Selegiline (BioDeep_00000406019)
Main id: BioDeep_00000001512
代谢物信息卡片
Selegiline
化学式: C13H17N (187.1360922)
中文名称: 司来吉兰 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C#CCN(C)C(C)CC=1C=CC=CC1
InChI: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3
描述信息
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BD - Monoamine oxidase b inhibitors
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
D020011 - Protective Agents
同义名列表
1 个代谢物同义名
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:50217
- ChEBI: CHEBI:9086
- KEGG: C07245
- KEGGdrug: D03731
- PubChem: 26757
- DrugBank: DB01037
- ChEMBL: CHEMBL972
- MeSH: Selegiline
- CAS: 102741-42-4
- CAS: 14611-51-9
- MoNA: FiehnHILIC002324
- MoNA: FiehnHILIC000760
- MetaboLights: MTBLC50217
- PubChem: 9454
- NIKKAJI: J34.132K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhen Tian, Xinyue Wang, Tianshu Han, Changhao Sun. Selegiline ameliorated dyslipidemia and hepatic steatosis in high-fat diet mice.
International immunopharmacology.
2023 Feb; 117(?):109901. doi:
10.1016/j.intimp.2023.109901. [PMID: 36822098] - Mohammad-Hadi Karimi-Harandi, Mehdi Shabani-Nooshabadi, Rozhin Darabi. Simultaneous determination of citalopram and selegiline using an efficient electrochemical sensor based on ZIF-8 decorated with RGO and g-C3N4 in real samples.
Analytica chimica acta.
2022 Apr; 1203(?):339662. doi:
10.1016/j.aca.2022.339662. [PMID: 35361426] - Yuehong Pu, Fenghua Qian, Jian Guo, Yuanyuan Sha, Yiming Qian. Selegiline Protects Against Lipopolysaccharide (LPS)-Induced Impairment of the Blood-Brain Barrier Through Regulating the NF-κB/MLCK/p-MLC Signaling Pathway.
Neurotoxicity research.
2022 Feb; 40(1):267-275. doi:
10.1007/s12640-021-00448-5. [PMID: 34981455] - Sid E O'Bryant, Melissa Petersen, Fan Zhang, Leigh Johnson, David Mason, James Hall. Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study.
Parkinsonism & related disorders.
2022 01; 94(?):15-21. doi:
10.1016/j.parkreldis.2021.11.027. [PMID: 34864471] - Zufika Qamar, Muhammad Usama Ashhar, Annu, Farheen Fatima Qizilibash, Pravat Kumar Sahoo, Asgar Ali, Javed Ali, Sanjula Baboota. Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin.
International journal of pharmaceutics.
2021 Nov; 609(?):121131. doi:
10.1016/j.ijpharm.2021.121131. [PMID: 34563617] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ilchung Shin, Hyeyoung Choi, Seojin Kang, Jihyun Kim, Yuran Park, Wonkyung Yang. Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites.
Journal of analytical toxicology.
2021 Feb; 45(1):99-104. doi:
10.1093/jat/bkaa058. [PMID: 32476010] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Pradeep Paudel, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Characterizing fucoxanthin as a selective dopamine D3/D4 receptor agonist: Relevance to Parkinson's disease.
Chemico-biological interactions.
2019 Sep; 310(?):108757. doi:
10.1016/j.cbi.2019.108757. [PMID: 31323226] - Yogita Tyagi, N V Satheesh Madhav. Design of selegiline-loaded bio-nanosuspension for the management of depression using novel bio-retardant from Manilkara zapota.
Drug development and industrial pharmacy.
2019 Aug; 45(8):1351-1360. doi:
10.1080/03639045.2019.1619760. [PMID: 31084445] - Rajalakshmi Rukmangathen, Indira Muzib Yallamalli, Prasanna Raju Yalavarthi. Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease.
Current drug discovery technologies.
2019; 16(4):417-425. doi:
10.2174/1570163815666180418144019. [PMID: 29669501] - Neeraj Mishra, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar, Ruchika Sharma. Development and Characterization of Nasal Delivery of Selegiline Hydrochloride Loaded Nanolipid Carriers for the Management of Parkinson's Disease.
Central nervous system agents in medicinal chemistry.
