Atractylon (BioDeep_00000000463)
代谢物信息卡片
Naphtho(2,3-b)furan, 4,4a,5,6,7,8,8a,9-octahydro-3,8a-dimethyl-5-methylene-, (4aS-trans)-
化学式: C15H20O (216.1514)
中文名称: 苍术酮
谱图信息:
最多检出来源 Mentha canadensis(plant) 91.18%
分子结构信息
SMILES: C1(=C)[C@H]2[C@](CCC1)(Cc1c(C2)c(co1)C)C
InChI: InChI=1S/C15H20O/c1-10-5-4-6-15(3)8-14-12(7-13(10)15)11(2)9-16-14/h9,13H,1,4-8H2,2-3H3
描述信息
Atractylone is a sesquiterpenoid.
Atractylon is a natural product found in Eugenia uniflora, Prumnopitys andina, and other organisms with data available.
同义名列表
13 个代谢物同义名
Naphtho(2,3-b)furan, 4,4a,5,6,7,8,8a,9-octahydro-3,8a-dimethyl-5-methylene-, (4aS-trans)-; Naphtho[2,3-b]furan, 4,4a,5,6,7,8,8a,9-octahydro-3,8a-dimethyl-5-methylene-, (4aS,8aR)-; (4AS,8AR)-3,8A-DIMETHYL-5-METHYLIDENE-4H,4AH,5H,6H,7H,8H,8AH,9H-NAPHTHO[2,3-B]FURAN; (4aS,8aR)-3,8a-Dimethyl-5-methylene-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3-b]furan; (4aS,8aR)-3,8a-dimethyl-5-methylidene-4,4a,6,7,8,9-hexahydrobenzo[f][1]benzofuran; Atractyline(Discontinued)(Sh); Atractyloxide; Atractylone; Atractylon; Atractylol; 4,4aalpha,5,6,7,8,8a,9-Octahydro-3,8alphabeta-dimethyl-5-methylenenaphtho[2,3-b]furan; Atractylone; Atractylon
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:80796
- KEGG: C16919
- PubChem: 3080635
- PubChem: 5321065
- Metlin: METLIN71432
- ChEMBL: CHEMBL486189
- MeSH: atractylon
- ChemIDplus: 0006989215
- KNApSAcK: C00012937
- CAS: 6989-21-5
- PMhub: MS000025484
- PubChem: 96023411
- NIKKAJI: J356.270K
- LOTUS: LTS0094428
- wikidata: Q27149840
- KNApSAcK: 80796
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 64042 - Actaea simplex: 10.1080/14786410500182037
- 41485 - Atractylodes:
- 2547412 - Atractylodes japonica:
- 69405 - Atractylodes koreana: 10.1248/YAKUSHI1947.115.7_543
- 41486 - Atractylodes lancea:
- 119951 - Eugenia uniflora:
- 120634 - Prumnopitys andina: 10.1016/S0031-9422(00)82471-1
- 56903 - Prumnopitys taxifolia: 10.1016/S0031-9422(00)82471-1
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Baohong Song, Wei Wang, Ruipeng Liu, Jinjin Cai, Yuanyuan Jiang, Xuemei Tang, Hongfei Wu, Hui Ao, Lu Chen. Geographic Differentiation of Essential Oil from Rhizome of Cultivated Atractylodes lancea by Using GC-MS and Chemical Pattern Recognition Analysis.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052216. [PMID: 36903461] - Cholil Yun, Zhuowen Zhao, Lin Gu, Zhonghua Zhang, Shengfang Wang, Yutong Shi, Na Miao, Ilbong Ri, Wenjie Wang, Huimei Wang. In vitro production of atractylon and β-eudesmol from Atractylodes chinensis by adventitious root culture.
Applied microbiology and biotechnology.
2022 Nov; 106(21):7027-7037. doi:
10.1007/s00253-022-12194-5. [PMID: 36171502] - Junjun Mao, Xinping Wang, Minghui Yu, Chenkun Sun. Effects of Atractylon on Proliferation and Apoptosis of Intestinal Cancer Cells Through PI3K/AKT/mTOR Signaling Pathway.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 May; 68(5):153-160. doi:
10.14715/cmb/2022.68.5.21. [PMID: 36029491] - Yang Cheng, Jian Ping, Jianjie Chen, Yifei Fu, Hui Zhao, Jiahua Xue. Molecular mechanism of atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing.
