Acetylphosphate (BioDeep_00000004138)

 

Secondary id: BioDeep_00000405448

natural product human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


Acetic acid, monoanhydride with phosphoric acid

化学式: C2H5O5P (139.9875)
中文名称: 乙酰磷酸
谱图信息: 最多检出来源 Homo sapiens(otcml) 38.58%

分子结构信息

SMILES: CC(=O)OP(=O)(O)O
InChI: InChI=1S/C2H5O5P/c1-2(3)7-8(4,5)6/h1H3,(H2,4,5,6)

描述信息

Acetylphosphate, also known as acetyl-p, belongs to the class of organic compounds known as acyl monophosphates. These are organic compounds containing a monophosphate linked to an acyl group. They have the general structure R-CO-P(O)(O)OH, R=H or organyl. Since acetylphosphate synthesis is known to depend on cholinesterase activity, pseudocholinesterase was assumed to participate to a small extent in acetylphosphate synthesis by cancerous serum. It is also an intermediate in pyruvate metabolism. Acetylphosphate is a drug. Acetylphosphate exists in all living organisms, ranging from bacteria to humans. Acetylphosphate can be converted into acetic acid; which is mediated by the enzyme acylphosphatase-1. It is generated from pyruvate and the formation is catalyzed by pyruvate oxidase (EC:1.2.3.3). In humans, acetylphosphate is involved in the metabolic disorder called the pyruvate dehydrogenase complex deficiency pathway. It is generated from sulfoacetaldehyde, converted to acetyl-CoA and acetate via phosphate acetyltransferase (EC:2.3.1.8) and acetate kinase (EC:2.7.2.1) respectively. Acetylphosphate or actyl phosphate is a compound involved in taurine and hypotaurine metabolism as well as pyruvate metabolism. Cancerous serum produced 37\\% less acetylphosphate than normal serum.
Cancerous serum produced 37\\% less acetylphosphate than normal serum. Since acetylphosphate synthesis is known to depend on cholinesterase activity, pseudocholinesterase was assumed to participate to a small extent in acetylphosphate synthesis by cancerous serum.( Rev. sci. Med., Acad. rep. populaire Roumaine (1960), 5 7-10) [HMDB]

同义名列表

12 个代谢物同义名

Acetic acid, monoanhydride with phosphoric acid; Acetate, monoanhydride with phosphate; Lithium potassium Acetyl phosphate; acetyl dihydrogen phosphate; Monoacetyl phosphoric acid; (acetyloxy)phosphonic acid; Acetyl phosphoric acid; Acetylphosphoric acid; Monoacetyl phosphate; Acetyl phosphate; acetylphosphate; Acetyl-p



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

24 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(23)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 FH, G6PD, GAPDH, GCK, GLI3, LARS1, PKM
Peripheral membrane protein 2 G6PD, GCK
Endoplasmic reticulum membrane 1 TKT
Nucleus 7 CS, FH, GAPDH, GCK, GLI3, PATZ1, PKM
cytosol 10 CLPX, FH, G6PD, GAPDH, GCK, GLI3, LARS1, PHKA2, PKM, TKT
nuclear body 2 LARS1, TKT
nucleoplasm 6 ATP2B1, CLPX, GCK, GLI3, PATZ1, TKT
Cell membrane 3 ATP2B1, PHKA2, TKT
Lipid-anchor 1 PHKA2
Cytoplasmic side 1 PHKA2
Multi-pass membrane protein 1 ATP2B1
Golgi apparatus membrane 1 GCK
Synapse 1 ATP2B1
cell surface 1 TNR
glutamatergic synapse 2 ATP2B1, TNR
Golgi membrane 1 GCK
mitochondrial inner membrane 1 CLPX
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 G6PD, GAPDH
Lysosome 1 LARS1
plasma membrane 5 ATP2B1, GAPDH, MUC7, PHKA2, TKT
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, CS, G6PD, GAPDH
apical plasma membrane 1 TKT
basolateral plasma membrane 2 ATP2B1, GCK
extracellular exosome 8 ATP2B1, CS, FH, G6PD, GAPDH, MUC7, PKM, TKT
endoplasmic reticulum 1 LARS1
extracellular space 1 TNR
perinuclear region of cytoplasm 1 GAPDH
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 5 CLPX, CS, FH, GCK, PKM
intracellular membrane-bounded organelle 4 ATP2B1, G6PD, GAPDH, GLI3
Single-pass type I membrane protein 1 TKT
Secreted 1 MUC7
extracellular region 2 PKM, TNR
cytoplasmic side of plasma membrane 1 G6PD
Mitochondrion matrix 1 CS
mitochondrial matrix 3 CLPX, CS, FH
centriolar satellite 1 G6PD
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 GAPDH
Extracellular vesicle 1 PKM
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 TKT
microtubule cytoskeleton 1 GAPDH
nucleolus 1 GLI3
vesicle 3 GAPDH, PKM, TKT
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 1 TNR
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 1 TKT
mitochondrial nucleoid 1 CLPX
Peroxisome 1 TKT
collagen-containing extracellular matrix 2 PKM, TNR
lateral plasma membrane 1 ATP2B1
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
receptor complex 1 TKT
ciliary base 1 GLI3
cilium 2 GLI3, PKM
cell projection 1 ATP2B1
Chromosome 1 FH
cytoskeleton 1 GAPDH
Basolateral cell membrane 2 ATP2B1, GCK
site of double-strand break 1 FH
Endomembrane system 1 LARS1
Lipid droplet 1 GAPDH
Presynaptic cell membrane 1 ATP2B1
ficolin-1-rich granule lumen 1 PKM
secretory granule lumen 1 PKM
Golgi lumen 1 MUC7
transcription repressor complex 1 GLI3
male germ cell nucleus 1 PATZ1
immunological synapse 1 ATP2B1
perineuronal net 1 TNR
ribonucleoprotein complex 1 GAPDH
aminoacyl-tRNA synthetase multienzyme complex 1 LARS1
Rough endoplasmic reticulum 1 PKM
GAIT complex 1 GAPDH
endopeptidase Clp complex 1 CLPX
mitochondrial endopeptidase Clp complex 1 CLPX
[Isoform Mitochondrial]: Mitochondrion 1 FH
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 FH
GLI-SUFU complex 1 GLI3
photoreceptor ribbon synapse 1 ATP2B1
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
phosphorylase kinase complex 1 PHKA2
tenascin complex 1 TNR


