trazodone (BioDeep_00000406049)
Main id: BioDeep_00000001964
Volatile Flavor Compounds
代谢物信息卡片
化学式: C19H22ClN5O (371.15127920000003)
中文名称: 曲唑酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: c1ccn2c(c1)nn(CCCN1CCN(CC1)c1cccc(c1)Cl)c2=O
InChI: InChI=1S/C19H22ClN5O/c20-16-5-3-6-17(15-16)23-13-11-22(12-14-23)8-4-10-25-19(26)24-9-2-1-7-18(24)21-25/h1-3,5-7,9,15H,4,8,10-14H2
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017367 - Selective Serotonin Reuptake Inhibitors
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D049990 - Membrane Transport Modulators
Trazodone (AF-1161 free base) is a serotonin receptor antagonist and reuptake inhibitor. Trazodone can be used for the research of major depressive disorder. Trazodone also has potential for sleep disorder research[1].
同义名列表
3 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:9654
- KEGG: C07156
- KEGGdrug: D08626
- PubChem: 5533
- DrugBank: DB00656
- ChEMBL: CHEMBL621
- MeSH: Trazodone
- CAS: 19794-93-5
- MoNA: FiehnHILIC002378
- MoNA: FiehnHILIC000811
- PubChem: 9365
- NIKKAJI: J10.767K
- RefMet: Trazodone
- medchemexpress: HY-B0478A
- KNApSAcK: 9654
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review.
Medicine.
2024 Mar; 103(11):e37612. doi:
10.1097/md.0000000000037612
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Journal of lipid research.
2022 08; 63(8):100249. doi:
10.1016/j.jlr.2022.100249
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International journal of environmental research and public health.
2022 06; 19(12):. doi:
10.3390/ijerph19127397
. [PMID: 35742646] - Jing Ding, Yan Zhang, Xiaohua Cui, Caiping Zhao, Suo Zhang. Development of a Novel Analytical Method for Determining Trazodone in Human Plasma by Liquid Chromatography Coupled With Mass Spectrometry Coupled With Automatic 2-Dimensional Liquid Chromatograph-Mass Spectrometer Coupler 9500 and Its Application to Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2022 06; 44(3):465-473. doi:
10.1097/ftd.0000000000000921
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Journal of clinical psychopharmacology.
2022 May; 42(3):284-292. doi:
10.1097/jcp.0000000000001543
. [PMID: 35420565] - Isabel Seguro, Patrícia Rebelo, João G Pacheco, Cristina Delerue-Matos. Electropolymerized, Molecularly Imprinted Polymer on a Screen-Printed Electrode-A Simple, Fast, and Disposable Voltammetric Sensor for Trazodone.
Sensors (Basel, Switzerland).
2022 Apr; 22(7):. doi:
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. [PMID: 35408433] - Basar Cenik, Jayme M Palka, Bonne M Thompson, Jeffrey G McDonald, Carol A Tamminga, Can Cenik, E Sherwood Brown. Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone.
Translational psychiatry.
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2022 03; 24(2):. doi:
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Life sciences.
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Translational psychiatry.
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American journal of veterinary research.
2021 Feb; 82(2):138-143. doi:
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2021 Jan; 59(1):71-86. doi:
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2020 11; 60(11):1483-1495. doi:
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2020 Sep; 81(9):739-746. doi:
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Scientific reports.
2020 02; 10(1):1964. doi:
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. [PMID: 32029776] - Alexandra Warnant, Ludovic Gerard, Vincent Haufroid, Philippe Hantson. Coma Reversal After Intravenous Lipid Emulsion Therapy in a Trazodone-Poisoned Patient.
Clinical neuropharmacology.
2020 Jan; 43(1):31-33. doi:
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American journal of Alzheimer's disease and other dementias.
2020 Jan; 35(?):1533317520960875. doi:
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Molecular pharmacology.
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2019 10; 104(10):4619-4625. doi:
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. [PMID: 31265070] - Jia-Lian Zhu, Yi Gong, Wen-Wen Luo, Qi-Zhi Zhang, Rong-Hua Zhu, Wen-Xing Peng. Pharmacokinetics of trazodone sustained-release tablets in healthy subjects: Three open-label, randomized crossover studies
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2019 Oct; 57(10):520-530. doi:
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2019 Jul; 77(4):286-294. doi:
10.1016/j.pharma.2019.02.003
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Bioanalysis.
2019 Jan; 11(1):21-32. doi:
10.4155/bio-2018-0236
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American journal of veterinary research.
2019 Jan; 80(1):102-109. doi:
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2019 Jan; 38(1):45-55. doi:
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2018 Jun; 41(3):393-401. doi:
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Electrophoresis.
2018 05; 39(9-10):1301-1308. doi:
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Oxidative medicine and cellular longevity.
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Journal of lipid research.
2017 11; 58(11):2139-2146. doi:
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Pharmacogenomics.
2017 Nov; 18(16):1491-1502. doi:
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Journal of analytical toxicology.
2011 Jul; 35(6):364-8. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jun; 879(19):1544-50. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2011 Feb; 39(2):312-21. doi:
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Current medicinal chemistry.
2011; 18(31):4836-50. doi:
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Neuropsychiatric disease and treatment.
2011; 7(?):507-18. doi:
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Journal of clinical pharmacology.
2010 Dec; 50(12):1438-49. doi:
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Journal of Korean medical science.
2010 Nov; 25(11):1688-91. doi:
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Molecular pharmacology.
2010 Nov; 78(5):818-26. doi:
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Indian journal of experimental biology.
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Journal of analytical toxicology.
2010 Nov; 34(9):587-9. doi:
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Pediatric emergency care.
2010 Oct; 26(10):754-6. doi:
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Brain research.
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Oxidative medicine and cellular longevity.
2010 Sep; 3(5):325-31. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Aug; 67(16):1344-50. doi:
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Drug discoveries & therapeutics.
2010 Aug; 4(4):285-97. doi:
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Journal of Korean medical science.
2010 Mar; 25(3):337-41. doi:
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International journal of clinical practice.
2010 Jan; 64(2):240-55. doi:
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Dialogues in clinical neuroscience.
2010; 12(1):69-76. doi:
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The Journal of head trauma rehabilitation.
2010 Jan; 25(1):61-7. doi:
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HIV/AIDS (Auckland, N.Z.).
2010; 2(?):157-66. doi:
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Se pu = Chinese journal of chromatography.
2010 Jan; 28(1):23-33. doi:
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International journal of legal medicine.
2009 Nov; 123(6):451-8. doi:
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Toxicology in vitro : an international journal published in association with BIBRA.
2009 Sep; 23(6):1179-87. doi:
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Journal of separation science.
2009 Sep; 32(18):3074-83. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2009 Aug; 66(16):1468-70. doi:
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Talanta.
2009 Jul; 79(2):361-8. doi:
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Methods and findings in experimental and clinical pharmacology.
2009 Jul; 31(6):383-7. doi:
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Analytical and bioanalytical chemistry.
2009 Jul; 394(6):1563-7. doi:
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Clinical pharmacology and therapeutics.
2009 Jun; 85(6):644-50. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 May; 49(4):1082-7. doi:
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Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
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Drugs.
2009; 69(13):1777-98. doi:
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The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.
2009; 10(4 Pt 2):385-9. doi:
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Canadian Urological Association journal = Journal de l'Association des urologues du Canada.
2008 Dec; 2(6):604-8. doi:
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Current neuropharmacology.
2008 Dec; 6(4):344-66. doi:
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Pharmacy world & science : PWS.
2008 Oct; 30(5):613-6. doi:
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