Pantetheine (BioDeep_00000004326)

 

Secondary id: BioDeep_00001868603

human metabolite Endogenous


代谢物信息卡片


2,4-dihydroxy-3,3-dimethyl-N-{2-[(2-sulfanylethyl)carbamoyl]ethyl}butanamide

化学式: C11H22N2O4S (278.13)
中文名称: 泛硫醇
谱图信息: 最多检出来源 Homo sapiens(plant) 14.32%

分子结构信息

SMILES: CC(C)(CO)C(C(=O)NCCC(=O)NCCS)O
InChI: InChI=1S/C11H22N2O4S/c1-11(2,7-14)9(16)10(17)13-4-3-8(15)12-5-6-18/h9,14,16,18H,3-7H2,1-2H3,(H,12,15)(H,13,17)

描述信息

Pantetheine is the mercaptoethyl conjugated amide analogue of pantothenic acid (Vitamin B5). The dimer of this compound, pantethine is more commonly known, and is considered to be a more potent form of vitamin B5 than pantothenic acid. Pantetheine is an intermediate in the production of Coenzyme A by the body. An intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.
Pantetheine is the mercaptoethyl conjugated amide analogue of pantothenic acid (Vitamin B5). The dimer of this compound, pantethine is more commonly known, and is considered to be a more potent form of vitamin B5 than pantothenic acid. Pantetheine is an intermediate in the production of Coenzyme A by the body.
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同义名列表

8 个代谢物同义名

2,4-dihydroxy-3,3-dimethyl-N-{2-[(2-sulfanylethyl)carbamoyl]ethyl}butanamide; Lactobacillus bulgaricus factor; (R)-Pantetheine; D-Pantetheine; pantotheine; Pantetheine; LBF; Pantetheine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

78 个相关的代谢反应过程信息。

Reactome(56)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(21)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 DEPP1, EP300, FASN, PANK1, SAT1, WNT1
Peripheral membrane protein 1 CRAT
Endoplasmic reticulum membrane 2 HMGCR, HSP90B1
Nucleus 5 AURKA, EP300, HSP90B1, PANK1, PPARA
cytosol 10 APOA4, AURKA, CRAT, EP300, FASN, GCLM, HSP90B1, OXSM, PANK1, SAT1
centrosome 1 AURKA
nucleoplasm 3 AURKA, EP300, PPARA
Cell membrane 3 PCP2, SAT1, VNN1
Multi-pass membrane protein 2 HMGCR, SAT1
Synapse 1 APOA4
cell junction 1 PCP2
cell surface 1 WNT1
glutamatergic synapse 1 AURKA
Golgi apparatus 1 FASN
mitochondrial inner membrane 1 CRAT
neuronal cell body 2 PCP2, SAT1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 SAT1
Lysosome 1 IL4I1
acrosomal vesicle 1 IL4I1
plasma membrane 5 FASN, PCP2, SAT1, VNN1, WNT1
Membrane 5 FASN, HMGCR, HSP90B1, SAT1, VNN1
axon 1 SAT1
basolateral plasma membrane 2 AURKA, SAT1
extracellular exosome 5 APOA4, FASN, HSP90B1, SAT1, WNT1
endoplasmic reticulum 3 CRAT, HMGCR, HSP90B1
extracellular space 3 APOA4, TST, WNT1
perinuclear region of cytoplasm 2 AURKA, HSP90B1
mitochondrion 5 CRAT, DEPP1, OXCT1, OXSM, TST
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 1 DEPP1
postsynaptic density 1 AURKA
pronucleus 1 AURKA
Single-pass type I membrane protein 1 PCP2
Secreted 3 APOA4, IL4I1, WNT1
extracellular region 5 APOA4, HSP90B1, IL4I1, VNN1, WNT1
Mitochondrion matrix 1 TST
mitochondrial matrix 3 OXCT1, OXSM, TST
transcription regulator complex 1 EP300
Cell projection, cilium 1 AURKA
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 AURKA
Extracellular vesicle 1 APOA4
Secreted, extracellular space, extracellular matrix 1 WNT1
chylomicron 1 APOA4
high-density lipoprotein particle 1 APOA4
low-density lipoprotein particle 1 APOA4
very-low-density lipoprotein particle 1 APOA4
microtubule cytoskeleton 1 AURKA
nucleolus 1 PANK1
midbody 2 AURKA, HSP90B1
Early endosome 1 APOA4
cell-cell junction 1 PCP2
recycling endosome 1 PANK1
spindle midzone 1 AURKA
Mitochondrion inner membrane 1 CRAT
Matrix side 1 CRAT
Cytoplasm, cytoskeleton, spindle 1 AURKA
focal adhesion 1 HSP90B1
microtubule 1 AURKA
spindle 1 AURKA
Peroxisome 2 CRAT, DEPP1
peroxisomal matrix 1 CRAT
peroxisomal membrane 1 HMGCR
collagen-containing extracellular matrix 2 APOA4, HSP90B1
Cell projection, neuron projection 1 AURKA
neuron projection 1 AURKA
ciliary basal body 1 AURKA
cilium 1 AURKA
chromatin 2 EP300, PPARA
cell periphery 1 PANK1
mitotic spindle 1 AURKA
Chromosome 1 EP300
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 AURKA
Cytoplasm, cytoskeleton, cilium basal body 1 AURKA
centriole 1 AURKA
[Isoform 1]: Mitochondrion 1 CRAT
Nucleus, nucleolus 1 PANK1
Cytoplasmic vesicle, secretory vesicle, acrosome 1 IL4I1
blood microparticle 1 APOA4
sperm midpiece 1 IL4I1
Basolateral cell membrane 2 AURKA, SAT1
Lipid-anchor, GPI-anchor 1 VNN1
Cytoplasm, cytoskeleton, spindle pole 1 AURKA
Melanosome 2 FASN, HSP90B1
[Isoform 2]: Cytoplasm, cytosol 1 PANK1
side of membrane 1 VNN1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
clathrin-coated vesicle 1 PANK1
Golgi lumen 1 WNT1
endoplasmic reticulum lumen 3 APOA4, HSP90B1, WNT1
kinetochore 1 AURKA
endocytic vesicle membrane 1 WNT1
mitotic spindle pole 1 AURKA
Cytoplasmic vesicle, clathrin-coated vesicle 1 PANK1
azurophil granule membrane 1 VNN1
immunological synapse 1 IL4I1
Sarcoplasmic reticulum lumen 1 HSP90B1
axon hillock 1 AURKA
chromosome passenger complex 1 AURKA
germinal vesicle 1 AURKA
meiotic spindle 1 AURKA
spindle pole centrosome 1 AURKA
[Isoform 1]: Nucleus 1 PANK1
histone acetyltransferase complex 1 EP300
protein-DNA complex 1 EP300
external side of apical plasma membrane 1 SAT1
endocytic vesicle lumen 1 HSP90B1
endoplasmic reticulum chaperone complex 1 HSP90B1
[Isoform 2]: Peroxisome 1 CRAT
glutamate-cysteine ligase complex 1 GCLM
glycogen granule 1 FASN


