Tacrine (BioDeep_00000406028)

Main id: BioDeep_00000002001

 


代谢物信息卡片


Tacrine

化学式: C13H14N2 (198.1156924)
中文名称: 他克林
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)N
InChI: InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)

描述信息

D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
N - Nervous system > N06 - Psychoanaleptics > N06D - Anti-dementia drugs > N06DA - Anticholinesterases
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6299; ORIGINAL_PRECURSOR_SCAN_NO 6297
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6327; ORIGINAL_PRECURSOR_SCAN_NO 6325
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6332; ORIGINAL_PRECURSOR_SCAN_NO 6331
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6338; ORIGINAL_PRECURSOR_SCAN_NO 6337
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6352; ORIGINAL_PRECURSOR_SCAN_NO 6351
CONFIDENCE standard compound; INTERNAL_ID 499; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6355; ORIGINAL_PRECURSOR_SCAN_NO 6351

同义名列表

1 个代谢物同义名

Tacrine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, Qi Li, Hongyu Yang, Yuting Qiao, Qihang Li, Ziwei Xu, Weiping Lyu, Wei Qu, Wenyuan Liu, Yao Chen, Feng Feng, Haopeng Sun. Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease. European journal of medicinal chemistry. 2022 Dec; 244(?):114806. doi: 10.1016/j.ejmech.2022.114806. [PMID: 36223681]
  • Changyan Li, Yating Shao, Wei Li, Tianpeng Yin, Hongtao Li, Hui Yan, Xingyi Guo, Bo Liu, Bo He. Hybrid Diterpenic Meroterpenoids from an Endophytic Penicillium sp. Induced by Chemical Epigenetic Manipulation. Journal of natural products. 2022 06; 85(6):1486-1494. doi: 10.1021/acs.jnatprod.1c01155. [PMID: 35658485]
  • Fanxin Zeng, Tao Lu, Jie Wang, Xuliang Nie, Wanming Xiong, Zhongping Yin, Dayong Peng. Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072142. [PMID: 35408542]
  • Beenita Saikia, Lipika Buragohain, Chandana Choudhury Barua, Jadav Sarma, Sarojini Mahanta Tamuli, Dhruba Jyoti Kalita, Acheenta Gohain Barua, Iswar Chandra Barua, Ramakrishna Elancheran. Evaluation of anti-amnesic effect of Conyza bonariensis in rats. Indian journal of pharmacology. 2022 Mar; 54(2):102-109. doi: 10.4103/ijp.ijp_201_19. [PMID: 35546461]
  • Prayasee Baruah, Debojit Paul, Jitesh Doshi, Sivaprasad Mitra. Elevated Fibrinogen Level Reduces Therapeutic Efficiency of AD Drugs: Biophysical Insights into the Interaction of FDA-Approved Cholinesterase Inhibitors with Human Fibrinogen. The journal of physical chemistry. B. 2022 01; 126(1):30-43. doi: 10.1021/acs.jpcb.1c07495. [PMID: 34964643]
  • Danish Iqbal, M Salman Khan, Mohd Waiz, Md Tabish Rehman, Mohammed Alaidarous, Azfar Jamal, Abdulaziz S Alothaim, Mohamed F AlAjmi, Bader Mohammed Alshehri, Saeed Banawas, Mohammed Alsaweed, Yahya Madkhali, Abdulrahman Algarni, Suliman A Alsagaby, Wael Alturaiki. Exploring the Binding Pattern of Geraniol with Acetylcholinesterase through In Silico Docking, Molecular Dynamics Simulation, and In Vitro Enzyme Inhibition Kinetics Studies. Cells. 2021 12; 10(12):. doi: 10.3390/cells10123533. [PMID: 34944045]
  • Etta Y L Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K L Kwan, Miranda L Xu, Karl W K Tsim. Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Molecular pharmacology. 2021 11; 100(5):456-469. doi: 10.1124/molpharm.121.000269. [PMID: 34531295]
