O-TOLUIC ACID (BioDeep_00000416057)

Main id: BioDeep_00000001678

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-Methylbenzoic acid

化学式: C8H8O2 (136.0524)
中文名称: 邻甲基苯甲酸, 邻甲苯甲酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=CC=C1C(=O)O
InChI: InChI=1S/C8H8O2/c1-6-4-2-3-5-7(6)8(9)10/h2-5H,1H3,(H,9,10)

描述信息

A methylbenzoic acid that is benzoic acid substituted by a methyl group at position 2.
o-Toluic acid (2-Methylbenzoic acid) is a benzoic acid?substituted by a?methyl?group at position 2. O-Toluic acid plays a role as a xenobiotic metabolite.

同义名列表

4 个代谢物同义名

2-Methylbenzoic acid; O-TOLUIC ACID; o-Toluate; o-Toluic acid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 DAO, HDC, LIN28A, PMP2, TUBB4B
Peripheral membrane protein 1 DAO
Endoplasmic reticulum membrane 2 HSP90B1, PIEZO1
Nucleus 6 HDC, HSP90B1, LIN28A, LMNA, PMP2, TUBB4B
cytosol 8 DAO, HDC, HSP90B1, IL2RG, LIN28A, LMNA, PMP2, TUBB4B
nucleoplasm 2 IL2RG, LMNA
Cell membrane 6 C5AR1, DAO, IL2RG, ITGAM, PIEZO1, PIEZO2
Multi-pass membrane protein 3 C5AR1, PIEZO1, PIEZO2
cell surface 2 IL2RG, ITGAM
lysosomal membrane 1 GAA
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 DAO
Lysosome 1 GAA
endosome 1 IL2RG
plasma membrane 7 C5AR1, DAO, GAA, IL2RG, ITGAM, PIEZO1, PIEZO2
presynaptic active zone 1 DAO
Membrane 7 GAA, HDC, HSP90B1, IL2RG, ITGAM, PIEZO1, PIEZO2
basolateral plasma membrane 1 C5AR1
extracellular exosome 6 DAO, GAA, HSP90B1, ITGAM, PMP2, TUBB4B
Lysosome membrane 1 GAA
endoplasmic reticulum 3 HSP90B1, IL2RG, PIEZO1
extracellular space 2 DAO, ITGAM
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 HSP90B1, LMNA
bicellular tight junction 1 DAO
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 1 GAA
Single-pass type I membrane protein 2 IL2RG, ITGAM
Secreted 2 DAO, GAA
extracellular region 4 DAO, GAA, HSP90B1, TUBB4B
neuronal cell body membrane 1 PIEZO2
Extracellular side 1 DAO
nuclear membrane 1 LMNA
external side of plasma membrane 2 IL2RG, ITGAM
Extracellular vesicle 1 TUBB4B
cytoplasmic vesicle 1 C5AR1
microtubule cytoskeleton 1 TUBB4B
nucleolus 1 LIN28A
midbody 1 HSP90B1
Cytoplasm, P-body 1 LIN28A
P-body 1 LIN28A
apical part of cell 1 C5AR1
Membrane raft 1 ITGAM
Cytoplasm, cytoskeleton 1 TUBB4B
focal adhesion 1 HSP90B1
microtubule 1 TUBB4B
Peroxisome 1 DAO
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
collagen-containing extracellular matrix 1 HSP90B1
intermediate filament 1 LMNA
nuclear speck 1 LMNA
receptor complex 1 IL2RG
cell projection 1 DAO
mitotic spindle 1 TUBB4B
cytoskeleton 1 TUBB4B
Secreted, extracellular space 1 DAO
Nucleus, nucleolus 1 LIN28A
site of double-strand break 1 LMNA
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
nuclear envelope 1 LMNA
Nucleus envelope 1 LMNA
axonemal microtubule 1 TUBB4B
stereocilium 2 PIEZO1, PIEZO2
Nucleus, nucleoplasm 1 LMNA
specific granule membrane 1 ITGAM
tertiary granule membrane 2 GAA, ITGAM
Melanosome 1 HSP90B1
Cytoplasm, Stress granule 1 LIN28A
cytoplasmic stress granule 1 LIN28A
myelin sheath 1 PMP2
sperm plasma membrane 1 HSP90B1
plasma membrane raft 1 ITGAM
secretory granule membrane 1 C5AR1
endoplasmic reticulum lumen 1 HSP90B1
nuclear matrix 1 LMNA
specific granule lumen 1 DAO
azurophil granule membrane 1 GAA
azurophil granule lumen 1 TUBB4B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 PIEZO1
Nucleus matrix 1 LMNA
nuclear lamina 1 LMNA
Sarcoplasmic reticulum lumen 1 HSP90B1
ficolin-1-rich granule membrane 1 GAA
Rough endoplasmic reticulum 1 LIN28A
integrin complex 1 ITGAM
cuticular plate 2 PIEZO1, PIEZO2
lamellipodium membrane 1 PIEZO1
endocytic vesicle lumen 1 HSP90B1
Nucleus lamina 1 LMNA
[Isoform C]: Nucleus speckle 1 LMNA
lamin filament 1 LMNA
Cell projection, lamellipodium membrane 1 PIEZO1
integrin alphaM-beta2 complex 1 ITGAM
endoplasmic reticulum chaperone complex 1 HSP90B1
autolysosome lumen 1 GAA