文献列表

  • Rebeca Serrano, David Martin-Hidalgo, Jon Bilbao, Ganeko Bernardo-Seisdedos, Oscar Millet, Luis J Garcia-Marin, Maria Julia Bragado. Quantitative Analysis of the Human Semen Phosphorometabolome by 31P-NMR. International journal of molecular sciences. 2024 Jan; 25(3):. doi: 10.3390/ijms25031682. [PMID: 38338962]
  • Meaghan A Valliere, Tyler P Korman, Mark A Arbing, James U Bowie. A bio-inspired cell-free system for cannabinoid production from inexpensive inputs. Nature chemical biology. 2020 12; 16(12):1427-1433. doi: 10.1038/s41589-020-0631-9. [PMID: 32839605]
  • Sabrina Kaiser, Lisa Marie Hoppstädter, Kevser Bilici, Kevin Heieck, Reinhold Brückner. Control of acetyl phosphate-dependent phosphorylation of the response regulator CiaR by acetate kinase in Streptococcus pneumoniae. Microbiology (Reading, England). 2020 04; 166(4):411-421. doi: 10.1099/mic.0.000894. [PMID: 32553069]
  • Jie Ren, Yu Sang, Ran Qin, Yang Su, Zhongli Cui, Zhiguo Mang, Hao Li, Shaoyong Lu, Jian Zhang, Sen Cheng, Xiaoyun Liu, Jixi Li, Jie Lu, Wenjuan Wu, Guo-Ping Zhao, Feng Shao, Yu-Feng Yao. Metabolic intermediate acetyl phosphate modulates bacterial virulence via acetylation. Emerging microbes & infections. 2019; 8(1):55-69. doi: 10.1080/22221751.2018.1558963. [PMID: 30866760]
  • Qiufen Zhang, Aiping Zhou, Shuxian Li, Jinjing Ni, Jing Tao, Jie Lu, Baoshan Wan, Shuai Li, Jian Zhang, Shimin Zhao, Guo-Ping Zhao, Feng Shao, Yu-Feng Yao. Reversible lysine acetylation is involved in DNA replication initiation by regulating activities of initiator DnaA in Escherichia coli. Scientific reports. 2016 08; 6(?):30837. doi: 10.1038/srep30837. [PMID: 27484197]
  • Crystal L Richards, Kevin A Lawrence, Hua Su, Youyun Yang, X Frank Yang, Daniel P Dulebohn, Frank C Gherardini. Acetyl-Phosphate Is Not a Global Regulatory Bridge between Virulence and Central Metabolism in Borrelia burgdorferi. PloS one. 2015; 10(12):e0144472. doi: 10.1371/journal.pone.0144472. [PMID: 26681317]
  • Arijit Kumar Das, Vijjamarri Anil Kumar, Ritesh Rajesh Sevalkar, Roohi Bansal, Dibyendu Sarkar. Unique N-terminal arm of Mycobacterium tuberculosis PhoP protein plays an unusual role in its regulatory function. The Journal of biological chemistry. 2013 Oct; 288(40):29182-92. doi: 10.1074/jbc.m113.499905. [PMID: 23963455]
  • Guennaëlle Dieppois, Véréna Ducret, Olivier Caille, Karl Perron. The transcriptional regulator CzcR modulates antibiotic resistance and quorum sensing in Pseudomonas aeruginosa. PloS one. 2012; 7(5):e38148. doi: 10.1371/journal.pone.0038148. [PMID: 22666466]
  • Michael Kube, Jelena Mitrovic, Bojan Duduk, Ralf Rabus, Erich Seemüller. Current view on phytoplasma genomes and encoded metabolism. TheScientificWorldJournal. 2012; 2012(?):185942. doi: 10.1100/2012/185942. [PMID: 22550465]
  • Yong Nie, Yue-Qin Tang, Yan Li, Chang-Qiao Chi, Man Cai, Xiao-Lei Wu. The genome sequence of Polymorphum gilvum SL003B-26A1(T) reveals its genetic basis for crude oil degradation and adaptation to the saline soil. PloS one. 2012; 7(2):e31261. doi: 10.1371/journal.pone.0031261. [PMID: 22359583]
