trazodone (BioDeep_00000406049)
Main id: BioDeep_00000001964
代谢物信息卡片
trazodone
化学式: C19H22ClN5O (371.1513)
中文名称: 曲唑酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c1ccn2c(c1)nn(CCCN1CCN(CC1)c1cccc(c1)Cl)c2=O
InChI: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D049990 - Membrane Transport Modulators
Trazodone (AF-1161 free base) is a serotonin receptor antagonist and reuptake inhibitor. Trazodone can be used for the research of major depressive disorder. Trazodone also has potential for sleep disorder research[1].
同义名列表
3 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:9654
- KEGG: C07156
- KEGGdrug: D08626
- PubChem: 5533
- DrugBank: DB00656
- ChEMBL: CHEMBL621
- MeSH: Trazodone
- CAS: 19794-93-5
- MoNA: FiehnHILIC002378
- MoNA: FiehnHILIC000811
- PubChem: 9365
- NIKKAJI: J10.767K
- RefMet: Trazodone
- medchemexpress: HY-B0478A
- KNApSAcK: 9654
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine.
2024 Mar; 103(11):e37612. doi:
10.1097/md.0000000000037612. [PMID: 38489675] - Marta Balog, Allison Anderson, Thiago C Genaro-Mattos, Zeljka Korade, Karoly Mirnics. Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain.
Journal of lipid research.
2022 08; 63(8):100249. doi:
10.1016/j.jlr.2022.100249. [PMID: 35839864] - Marianna Mazza, Emanuele Caroppo, Giuseppe Marano, Georgios D Kotzalidis, Carla Avallone, Giovanni Camardese, Delfina Janiri, Lorenzo Moccia, Alessio Simonetti, Luigi Janiri, Gabriele Sani. Trazodone Prolonged-Release Monotherapy in Cannabis Dependent Patients during Lockdown Due to COVID-19 Pandemic: A Case Series.
International journal of environmental research and public health.
2022 06; 19(12):. doi:
10.3390/ijerph19127397. [PMID: 35742646] - Jing Ding, Yan Zhang, Xiaohua Cui, Caiping Zhao, Suo Zhang. Development of a Novel Analytical Method for Determining Trazodone in Human Plasma by Liquid Chromatography Coupled With Mass Spectrometry Coupled With Automatic 2-Dimensional Liquid Chromatograph-Mass Spectrometer Coupler 9500 and Its Application to Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2022 06; 44(3):465-473. doi:
10.1097/ftd.0000000000000921. [PMID: 34469419] - Udo Bonnet, Georg Juckel. COVID-19 Outcomes: Does the Use of Psychotropic Drugs Make a Difference? Accumulating Evidence of a Beneficial Effect of Antidepressants-A Scoping Review.
Journal of clinical psychopharmacology.
2022 May; 42(3):284-292. doi:
10.1097/jcp.0000000000001543. [PMID: 35420565] - Isabel Seguro, Patrícia Rebelo, João G Pacheco, Cristina Delerue-Matos. Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode-A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone.
Sensors (Basel, Switzerland).
2022 Apr; 22(7):. doi:
10.3390/s22072819. [PMID: 35408433] - Basar Cenik, Jayme M Palka, Bonne M Thompson, Jeffrey G McDonald, Carol A Tamminga, Can Cenik, E Sherwood Brown. Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone.
Translational psychiatry.
2022 04; 12(1):139. doi:
10.1038/s41398-022-01903-3. [PMID: 35379782] - Sun-A Kim, Michelle R Borchardt, Kyuyoung Lee, Elizabeth A Stelow, Melissa J Bain. Effects of trazodone on behavioral and physiological signs of stress in dogs during veterinary visits: a randomized double-blind placebo-controlled crossover clinical trial.
Journal of the American Veterinary Medical Association.
2022 03; 260(8):876-883. doi:
10.2460/javma.20.10.0547. [PMID: 35333743] - Gauthier Nendumba, Lidvine Boland, Vincent Haufroid, Pierre-François Laterre, Philippe Hantson. Intravenous Lipid Emulsion in a Case of Trazodone Overdose.
The primary care companion for CNS disorders.
2022 03; 24(2):. doi:
10.4088/pcc.21cr02994. [PMID: 35768021] - Naglaa F Khedr, Rehab H Werida. l-carnitine modulates autophagy, oxidative stress and inflammation in trazodone induced testicular toxicity.
Life sciences.