文献列表

  • Xi Meng, Guoqi Yu, Tingyu Luo, Ruiyuan Zhang, Jun Zhang, Yongjie Liu. Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring. Chemosphere. 2023 Sep; 341(?):140120. doi: 10.1016/j.chemosphere.2023.140120. [PMID: 37696479]
  • Xiaodan Fu, Zhemin Liu, Rong Li, Junyi Yin, Han Sun, Changliang Zhu, Qing Kong, Haijin Mou, Shaoping Nie. Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome. Carbohydrate polymers. 2022 Dec; 297(?):120051. doi: 10.1016/j.carbpol.2022.120051. [PMID: 36184152]
  • Xuting Chang, Jie Zhang, Yuwu Jiang, Bufan Yao, Jingmin Wang, Ye Wu. Pilot trial on the efficacy and safety of pantethine in children with pantothenate kinase-associated neurodegeneration: a single-arm, open-label study. Orphanet journal of rare diseases. 2020 09; 15(1):248. doi: 10.1186/s13023-020-01530-5. [PMID: 32928263]
  • Yiming Hu, Hongyu Li, Wen Shi, Huimin Ma. Ratiometric Fluorescent Probe for Imaging of Pantetheinase in Living Cells. Analytical chemistry. 2017 10; 89(20):11107-11112. doi: 10.1021/acs.analchem.7b03303. [PMID: 28911222]
  • Ivano Di Meo, Cristina Colombelli, Balaji Srinivasan, Marianne de Villiers, Jeffrey Hamada, Suh Y Jeong, Rachel Fox, Randall L Woltjer, Pieter G Tepper, Liza L Lahaye, Emanuela Rizzetto, Clara H Harrs, Theo de Boer, Marianne van der Zwaag, Branko Jenko, Alen Čusak, Jerca Pahor, Gregor Kosec, Nicola A Grzeschik, Susan J Hayflick, Valeria Tiranti, Ody C M Sibon. Acetyl-4'-phosphopantetheine is stable in serum and prevents phenotypes induced by pantothenate kinase deficiency. Scientific reports. 2017 09; 7(1):11260. doi: 10.1038/s41598-017-11564-8. [PMID: 28900161]
  • Rostyslav R Panchuk, Nadia R Skorokhyd, Yuliya S Kozak, Liliya V Lehka, Vira V Chumak, Sofya N Omelyanchik, Valery A Gurinovich, Andrey G Moiseenok, Rostyslav S Stoika. Antioxidants selenomethionine and D-pantethine decrease the negative side effects of doxorubicin in NL/Ly lymphoma-bearing mice. Croatian medical journal. 2016 Apr; 57(2):180-92. doi: 10.3325/cmj.2016.57.180. [PMID: 27106359]
  • Manuel van Gijsel-Bonnello, Niyazi Acar, Yves Molino, Lionel Bretillon, Michel Khrestchatisky, Max de Reggi, Bouchra Gharib. Pantethine Alters Lipid Composition and Cholesterol Content of Membrane Rafts, With Down-Regulation of CXCL12-Induced T Cell Migration. Journal of cellular physiology. 2015 Oct; 230(10):2415-25. doi: 10.1002/jcp.24971. [PMID: 25728249]
  • Ya-qin Chen, Shui-ping Zhao, Yu-hong Zhao. Efficacy and tolerability of coenzyme A vs pantethine for the treatment of patients with hyperlipidemia: A randomized, double-blind, multicenter study. Journal of clinical lipidology. 2015 Sep; 9(5):692-7. doi: 10.1016/j.jacl.2015.07.003. [PMID: 26350816]
  • Ariane Roseblade, Frederick Luk, Alison Ung, Mary Bebawy. Targeting microparticle biogenesis: a novel approach to the circumvention of cancer multidrug resistance. Current cancer drug targets. 2015; 15(3):205-14. doi: 10.2174/1568009615666150225121508. [PMID: 25714701]
  • Rossana Canavesi, Silvio Aprile, Elena Varese, Giorgio Grosa. Development and validation of a stability-indicating LC-UV method for the determination of pantethine and its degradation product based on a forced degradation study. Journal of pharmaceutical and biomedical analysis. 2014 Aug; 97(?):141-50. doi: 10.1016/j.jpba.2014.04.025. [PMID: 24863372]
  • Rostyslav Panchuk, Nadia Skorokhyd, Vira Chumak, Lilya Lehka, Sofya Omelyanchik, Valery Gurinovich, Andrey Moiseenok, Petra Heffeter, Walter Berger, Rostyslav Stoika. Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study. Croatian medical journal. 2014 Jun; 55(3):206-17. doi: 10.3325/cmj.2014.55.206. [PMID: 24891279]