  • Mauricio Henriques Pontes, Kari Lyn Smith, Linda De Vooght, Jan Van Den Abbeele, Colin Dale. Attenuation of the sensing capabilities of PhoQ in transition to obligate insect-bacterial association. PLoS genetics. 2011 Nov; 7(11):e1002349. doi: 10.1371/journal.pgen.1002349. [PMID: 22072980]
  • Alain Perret, Christophe Lechaplais, Sabine Tricot, Nadia Perchat, Carine Vergne, Christine Pellé, Karine Bastard, Annett Kreimeyer, David Vallenet, Anne Zaparucha, Jean Weissenbach, Marcel Salanoubat. A novel acyl-CoA beta-transaminase characterized from a metagenome. PloS one. 2011; 6(8):e22918. doi: 10.1371/journal.pone.0022918. [PMID: 21826218]
  • Marc Tessera. Origin of evolution versus origin of life: a shift of paradigm. International journal of molecular sciences. 2011; 12(6):3445-58. doi: 10.3390/ijms12063445. [PMID: 21747687]
  • Arjun Sengupta, Angika Basant, Soumita Ghosh, Shobhona Sharma, Haripalsingh M Sonawat. Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria. Journal of parasitology research. 2011; 2011(?):901854. doi: 10.1155/2011/901854. [PMID: 21772982]
  • Erin C Hagan, Amanda L Lloyd, David A Rasko, Gary J Faerber, Harry L T Mobley. Escherichia coli global gene expression in urine from women with urinary tract infection. PLoS pathogens. 2010 Nov; 6(11):e1001187. doi: 10.1371/journal.ppat.1001187. [PMID: 21085611]
  • Heidi C Vebø, Margrete Solheim, Lars Snipen, Ingolf F Nes, Dag A Brede. Comparative genomic analysis of pathogenic and probiotic Enterococcus faecalis isolates, and their transcriptional responses to growth in human urine. PloS one. 2010 Aug; 5(8):e12489. doi: 10.1371/journal.pone.0012489. [PMID: 20824220]
  • Xristo Zárate, David C Henderson, Keenan C Phillips, April D Lake, David W Galbraith. Development of high-yield autofluorescent protein microarrays using hybrid cell-free expression with combined Escherichia coli S30 and wheat germ extracts. Proteome science. 2010 Jun; 8(?):32. doi: 10.1186/1477-5956-8-32. [PMID: 20546627]
  • Willem van Schaik, Janetta Top, David R Riley, Jos Boekhorst, Joyce E P Vrijenhoek, Claudia M E Schapendonk, Antoni P A Hendrickx, Isaäc J Nijman, Marc J M Bonten, Hervé Tettelin, Rob J L Willems. Pyrosequencing-based comparative genome analysis of the nosocomial pathogen Enterococcus faecium and identification of a large transferable pathogenicity island. BMC genomics. 2010 Apr; 11(?):239. doi: 10.1186/1471-2164-11-239. [PMID: 20398277]
  • Maria A Trainer, David Capstick, Alicja Zachertowska, Kathy N Lam, Scott R D Clark, Trevor C Charles. Identification and characterization of the intracellular poly-3-hydroxybutyrate depolymerase enzyme PhaZ of Sinorhizobium meliloti. BMC microbiology. 2010 Mar; 10(?):92. doi: 10.1186/1471-2180-10-92. [PMID: 20346169]
  • Pranav R Prabhu, André O Hudson. Identification and Partial Characterization of an L-Tyrosine Aminotransferase (TAT) from Arabidopsis thaliana. Biochemistry research international. 2010; 2010(?):549572. doi: 10.1155/2010/549572. [PMID: 21188077]