  • Jiarui Wu, Xiaodi Kou, Hui Ju, Hongwei Zhang, Aihong Yang, Rui Shen. Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters. 2021 10; 49(?):128316. doi: 10.1016/j.bmcl.2021.128316. [PMID: 34391893]
  • Anu Rani, Amandeep Singh, Jashanpreet Kaur, Gurjit Singh, Rajbir Bhatti, Njabulo Gumede, Prishani Kisten, Parvesh Singh, Sumanjit, Vipan Kumar. 1H-1,2,3-triazole grafted tacrine-chalcone conjugates as potential cholinesterase inhibitors with the evaluation of their behavioral tests and oxidative stress in mice brain cells. Bioorganic chemistry. 2021 09; 114(?):105053. doi: 10.1016/j.bioorg.2021.105053. [PMID: 34120027]
  • Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Maria Karlgren, Heather Hulme, Elva Fridjonsdottir, Per Svenningsson, Per E Andrén. Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain. ACS chemical neuroscience. 2021 05; 12(10):1811-1823. doi: 10.1021/acschemneuro.1c00103. [PMID: 33939923]
  • Slavka Hamulakova, Zuzana Kudlickova, Ladislav Janovec, Roman Mezencev, Zachery J Deckner, Yury O Chernoff, Jana Janockova, Veronika Ihnatova, Petr Bzonek, Nikola Novakova, Vendula Hepnarova, Martina Hrabinova, Daniel Jun, Jan Korabecny, Ondrej Soukup, Kamil Kuca. Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease. Future medicinal chemistry. 2021 05; 13(9):785-804. doi: 10.4155/fmc-2020-0184. [PMID: 33829876]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Michele Rossi, Michela Freschi, Luciana de Camargo Nascente, Alessandra Salerno, Sarah de Melo Viana Teixeira, Florian Nachon, Fabien Chantegreil, Ondrej Soukup, Lukáš Prchal, Marco Malaguti, Christian Bergamini, Manuela Bartolini, Cristina Angeloni, Silvana Hrelia, Luiz Antonio Soares Romeiro, Maria Laura Bolognesi. Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. Journal of medicinal chemistry. 2021 04; 64(8):4972-4990. doi: 10.1021/acs.jmedchem.1c00048. [PMID: 33829779]
  • Jana Zdarova Karasova, Ondrej Soukup, Jan Korabecny, Milos Hroch, Marketa Krejciova, Martina Hrabinova, Jan Misik, Ladislav Novotny, Vendula Hepnarova, Kamil Kuca. Tacrine and its 7-methoxy derivate; time-change concentration in plasma and brain tissue and basic toxicological profile in rats. Drug and chemical toxicology. 2021 Mar; 44(2):207-214. doi: 10.1080/01480545.2019.1566350. [PMID: 31257938]
  • Rongtian Lin, Shuwen Rao, Yanbing Li, Lei Zhang, Liyu Xu, Yepu He, Zhijun Liu, Heru Chen. Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease. European journal of medicinal chemistry. 2021 Feb; 211(?):113067. doi: 10.1016/j.ejmech.2020.113067. [PMID: 33338868]
  • Ruba Ismail, Thi Nhu Quynh Phan, Flavia Laffleur, Ildikó Csóka, Andreas Bernkop-Schnürch. Hydrophobic ion pairing of a GLP-1 analogue for incorporating into lipid nanocarriers designed for oral delivery. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2020 Jul; 152(?):10-17. doi: 10.1016/j.ejpb.2020.04.025. [PMID: 32371152]
  • Luiz C Klein-Júnior, Sylvian Cretton, Yvan Vander Heyden, André L Gasper, Samad Nejad-Ebrahimi, Philippe Christen, Amélia T Henriques. Bioactive Azepine-Indole Alkaloids from Psychotria nemorosa. Journal of natural products. 2020 04; 83(4):852-863. doi: 10.1021/acs.jnatprod.9b00469. [PMID: 32150413]
  • Xiaodi Kou, Lulu Song, Yunhua Wang, Qiao Yu, Hui Ju, Aihong Yang, Rui Shen. Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy. Bioorganic & medicinal chemistry letters. 2020 02; 30(4):126927. doi: 10.1016/j.bmcl.2019.126927. [PMID: 31901382]