2019; 19(1):46-56. doi:
10.2174/1871524919666181126124846. [PMID: 30474538] - Vinay Sridhar, Ram Gaud, Amrita Bajaj, Sarika Wairkar. Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease.
Nanomedicine : nanotechnology, biology, and medicine.
2018 11; 14(8):2609-2618. doi:
10.1016/j.nano.2018.08.004. [PMID: 30171904] - Vinicius Figueiredo Sardela, Carina de Souza Anselmo, Isabelle Karine da Costa Nunes, Gabriel Reis Alves Carneiro, Gustavo Ramalho Cardoso Dos Santos, Aline Reis de Carvalho, Bruna de Jesus Labanca, Daniely Silva Oliveira, William Dias Ribeiro, Amanda Lessa Dutra de Araujo, Monica Costa Padilha, Cleverton Kleiton Freitas de Lima, Valeria Pereira de Sousa, Francisco Radler de Aquino Neto, Henrique Marcelo Gualberto Pereira. Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges.
Drug testing and analysis.
2018 Nov; 10(11-12):1657-1669. doi:
10.1002/dta.2523. [PMID: 30341930] - Carolina Noble, Niels Bjerre Holm, Marie Mardal, Kristian Linnet. Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A.
Toxicology letters.
2018 Oct; 295(?):397-407. doi:
10.1016/j.toxlet.2018.07.018. [PMID: 30036687] - Michael Strupp, Ludwig Kraus, Franz Schautzer, Dan Rujescu. Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study.
Journal of neurology.
2018 Oct; 265(Suppl 1):80-85. doi:
10.1007/s00415-018-8809-8. [PMID: 29532287] - Csilla Terézia Nagy, Gábor Koncsos, Zoltán V Varga, Tamás Baranyai, Sebestyén Tuza, Ferenc Kassai, Aliz Judit Ernyey, István Gyertyán, Kornél Király, Attila Oláh, Tamás Radovits, Béla Merkely, Nóra Bukosza, Gábor Szénási, Péter Hamar, Domokos Mathé, Krisztián Szigeti, Csilla Pelyhe, Marek Jelemenský, Zsófia Onódi, Zsuzsanna Helyes, Rainer Schulz, Zoltán Giricz, Péter Ferdinandy. Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats.
British journal of pharmacology.
2018 09; 175(18):3713-3726. doi:
10.1111/bph.14437. [PMID: 29971762] - Ronan Gealageas, Alice Devineau, Pauline P L So, Catrina M J Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M Dullaghan, David S Grierson, Edward E Putnins. Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases.
Journal of medicinal chemistry.
2018 08; 61(16):7043-7064. doi:
10.1021/acs.jmedchem.7b01588. [PMID: 30016860] - Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka. Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements.
Behavioural brain research.
2018 07; 347(?):350-359. doi:
10.1016/j.bbr.2018.03.002. [PMID: 29526790] - Chadwick W Christine, Peggy Auinger, Amelia Joslin, Yuora Yelpaala, Ralph Green. Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society.
2018 05; 33(5):762-770. doi:
10.1002/mds.27301. [PMID: 29508904] - P Xiang, J Bu, Z Qiao, X Y Zhuo, H J Wu, M Shen. [Identification of Methamphetamine Abuse and Selegiline Use： Chiral Analysis of Methamphetamine and Amphetamine in Urine].
Fa yi xue za zhi.
2017 Dec; 33(6):599-603. doi:
10.3969/j.issn.1004-5619.2017.06.006. [PMID: 29441766] - Sara A Wahdan, Mariane G Tadros, Amani E Khalifa. Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Sep; 390(9):905-917. doi:
10.1007/s00210-017-1392-1. [PMID: 28643087] - Thomas Müller, Peter Riederer, Edna Grünblatt. Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2017 06; 124(6):745-748. doi:
10.1007/s00702-017-1705-z. [PMID: 28299453] - Yun-Song Wang, Bi-Tao Li, Shi-Xi Liu, Zheng-Qi Wen, Jing-Hua Yang, Hong-Bin Zhang, Xiao-Jiang Hao. Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens.
Journal of natural products.
2017 04; 80(4):798-804. doi:
10.1021/acs.jnatprod.6b00391. [PMID: 28368606] - Christoffer Bundgaard, Liliana P Montezinho, Neil Anderson, Christian Thomsen, Arne Mørk. Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites.
Pharmacology, biochemistry, and behavior.
