciliary basal body 1 ALB
cell projection 2 ATP2B1, SPP1
phagocytic cup 1 TNF
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
Presynaptic cell membrane 1 ATP2B1
side of membrane 1 ACHE
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, SPP1
platelet alpha granule lumen 1 ALB
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 AVP
clathrin-coated endocytic vesicle membrane 1 AVP
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 ATRN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
Cytoplasm, sarcoplasm 1 MB
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
photoreceptor ribbon synapse 1 ATP2B1
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Acharya Balkrishna, Sandeep Sinha, Moumita Manik, Anupam Pandey, Madhulina Maity, Rishabh Dev, Anurag Varshney. Herbo-Mineral Medicine, Lithom Exhibits Anti-Nephrolithiasis Activity in Rat Model of Hyperoxaluria by Attenuating Calcium Oxalate Crystal Formation and Oxidative Stress. Discovery medicine. 2024 Apr; 36(183):799-815. doi: 10.24976/discov.med.202436183.75. [PMID: 38665028]
  • Mohammad Pourahmadi, Mehran Fathi, Marzieh Rahimipour, Negar Shaterian, Hossein Kargar Jahromi. Hydroalcoholic Extract of Ziziphus Jujuba Leaf to Prevent Ethylene Glycol and Ammonium Chloride-Induced Kidney Stones in Male Rat: Is it Effective?. Urology journal. 2023 May; ?(?):. doi: 10.22037/uj.v20i.7347. [PMID: 37245086]
  • M A Abdelaziz, O M Ahmed, M Abdel-Gabbar, M R Mohammad, S R Ibrahim, M H Abdelzaher, A P Mohideen, S A Moawd, A I Geddawy. The preventive effects of Ulva lactuca aqueous extract, ulvan polysaccharides and atorvastatin on ethylene glycol-induced hyperoxaluria. European review for medical and pharmacological sciences. 2023 Apr; 27(8):3699-3713. doi: 10.26355/eurrev_202304_32169. [PMID: 37140319]
  • Shuai Yuan, Ibrahim Abdel Aziz Ibrahim, Ruimin Ren. Anti-urolithiatic Activity of Daidzin in Ethylene Glycol-Induced Urolithiasis in Rats. Applied biochemistry and biotechnology. 2023 Feb; 195(2):905-918. doi: 10.1007/s12010-022-04124-y. [PMID: 36227501]
  • Lennart Schada von Borzyskowski, Helena Schulz-Mirbach, Mauricio Troncoso Castellanos, Francesca Severi, Paul A Gómez-Coronado, Nicole Paczia, Timo Glatter, Arren Bar-Even, Steffen N Lindner, Tobias J Erb. Implementation of the β-hydroxyaspartate cycle increases growth performance of Pseudomonas putida on the PET monomer ethylene glycol. Metabolic engineering. 2023 Jan; 76(?):97-109. doi: 10.1016/j.ymben.2023.01.011. [PMID: 36731627]
  • Summya Rashid, Maryam Sameti, Mohammed H Alqarni, Fatma M Abdel Bar. In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats. Journal of ethnopharmacology. 2023 Jan; 300(?):115752. doi: 10.1016/j.jep.2022.115752. [PMID: 36174807]
  • Qiqi He, Yangguo Tang, Yuzhuo Li, Fei Wang, Junsheng Bao, Sanjay Gupta. A pilot dynamic analysis of formative factors of nephrolithiasis related to metabolic syndrome: evidence in a rat model. Renal failure. 2022 Dec; 44(1):1134-1143. doi: 10.1080/0886022x.2022.2097922. [PMID: 35837686]
  • Amir Hossein Shiravi, Mohammad Firoozzadeh, Mohammad Passandideh-Fard. A modified exergy evaluation of using carbon-black/water/EG nanofluids as coolant of photovoltaic modules. Environmental science and pollution research international. 2022 Aug; 29(38):57603-57617. doi: 10.1007/s11356-022-19769-9. [PMID: 35355183]
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  • Asmae Elghouizi, Noori Al-Waili, Nawal Elmenyiy, Salma Elfetri, Abderrazak Aboulghazi, Ahmed Al-Waili, Badiaa Lyoussi. Protective effect of bee pollen in acute kidney injury, proteinuria, and crystalluria induced by ethylene glycol ingestion in rats. Scientific reports. 2022 05; 12(1):8351. doi: 10.1038/s41598-022-12086-8. [PMID: 35589738]
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  • Fanny de Landsheere, Franck Saint-Marcoux, Vincent Haufroid, Sylvain Dulaurent, Joseph P Dewulf, Lidvine Boland, Pierre-François Laterre, Philippe Hantson. Unexplained Metabolic Acidosis: Alcoholic Ketoacidosis or Propylene Glycol Toxicity. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2022 04; 18(2):155-158. doi: 10.1007/s13181-022-00876-5. [PMID: 35043364]