  • Ioannis Mantas, Yunting Yang, Clotilde Mannoury-la-Cour, Mark J Millan, Xiaoqun Zhang, Per Svenningsson. Genetic deletion of GPR88 enhances the locomotor response to L-DOPA in experimental parkinsonism while counteracting the induction of dyskinesia. Neuropharmacology. 2020 01; 162(?):107829. doi: 10.1016/j.neuropharm.2019.107829. [PMID: 31666199]
  • Wei Hong, Yu Zhang, Jun Yang, Meng-Yuan Xia, Ji-Feng Luo, Xiao-Nian Li, Yue-Hu Wang, Jun-Song Wang. Alkaloids from the Branches and Leaves of Elaeocarpus angustifolius. Journal of natural products. 2019 12; 82(12):3221-3226. doi: 10.1021/acs.jnatprod.8b01027. [PMID: 31736307]
  • Soyeon Yoo, Min Su Han. A fluorescent probe for butyrylcholinesterase activity in human serum based on a fluorophore with specific binding affinity for human serum albumin. Chemical communications (Cambridge, England). 2019 Dec; 55(97):14574-14577. doi: 10.1039/c9cc07737e. [PMID: 31663530]
  • João Paulo Bizarro Lopes, Luana Silva, Marco Antonio Ceschi, Diogo Seibert Lüdtke, Aline Rigon Zimmer, Thais Carine Ruaro, Rafael Ferreira Dantas, Cristiane Martins Cardoso de Salles, Floriano Paes Silva-Jr, Mario Roberto Senger, Gisele Barbosa, Lídia Moreira Lima, Isabella Alvim Guedes, Laurent Emmanuel Dardenne. Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. MedChemComm. 2019 Dec; 10(12):2089-2101. doi: 10.1039/c9md00358d. [PMID: 32904099]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Xiao-Jing Cheng, Jing-Xue Gu, Yi-Peng Pang, Jiao Liu, Ting Xu, Xin-Rui Li, Yu-Zhou Hua, Kelly A Newell, Xu-Feng Huang, Yinghua Yu, Yi Liu. Tacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer's Disease. ACS chemical neuroscience. 2019 08; 10(8):3500-3509. doi: 10.1021/acschemneuro.9b00120. [PMID: 31244052]
  • Ling Feng, Yu Zhang, Yan-Chun Liu, Yan Liu, Shi-Hong Luo, Chun-Shuai Huang, Sheng-Hong Li. Leucoflavonine, a new bioactive racemic flavoalkaloid from the leaves of Leucosceptrum canum. Bioorganic & medicinal chemistry. 2019 01; 27(2):442-446. doi: 10.1016/j.bmc.2018.12.023. [PMID: 30579802]
  • Sonal Setya, Tushar Madaan, Bal Kishen Razdan, Mamta Farswan, Sushama Talegaonkar. Design and Development of Novel Transdermal Nanoemulgel for Alzheimer's Disease: Pharmacokinetic, Pharmacodynamic and Biochemical Investigations. Current drug delivery. 2019; 16(10):902-912. doi: 10.2174/1567201816666191022105036. [PMID: 31642410]
  • Jie Zhu, Hongyu Yang, Yao Chen, Hongzhi Lin, Qi Li, Jun Mo, Yaoyao Bian, Yuqiong Pei, Haopeng Sun. Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. 2018 Dec; 33(1):496-506. doi: 10.1080/14756366.2018.1430691. [PMID: 29405075]
  • Changting Cui, Chuanbo Huang, Kejia Liu, Guoheng Xu, Jichun Yang, Yong Zhou, Yingmei Feng, Georgios Kararigas, Bin Geng, Qinghua Cui. Large-scale in silico identification of drugs exerting sex-specific effects in the heart. Journal of translational medicine. 2018 08; 16(1):236. doi: 10.1186/s12967-018-1612-6. [PMID: 30157868]
  • Shuai Qian, Lisi He, Qianwen Wang, Yin Cheong Wong, Marvin Mak, Chun-Yu Ho, Yifan Han, Zhong Zuo. Intranasal delivery of a novel acetylcholinesterase inhibitor HLS-3 for treatment of Alzheimer's disease. Life sciences. 2018 Aug; 207(?):428-435. doi: 10.1016/j.lfs.2018.06.032. [PMID: 29966606]