2016 Nov; 150-151(?):147-152. doi:
10.1016/j.pbb.2016.10.003. [PMID: 27984094] - Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M Catafau, Jonas Hannestad, Andrea Varrone, Christer Halldin. In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Feb; 57(2):315-20. doi:
10.2967/jnumed.115.161083. [PMID: 26585057] - Andrea E Steuer, Martina I Boxler, Lorena Stock, Thomas Kraemer. Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine.
Toxicology letters.
2016 Jan; 243(?):48-55. doi:
10.1016/j.toxlet.2015.12.001. [PMID: 26721607] - Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.
PloS one.
2016; 11(11):e0166750. doi:
10.1371/journal.pone.0166750. [PMID: 27861613] - Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muench. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Feb; 40(3):650-7. doi:
10.1038/npp.2014.214. [PMID: 25249059] - Zita Pöstényi, Kornélia Tekes, Edit Tóth-Molnár, Huba Kalász. HPLC analysis of blood-brain barrier penetration of 4-fluorodeprenyl.
Journal of pharmaceutical and biomedical analysis.
2015 Jan; 102(?):529-34. doi:
10.1016/j.jpba.2014.09.035. [PMID: 25459953] - Soutarou Taguchi, Jun-ichi Niwa, Tohru Ibi, Manabu Doyu. [Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report].
Rinsho shinkeigaku = Clinical neurology.
2015; 55(3):182-4. doi:
10.5692/clinicalneurol.55.182. [PMID: 25786757] - Hideyuki Sawada, Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Kenji Yamamoto, Shinji Sudoh, Hiroshi Sugiyama. Subclinical elevation of plasma C-reactive protein and illusions/hallucinations in subjects with Parkinson's disease: case-control study.
PloS one.
2014; 9(1):e85886. doi:
10.1371/journal.pone.0085886. [PMID: 24497930] - Elizete De Moraes Reis, Francisco Waldomiro Schreiner Neto, Vitória Berg Cattani, Luis Ricardo Peroza, Alcindo Busanello, Caroline Queiroz Leal, Aline Augusti Boligon, Tássia Fontana Lehmen, Milena Libardoni, Margareth Linde Athayde, Roselei Fachinetto. Antidepressant-like effect of Ilex paraguariensis in rats.
BioMed research international.
2014; 2014(?):958209. doi:
10.1155/2014/958209. [PMID: 24895633] - Cheng-Ming Tsao, Jhih-Gang Jhang, Shiu-Jen Chen, Shuk-Man Ka, Tao-Cheng Wu, Wen-Jinn Liaw, Hsieh-Chou Huang, Chin-Chen Wu. Adjuvant potential of selegiline in attenuating organ dysfunction in septic rats with peritonitis.
PloS one.
2014; 9(9):e108455. doi:
10.1371/journal.pone.0108455. [PMID: 25268350] - Qing Zhao, Dingfang Cai, Yu Bai. Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease.
International journal of molecular medicine.
2013 Oct; 32(4):883-91. doi:
10.3892/ijmm.2013.1450. [PMID: 23877198] - W A Baumgartner, A M Baumgartner. Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient.
Medical hypotheses.
2013 Oct; 81(4):720-8. doi:
10.1016/j.mehy.2013.07.036. [PMID: 23948599] - Thomas Müller, Josef A Hoffmann, Walter Dimpfel, Christian Oehlwein. Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2013 May; 120(5):761-5. doi:
10.1007/s00702-012-0927-3. [PMID: 23196982] - Hannah P Priyanka, Preetam Bala, Sindhu Ankisettipalle, Srinivasan ThyagaRajan. Bacopa monnieri and L-deprenyl differentially enhance the activities of antioxidant enzymes and the expression of tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-κB pathways in the spleen of female wistar rats.
Neurochemical research.
2013 Jan; 38(1):141-52. doi:
10.1007/s11064-012-0902-2. [PMID: 23076629] - S Nag, G Kettschau, T Heinrich, A Varrone, L Lehmann, B Gulyas, A Thiele, É Keller, C Halldin. Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.
Bioorganic & medicinal chemistry.
2013 Jan; 21(1):186-95. doi:
10.1016/j.bmc.2012.10.050. [PMID: 23211968] - Evi V Nagler, Angela C Webster, Raymond Vanholder, Carmine Zoccali. Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP).