  • Ronald J Jenkins, Kyle A Heslip, Jennifer L Meagher, Jeanne A Stuckey, Garry D Dotson. Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis. The Journal of biological chemistry. 2014 May; 289(22):15527-35. doi: 10.1074/jbc.m114.564278. [PMID: 24742680]
  • Dario Brunetti, Sabrina Dusi, Carla Giordano, Costanza Lamperti, Michela Morbin, Valeria Fugnanesi, Silvia Marchet, Gigliola Fagiolari, Ody Sibon, Maurizio Moggio, Giulia d'Amati, Valeria Tiranti. Pantethine treatment is effective in recovering the disease phenotype induced by ketogenic diet in a pantothenate kinase-associated neurodegeneration mouse model. Brain : a journal of neurology. 2014 Jan; 137(Pt 1):57-68. doi: 10.1093/brain/awt325. [PMID: 24316510]
  • Malkanthi Evans, John A Rumberger, Isao Azumano, Joseph J Napolitano, Danielle Citrolo, Toshikazu Kamiya. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vascular health and risk management. 2014; 10(?):89-100. doi: 10.2147/vhrm.s57116. [PMID: 24600231]
  • Patrick A M Jansen, Janna A van Diepen, Bas Ritzen, Patrick L J M Zeeuwen, Ivana Cacciatore, Catia Cornacchia, Ivonne M J J van Vlijmen-Willems, Erik de Heuvel, Peter N M Botman, Richard H Blaauw, Pedro H H Hermkens, Floris P J T Rutjes, Joost Schalkwijk. Discovery of small molecule vanin inhibitors: new tools to study metabolism and disease. ACS chemical biology. 2013 Mar; 8(3):530-4. doi: 10.1021/cb3006424. [PMID: 23270378]
  • Ruth Muchiri, Kevin D Walker. Taxol biosynthesis: tyrocidine synthetase A catalyzes the production of phenylisoserinyl CoA and other amino phenylpropanoyl thioesters. Chemistry & biology. 2012 Jun; 19(6):679-85. doi: 10.1016/j.chembiol.2012.05.007. [PMID: 22726682]
  • Mark Houston. The role of nutraceutical supplements in the treatment of dyslipidemia. Journal of clinical hypertension (Greenwich, Conn.). 2012 Feb; 14(2):121-132. doi: 10.1111/j.1751-7176.2011.00576.x. [PMID: 22277145]
  • S A Sheveleva, S Iu Batishcheva. [Characteristics of collagen's material bifidogenic properties]. Voprosy pitaniia. 2012; 81(1):13-23. doi: NULL. [PMID: 22642160]
  • Theresa A Ramelot, Matthew J Smola, Hsiau-Wei Lee, Colleen Ciccosanti, Keith Hamilton, Thomas B Acton, Rong Xiao, John K Everett, James H Prestegard, Gaetano T Montelione, Michael A Kennedy. Solution structure of 4'-phosphopantetheine - GmACP3 from Geobacter metallireducens: a specialized acyl carrier protein with atypical structural features and a putative role in lipopolysaccharide biosynthesis. Biochemistry. 2011 Mar; 50(9):1442-53. doi: 10.1021/bi101932s. [PMID: 21235239]
  • Eric Lyons, Michael Freeling, Sydney Kustu, William Inwood. Using genomic sequencing for classical genetics in E. coli K12. PloS one. 2011 Feb; 6(2):e16717. doi: 10.1371/journal.pone.0016717. [PMID: 21364914]
  • Yosuke Suzuki, Hiroki Itoh, Tomohide Abe, Fumihiro Nishimura, Yuhki Sato, Masaharu Takeyama. Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers. Biological & pharmaceutical bulletin. 2011; 34(10):1640-3. doi: 10.1248/bpb.34.1640. [PMID: 21963510]
  • ". Pantethine. Monograph. Alternative medicine review : a journal of clinical therapeutic. 2010 Sep; 15(3):279-82. doi: ". [PMID: 21155629]
  • Benfang H Ruan, Derek C Cole, Paul Wu, Amira Quazi, Karen Page, Jill F Wright, Nelson Huang, Joseph R Stock, Karl Nocka, Ann Aulabaugh, Rustem Krykbaev, Lori J Fitz, Neil M Wolfman, Margaret L Fleming. A fluorescent assay suitable for inhibitor screening and vanin tissue quantification. Analytical biochemistry. 2010 Apr; 399(2):284-92. doi: 10.1016/j.ab.2009.12.010. [PMID: 20018163]
  • Schonna R Manning, John W La Claire. Prymnesins: toxic metabolites of the golden alga, Prymnesium parvum Carter (Haptophyta). Marine drugs. 2010 Mar; 8(3):678-704. doi: 10.3390/md8030678. [PMID: 20411121]