  • Sujith Puthiyaveetil, John F Allen. Chloroplast two-component systems: evolution of the link between photosynthesis and gene expression. Proceedings. Biological sciences. 2009 Jun; 276(1665):2133-45. doi: 10.1098/rspb.2008.1426. [PMID: 19324807]
  • Won Suk An, Seong-Eun Kim, Ki-Hyun Kim, Hae-Rahn Bae, Seo-Hee Rha. Associations between oxidized LDL to LDL ratio, HDL and vascular calcification in the feet of hemodialysis patients. Journal of Korean medical science. 2009 Jan; 24 Suppl(?):S115-20. doi: 10.3346/jkms.2009.24.s1.s115. [PMID: 19194540]
  • T A Hirani, I Suzuki, N Murata, H Hayashi, J J Eaton-Rye. Characterization of a two-component signal transduction system involved in the induction of alkaline phosphatase under phosphate-limiting conditions in Synechocystis sp. PCC 6803. Plant molecular biology. 2001 Jan; 45(2):133-44. doi: 10.1023/a:1006425214168. [PMID: 11289505]
  • T Tsuda, S Kaya, T Yokoyama, Y Hayashi, K Taniguchi. ATP and acetyl phosphate induces molecular events near the ATP binding site and the membrane domain of Na+,K+-ATPase. The tetrameric nature of the enzyme. The Journal of biological chemistry. 1998 Sep; 273(38):24339-45. doi: 10.1074/jbc.273.38.24339. [PMID: 9733721]
  • G Wang, D S Perlin. Probing energy coupling in the yeast plasma membrane H+-ATPase with acetyl phosphate. Archives of biochemistry and biophysics. 1997 Aug; 344(2):309-15. doi: 10.1006/abbi.1997.0213. [PMID: 9264544]
  • S Kaya, T Tsuda, K Hagiwara, T Fukui, K Taniguchi. Pyridoxal 5'-phosphate probes at Lys-480 can sense the binding of ATP and the formation of phosphoenzymes in Na+,K(+)-ATPase. The Journal of biological chemistry. 1994 Mar; 269(10):7419-22. doi: . [PMID: 8125960]
  • G Berberián, L Beaugé. Phosphatase activity and potassium transport in liposomes with Na+,K(+)-ATPase incorporated. Biochimica et biophysica acta. 1992 Jan; 1103(1):85-93. doi: 10.1016/0005-2736(92)90060-y. [PMID: 1309662]
  • G Berberián, L Beaugé. Phosphorylation of Na,K-ATPase by acetyl phosphate and inorganic phosphate. Sidedness of Na+, K+ and nucleotide interactions and related enzyme conformations. Biochimica et biophysica acta. 1991 Apr; 1063(2):217-25. doi: 10.1016/0005-2736(91)90374-h. [PMID: 1849429]
  • M Campos, G Berberián, L Beaugé. Some total and partial reactions of Na+/K+-ATPase using ATP and acetyl phosphate as a substrate. Biochimica et biophysica acta. 1988 Feb; 938(1):7-16. doi: 10.1016/0005-2736(88)90116-2. [PMID: 2827776]
  • D H Gonzalez, A A Iglesias, C S Andreo. Interaction of acetyl phosphate and carbamyl phosphate with plant phosphoenolpyruvate carboxylase. The Biochemical journal. 1987 Jan; 241(2):543-8. doi: 10.1042/bj2410543. [PMID: 3036067]
  • A Rephaeli, D E Richards, S J Karlish. Electrical potential accelerates the E1P(Na)----E2P conformational transition of (Na,K)-ATPase in reconstituted vesicles. The Journal of biological chemistry. 1986 Sep; 261(27):12437-40. doi: NULL. [PMID: 3017974]
  • O COSTAKEL, I KITZOULESCU. [The capacity for acetylphosphate synthesis in the serum of cancer and noncancer patients at pH 4]. Revue des sciences medicales. 1960; 5(?):7-10. doi: . [PMID: 13695818]
  • . . . . doi: . [PMID: 21212945]