phenazopyridine (BioDeep_00000413049)

代谢物信息卡片

3-(Phenylazo)-2,6-pyridinediamine

化学式: C11H11N5 (213.1014406)
中文名称: 非那吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)N=NC2=C(N=C(C=C2)N)N
InChI: InChI=1S/C11H11N5/c12-10-7-6-9(11(13)14-10)16-15-8-4-2-1-3-5-8/h1-7H,(H4,12,13,14)

描述信息

C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
G - Genito urinary system and sex hormones > G04 - Urologicals > G04B - Urologicals
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7480; ORIGINAL_PRECURSOR_SCAN_NO 7478
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7493; ORIGINAL_PRECURSOR_SCAN_NO 7491
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7521; ORIGINAL_PRECURSOR_SCAN_NO 7518
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7529; ORIGINAL_PRECURSOR_SCAN_NO 7525
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7547; ORIGINAL_PRECURSOR_SCAN_NO 7544
CONFIDENCE standard compound; INTERNAL_ID 801; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 7531; ORIGINAL_PRECURSOR_SCAN_NO 7528

同义名列表

2 个代谢物同义名

3-(Phenylazo)-2,6-pyridinediamine; phenazopyridine

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:71416
KEGG: C07429
KEGGdrug: D08346
PubChem: 4756
DrugBank: DB01438
ChEMBL: CHEMBL1625467
ChEMBL: CHEMBL1355537
ChEMBL: CHEMBL1242
MeSH: Phenazopyridine
CAS: 94-78-0
MoNA: LU080106
MoNA: LU080105
MoNA: LU080104
MoNA: LU080103
MoNA: LU080102
MoNA: LU080101
PubChem: 9633
NIKKAJI: J4.703A
RefMet: Phenazopyridine