  • Nalinthip Lordumrongkiat, Nattida Chotechuang, Mani Iyer Prasanth, Depicha Jindatip, Chakriwong Ma-On, Kamonchanok Chuenwisad, Asada Leelahavanichkul, Tewin Tencomnao, Chanchai Boonla. HydroZitLa inhibits calcium oxalate stone formation in nephrolithic rats and promotes longevity in nematode Caenorhabditis elegans. Scientific reports. 2022 03; 12(1):5102. doi: 10.1038/s41598-022-08316-8. [PMID: 35332173]
  • Jørgen Steen Agerholm, Kirsten Søndergaard Hansen, Hanne Lerche Voogd, Anne Kirstine Havnsøe Krogh. Ethylene glycol toxicosis in milk-fed dairy calves. Acta veterinaria Scandinavica. 2022 Mar; 64(1):7. doi: 10.1186/s13028-022-00626-1. [PMID: 35331297]
  • Emma Kuusela, Mikko J Järvisalo, Tapio Hellman, Panu Uusalo. Mortality and associated risk factors in patients with severe methanol or ethylene glycol poisoning treated with dialysis: a retrospective cohort study. The Journal of international medical research. 2022 Feb; 50(2):3000605221081427. doi: 10.1177/03000605221081427. [PMID: 35209742]
  • Fangmin Zhou, Xingshan Wang. Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response. Disease markers. 2022; 2022(?):1913067. doi: 10.1155/2022/1913067. [PMID: 35968503]
  • Kenneth McMartin, Jeffrey Brent. Analysis of Fomepizole Elimination in Methanol- and Ethylene Glycol-Poisoned Patients. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2022 01; 18(1):19-29. doi: 10.1007/s13181-021-00862-3. [PMID: 34697779]
  • Gabriela Raluca Grigorasi, Ionut Nistor, Mihaela Corlade-Andrei, Luminita Voroneanu, Dimitrie Siriopol, Mugurel Apetrei, Diana Carmen Cimpoesu, Adrian Covic. Outcomes of death and prolonged renal insufficiency in ethylene glycol poisoned patients. International urology and nephrology. 2022 Jan; 54(1):149-155. doi: 10.1007/s11255-021-02837-3. [PMID: 33738645]
  • Xiaoran Li, Siyu Chen, Demei Feng, Yuqiang Fu, Huang Wu, Jianzhong Lu, Junsheng Bao. Calcium-sensing receptor promotes calcium oxalate crystal adhesion and renal injury in Wistar rats by promoting ROS production and subsequent regulation of PS ectropion, OPN, KIM-1, and ERK expression. Renal failure. 2021 Dec; 43(1):465-476. doi: 10.1080/0886022x.2021.1881554. [PMID: 33678127]
  • Ioana Chiulan, Denis Mihaela Panaitescu, Elena-Ruxandra Radu, Sorin Vizireanu, Vera Sătulu, Bogdan Biţă, Raluca Augusta Gabor, Cristian Andi Nicolae, Monica Raduly, Valentin Rădiţoiu. Influence of TEMPO oxidation on the properties of ethylene glycol methyl ether acrylate grafted cellulose sponges. Carbohydrate polymers. 2021 Nov; 272(?):118458. doi: 10.1016/j.carbpol.2021.118458. [PMID: 34420718]
  • Xia Xu, Jiamiao Yan. β-Caryophyllene may attenuate hyperoxaluria-induced kidney dysfunction in rats by regulating stress marker KIM-1/MCP-1 and NF-κB signaling pathway. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22891. doi: 10.1002/jbt.22891. [PMID: 34468068]
  • Zhitao Wei, Yaqian Cui, Lei Tian, Yu Liu, Yang Yu, Xi Jin, Hong Li, Kunjie Wang, Qun Sun. Probiotic Lactiplantibacillus plantarum N-1 could prevent ethylene glycol-induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2021 11; 35(11):e21937. doi: 10.1096/fj.202100887rr. [PMID: 34606628]
  • Kohei Sato, Takahiro Muraoka, Kazushi Kinbara. Supramolecular Transmembrane Ion Channels Formed by Multiblock Amphiphiles. Accounts of chemical research. 2021 10; 54(19):3700-3709. doi: 10.1021/acs.accounts.1c00397. [PMID: 34496564]
  • Yu Lan, Wei Zhu, Xiaolu Duan, Tuo Deng, Shujue Li, Yang Liu, Zhou Yang, Yaoan Wen, Lianming Luo, Shankun Zhao, Jiamin Wang, Zhijian Zhao, Wenqi Wu, Guohua Zeng. Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate. Journal of cellular physiology. 2021 10; 236(10):6824-6835. doi: 10.1002/jcp.30370. [PMID: 33772775]
  • Y Ahmad, S Kissling, C Torrent, J-D Chiche, L Liaudet, Z Ltaief. The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review. European review for medical and pharmacological sciences. 2021 Oct; 25(20):6295-6299. doi: 10.26355/eurrev_202110_26999. [PMID: 34730209]
  • Ayesha Jamshed, Qaiser Jabeen. Prophylactic and curative potential of peppermint oil against calcium oxalate kidney stones. Pakistan journal of pharmaceutical sciences. 2021 Sep; 34(5(Supplementary)):1867-1872. doi: NULL. [PMID: 34836852]