  • Timothy L Foley, Michael D Burkart. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Analytical biochemistry. 2009 Nov; 394(1):39-47. doi: 10.1016/j.ab.2009.06.037. [PMID: 19573516]
  • Zoltán Horváth, László Vécsei. Current medical aspects of pantethine. Ideggyogyaszati szemle. 2009 Jul; 62(7-8):220-9. doi: . [PMID: 19685700]
  • Lori I Robins, Allison H Williams, Christian R H Raetz. Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry. 2009 Jul; 48(26):6191-201. doi: 10.1021/bi900629e. [PMID: 19456129]
  • Jeffrey S Moffit, Petra H Koza-Taylor, Ricky D Holland, Michael S Thibodeau, Richard D Beger, Michael P Lawton, José E Manautou. Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibrate. Toxicology and applied pharmacology. 2007 Jul; 222(2):169-79. doi: 10.1016/j.taap.2007.04.008. [PMID: 17585979]
  • Yousang Hwang, Surajit Ganguly, Anthony K Ho, David C Klein, Philip A Cole. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & medicinal chemistry. 2007 Mar; 15(5):2147-55. doi: 10.1016/j.bmc.2006.12.016. [PMID: 17258461]
  • Silvia Rubio, Tony R Larson, Miguel Gonzalez-Guzman, Santiago Alejandro, Ian A Graham, Ramón Serrano, Pedro L Rodriguez. An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment. Plant physiology. 2006 Mar; 140(3):830-43. doi: 10.1104/pp.105.072066. [PMID: 16415216]
  • Joel J Pins, Joseph M Keenan. Dietary and nutraceutical options for managing the hypertriglyceridemic patient. Progress in cardiovascular nursing. 2006; 21(2):89-93. doi: 10.1111/j.0889-7204.2006.01776.x. [PMID: 16760691]
  • Thomas Kupke, Pilar Hernández-Acosta, Francisco A Culiáñez-Macià. 4'-phosphopantetheine and coenzyme A biosynthesis in plants. The Journal of biological chemistry. 2003 Oct; 278(40):38229-37. doi: 10.1074/jbc.m306321200. [PMID: 12860978]
  • Allen C Price, Charles O Rock, Stephen W White. The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae. Journal of bacteriology. 2003 Jul; 185(14):4136-43. doi: 10.1128/jb.185.14.4136-4143.2003. [PMID: 12837788]
  • Pilar Hernández-Acosta, Dietmar G Schmid, Günther Jung, Francisco A Culiáñez-Macià, Thomas Kupke. Molecular characterization of the Arabidopsis thaliana flavoprotein AtHAL3a reveals the general reaction mechanism of 4'-phosphopantothenoylcysteine decarboxylases. The Journal of biological chemistry. 2002 Jun; 277(23):20490-8. doi: 10.1074/jbc.m201557200. [PMID: 11923307]
  • H D Mootz, R Finking, M A Marahiel. 4'-phosphopantetheine transfer in primary and secondary metabolism of Bacillus subtilis. The Journal of biological chemistry. 2001 Oct; 276(40):37289-98. doi: 10.1074/jbc.m103556200. [PMID: 11489886]
  • T Kupke, P Hernandez-Acosta, S Steinbacher, F A Culianez-Macia. Arabidopsis thaliana flavoprotein AtHAL3a catalyzes the decarboxylation of 4'-Phosphopantothenoylcysteine to 4'-phosphopantetheine, a key step in coenzyme A biosynthesis. The Journal of biological chemistry. 2001 Jun; 276(22):19190-6. doi: 10.1074/jbc.m100776200. [PMID: 11279129]
  • J A Broadwater, B G Fox. Spinach holo-acyl carrier protein: overproduction and phosphopantetheinylation in Escherichia coli BL21(DE3), in vitro acylation, and enzymatic desaturation of histidine-tagged isoform I. Protein expression and purification. 1999 Apr; 15(3):314-26. doi: 10.1006/prep.1998.1016. [PMID: 10092491]
  • H Nomura, Y Kimura, O Okamoto, G Shiraishi. Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate hypercholesterolemia. Clinical therapeutics. 1996 May; 18(3):477-82. doi: 10.1016/s0149-2918(96)80028-2. [PMID: 8829023]
  • V S Slyshenkov, M Rakowska, A G Moiseenok, L Wojtczak. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation. Free radical biology & medicine. 1995 Dec; 19(6):767-72. doi: 10.1016/0891-5849(95)00084-b. [PMID: 8582649]