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Oct; 27(10):3736-45. doi:
10.1093/ndt/gfs295. [PMID: 22859791] - S Nag, L Lehmann, G Kettschau, T Heinrich, A Thiele, A Varrone, B Gulyas, C Halldin. Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).
Bioorganic & medicinal chemistry.
2012 May; 20(9):3065-71. doi:
10.1016/j.bmc.2012.02.056. [PMID: 22436387] - Con K Stough, Matthew P Pase, Vanessa Cropley, Stephen Myers, Karen Nolidin, Rebecca King, David Camfield, Keith Wesnes, Andrew Pipingas, Kevin Croft, Dennis Chang, Andrew B Scholey. A randomized controlled trial investigating the effect of Pycnogenol and Bacopa CDRI08 herbal medicines on cognitive, cardiovascular, and biochemical functioning in cognitively healthy elderly people: the Australian Research Council Longevity Intervention (ARCLI) study protocol (ANZCTR12611000487910).
Nutrition journal.
2012 Mar; 11(?):11. doi:
10.1186/1475-2891-11-11. [PMID: 22390677] - Paul W Andrews, J Anderson Thomson, Ananda Amstadter, Michael C Neale. Primum non nocere: an evolutionary analysis of whether antidepressants do more harm than good.
Frontiers in psychology.
2012; 3(?):117. doi:
10.3389/fpsyg.2012.00117. [PMID: 22536191] - Gabor Bekesi, Zsolt Tulassay, Gabriella Lengyel, Zsuzsa Schaff, Dezso Szombath, Julia Stark, Istvan Marczell, Peter Nagy-Repas, Ildiko Adler, Elek Dinya, Karoly Racz, Kalman Magyar. The effect of selegiline on total scavenger capacity and liver fat content: a preliminary study in an animal model.
Journal of neural transmission (Vienna, Austria : 1996).
2012 Jan; 119(1):25-30. doi:
10.1007/s00702-011-0666-x. [PMID: 21643961] - Puchchakayala Goverdhan, Akina Sravanthi, Thati Mamatha. Neuroprotective effects of meloxicam and selegiline in scopolamine-induced cognitive impairment and oxidative stress.
International journal of Alzheimer's disease.
2012; 2012(?):974013. doi:
10.1155/2012/974013. [PMID: 22536538] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Tahira Farooqui, Akhlaq A Farooqui. Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson's disease.
Parkinson's disease.
2011 Feb; 2011(?):247467. doi:
10.4061/2011/247467. [PMID: 21403820] - Giovanni Schifitto, Lijuan Deng, Tzu-Min Yeh, Scott R Evans, Thomas Ernst, Jianhui Zhong, David Clifford. Clinical, laboratory, and neuroimaging characteristics of fatigue in HIV-infected individuals.
Journal of neurovirology.
2011 Feb; 17(1):17-25. doi:
10.1007/s13365-010-0010-5. [PMID: 21181521] - Martin R Farlow, Monique Somogyi. Transdermal patches for the treatment of neurologic conditions in elderly patients: a review.
The primary care companion for CNS disorders.
2011; 13(6):. doi:
10.4088/pcc.11r01149. [PMID: 22454804] - Xuemei Huang, Peggy Auinger, Shirley Eberly, David Oakes, Michael Schwarzschild, Alberto Ascherio, Richard Mailman, Honglei Chen. Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.
PloS one.
2011; 6(8):e22854. doi:
10.1371/journal.pone.0022854. [PMID: 21853051] - Tamar Goren, Liat Adar, Nissim Sasson, Yoni M Weiss. Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Journal of clinical pharmacology.
2010 Dec; 50(12):1420-8. doi:
10.1177/0091270010369674. [PMID: 20445015] - Chandra Sekhar Kolli, Gurkishan Chadha, Jin Xiao, Daniel L Parsons, R Jayachandra Babu. Transdermal iontophoretic delivery of selegiline hydrochloride, in vitro.
Journal of drug targeting.
2010 Nov; 18(9):657-64. doi:
10.3109/10611860903494237. [PMID: 20038213] - Pilar del Hoyo, Alberto García-Redondo, Fernando de Bustos, José Antonio Molina, Youssef Sayed, Hortensia Alonso-Navarro, Luis Caballero, Joaquín Arenas, José A G Agúndez, Félix Javier Jiménez-Jiménez. Oxidative stress in skin fibroblasts cultures from patients with Parkinson's disease.