分类词条

Pyridine alkaloids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Zhiguo Pan, Xuan He, Yu Shao, Wenda Chen, Bangjiang Fang. ROS/JNK-mediated lysosomal injury in rat intestinal epithelial-6 cells during heat stress. Journal of thermal biology. 2022 Oct; 109(?):103326. doi: 10.1016/j.jtherbio.2022.103326. [PMID: 36195392]
Amy L Askew, Evan R Myers, Alexis A Dieter. Cost-effectiveness of agents used for evaluation of ureteral patency during intraoperative cystoscopy in gynecologic and urogynecologic surgery. American journal of obstetrics and gynecology. 2022 01; 226(1):100.e1-100.e6. doi: 10.1016/j.ajog.2021.08.055. [PMID: 34487702]
Matthew S Lee, Mark Assmus, Deepak Agarwal, Marcelino E Rivera, Tim Large, Amy E Krambeck. Opioid Free Ureteroscopy: What is the True Failure Rate?. Urology. 2021 08; 154(?):89-95. doi: 10.1016/j.urology.2021.03.011. [PMID: 33774043]
M I Davidov, M N Meltsina, N E Bunova, A M Metelkin, Prussakov R O, A A Lunev. [Phenazopyridine and fosfomycin for the acute cystitis treatment: results of multicenter randomized study]. Urologiia (Moscow, Russia : 1999). 2021 06; ?(3):20-27. doi: . [PMID: 34251097]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Namrta Choudhry, Xin Zhao, Dan Xu, Mark Zanin, Weisan Chen, Zifeng Yang, Jianxin Chen. Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Journal of medicinal chemistry. 2020 11; 63(22):13205-13227. doi: 10.1021/acs.jmedchem.0c00626. [PMID: 32845145]
Koosha Kamali, Javad Nikbakht, Erfan Ayubi, Mostafa Nabizadeh, Saeedeh Sarhadi. Comparison of the Efficacy of Oxybutynin, Phenazopyridine, Celecoxib, and Placebo in the Treatment of Urinary Tract Symptoms after BCG Therapy in Patients with Bladder Tumors. Urology journal. 2020 Sep; 18(4):439-444. doi: 10.22037/uj.v16i7.5947. [PMID: 32981029]
Shahram Seidi, Fahimeh Mohammadi, Mohammad Tajik, Mahroo Baharfar, Abdorreza Mohammadi, Tohid Otoufat. Quantitative determination of trace phenazopyridine in human urine samples by hyphenation of dispersive solid-phase extraction and liquid-phase microextraction followed by gas chromatography/mass spectrometry analysis. Journal of separation science. 2020 Jul; 43(14):2897-2904. doi: 10.1002/jssc.202000055. [PMID: 32396240]
Amir Mohammad Gholizadeh, Mahmoud Zarei, Masoud Ebratkhahan, Aliyeh Hasanzadeh, Fatemeh Vafaei. Removal of Phenazopyridine from wastewater by merging biological and electrochemical methods via Azolla filiculoides and electro-Fenton process. Journal of environmental management. 2020 Jan; 254(?):109802. doi: 10.1016/j.jenvman.2019.109802. [PMID: 31731027]
Elizabeth M Strom, Zaid Q Chaudhry, Rong Guo, Axeline J Maisonet, Christine H Holschneider, Cecilia K Wieslander. Effectiveness of Assessing Ureteral Patency Using Preoperative Phenazopyridine. Female pelvic medicine & reconstructive surgery. 2019 Jul; 25(4):289-293. doi: 10.1097/spv.0000000000000540. [PMID: 29300258]
Mahroo Baharfar, Yadollah Yamini, Shahram Seidi, Muhammad Balal Arain. Approach for Downscaling of Electromembrane Extraction as a Lab on-a-Chip Device Followed by Sensitive Red-Green-Blue Detection. Analytical chemistry. 2018 07; 90(14):8478-8486. doi: 10.1021/acs.analchem.8b01224. [PMID: 29847097]
Alexandra Rehfuss, Joseph Mahon, Igor Sorokin, Cynthia Smith, Barry S Stein. Phenazopyridine: A Preoperative Way to Identify Ureteral Orifices. Urology. 2018 May; 115(?):36-38. doi: 10.1016/j.urology.2018.02.023. [PMID: 29501712]
Jia Wang, Chaolei Wang, Zheng Wu, Xinnan Li, Shengtao Xu, Jie Liu, Qinying Lan, Zheying Zhu, Jinyi Xu. Design, synthesis, biological evaluation, and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II). Chemical biology & drug design. 2018 03; 91(3):756-762. doi: 10.1111/cbdd.13136. [PMID: 29112799]
Mihir R Atreya, Najla Al Jaberi, Donna J Claes, Oded Volovelsky. Case 6: Skin Discoloration, Methemoglobinemia, and Acute Interstitial Nephritis in a 15-year-old Girl. Pediatrics in review. 2017 Aug; 38(8):389. doi: 10.1542/pir.2016-0238. [PMID: 28765205]
Katie Propst, Elena Tunitsky-Bitton, David M O'Sullivan, Adam C Steinberg, Christine LaSala. Phenazopyridine for Evaluation of Ureteral Patency: A Randomized Controlled Trial. Obstetrics and gynecology. 2016 08; 128(2):348-355. doi: 10.1097/aog.0000000000001472. [PMID: 27399998]
Manar M Tolba, Mohamed M Salim. Derivative Quotient Spectrophotometry and an Eco-Friendly Micellar Chromatographic Approach with Time-Programmed UV-Detection for the Separation of Two Fluoroquinolones and Phenazopyridine. Journal of chromatographic science. 2016 May; 54(5):776-89. doi: 10.1093/chromsci/bmw010. [PMID: 26867555]
A Zommorrodi, S Hajebrahimi, S Zommorrodi. Bedside diagnosis of lymphorrhea after kidney transplantation surgery: A clinical study. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2015 Sep; 26(5):958-61. doi: 10.4103/1319-2442.164577. [PMID: 26354568]