  • J C Hsu, K Tanaka, I Inayama, S Ohtani. Effects of pantethine on lipogenesis and CO2 production in the isolated hepatocytes of the chick (Gallus domesticus). Comparative biochemistry and physiology. Comparative physiology. 1992 Jul; 102(3):569-72. doi: 10.1016/0300-9629(92)90211-8. [PMID: 1359945]
  • A O Kumerova, L Ia Utno, Z E Lipsberga, I Ia Shkestere. [Study of pantothenic acid derivatives as cardiac protectors in a model of experimental ischemia and reperfusion of the isolated heart]. Biulleten' eksperimental'noi biologii i meditsiny. 1992 Apr; 113(4):373-5. doi: ". [PMID: 1391892]
  • K Mimura, S Yukawa. [Hyperlipidemia and drug treatment]. Nihon rinsho. Japanese journal of clinical medicine. 1991 Dec; 49 Suppl(?):781-6. doi: NULL. [PMID: 1808350]
  • L Tonutti, C Taboga, C Noacco. [Comparison of the efficacy of pantethine, acipimox, and bezafibrate on plasma lipids and index of cardiovascular risk in diabetics with dyslipidemia]. Minerva medica. 1991 Oct; 82(10):657-63. doi: NULL. [PMID: 1745376]
  • A P Shkesters, L Ia Utno, M Ia Girgensone. [Regulation of superoxide dismutase activity during deep hypothermia by simultaneous administration of water and lipid soluble antioxidants]. Biulleten' eksperimental'noi biologii i meditsiny. 1991 Jun; 111(6):593-5. doi: ". [PMID: 1893178]
  • O Geiger, H P Spaink, E P Kennedy. Isolation of the Rhizobium leguminosarum NodF nodulation protein: NodF carries a 4'-phosphopantetheine prosthetic group. Journal of bacteriology. 1991 May; 173(9):2872-8. doi: 10.1128/jb.173.9.2872-2878.1991. [PMID: 2019559]
  • M D Fernandez, G K Lamppa. Acyl carrier protein import into chloroplasts. Both the precursor and mature forms are substrates for phosphopantetheine attachment by a soluble chloroplast holo-acyl carrier protein synthase. The Journal of biological chemistry. 1991 Apr; 266(11):7220-6. doi: . [PMID: 1849904]
  • N Hiramatsu, T Kishida, T Hamano, M Natake. Effects of dietary pantethine levels on contents of fatty acids and thiobarbituric acid reactive substances in the liver of rats orally administered varying amounts of autoxidized linoleate. Journal of nutritional science and vitaminology. 1991 Feb; 37(1):73-87. doi: 10.3177/jnsv.37.73. [PMID: 1880633]
  • A O Kumerova, A A Silova, L Ia Utno. [Effect of pantethine on post-heparin lipolytic activity and lipid peroxidation in the myocardium]. Biulleten' eksperimental'noi biologii i meditsiny. 1991 Jan; 111(1):33-5. doi: NULL. [PMID: 2054471]
  • F Coronel, F Tornero, J Torrente, P Naranjo, P De Oleo, M Macia, A Barrientos. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. American journal of nephrology. 1991; 11(1):32-6. doi: 10.1159/000168269. [PMID: 2048576]
  • P Binaghi, G Cellina, G Lo Cicero, F Bruschi, E Porcaro, M Penotti. [Evaluation of the cholesterol-lowering effectiveness of pantethine in women in perimenopausal age]. Minerva medica. 1990 Jun; 81(6):475-9. doi: NULL. [PMID: 2359503]
  • T M Jeitner, J R Oliver. The depletion of plasma prolactin by pantethine in oestrogen-primed hyperprolactinaemic rats. The Journal of endocrinology. 1990 Mar; 124(3):397-402. doi: 10.1677/joe.0.1240397. [PMID: 2332716]
  • M D Fernandez, G K Lamppa. Acyl carrier protein (ACP) import into chloroplasts does not require the phosphopantetheine: evidence for a chloroplast holo-ACP synthase. The Plant cell. 1990 Mar; 2(3):195-206. doi: 10.1105/tpc.2.3.195. [PMID: 1967053]
  • I Nagiel-Ostaszewski, C A Lau-Cam. Protection by pantethine, pantothenic acid and cystamine against carbon tetrachloride-induced hepatotoxicity in the rat. Research communications in chemical pathology and pharmacology. 1990 Feb; 67(2):289-92. doi: . [PMID: 2333416]