BMC neurology.
2010 Oct; 10(?):95. doi:
10.1186/1471-2377-10-95. [PMID: 20958999] - Paolo Solla, Antonino Cannas, Francesco Marrosu, Maria Giovanna Marrosu. Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo).
Neuropsychiatric disease and treatment.
2010 Sep; 6(?):483-90. doi:
10.2147/ndt.s5190. [PMID: 20856911] - Manju V Subramanian, T J James. Age-related protective effect of deprenyl on changes in the levels of diagnostic marker enzymes and antioxidant defense enzymes activities in cerebellar tissue in Wistar rats.
Cell stress & chaperones.
2010 Sep; 15(5):743-51. doi:
10.1007/s12192-010-0177-y. [PMID: 20224915] - B Szende, G Barna, Kálmán Magyar. Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells.
Journal of neural transmission (Vienna, Austria : 1996).
2010 Jun; 117(6):695-8. doi:
10.1007/s00702-010-0413-8. [PMID: 20454984] - Andrea H Weinberger, Erin L Reutenauer, Peter I Jatlow, Stephanie S O'Malley, Marc N Potenza, Tony P George. A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers.
Drug and alcohol dependence.
2010 Mar; 107(2-3):188-95. doi:
10.1016/j.drugalcdep.2009.10.009. [PMID: 19939587] - Ndidi Ngwuluka, Viness Pillay, Lisa C Du Toit, Valence Ndesendo, Yahya Choonara, Girish Modi, Dinesh Naidoo. Levodopa delivery systems: advancements in delivery of the gold standard.
Expert opinion on drug delivery.
2010 Feb; 7(2):203-24. doi:
10.1517/17425240903483166. [PMID: 20095943] - Jillian M Hagel, Peter J Facchini. Biochemistry and occurrence of o-demethylation in plant metabolism.
Frontiers in physiology.
2010; 1(?):14. doi:
10.3389/fphys.2010.00014. [PMID: 21423357] - Chuang C Chiueh. Methods for studying redox cycling of thioredoxin in mediating preconditioning-induced survival genes and proteins.
Methods in enzymology.
2010; 474(?):197-212. doi:
10.1016/s0076-6879(10)74012-x. [PMID: 20609912] - V E Tseilikman, A I Sinitsky, K A Poyarkov, E V Vojdaev. Effect of deprenyl on free radical oxidation in rat brain during immobilization stress.
Bulletin of experimental biology and medicine.
2009 Dec; 148(6):856-8. doi:
10.1007/s10517-010-0835-1. [PMID: 21116490] - André Charlett, R John Dobbs, Sylvia M Dobbs, Clive Weller, Mohammad A A Ibrahim, Tracy Dew, Roy Sherwood, Norman L Oxlade, J Malcolm Plant, James Bowthorpe, Andrew J Lawson, Alan Curry, Dale W Peterson, Ingvar T Bjarnason. Blood profile holds clues to role of infection in a premonitory state for idiopathic parkinsonism and of gastrointestinal infection in established disease.
Gut pathogens.
2009 Nov; 1(1):20. doi:
10.1186/1757-4749-1-20. [PMID: 19941660] - J Greg Whaley, Binu Tharakan, Benjamin Smith, Felicia A Hunter, Ed W Childs. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells.
Journal of burn care & research : official publication of the American Burn Association.
2009 Nov; 30(6):1018-27. doi:
10.1097/bcr.0b013e3181bfb825. [PMID: 19826263] - Krisztina K Johansen, Lei Wang, Jan O Aasly, Linda R White, Wayne R Matson, Claire Henchcliffe, M Flint Beal, Mikhail Bogdanov. Metabolomic profiling in LRRK2-related Parkinson's disease.
PloS one.
2009 Oct; 4(10):e7551. doi:
10.1371/journal.pone.0007551. [PMID: 19847307] - F Porta, A Mussa, D Concolino, M Spada, A Ponzone. Dopamine agonists in 6-pyruvoyl tetrahydropterin synthase deficiency.
Neurology.
2009 Aug; 73(8):633-7. doi:
10.1212/wnl.0b013e3181b38983. [PMID: 19704083] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
BMC clinical pharmacology.