2022 Feb; 290(?):120025. doi:
10.1016/j.lfs.2021.120025. [PMID: 34637798] - Jumpei Saito, Mariko Ishii, Asako Mito, Naho Yakuwa, Hiroyo Kawasaki, Yoshiyuki Tachibana, Tomo Suzuki, Akimasa Yamatani, Haruhiko Sago, Atsuko Murashima. Trazodone Levels in Maternal Serum, Cord Blood, Breast Milk, and Neonatal Serum.
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine.
2021 11; 16(11):922-925. doi:
10.1089/bfm.2021.0191. [PMID: 34348038] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Zeljka Korade, Luke B Allen, Allison Anderson, Keri A Tallman, Thiago C Genaro-Mattos, Ned A Porter, Karoly Mirnics. Trazodone effects on developing brain.
Translational psychiatry.
2021 02; 11(1):85. doi:
10.1038/s41398-021-01217-w. [PMID: 33526772] - Alexandra L Moss, Rachel L Hritz, Rachel C Hector, Kathryn L Wotman. Investigation of the effects of orally administered trazodone on intraocular pressure, pupil diameter, physical examination variables, and sedation level in healthy equids.
American journal of veterinary research.
2021 Feb; 82(2):138-143. doi:
10.2460/ajvr.82.2.138. [PMID: 33480276] - Alessandro Ruggieri, Rossella Picollo, Alessandra Del Vecchio, Fabrizio Calisti, Patrizia Dragone, Alessandro Comandini, Maria T Rosignoli, Agnese Cattaneo, Frank Donath, Ralph-Steven Wedemeyer, Marina Todorova-Sanjari, André Warnke, Henning H Blume. Investigations on dose proportionality and drug-drug interaction for a fixed-dose combination of trazodone and gabapentin.
International journal of clinical pharmacology and therapeutics.
2021 Jan; 59(1):71-86. doi:
10.5414/cp203845. [PMID: 33040841] - Fitri Fareez Ramli, Muhammad Hasif Azizi, Syed Alhafiz Syed Hashim. Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis.
International journal of medical sciences.
2021; 18(11):2372-2380. doi:
10.7150/ijms.57641. [PMID: 33967614] - Yasmeen Prud'homme, Shannon T Ferrell, Francis Beaudry, Guy Beauchamp, Sylvain Nichols, Marion Desmarchelier. PHARMACOKINETICS AND CLINICAL EFFECTS OF A SINGLE ORAL DOSE OF TRAZODONE IN THE DOMESTIC GOAT (CAPRA HIRCUS) AS A MODEL FOR WILD RUMINANTS.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2021 Jan; 51(4):896-904. doi:
10.1638/2019-0242. [PMID: 33480570] - Magdalene M Assimon, Jennifer E Flythe. Zolpidem Versus Trazodone Initiation and the Risk of Fall-Related Fractures among Individuals Receiving Maintenance Hemodialysis.
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2020 12; 16(1):88-97. doi:
10.2215/cjn.10070620. [PMID: 33355192] - Valeria Tellone, Maria Teresa Rosignoli, Rossella Picollo, Patrizia Dragone, Alessandra Del Vecchio, Alessandro Comandini, Milko Radicioni, Chiara Leuratti, Fabrizio Calisti. Effect of 3 Single Doses of Trazodone on QTc Interval in Healthy Subjects.
Journal of clinical pharmacology.
2020 11; 60(11):1483-1495. doi:
10.1002/jcph.1640. [PMID: 32488885] - Sung Il Bae, Ju-Tae Sohn. Lipid Emulsion Treatment for Trazodone Toxicity-Induced Coma.
Clinical neuropharmacology.
2020 Nov; 43(6):201. doi:
10.1097/wnf.0000000000000413. [PMID: 32925182] - Mark Unruh, Daniel Cukor, Tessa Rue, Kashif Abad, Maria-Eleni Roumelioti, Susan M McCurry, Patrick Heagerty, Rajnish Mehrotra. Sleep-HD trial: short and long-term effectiveness of existing insomnia therapies for patients undergoing hemodialysis.
BMC nephrology.
2020 10; 21(1):443. doi:
10.1186/s12882-020-02107-x. [PMID: 33081705] - Erica M O'Donnell, Saya A Press, Margo J Karriker, Stephanie A Istvan. Pharmacokinetics and efficacy of trazodone following rectal administration of a single dose to healthy dogs.
American journal of veterinary research.
2020 Sep; 81(9):739-746. doi:
10.2460/ajvr.81.9.739. [PMID: 33112166] - Nahla Elhesaisy, Shady Swidan. Trazodone Loaded Lipid Core Poly (ε-caprolactone) Nanocapsules: Development, Characterization and in Vivo Antidepressant Effect Evaluation.