Li-Chien Chang, Chia-Wen Kuo, Tom Chau, Shih-Hua Lin. Phenazopyridine-induced hemolytic anemia in advanced kidney disease. Journal of the American Geriatrics Society. 2014 Dec; 62(12):2464-6. doi: 10.1111/jgs.13161. [PMID: 25516057]
Manisha Singh, Fnu Shailesh, Upasana Tiwari, Shree G Sharma, Bilal Malik. Phenazopyridine associated acute interstitial nephritis and review of literature. Renal failure. 2014 Jun; 36(5):804-7. doi: 10.3109/0886022x.2014.890054. [PMID: 24575779]
Ali A Ensafi, B Arashpour, B Rezaei, Ali R Allafchian. Highly selective differential pulse voltammetric determination of phenazopyridine using MgCr2O4 nanoparticles decorated MWCNTs-modified glassy carbon electrode. Colloids and surfaces. B, Biointerfaces. 2013 Nov; 111(?):270-6. doi: 10.1016/j.colsurfb.2013.06.017. [PMID: 23838192]
Alina Wang, Parminder Nizran, Michael A Malone, Timothy Riley. Urinary tract infections. Primary care. 2013 Sep; 40(3):687-706. doi: 10.1016/j.pop.2013.06.005. [PMID: 23958364]
Mary K Feix, Frank A Polito, Mark A Cervinski. A urine sample with an orange to red hue, what should we do?. Clinical chemistry. 2012 Oct; 58(10):1497-8. doi: 10.1373/clinchem.2012.187864. [PMID: 23024130]
Mohammad Saraji, Ali Akbar Hajialiakbari Bidgoli, Bahman Farajmand. Hollow fiber-based liquid-liquid-liquid microextraction followed by flow injection analysis using column-less HPLC for the determination of phenazopyridine in plasma and urine. Journal of separation science. 2011 Jul; 34(14):1708-15. doi: 10.1002/jssc.201000929. [PMID: 21681956]
B Rezaei, M T Jafari, O Rahmanian. Selective pretreatment and determination of phenazopyridine using an imprinted polymer-electrospray ionization ion mobility spectrometry system. Talanta. 2011 Jan; 83(3):765-9. doi: 10.1016/j.talanta.2010.10.041. [PMID: 21147318]
Melissa L Holahan, Meryl P Littman, Cristine L Hayes. Presumptive hepatotoxicity and rhabdomyolysis secondary to phenazopyridine toxicity in a dog. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001). 2010 Jun; 20(3):352-8. doi: 10.1111/j.1476-4431.2010.00541.x. [PMID: 20636989]
Jane Y C Hui, Marie-Andrée Harvey, Shawna L Johnston. Confirmation of ureteric patency during cystoscopy using phenazopyridine HCl: a low-cost approach. Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC. 2009 Sep; 31(9):845-849. doi: 10.1016/s1701-2163(16)34303-1. [PMID: 19941709]
Kai-jun Li, Qin-hua Chen, Zhuo Zhang, Peng Zhou, Peng Li, Jia Liu, Jun Zhu. Determination of phenazopyridine in human plasma by GC-MS and its pharmacokinetics. Journal of chromatographic science. 2008 Sep; 46(8):686-9. doi: 10.1093/chromsci/46.8.686. [PMID: 18796223]
Nishith K Singh, Nureain Mirza. Elderly woman with orange urine and purple hands. Mayo Clinic proceedings. 2008 Jul; 83(7):744. doi: 10.4065/83.7.744. [PMID: 18613989]
John R Beuerle, Fermin Barrueto. Neurogenic bladder and chronic urinary retention associated with MDMA abuse. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2008 Jun; 4(2):106-8. doi: 10.1007/bf03160964. [PMID: 18570171]
David A Rosen, Thomas M Hooton, Walter E Stamm, Peter A Humphrey, Scott J Hultgren. Detection of intracellular bacterial communities in human urinary tract infection. PLoS medicine. 2007 Dec; 4(12):e329. doi: 10.1371/journal.pmed.0040329. [PMID: 18092884]
Qinhua Chen, Kaijun Li, Zhuo Zhang, Peng Li, Jia Liu, Qiang Li. Development and validation of a gas chromatography-mass spectrometry method for the determination of phenazopyridine in rat plasma: application to the pharmacokinetic study. Biopharmaceutics & drug disposition. 2007 Nov; 28(8):439-44. doi: 10.1002/bdd.567. [PMID: 17847064]
Hong Zhou, Chang-Yun Chen, An-Jian Xie. [Spectroscopic studies on the binding of phenazopyridine hydrochloride and bovine serum albumin]. Guang pu xue yu guang pu fen xi = Guang pu. 2007 Sep; 27(9):1830-3. doi: NULL. [PMID: 18051539]
Ali Mirza Onder, Veronica Espinoza, Mariana E Berho, Jayanthi Chandar, Gaston Zilleruelo, Carolyn Abitbol. Acute renal failure due to phenazopyridine (Pyridium) overdose: case report and review of the literature. Pediatric nephrology (Berlin, Germany). 2006 Nov; 21(11):1760-4. doi: 10.1007/s00467-006-0196-1. [PMID: 16897003]
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Erxin Shang, Bingren Xiang, Guangyu Liu, Shaofei Xie, Wenyan Wei, Jun Lu. Determination of phenazopyridine in human plasma via LC-MS and subsequent development of a pharmacokinetic model. Analytical and bioanalytical chemistry. 2005 May; 382(1):216-22. doi: 10.1007/s00216-005-3197-1. [PMID: 15900475]
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