L-Gulonolactone (BioDeep_00000415738)

Main id: BioDeep_00000003575

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


L-Gulonic g-lactone

化学式: C6H10O6 (178.0477)
中文名称: L-古洛糖酸-gamma-内酯, L-古洛糖酸-γ-内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C1C(C(C(=O)O1)O)O)O)O
InChI: InChI=1S/C6H10O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2-5,7-10H,1H2

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
L-Gulono-1,4-lactone is a substrate of L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic (Vatamin) C. In other words, L-Gulono-1,4-lactone is a direct precursor of vitamin C in animals, in plants and in some protists.

同义名列表

4 个代谢物同义名

L-Gulonic g-lactone; L-Gulonolactone; L-Gulono-1,4-lactone; L-Gulono-1,4-lactone



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(2)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CAT, DBH, HPGDS, ITPR3, MIOX, RGN, SLC23A2, XDH
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 1 RGN
cytosol 10 AKR1A1, CAT, GCLM, GPT, GSR, GSS, HPGDS, MIOX, SLC2A1, XDH
nucleoplasm 3 ATP2B1, HPGDS, ITPR3
Cell membrane 4 ATP2B1, SLC23A2, SLC2A1, TNF
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 ATP2B1, ITPR3, SLC23A2, SLC2A1
Synapse 3 AKR1A1, ATP2B1, DBH
cell surface 2 TF, TNF
glutamatergic synapse 1 ATP2B1
Golgi membrane 2 INS, SLC2A1
neuronal cell body 2 ITPR3, TNF
presynaptic membrane 1 ATP2B1
sarcolemma 1 SLC2A1
Cytoplasm, cytosol 1 AKR1A1
Presynapse 1 SLC2A1
plasma membrane 7 ATP2B1, ITPR3, NPR1, SLC23A2, SLC2A1, TF, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ATP2B1, CAT, DBH, ITPR3, NPR1, SLC23A2, SLC2A1
apical plasma membrane 4 AKR1A1, SLC23A2, SLC2A1, TF
basolateral plasma membrane 3 ATP2B1, SLC23A2, SLC2A1
brush border 1 ITPR3
caveola 1 SLC2A1
extracellular exosome 8 AKR1A1, ATP2B1, CAT, GPT, GSR, GSS, SLC2A1, TF
Lumenal side 1 HSD17B6
endoplasmic reticulum 3 DBH, HSD17B6, ITPR3
extracellular space 6 AKR1A1, DBH, INS, TF, TNF, XDH
perinuclear region of cytoplasm 1 TF
intercalated disc 1 SLC2A1
mitochondrion 2 CAT, GSR
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 5 ATP2B1, CAT, DBH, HPGDS, HSD17B6
Microsome membrane 1 HSD17B6
Secreted 3 DBH, INS, TF
extracellular region 5 CAT, DBH, INS, TF, TNF
basal part of cell 1 TF
mitochondrial matrix 2 CAT, GSR
centriolar satellite 1 DBH
photoreceptor inner segment 1 SLC2A1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
external side of plasma membrane 2 GSR, TNF
Z disc 1 SLC2A1
cytoplasmic vesicle 1 TF
nucleolus 1 ITPR3
midbody 1 SLC2A1
Early endosome 1 TF
apical part of cell 1 ITPR3
clathrin-coated pit 1 TF
recycling endosome 2 TF, TNF
Single-pass type II membrane protein 2 DBH, TNF
vesicle 1 TF
Apical cell membrane 1 AKR1A1
Membrane raft 1 TNF
focal adhesion 1 CAT
Peroxisome 2 CAT, XDH
sarcoplasmic reticulum 2 ITPR3, XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 ATP2B1
nuclear outer membrane 1 ITPR3
Late endosome 1 TF
receptor complex 2 ITPR3, NPR1
cell projection 1 ATP2B1
phagocytic cup 1 TNF
blood microparticle 2 SLC2A1, TF
Basolateral cell membrane 1 ATP2B1
endosome lumen 1 INS
female germ cell nucleus 1 SLC2A1
Melanosome 1 SLC2A1
Presynaptic cell membrane 1 ATP2B1
basal plasma membrane 2 SLC23A2, TF
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 4 CAT, DBH, INS, TF
HFE-transferrin receptor complex 1 TF
secretory granule membrane 2 DBH, ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, TF
cortical actin cytoskeleton 1 SLC2A1
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 TF
platelet dense tubular network membrane 1 ITPR3
female pronucleus 1 SLC2A1
Cytoplasmic vesicle, secretory vesicle membrane 2 DBH, ITPR3
vesicle coat 1 TF
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
transport vesicle membrane 2 DBH, ITPR3
catalase complex 1 CAT
inclusion body 1 MIOX
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
photoreceptor ribbon synapse 1 ATP2B1
glucose transporter complex 1 SLC2A1
ANPR-A receptor complex 1 NPR1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
glutamate-cysteine ligase complex 1 GCLM
dense body 1 TF
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hongbin Tu, Yu Wang, Hongyan Li, Lauren R Brinster, Mark Levine. Chemical Transport Knockout for Oxidized Vitamin C, Dehydroascorbic Acid, Reveals Its Functions in vivo. EBioMedicine. 2017 Sep; 23(?):125-135. doi: 10.1016/j.ebiom.2017.08.017. [PMID: 28851583]
  • Yi Li, Chang-Xin Shi, Karen L Mossman, Jack Rosenfeld, Yong Chool Boo, Herb E Schellhorn. Restoration of vitamin C synthesis in transgenic Gulo-/- mice by helper-dependent adenovirus-based expression of gulonolactone oxidase. Human gene therapy. 2008 Dec; 19(12):1349-58. doi: 10.1089/hum.2008.0106. [PMID: 18764764]
  • F H Kratzer, H J Almquist, P Vohra. Effect of diet on growth and plasma ascorbic acid in chicks. Poultry science. 1996 Jan; 75(1):82-9. doi: 10.3382/ps.0750082. [PMID: 8650116]
  • . . . . doi: . [PMID: 7138847]