Scientific reports.
2020 02; 10(1):1964. doi:
10.1038/s41598-020-58803-z. [PMID: 32029776] - Alexandra Warnant, Ludovic Gerard, Vincent Haufroid, Philippe Hantson. Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient.
Clinical neuropharmacology.
2020 Jan; 43(1):31-33. doi:
10.1097/wnf.0000000000000376. [PMID: 31934922] - Kalpana P Padala, Christopher M Parkes, Prasad R Padala. Neuropsychological and Functional Impact of COVID-19 on Mild Cognitive Impairment.
American journal of Alzheimer's disease and other dementias.
2020 Jan; 35(?):1533317520960875. doi:
10.1177/1533317520960875. [PMID: 32969235] - Lakshmi P Digala, Scott Lucchese. IV Lidocaine Infusion Leading to the Toxic Levels in Serum Causing Asystole - A Case Report.
Headache.
2020 01; 60(1):269-270. doi:
10.1111/head.13699. [PMID: 31743428] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hong-Ming Chen, Yao-Hsu Yang, Ko-Jung Chen, Yena Lee, Roger S McIntyre, Mong-Liang Lu, Yi-Chen Lee, Ming-Chia Hsieh, Vincent Chin-Hung Chen. Antidepressants Reduced Risk of Mortality in Patients With Diabetes Mellitus: A Population-Based Cohort Study in Taiwan.
The Journal of clinical endocrinology and metabolism.
2019 10; 104(10):4619-4625. doi:
10.1210/jc.2018-02362. [PMID: 31265070] - Jia-Lian Zhu, Yi Gong, Wen-Wen Luo, Qi-Zhi Zhang, Rong-Hua Zhu, Wen-Xing Peng. Pharmacokinetics of trazodone sustained-release tablets in healthy subjects: Three open-label, randomized crossover studies
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International journal of clinical pharmacology and therapeutics.
2019 Oct; 57(10):520-530. doi:
10.5414/cp203482. [PMID: 31262398] - G H Ragab, E A Bahgat. Development of HPLC method coupled with fluorescence detection for simultaneous determination of donepezil HCl and trazodone HCl in spiked human plasma and tablets dosage forms.
Annales pharmaceutiques francaises.
2019 Jul; 77(4):286-294. doi:
10.1016/j.pharma.2019.02.003. [PMID: 31027753] - Silvana Olivieri, Graziella Bovi, Vanessa Petrucci, Anna Alfieri, Laura Oggianu, Rossella Picollo, Carolina Devastato, Patrizia Dragone, Fabio Garofolo, Serena Tongiani. Juvenile rat and pediatric trazodone studies: how to gain extra sensitivity to overcome bioanalytical challenges.
Bioanalysis.
2019 Jan; 11(1):21-32. doi:
10.4155/bio-2018-0236. [PMID: 30525928] - Marion R Desmarchelier, Francis Beaudry, Shannon T Ferrell, Diane Frank. Determination of the pharmacokinetics of a single oral dose of trazodone and its effect on the activity level of domestic pigeons (Columba livia).
American journal of veterinary research.
2019 Jan; 80(1):102-109. doi:
10.2460/ajvr.80.1.102. [PMID: 30605036] - O Atli, V Kilic, M Baysal, G Kilic, G Gormus, S Ucarcan, B Korkut, S Ilgin. Assessment of trazodone-induced cardiotoxicity after repeated doses in rats.
Human & experimental toxicology.
2019 Jan; 38(1):45-55. doi:
10.1177/0960327118769717. [PMID: 29774748] - J L Davis, J Schirmer, E Medlin. Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Journal of veterinary pharmacology and therapeutics.
2018 Jun; 41(3):393-401. doi:
10.1111/jvp.12477. [PMID: 29333613] - Bernd Reichl, Markus Himmelsbach, Lisa Emhofer, Christian W Klampfl, Wolfgang Buchberger. Uptake and metabolism of the antidepressants sertraline, clomipramine, and trazodone in a garden cress (Lepidium sativum) model.
Electrophoresis.
2018 05; 39(9-10):1301-1308. doi:
10.1002/elps.201700482. [PMID: 29427324] - Sinem Ilgın, Gözde Aydoğan-Kılıç, Merve Baysal, Volkan Kılıç, Mina Ardıç, Şeyda Uçarcan, Özlem Atlı. Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress.
Oxidative medicine and cellular longevity.