  • J G Jaworski, M A Post-Beittenmiller, J B Ohlrogge. Site-directed mutagenesis of the spinach acyl carrier protein-I prosthetic group attachment site. European journal of biochemistry. 1989 Oct; 184(3):603-9. doi: 10.1111/j.1432-1033.1989.tb15056.x. [PMID: 2553397]
  • Z L Lu. [A double-blind clinical trial--the effects of pantethine on serum lipids in patients with hyperlipidemia]. Zhonghua xin xue guan bing za zhi. 1989 Aug; 17(4):221-3. doi: NULL. [PMID: 2697544]
  • S Kobayashi. Investigation of the roles of the substances in serum lipids and their constitutive fatty acids in chronic urticaria. The Journal of dermatology. 1989 Jun; 16(3):196-206. doi: 10.1111/j.1346-8138.1989.tb01249.x. [PMID: 2794222]
  • C Donati, R S Bertieri, G Barbi. [Pantethine, diabetes mellitus and atherosclerosis. Clinical study of 1045 patients]. La Clinica terapeutica. 1989 Mar; 128(6):411-22. doi: ". [PMID: 2524328]
  • H Therisod, E P Kennedy. The function of acyl carrier protein in the synthesis of membrane-derived oligosaccharides does not require its phosphopantetheine prosthetic group. Proceedings of the National Academy of Sciences of the United States of America. 1987 Dec; 84(23):8235-8. doi: 10.1073/pnas.84.23.8235. [PMID: 3479786]
  • C T Wittwer, C P Graves, M A Peterson, E Jorgensen, D E Wilson, J G Thoene, B W Wyse, C T Windham, R G Hansen. Pantethine lipomodulation: evidence for cysteamine mediation in vitro and in vivo. Atherosclerosis. 1987 Nov; 68(1-2):41-9. doi: 10.1016/0021-9150(87)90092-x. [PMID: 3689482]
  • V M Borets, M A Lis, V M Pyrochkin, V P Kishkovich, N D Butkevich. [Therapeutic efficacy of pantothenic acid preparations in ischemic heart disease patients]. Voprosy pitaniia. 1987 Mar; ?(2):15-7. doi: . [PMID: 3590676]
  • D Prisco, P G Rogasi, M Matucci, R Paniccia, R Abbate, G F Gensini, G G Neri Serneri. Effect of oral treatment with pantethine on platelet and plasma phospholipids in IIa hyperlipoproteinemia. Angiology. 1987 Mar; 38(3):241-7. doi: 10.1177/000331978703800307. [PMID: 3551695]
  • J C Hsu, K Tanaka, S Ohtani, C M Collado. Effects of pantethine supplementation to diets with different energy cereals on hepatic lipogenesis of laying hens. Poultry science. 1987 Feb; 66(2):280-8. doi: 10.3382/ps.0660280. [PMID: 3588494]
  • G Cighetti, M Del Puppo, R Paroni, E Fiorica, M Galli Kienle. Pantethine inhibits cholesterol and fatty acid syntheses and stimulates carbon dioxide formation in isolated rat hepatocytes. Journal of lipid research. 1987 Feb; 28(2):152-61. doi: 10.1016/s0022-2275(20)38717-4. [PMID: 3106549]
  • L Arsenio, P Bodria, S Bossi, M Lateana, A Strata. [Clinical use of pantethine by parenteral route in the treatment of hyperlipidemia]. Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma. 1987; 58(5-6):143-52. doi: . [PMID: 2970754]
  • M Eto, K Watanabe, N Chonan, K Ishii. Lowering effect of pantethine on plasma beta-thromboglobulin and lipids in diabetes mellitus. Artery. 1987; 15(1):1-12. doi: NULL. [PMID: 2963604]
  • L I Sushko, V M Sheĭbak, G Z Abakumov, A K Moĭseenok. [Cytochrome P-450-dependent reactions during intensified biosynthesis of coenzyme A in hepatocytes]. Voprosy meditsinskoi khimii. 1986 Jul; 32(4):20-4. doi: . [PMID: 3765494]
  • K Tawara, M Ishihara, H Ogawa, M Tomikawa. Effect of probucol, pantethine and their combinations on serum lipoprotein metabolism and on the incidence of atheromatous lesions in the rabbit. Japanese journal of pharmacology. 1986 Jun; 41(2):211-22. doi: 10.1254/jjp.41.211. [PMID: 3747267]
  • G Cighetti, M Del Puppo, R Paroni, G Galli, M G Kienle. Effects of pantethine on cholesterol synthesis from mevalonate in isolated rat hepatocytes. Atherosclerosis. 1986 Apr; 60(1):67-77. doi: 10.1016/0021-9150(86)90089-4. [PMID: 3707674]