2009 Aug; 9(?):13. doi:
10.1186/1472-6904-9-13. [PMID: 19646280] - D I Zafeiriou, M A Willemsen, M M Verbeek, E Vargiami, A Ververi, R Wevers. Tyrosine hydroxylase deficiency with severe clinical course.
Molecular genetics and metabolism.
2009 May; 97(1):18-20. doi:
10.1016/j.ymgme.2009.02.001. [PMID: 19282209] - Hong Wan, Madeleine Ahman, Anders G Holmén. Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Journal of medicinal chemistry.
2009 Mar; 52(6):1693-700. doi:
10.1021/jm801441s. [PMID: 19256501] - Muge Kiray, H A Bagriyanik, B U Ergur, C Pekcetin, Ayca Topcu. Antioxidant and antiapoptotic activities of deprenyl and estradiol co-administration in aged rat kidney.
Acta biologica Hungarica.
2009 Mar; 60(1):69-77. doi:
10.1556/abiol.60.2009.1.7. [PMID: 19378925] - Andreas Wentrup, Wolfgang H Oertel, Richard Dodel. Once-daily transdermal rivastigmine in the treatment of Alzheimer's disease.
Drug design, development and therapy.
2009 Feb; 2(?):245-54. doi:
10.2147/dddt.s3102. [PMID: 19920911] - Muhammad M Nashatizadeh, Kelly E Lyons, Rajesh Pahwa. A review of ropinirole prolonged release in Parkinson's disease.
Clinical interventions in aging.
2009; 4(?):179-86. doi:
10.2147/cia.s3358. [PMID: 19503779] - D Concolino, G Muzzi, M Rapsomaniki, M T Moricca, M G Pascale, P Strisciuglio. Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients.
Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S193-7. doi:
10.1007/s10545-007-0788-3. [PMID: 18425437] - Banthit Chetsawang, Patcharee Kooncumchoo, Piyarat Govitrapong, Manuchair Ebadi. 1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline.
Neurochemistry international.
2008 Dec; 53(6-8):283-8. doi:
10.1016/j.neuint.2008.08.007. [PMID: 18805449] - Muge Kiray, Husnu Alper Bagriyanik, Cetin Pekcetin, Bekir Ugur Ergur, Nazan Uysal. Protective effects of deprenyl in transient cerebral ischemia in rats.
The Chinese journal of physiology.
2008 Oct; 51(5):275-81. doi:
. [PMID: 19175183] - Yuji Fujita, Katsuo Takahashi, Masao Takei, Hisae Niitsu, Yasuhiro Aoki, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue, Shigeatsu Endo. Detection of levorotatory methamphetamine and levorotatory amphetamine in urine after ingestion of an overdose of selegiline.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Oct; 128(10):1507-12. doi:
10.1248/yakushi.128.1507. [PMID: 18827472] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Rashmi Sisodia, Ritu K Yadav, K V Sharma, A L Bhatia. Spinacia oleracea Modulates Radiation-Induced Biochemical Changes in Mice Testis.
Indian journal of pharmaceutical sciences.
2008 May; 70(3):320-6. doi:
10.4103/0250-474x.42980. [PMID: 20046739] - Eric C K Siu, Rachel F Tyndale. Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice.
The Journal of pharmacology and experimental therapeutics.
2008 Mar; 324(3):992-9. doi:
10.1124/jpet.107.133900. [PMID: 18065502] - Eva Toronyi. [Role of apoptosis in the kidney after reperfusion].
Orvosi hetilap.
2008 Feb; 149(7):305-15. doi:
10.1556/oh.2008.28212. [PMID: 18258561] - Angelo Antonini, Giovanni Abbruzzese, Paolo Barone, Ubaldo Bonuccelli, Leonardo Lopiano, Marco Onofrj, Mario Zappia, Aldo Quattrone. COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features.
Neuropsychiatric disease and treatment.
2008 Feb; 4(1):1-9. doi:
10.2147/ndt.s2404. [PMID: 18728767] - Sabina Strano-Rossi, Cristiana Colamonici, Francesco Botrè. Parallel analysis of stimulants in saliva and urine by gas chromatography/mass spectrometry: perspectives for 'in competition' anti-doping analysis.
Analytica chimica acta.