Molecular medicine reports.
2022 04; 25(4):. doi:
10.3892/mmr.2022.12628. [PMID: 35119084] - Hongli Li, Fei Wang, Zhenyu Zhou, Xi Jiang, Fei Li, Yaru Feng, Chuhe Liu, Yu Zhang, Shengjie Fan, Xiaojun Wu, Cheng Huang. Atractylon, a novel dopamine 2 receptor agonist, ameliorates Parkinsonian like motor dysfunctions in MPTP-induced mice.
Neurotoxicology.
2022 03; 89(?):121-126. doi:
10.1016/j.neuro.2022.01.010. [PMID: 35104500] - Chunmei Zhai, Jianping Zhao, Amar G Chittiboyina, Yonghai Meng, Mei Wang, Ikhlas A Khan. Newly Generated Atractylon Derivatives in Processed Rhizomes of Atractylodes macrocephala Koidz.
Molecules (Basel, Switzerland).
2020 Dec; 25(24):. doi:
10.3390/molecules25245904. [PMID: 33322214] - Yan Lin, Xiuxiu Liu, Dan Tan, Zhiyan Jiang. Atractylon treatment prevents sleep-disordered breathing-induced cognitive dysfunction by suppression of chronic intermittent hypoxia-induced M1 microglial activation.
Bioscience reports.
2020 06; 40(6):. doi:
10.1042/bsr20192800. [PMID: 32490526] - Na-Ra Han, Phil-Dong Moon, Sun-Young Nam, Ka-Jung Ryu, Myoung-Schook Yoou, Jung-Hye Choi, Sung-Yeoun Hwang, Hyung-Min Kim, Hyun-Ja Jeong. Inhibitory effects of atractylone on mast cell-mediated allergic reactions.
Chemico-biological interactions.
2016 Oct; 258(?):59-68. doi:
10.1016/j.cbi.2016.08.015. [PMID: 27553716] - Hee-Yun Kim, Sun-Young Nam, Sung-Yeoun Hwang, Hyung-Min Kim, Hyun-Ja Jeong. Atractylone, an active constituent of KMP6, attenuates allergic inflammation on allergic rhinitis in vitro and in vivo models.
Molecular immunology.
2016 10; 78(?):121-132. doi:
10.1016/j.molimm.2016.09.007. [PMID: 27636508] - Yang Cheng, Jing-Yin Mai, Tian-Lu Hou, Jian Ping, Jian-Jie Chen. Antiviral activities of atractylon from Atractylodis Rhizoma.
Molecular medicine reports.
2016 Oct; 14(4):3704-10. doi:
10.3892/mmr.2016.5713. [PMID: 27600871] - Lih-Geeng Chen, Yun-Sheng Jan, Po-Wei Tsai, Hisayoshi Norimoto, Seiwa Michihara, Chiaki Murayama, Ching-Chiung Wang. Anti-inflammatory and Antinociceptive Constituents of Atractylodes japonica Koidzumi.
Journal of agricultural and food chemistry.
2016 Mar; 64(11):2254-62. doi:
10.1021/acs.jafc.5b05841. [PMID: 26919689] - Megumi Iwasa, Toshiki Iwasaki, Toshirou Ono, Mitsuo Miyazawa. Chemical composition and major odor-active compounds of essential oil from PINELLIA TUBER (dried rhizome of Pinellia ternata) as crude drug.
Journal of oleo science.