  • C Donati, G Barbi, G Cairo, G F Prati, E Degli Esposti. Pantethine improves the lipid abnormalities of chronic hemodialysis patients: results of a multicenter clinical trial. Clinical nephrology. 1986 Feb; 25(2):70-4. doi: NULL. [PMID: 3516477]
  • L Arsenio, P Bodria, G Magnati, A Strata, R Trovato. Effectiveness of long-term treatment with pantethine in patients with dyslipidemia. Clinical therapeutics. 1986; 8(5):537-45. doi: . [PMID: 3094958]
  • C T Wittwer, B W Wyse, R G Hansen. Enzymatic hydrolysis of pantetheine. Methods in enzymology. 1986; 122(?):36-43. doi: 10.1016/0076-6879(86)22145-x. [PMID: 3517567]
  • F Bergesio, R Ciuti, D Innocenti, G A Galli, V Frizzi. [Use of pantethine in dyslipidemia of chronic uremic patients under dialysis treatment]. Giornale di clinica medica. 1985 Nov; 66(11-12):433-40. doi: NULL. [PMID: 3835087]
  • C T Wittwer, W A Gahl, J D Butler, M Zatz, J G Thoene. Metabolism of pantethine in cystinosis. The Journal of clinical investigation. 1985 Oct; 76(4):1665-72. doi: 10.1172/jci112152. [PMID: 4056044]
  • G B Bon, G Cazzolato, S Zago, P Avogaro. Effects of pantethine on in-vitro peroxidation of low density lipoproteins. Atherosclerosis. 1985 Oct; 57(1):99-106. doi: 10.1016/0021-9150(85)90141-8. [PMID: 4074466]
  • S Reichlin, J A Bollinger-Gruber. Pantethine, a cysteamine precursor, depletes immunoreactive somatostatin and prolactin in the rat. Endocrinology. 1985 Aug; 117(2):492-5. doi: 10.1210/endo-117-2-492. [PMID: 2862009]
  • D Vignola, A Fanini, P Biffignandi. [Effects of D(+)-bis-(N-pantothenyl-amidoethyl)-disulphur on the blood lipid profile and apoproteins A and B levels]. La Clinica terapeutica. 1985 Jun; 113(6):479-83. doi: ". [PMID: 4028653]
  • A Watanabe, N Hobara, M Kobayashi, H Nakatsukasa, H Nagashima. Lowering of blood acetaldehyde but not ethanol concentrations by pantethine following alcohol ingestion: different effects in flushing and nonflushing subjects. Alcoholism, clinical and experimental research. 1985 May; 9(3):272-6. doi: 10.1111/j.1530-0277.1985.tb05748.x. [PMID: 3893199]
  • G Seghieri, G Maffucci, G Toscano, F Santoni, S Tuci, L A De Giorgio. [Effect of pantethine therapy in chronic uremic patients undergoing hemodialysis with type IV hyperlipoproteinemia]. Giornale di clinica medica. 1985 May; 66(5-6):187-92. doi: NULL. [PMID: 4065470]
  • G Picciòla, E Calvi, F Ravenna, P Gentili, S Manzardo, M Riva. Pantetheine and pantethine esters with hypolipidemic nicotinic acid derivatives. Arzneimittel-Forschung. 1985; 35(12):1768-71. doi: . [PMID: 4096728]
  • A Murai, T Miyahara, T Tanaka, Y Sako, N Nishimura, M Kameyama. The effects of pantethine on lipid and lipoprotein abnormalities in survivors of cerebral infarction. Artery. 1985; 12(4):234-43. doi: NULL. [PMID: 3935096]
  • G F Gensini, D Prisco, P G Rogasi, M Matucci, G G Neri Serneri. Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment. International journal of clinical pharmacology research. 1985; 5(5):309-18. doi: NULL. [PMID: 4066081]
  • P Gentili, S Manzardo, M Riva. Pharmacological study of a new hypolipidemic drug of prolonged activity, the tetraester of pantethine with 3-(3-pyridinemethoxycarbonyl)propionic acid. Arzneimittel-Forschung. 1985; 35(12):1772-7. doi: NULL. [PMID: 3841636]
  • P Carrara, L Matturri, M Galbussera, M R Lovati, G Franceschini, C R Sirtori. Pantethine reduces plasma cholesterol and the severity of arterial lesions in experimental hypercholesterolemic rabbits. Atherosclerosis. 1984 Dec; 53(3):255-64. doi: 10.1016/0021-9150(84)90126-6. [PMID: 6442152]