  • Atefeh Azimi, Akram Eidi, Pejman Mortazavi, Ali Haeri Rohani. Protective effect of apigenin on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats. Life sciences. 2021 Aug; 279(?):119641. doi: 10.1016/j.lfs.2021.119641. [PMID: 34043992]
  • Muhammad Afzal, Khalid Saad Alharbi, Sami I Alzarea, Anwarulabedin Mohsin Quazi, Ameeduzzafar Zafar, Dhaval M Patel, Advaita B Patel, Riddhi Trivedi, Imran Kazmi, Fahad A Al-Abaasi. Methanolic extract of Cucumis melo attenuates ethylene glycol-induced nephrolithiasis in Wistar rats. Urolithiasis. 2021 Aug; 49(4):301-308. doi: 10.1007/s00240-021-01263-5. [PMID: 33835227]
  • Emily T Cohen, Mark K Su, Rana Biary, Robert S Hoffman. Distinguishing between toxic alcohol ingestion vs alcoholic ketoacidosis: how can we tell the difference?. Clinical toxicology (Philadelphia, Pa.). 2021 Aug; 59(8):715-720. doi: 10.1080/15563650.2020.1865542. [PMID: 33475435]
  • Tania García-Martínez, Teresa Mogas, Steven F Mullen, Iris Martínez-Rodero, Ramila E Gulieva, Adam Z Higgins. Effect of cryoprotectant concentration on bovine oocyte permeability and comparison of two membrane permeability modelling approaches. Scientific reports. 2021 07; 11(1):15387. doi: 10.1038/s41598-021-94884-0. [PMID: 34321576]
  • Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C Kruegel, John E Pintar, Susruta Majumdar, Jonathan A Javitch, Dalibor Sames. Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy. Nature communications. 2021 06; 12(1):3858. doi: 10.1038/s41467-021-23736-2. [PMID: 34158473]
  • Pouria Mohammadparast Tabas, Hamed Aramjoo, Ali Yousefinia, Mahmoud Zardast, Mohammad Reza Abedini, Mohammad Malekaneh. Therapeutic and Preventive Effects of Aqueous Extract of Date Palm (Phoenix dactylifera L.) Pits on Ethylene Glycol-Induced Kidney Calculi in Rats. Urology journal. 2021 Jun; 18(6):612-617. doi: 10.22037/uj.v18i.6530. [PMID: 34089178]
  • Derya Karabulut, Emin Kaymak, Betül Yalçin, Harun Ulger, Didem Barlak Keti. A different perspective on the filtration barrier after kidney stone formation: An immunohistochemical and biochemical study. Urolithiasis. 2021 Jun; 49(3):201-210. doi: 10.1007/s00240-020-01227-1. [PMID: 33155094]
  • I V Arutyunyan, E Yu Kananykhina, A V Elchaninov, T Kh Fatkhudinov. Influence of Sucrose on the Efficiency of Cryopreservation of Human Umbilical Cord-Derived Multipotent Stromal Cells with the Use of Various Penetrating Cryoprotectants. Bulletin of experimental biology and medicine. 2021 May; 171(1):150-155. doi: 10.1007/s10517-021-05187-3. [PMID: 34050836]
  • Revati Dighade, Ranjit Ingole, Pramod Ingle, Aniket Gade, Sunil Hajare, Maheshkumar Ingawale. Nephroprotective effect of Bryophyllum pinnatum-mediated silver nanoparticles in ethylene glycol-induced urolithiasis in rat. IET nanobiotechnology. 2021 May; 15(3):266-276. doi: 10.1049/nbt2.12011. [PMID: 34694671]
  • Aslam Khan, Samra Bashir, Saeed R Khan. Antiurolithic effects of medicinal plants: results of in vivo studies in rat models of calcium oxalate nephrolithiasis-a systematic review. Urolithiasis. 2021 Apr; 49(2):95-122. doi: 10.1007/s00240-020-01236-0. [PMID: 33484322]
  • Markose Bini, Bhargavan Rajesh, Thekkekara Devassy Babu. Chronic exposure of industrial grade calcium carbide and ethylene glycol alter histological architecture of systemic organs by disrupting redox balance in rat. Journal of basic and clinical physiology and pharmacology. 2021 Mar; 33(3):265-271. doi: 10.1515/jbcpp-2020-0087. [PMID: 33770829]
  • Fatima Zahra Marhoume, Rachida Aboufatima, Younes Zaid, Youness Limami, Raphaël E Duval, Jawad Laadraoui, Anass Belbachir, Abderrahmane Chait, Abdallah Bagri. Antioxidant and Polyphenol-Rich Ethanolic Extract of Rubia tinctorum L. Prevents Urolithiasis in an Ethylene Glycol Experimental Model in Rats. Molecules (Basel, Switzerland). 2021 Feb; 26(4):. doi: 10.3390/molecules26041005. [PMID: 33672875]
  • Irina M Le-Deygen, Oxana E Musatova, Victor N Orlov, Nikolay S Melik-Nubarov, Irina D Grozdova. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media. Biomacromolecules. 2021 02; 22(2):681-689. doi: 10.1021/acs.biomac.0c01504. [PMID: 33325680]
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