  • Edoardo Fabini, Anna Tramarin, Manuela Bartolini. Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening. Journal of pharmaceutical and biomedical analysis. 2018 Jun; 155(?):177-184. doi: 10.1016/j.jpba.2018.03.060. [PMID: 29635172]
  • Jana Zdarova Karasova, Martin Mzik, Milos Hroch, Jan Korabecny, Eugenie Nepovimova, Viktor Vorisek, Vladimir Palicka, Kamil Kuca. The New Acetylcholinesterase Inhibitors PC-37 and PC-48 (7-Methoxytacrine-Donepezil-Like Compounds): Characterization of Their Metabolites in Human Liver Microsomes, Pharmacokinetics and In Vivo Formation of the Major Metabolites in Rats. Basic & clinical pharmacology & toxicology. 2018 Apr; 122(4):373-382. doi: 10.1111/bcpt.12922. [PMID: 29067789]
  • Neng Jiang, Qichun Huang, Jing Liu, Ningsheng Liang, Qing Li, Qinghua Li, Sai-Sai Xie. Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease. European journal of medicinal chemistry. 2018 Feb; 146(?):287-298. doi: 10.1016/j.ejmech.2018.01.055. [PMID: 29407958]
  • Gaochan Wu, Yun Gao, Dongwei Kang, Boshi Huang, Zhipeng Huo, Huiqing Liu, Vasanthanathan Poongavanam, Peng Zhan, Xinyong Liu. Design, synthesis and biological evaluation of tacrine-1,2,3-triazole derivatives as potent cholinesterase inhibitors. MedChemComm. 2018 Jan; 9(1):149-159. doi: 10.1039/c7md00457e. [PMID: 30108908]
  • Jan Misik, Eugenie Nepovimova, Jaroslav Pejchal, Jiri Kassa, Jan Korabecny, Ondrej Soukup. Cholinesterase Inhibitor 6-Chlorotacrine - In Vivo Toxicological Profile and Behavioural Effects. Current Alzheimer research. 2018; 15(6):552-560. doi: 10.2174/1567205015666171212105412. [PMID: 29231138]
  • Marianna Mamusa, Francesco Barbero, Costanza Montis, Laura Cutillo, Ana Gonzalez-Paredes, Debora Berti. Inclusion of oligonucleotide antimicrobials in biocompatible cationic liposomes: A structural study. Journal of colloid and interface science. 2017 Dec; 508(?):476-487. doi: 10.1016/j.jcis.2017.08.080. [PMID: 28865342]
  • Luiz C Klein-Júnior, Sylvian Cretton, Pierre-Marie Allard, Grégory Genta-Jouve, Carolina S Passos, Juliana Salton, Pablo Bertelli, Marion Pupier, Damien Jeannerat, Yvan Vander Heyden, André L Gasper, Jean-Luc Wolfender, Philippe Christen, Amélia T Henriques. Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis. Journal of natural products. 2017 11; 80(11):3032-3037. doi: 10.1021/acs.jnatprod.7b00681. [PMID: 29120642]
  • Fang Ma, Hongtao Du. Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation. European journal of medicinal chemistry. 2017 Nov; 140(?):118-127. doi: 10.1016/j.ejmech.2017.09.008. [PMID: 28923380]
  • Regina Messerer, Clelia Dallanoce, Carlo Matera, Sarah Wehle, Lisa Flammini, Brian Chirinda, Andreas Bock, Matthias Irmen, Christian Tränkle, Elisabetta Barocelli, Michael Decker, Christoph Sotriffer, Marco De Amici, Ulrike Holzgrabe. Novel bipharmacophoric inhibitors of the cholinesterases with affinity to the muscarinic receptors M1 and M2. MedChemComm. 2017 Jun; 8(6):1346-1359. doi: 10.1039/c7md00149e. [PMID: 30108847]
  • Yi Guo, Na Zhang, Chunmei Chen, Jinfeng Huang, Xiao-Nian Li, Junjun Liu, Hucheng Zhu, Qingyi Tong, Jinwen Zhang, Zengwei Luo, Yongbo Xue, Yonghui Zhang. Tricyclic Polyprenylated Acylphloroglucinols from St John's Wort, Hypericum perforatum. Journal of natural products. 2017 05; 80(5):1493-1504. doi: 10.1021/acs.jnatprod.6b01178. [PMID: 28445039]