2014; 63(2):127-35. doi:
10.5650/jos.ess13092. [PMID: 24500103] - Wen-Long Zhao, Hui Wiu, Guo-Shun Shan, Tian-Zhu Jia. [Verification of processing theory of "reducing ketone and dryness, and increasing ester and effect" for bran-fried atractylodes].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Oct; 38(20):3493-7. doi:
. [PMID: 24490560] - Suihar Rong, Hai Lin, Ni Gao. [Study on processing technology and processing principles of atractrylodis macrocephalae rhizoma].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2011 Apr; 36(8):1001-3. doi:
". [PMID: 21809571] - Keiko Hasada, Takamitsu Yoshida, Takeshi Yamazaki, Naoki Sugimoto, Tetsuji Nishimura, Akito Nagatsu, Hajime Mizukami. Quantitative determination of atractylon in Atractylodis Rhizoma and Atractylodis Lanceae Rhizoma by 1H-NMR spectroscopy.
Journal of natural medicines.
2010 Apr; 64(2):161-6. doi:
10.1007/s11418-010-0393-x. [PMID: 20165926] - Dan Shou, Shiwen Dai, Jianmin Zhang, Hongyu Li, Zhongming Yu. [Simultaneous determination of atractylenolide III, atractylenolide I and atractylon in Artactylodis macrocephala using microbore liquid chromatography].
Se pu = Chinese journal of chromatography.
2008 Sep; 26(5):637-9. doi:
. [PMID: 19160769] - Zhen Ouyang, Ling Yang, Shu-Lan Su, Xu Feng, Ming Wang. [Fingerprint of volatile oil of Atractylodes lancea by GC-MS].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Sep; 42(9):968-72. doi:
. [PMID: 18050740] - Mitsuo Miyazawa, Jyunichi Kawata. Composition of the essential oil of rootstock from Cimicifuga simplex.
Natural product research.
2006 May; 20(6):542-7. doi:
10.1080/14786410500182037. [PMID: 16835085] - Ching-Chiung Wang, Lih-Geeng Chen, Ling-Ling Yang. Cytotoxic activity of sesquiterpenoids from Atractylodes ovata on leukemia cell lines.
Planta medica.
2002 Mar; 68(3):204-8. doi:
10.1055/s-2002-23144. [PMID: 11914954] - M Resch, A Steigel, Z L Chen, R Bauer. 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.
Journal of natural products.
1998 Mar; 61(3):347-50. doi:
10.1021/np970430b. [PMID: 9544564] - M Kohjyouma, S Nakajima, A Namera, R Shimizu, H Mizukami, H Kohda. Random amplified polymorphic DNA analysis and variation of essential oil components of Atractylodes plants.
Biological & pharmaceutical bulletin.
1997 May; 20(5):502-6. doi:
10.1248/bpb.20.502. [PMID: 9178929] - H Mizukami, R Shimizu, H Kohda, M Kohjyouma, F Kawanishi, N Hiraoka. Restriction fragment length polymorphisms of rDNA and variation of essential oil composition in Atractylodes plants.
Biological & pharmaceutical bulletin.
1996 Apr; 19(4):577-80. doi:
10.1248/bpb.19.577. [PMID: 8860962] - K Satoh, F Nagai, K Ushiyama, I Kano. Specific inhibition of Na+,K(+)-ATPase activity by atractylon, a major component of byaku-jutsu, by interaction with enzyme in the E2 state.
Biochemical pharmacology.
1996 Feb; 51(3):339-43. doi:
10.1016/0006-2952(95)02188-4. [PMID: 8573201] - J M Hwang, T H Tseng, Y S Hsieh, F P Chou, C J Wang, C Y Chu. Inhibitory effect of atractylon on tert-butyl hydroperoxide induced DNA damage and hepatic toxicity in rat hepatocytes.
Archives of toxicology.
1996; 70(10):640-4. doi:
10.1007/s002040050323. [PMID: 8870957] - Y Kiso, M Tohkin, H Hikino. Mechanism of antihepatotoxic activity of atractylon, I: Effect on free radical generation and lipid peroxidation.
Planta medica.
1985 Apr; ?(2):97-100. doi:
10.1055/s-2007-969416. [PMID: 4034742] - Y Kiso, M Tohkin, H Hikino. Antihepatotoxic principles of Atractylodes rhizomes.
Journal of natural products.
1983 Sep; 46(5):651-4. doi:
10.1021/np50029a010. [PMID: 6418860]