文献列表

  • Alex Van Moerkercke, Carlos S Galván-Ampudia, Julian C Verdonk, Michel A Haring, Robert C Schuurink. Regulators of floral fragrance production and their target genes in petunia are not exclusively active in the epidermal cells of petals. Journal of experimental botany. 2012 May; 63(8):3157-71. doi: 10.1093/jxb/ers034. [PMID: 22345641]
  • Antje Klempien, Yasuhisa Kaminaga, Anthony Qualley, Dinesh A Nagegowda, Joshua R Widhalm, Irina Orlova, Ajit Kumar Shasany, Goro Taguchi, Christine M Kish, Bruce R Cooper, John C D'Auria, David Rhodes, Eran Pichersky, Natalia Dudareva. Contribution of CoA ligases to benzenoid biosynthesis in petunia flowers. The Plant cell. 2012 May; 24(5):2015-30. doi: 10.1105/tpc.112.097519. [PMID: 22649270]
  • Inmaculada Andreu, Dmytro Neshchadin, Enrique Rico, Markus Griesser, Abdelouahid Samadi, Isabel M Morera, Georg Gescheidt, Miguel A Miranda. Probing lipid peroxidation by using linoleic acid and benzophenone. Chemistry (Weinheim an der Bergstrasse, Germany). 2011 Aug; 17(36):10089-96. doi: 10.1002/chem.201100983. [PMID: 21793062]
  • Thomas A Colquhoun, Joo Young Kim, Ashlyn E Wedde, Laura A Levin, Kyle C Schmitt, Robert C Schuurink, David G Clark. PhMYB4 fine-tunes the floral volatile signature of Petunia x hybrida through PhC4H. Journal of experimental botany. 2011 Jan; 62(3):1133-43. doi: 10.1093/jxb/erq342. [PMID: 21068208]
  • Sandrine Mathieu, Valeriano Dal Cin, Zhangjun Fei, Hua Li, Peter Bliss, Mark G Taylor, Harry J Klee, Denise M Tieman. Flavour compounds in tomato fruits: identification of loci and potential pathways affecting volatile composition. Journal of experimental botany. 2009; 60(1):325-37. doi: 10.1093/jxb/ern294. [PMID: 19088332]
  • Katherine G Zulak, Aalim M Weljie, Hans J Vogel, Peter J Facchini. Quantitative 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. BMC plant biology. 2008 Jan; 8(?):5. doi: 10.1186/1471-2229-8-5. [PMID: 18211706]
  • Irina Orlova, Amy Marshall-Colón, Jennifer Schnepp, Barbara Wood, Marina Varbanova, Eyal Fridman, Joshua J Blakeslee, Wendy Ann Peer, Angus S Murphy, David Rhodes, Eran Pichersky, Natalia Dudareva. Reduction of benzenoid synthesis in petunia flowers reveals multiple pathways to benzoic acid and enhancement in auxin transport. The Plant cell. 2006 Dec; 18(12):3458-75. doi: 10.1105/tpc.106.046227. [PMID: 17194766]
  • Moran Farhi, Natalia Dudareva, Tania Masci, David Weiss, Alexander Vainstein, Hagai Abeliovich. Synthesis of the food flavoring methyl benzoate by genetically engineered Saccharomyces cerevisiae. Journal of biotechnology. 2006 Apr; 122(3):307-15. doi: 10.1016/j.jbiotec.2005.12.007. [PMID: 16442655]
  • H Moriwaki, Y Tsujimoto, M Shimizu, T Noda, M Warashina, M Tanaka. Influence of sodium benzoate on the metabolism of o-xylene in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 2005 May; 35(5):487-97. doi: 10.1080/00498250500057476. [PMID: 16012080]
  • Beverly A Underwood, Denise M Tieman, Kenichi Shibuya, Richard J Dexter, Holly M Loucas, Andrew J Simkin, Charles A Sims, Eric A Schmelz, Harry J Klee, David G Clark. Ethylene-regulated floral volatile synthesis in petunia corollas. Plant physiology. 2005 May; 138(1):255-66. doi: 10.1104/pp.104.051144. [PMID: 15849311]
  • Florence Negre, Christine M Kish, Jennifer Boatright, Beverly Underwood, Kenichi Shibuya, Conrad Wagner, David G Clark, Natalia Dudareva. Regulation of methylbenzoate emission after pollination in snapdragon and petunia flowers. The Plant cell. 2003 Dec; 15(12):2992-3006. doi: 10.1105/tpc.016766. [PMID: 14630969]
  • Natalia Dudareva, Diane Martin, Christine M Kish, Natalia Kolosova, Nina Gorenstein, Jenny Fäldt, Barbara Miller, Jörg Bohlmann. (E)-beta-ocimene and myrcene synthase genes of floral scent biosynthesis in snapdragon: function and expression of three terpene synthase genes of a new terpene synthase subfamily. The Plant cell. 2003 May; 15(5):1227-41. doi: 10.1105/tpc.011015. [PMID: 12724546]
  • Julian C Verdonk, C H Ric de Vos, Harrie A Verhoeven, Michel A Haring, Arjen J van Tunen, Robert C Schuurink. Regulation of floral scent production in petunia revealed by targeted metabolomics. Phytochemistry. 2003 Mar; 62(6):997-1008. doi: 10.1016/s0031-9422(02)00707-0. [PMID: 12590126]
  • N Kolosova, D Sherman, D Karlson, N Dudareva. Cellular and subcellular localization of S-adenosyl-L-methionine:benzoic acid carboxyl methyltransferase, the enzyme responsible for biosynthesis of the volatile ester methylbenzoate in snapdragon flowers. Plant physiology. 2001 Jul; 126(3):956-64. doi: 10.1104/pp.126.3.956. [PMID: 11457946]
  • M Sakurai, M Ohsako, M Nagano, C Nakamura, O Tsuzuki, M Ichikawa, Y Matsumoto. [Effect of human serum albumin on transport of drugs through human erythrocyte membranes]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 1996 Aug; 116(8):630-8. doi: 10.1248/yakushi1947.116.8_630. [PMID: 8831264]
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