  • S Duprè, R Chiaraluce, M Nardini, C Cannella, G Ricci, D Cavallini. Continuous spectrophotometric assay of pantetheinase activity. Analytical biochemistry. 1984 Oct; 142(1):175-81. doi: 10.1016/0003-2697(84)90534-7. [PMID: 6549111]
  • A Noma, M Kita, T Okamiya. Effect of pantethine on post-heparin plasma lipolytic activities and adipose tissue lipoprotein lipase in rats. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 1984 May; 16(5):233-6. doi: 10.1055/s-2007-1014754. [PMID: 6735346]
  • S Jackowski, C O Rock. Turnover of the 4'-phosphopantetheine prosthetic group of acyl carrier protein. The Journal of biological chemistry. 1984 Feb; 259(3):1891-5. doi: ". [PMID: 6363417]
  • A Gaddi, G C Descovich, G Noseda, C Fragiacomo, L Colombo, A Craveri, G Montanari, C R Sirtori. Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia. Atherosclerosis. 1984 Jan; 50(1):73-83. doi: 10.1016/0021-9150(84)90009-1. [PMID: 6365107]
  • O L Pellett, M L Smith, J G Thoene, J A Schneider, A J Jonas. Renal cell culture using autopsy material from children with cystinosis. In vitro. 1984 Jan; 20(1):53-8. doi: 10.1007/bf02633332. [PMID: 6698573]
  • C T Wittwer, D Burkhard, K Ririe, R Rasmussen, J Brown, B W Wyse, R G Hansen. Purification and properties of a pantetheine-hydrolyzing enzyme from pig kidney. The Journal of biological chemistry. 1983 Aug; 258(16):9733-8. doi: NULL. [PMID: 6885768]
  • S Ranganathan, R L Jackson, J A Harmony. Effect of pantethine on the biosynthesis of cholesterol in human skin fibroblasts. Atherosclerosis. 1982 Sep; 44(3):261-73. doi: 10.1016/0021-9150(82)90002-8. [PMID: 7150392]
  • C Wittwer, B Wyse, R G Hansen. Assay of the enzymatic hydrolysis of pantetheine. Analytical biochemistry. 1982 May; 122(2):213-22. doi: 10.1016/0003-2697(82)90273-1. [PMID: 7114442]
  • M Tomikawa, T Nakayasu, K Tawara, K Y Kameda, Y Abiko. Effect of pantethine on lipoprotein profiles and HDL subfractions in experimentally hypercholesterolemic rabbits. Atherosclerosis. 1982 Feb; 41(2-3):267-77. doi: 10.1016/0021-9150(82)90191-5. [PMID: 7066075]
  • T Watanabe, H Manna, T Suga. Effects of some hypolipidemic drugs on biochemical values and on hepatic peroxisomal enzymes of normolipemic rat. Journal of pharmacobio-dynamics. 1981 Oct; 4(10):743-50. doi: 10.1248/bpb1978.4.743. [PMID: 6798192]
  • G Kajiyama, T Kawamoto, C Fukuhara, I Horiuchi, M Nakagawa, A Miyoshi. The effect of pantethine, a precursor of coenzyme A, on bile acids and lipids in rats fed with a cholesterol diet. Hiroshima journal of medical sciences. 1981 Sep; 30(3):215-20. doi: ". [PMID: 7298371]
  • S Nakayama, K Negishi, K Sakamoto. [Effects of soysterol, pantethine and dl-alpha-tocopheryl nicotinate on hyperlipemia in rats (author's transl)]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 1981 Sep; 78(3):191-202. doi: 10.1254/fpj.78.191. [PMID: 7327448]
  • K Hiramatsu, H Nozaki, S Arimori. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. The Tokai journal of experimental and clinical medicine. 1981 Jan; 6(1):49-57. doi: . [PMID: 7256794]
  • M Shinomiya, N Matsuoka, K Shirai, N Morisaki, N Sasaki, S Murano, Y Saito, A Kumagai. Effect of pantethine on cholesterol ester metabolism in rat arterial wall. Atherosclerosis. 1980 May; 36(1):75-80. doi: 10.1016/0021-9150(80)90200-2. [PMID: 7387778]
  • T Murata, H Oniki, Y Koga, H Tsugi, T Komori. [Study of enhancement of LCAT activity (author's transl)]. Igaku kenkyu. Acta medica. 1980 Apr; 50(3):247-54. doi: NULL. [PMID: 7304100]
  • A Christiansson, A Wieslander. Control of membrane polar lipid composition in Acholeplasma laidlawii a by the extent of saturated fatty acid synthesis. Biochimica et biophysica acta. 1980 Jan; 595(2):189-99. doi: 10.1016/0005-2736(80)90083-8. [PMID: 7352994]