Danthron (BioDeep_00000406552)

 

Secondary id: BioDeep_00000002382, BioDeep_00000864926

natural product PANOMIX_OTCML-2023


代谢物信息卡片


1,8-dihydroxyanthraquinone

化学式: C14H8O4 (240.0423)
中文名称: 1,8-二羟基蒽醌
谱图信息: 最多检出来源 Viridiplantae(plant) 38.06%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
InChI: InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H

描述信息

A - Alimentary tract and metabolism > A06 - Drugs for constipation > A06A - Drugs for constipation > A06AB - Contact laxatives
D005765 - Gastrointestinal Agents > D002400 - Cathartics
D009676 - Noxae > D009153 - Mutagens
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.

同义名列表

5 个代谢物同义名

1,8-dihydroxyanthraquinone; Danthron; Dantron; Chrysazin; Danthron



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

46 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ALB, ANXA5, APOE, BCL2, CASP3, CASP9, CAT, NLRP3, NQO1, NR1H3, ODC1
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 2 ABCG1, BCL2
Nucleus 9 ALB, APOE, BCL2, CASP3, CASP9, ENDOG, NLRP3, NQO1, NR1H3
cytosol 12 ALB, ANXA5, BCL2, CASP3, CASP9, CAT, IL1B, NLRP3, NQO1, NR1H3, ODC1, SCLY
dendrite 2 APOE, NQO1
centrosome 1 ALB
nucleoplasm 2 CASP3, NR1H3
RNA polymerase II transcription regulator complex 1 NR1H3
Cell membrane 3 ABCB1, ABCG1, ADIPOR2
Multi-pass membrane protein 3 ABCB1, ABCG1, ADIPOR2
Golgi apparatus membrane 2 ABCG1, NLRP3
Synapse 2 NQO1, TAC1
cell surface 1 ABCB1
glutamatergic synapse 2 APOE, CASP3
Golgi apparatus 4 ABCG1, ALB, APOE, SCLY
Golgi membrane 3 ABCG1, INS, NLRP3
mitochondrial inner membrane 1 ENDOG
neuronal cell body 4 APOE, CASP3, NQO1, TAC1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 4 IL1B, NLRP3, NQO1, SCLY
Lysosome 1 IL1B
endosome 1 ABCG1
plasma membrane 4 ABCB1, ABCG1, ADIPOR2, APOE
Membrane 8 ABCB1, ABCG1, ANXA5, APOE, BCL2, CAT, NLRP3, NQO1
apical plasma membrane 1 ABCB1
axon 1 TAC1
extracellular exosome 5 ABCB1, ALB, ANXA5, APOE, CAT
endoplasmic reticulum 4 ALB, APOE, BCL2, NLRP3
extracellular space 5 ALB, APOE, IL1B, INS, TAC1
mitochondrion 6 ABCG1, BCL2, CASP9, CAT, ENDOG, NLRP3
protein-containing complex 4 ALB, BCL2, CASP9, CAT
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 CASP3
Secreted 5 ALB, APOE, IL1B, INS, NLRP3
extracellular region 8 ALB, ANXA5, APOE, CAT, IL1B, INS, NLRP3, TAC1
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ABCG1, ANXA5
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
Early endosome 1 APOE
recycling endosome 1 ABCG1
Apical cell membrane 1 ABCB1
pore complex 1 BCL2
focal adhesion 2 ANXA5, CAT
extracellular matrix 1 APOE
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 ANXA5, APOE
secretory granule 1 IL1B
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
receptor complex 1 NR1H3
Zymogen granule membrane 1 ANXA5
ciliary basal body 1 ALB
chromatin 1 NR1H3
centriole 1 ALB
Secreted, extracellular space 1 APOE
spindle pole 1 ALB
blood microparticle 2 ALB, APOE
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
Melanosome 1 APOE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, APOE, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Secreted, extracellular exosome 1 IL1B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 1 APOE
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
catalytic complex 1 SCLY
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
ciliary transition fiber 1 ALB
caspase complex 1 CASP9


文献列表

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  • Chuanrui Ma, Zhongyan Wang, Ronglin Xia, Lingling Wei, Chao Zhang, Jing Zhang, Linna Zhao, Han Wu, Lin Kang, Shu Yang. Danthron ameliorates obesity and MAFLD through activating the interplay between PPARα/RXRα heterodimer and adiponectin receptor 2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 May; 137(?):111344. doi: 10.1016/j.biopha.2021.111344. [PMID: 33581653]
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  • Xiujin Shi, Yi Zhang, Baidi Lin, Yang Zhou, Wei Suo, Juanjuan Wei, Lin Zhang, Jie Lin, Fucheng Xiao, Limin Zhao, Yang Lin. Danthron attenuates experimental atherosclerosis by targeting foam cell formation. Experimental physiology. 2021 03; 106(3):653-662. doi: 10.1113/ep089021. [PMID: 33450102]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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