  • Ewa Gniazdowska, Przemysław Koźmiński, Marek Wasek, Marek Bajda, Joanna Sikora, Elżbieta Mikiciuk-Olasik, Paweł Szymański. Synthesis, physicochemical and biological studies of technetium-99m labeled tacrine derivative as a diagnostic tool for evaluation of cholinesterase level. Bioorganic & medicinal chemistry. 2017 02; 25(3):912-920. doi: 10.1016/j.bmc.2016.12.004. [PMID: 27998671]
  • Zdenka Kristofikova, Jan Ricny, Ondrej Soukup, Jan Korabecny, Eugenie Nepovimova, Kamil Kuca, Daniela Ripova. Inhibitors of Acetylcholinesterase Derived from 7-Methoxytacrine and Their Effects on the Choline Transporter CHT1. Dementia and geriatric cognitive disorders. 2017; 43(1-2):45-58. doi: 10.1159/000453256. [PMID: 27988521]
  • Niketkumar Patel, Shashank Jain, Senshang Lin. Transdermal iontophoretic delivery of tacrine hydrochloride: Correlation between in vitro permeation and in vivo performance in rats. International journal of pharmaceutics. 2016 Nov; 513(1-2):393-403. doi: 10.1016/j.ijpharm.2016.09.038. [PMID: 27633278]
  • Niketkumar Patel, Shashank Jain, Parshotam Madan, Senshang Lin. Application of design of experiments for formulation development and mechanistic evaluation of iontophoretic tacrine hydrochloride delivery. Drug development and industrial pharmacy. 2016 Nov; 42(11):1894-902. doi: 10.1080/03639045.2016.1181646. [PMID: 27100474]
  • Giuseppina Tommonaro, Nuria García-Font, Rosa Maria Vitale, Boris Pejin, Carmine Iodice, Sixta Cañadas, José Marco-Contelles, María Jesús Oset-Gasque. Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease. European journal of medicinal chemistry. 2016 Oct; 122(?):326-338. doi: 10.1016/j.ejmech.2016.06.036. [PMID: 27376495]
  • I O Ishola, A A Awoyemi, G O Afolayan. Involvement of Antioxidant System in the Amelioration of Scopolamine-Induced Memory Impairment by Grains of Paradise (Aframomum melegueta K. Schum.) Extract. Drug research. 2016 Sep; 66(9):455-463. doi: 10.1055/s-0042-109391. [PMID: 27403576]
  • Martin Mzik, Jan Korabecny, Eugenie Nepovimova, Viktor Voříšek, Vladimir Palička, Kamil Kuca, Jana Zdarova Karasova. An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 May; 1020(?):85-9. doi: 10.1016/j.jchromb.2016.02.038. [PMID: 27030895]
  • Shuqun Zhang, Bo Hou, Huaiyu Yang, Zhili Zuo. Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives. Archives of pharmacal research. 2016 May; 39(5):591-602. doi: 10.1007/s12272-016-0709-9. [PMID: 26832327]
  • Mullah Muhaiminul Islam, Arun Bahadur Gurung, Atanu Bhattacharjee, Kripamoy Aguan, Sivaprasad Mitra. Human serum albumin reduces the potency of acetylcholinesterase inhibitor based drugs for Alzheimer's disease. Chemico-biological interactions. 2016 Apr; 249(?):1-9. doi: 10.1016/j.cbi.2016.02.012. [PMID: 26902639]
  • Suresh Ponnayyan Sulochana, Vishnuvardh Ravichandiran, Ramesh Mullangi, Sathesh Kumar Sukumaran. Highly Sensitive LC-MS-MS Method for the Determination of Tacrine in Rat Plasma: Application to Pharmacokinetic Studies in Rats. Journal of chromatographic science. 2016 Mar; 54(3):397-404. doi: 10.1093/chromsci/bmv155. [PMID: 26561498]
  • Jing-Jing Zhang, Xing-Wei Yang, Xia Liu, Jun-Zeng Ma, Yang Liao, Gang Xu. 1,9-seco-Bicyclic Polyprenylated Acylphloroglucinols from Hypericum uralum. Journal of natural products. 2015 Dec; 78(12):3075-9. doi: 10.1021/acs.jnatprod.5b00830. [PMID: 26583263]
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