2018; 2018(?):7196142. doi:
10.1155/2018/7196142. [PMID: 30151072] - Zeljka Korade, Thiago C Genaro-Mattos, Keri A Tallman, Wei Liu, Krassimira A Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A Porter. Vulnerability of DHCR7+/- mutation carriers to aripiprazole and trazodone exposure.
Journal of lipid research.
2017 11; 58(11):2139-2146. doi:
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Pharmacogenomics.
2017 Nov; 18(16):1491-1502. doi:
10.2217/pgs-2017-0116. [PMID: 29061081] - Heather K Knych, Khursheed R Mama, Eugene P Steffey, Scott D Stanley, Philip H Kass. Pharmacokinetics and selected pharmacodynamics of trazodone following intravenous and oral administration to horses undergoing fitness training.
American journal of veterinary research.
2017 Oct; 78(10):1182-1192. doi:
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Journal of the American Animal Hospital Association.
2017 Mar; 53(2):111-118. doi:
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Drug research.
2016 Nov; 66(11):592-596. doi:
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Human & experimental toxicology.
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The New England journal of medicine.
2015 Jan; 372(5):465-73. doi:
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Frontiers in pharmacology.
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Journal of pharmacological and toxicological methods.
2014 Nov; 70(3):276-82. doi:
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2014 Oct; 1838(10):2369-79. doi:
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Drug testing and analysis.
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Behavioral and brain functions : BBF.
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2011 Jul; 35(6):364-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jun; 879(19):1544-50. doi:
10.1016/j.jchromb.2011.03.049. [PMID: 21524943] - Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Feb; 39(2):312-21. doi:
10.1124/dmd.110.036095. [PMID: 21071520] - X-W Chen, E S Serag, K B Sneed, J Liang, H Chew, S-Y Pan, S-F Zhou. Clinical herbal interactions with conventional drugs: from molecules to maladies.
Current medicinal chemistry.
2011; 18(31):4836-50. doi:
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Neuropsychiatric disease and treatment.
2011; 7(?):507-18. doi:
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Journal of clinical pharmacology.
2010 Dec; 50(12):1438-49. doi:
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Journal of Korean medical science.
2010 Nov; 25(11):1688-91. doi:
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Molecular pharmacology.
2010 Nov; 78(5):818-26. doi:
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Indian journal of experimental biology.
2010 Nov; 48(11):1131-5. doi:
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Journal of analytical toxicology.
2010 Nov; 34(9):587-9. doi:
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Pediatric emergency care.
2010 Oct; 26(10):754-6. doi:
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Brain research.
2010 Sep; 1353(?):204-12. doi:
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Oxidative medicine and cellular longevity.
2010 Sep; 3(5):325-31. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Aug; 67(16):1344-50. doi:
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Drug discoveries & therapeutics.
2010 Aug; 4(4):285-97. doi:
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Journal of Korean medical science.
2010 Mar; 25(3):337-41. doi:
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International journal of clinical practice.
2010 Jan; 64(2):240-55. doi:
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Dialogues in clinical neuroscience.
2010; 12(1):69-76. doi:
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The Journal of head trauma rehabilitation.
2010 Jan; 25(1):61-7. doi:
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HIV/AIDS (Auckland, N.Z.).
2010; 2(?):157-66. doi:
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Se pu = Chinese journal of chromatography.
2010 Jan; 28(1):23-33. doi:
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International journal of legal medicine.
2009 Nov; 123(6):451-8. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2009 Sep; 23(6):1179-87. doi:
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Journal of separation science.
2009 Sep; 32(18):3074-83. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2009 Aug; 66(16):1468-70. doi:
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Talanta.
2009 Jul; 79(2):361-8. doi:
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Methods and findings in experimental and clinical pharmacology.
2009 Jul; 31(6):383-7. doi:
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Analytical and bioanalytical chemistry.
2009 Jul; 394(6):1563-7. doi:
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Clinical pharmacology and therapeutics.
2009 Jun; 85(6):644-50. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 May; 49(4):1082-7. doi:
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Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
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Drugs.
2009; 69(13):1777-98. doi:
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2009; 10(4 Pt 2):385-9. doi:
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Canadian Urological Association journal = Journal de l'Association des urologues du Canada.
2008 Dec; 2(6):604-8. doi:
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Current neuropharmacology.
2008 Dec; 6(4):344-66. doi:
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Pharmacy world & science : PWS.
2008 Oct; 30(5):613-6. doi:
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Pharmacological reports : PR.
2008 Sep; 60(5):664-72. doi:
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