2008 Jan; 606(2):217-22. doi:
10.1016/j.aca.2007.10.053. [PMID: 18082653] - Martin R Farlow, Michael L Miller, Vojislav Pejovic. Treatment options in Alzheimer's disease: maximizing benefit, managing expectations.
Dementia and geriatric cognitive disorders.
2008; 25(5):408-22. doi:
10.1159/000122962. [PMID: 18391487] - Kiyoshi Ando, Jun Maeda, Motoki Inaji, Takashi Okauchi, Shigeru Obayashi, Makoto Higuchi, Tetsuya Suhara, Yoshikuni Tanioka. Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.
Psychopharmacology.
2008 Jan; 195(4):509-16. doi:
10.1007/s00213-007-0929-2. [PMID: 17879087] - Jakub Drozak, Marcin Kozlowski, Renata Doroszewska, Lukasz Pera, Rafal Derlacz, Robert Jarzyna, Jadwiga Bryla. Differential effects of selegiline on glucose synthesis in rabbit kidney-cortex tubules and hepatocytes. In vitro and in vivo studies.
Chemico-biological interactions.
2007 Dec; 170(3):162-76. doi:
10.1016/j.cbi.2007.07.013. [PMID: 17767924] - Albert J Azzaro, John Ziemniak, Eva Kemper, Bryan J Campbell, Chad VanDenBerg. Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules.
Journal of clinical pharmacology.
2007 Oct; 47(10):1256-67. doi:
10.1177/0091270007304779. [PMID: 17715422] - Ema Alves, Teresa Summavielle, Cecília Juliana Alves, Joana Gomes-da-Silva, José Custódio Barata, Eduarda Fernandes, Maria de Lourdes Bastos, Maria Amélia Tavares, Félix Carvalho. Monoamine oxidase-B mediates ecstasy-induced neurotoxic effects to adolescent rat brain mitochondria.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Sep; 27(38):10203-10. doi:
10.1523/jneurosci.2645-07.2007. [PMID: 17881526] - Tua Annanmaki, Antti Muuronen, Kari Murros. Low plasma uric acid level in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2007 Jun; 22(8):1133-7. doi:
10.1002/mds.21502. [PMID: 17443703] - Ashwin A Patkar, Chi-Un Pae, Michael Zarzar. Transdermal selegiline.
Drugs of today (Barcelona, Spain : 1998).
2007 Jun; 43(6):361-77. doi:
10.1358/dot.2006.43.6.1050794. [PMID: 17612708] - Amar Jyoti, Pallavi Sethi, Deepak Sharma. Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain.
Journal of ethnopharmacology.
2007 Apr; 111(1):56-62. doi:
10.1016/j.jep.2006.10.037. [PMID: 17189676] - Joseph Jankovic, Mark Stacy. Medical management of levodopa-associated motor complications in patients with Parkinson's disease.
CNS drugs.
2007; 21(8):677-92. doi:
10.2165/00023210-200721080-00005. [PMID: 17630819] - Han Yan, Lin Li, Xi Can Tang. Treating senile dementia with traditional Chinese medicine.
Clinical interventions in aging.
2007; 2(2):201-8. doi:
". [PMID: 18044136] - Anthony S L Chan, Linda W C Ng, Lydia S W Poon, Winnie W Y Chan, Yung H Wong. Dopaminergic and adrenergic toxicities on SK-N-MC human neuroblastoma cells are mediated through G protein signaling and oxidative stress.
Apoptosis : an international journal on programmed cell death.
2007 Jan; 12(1):167-79. doi:
10.1007/s10495-006-0524-8. [PMID: 17136323] - K Magyar, I Szatmáry, G Szebeni, J Lengyel. Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse.
Journal of neural transmission. Supplementum.
2007; ?(72):165-73. doi:
10.1007/978-3-211-73574-9_21. [PMID: 17982891] - Muge Kiray, Bekir Ugur Ergur, Alper Bagriyanik, Cetin Pekcetin, Ilkay Aksu, Zisan Buldan. Suppression of apoptosis and oxidative stress by deprenyl and estradiol in aged rat liver.
Acta histochemica.
2007; 109(6):480-5. doi:
10.1016/j.acthis.2007.04.008. [PMID: 17698173] - Ayako Kuriki, Takeshi Kumazawa, Xiao-Pen Lee, Chika Hasegawa, Mitsuru Kawamura, Osamu Suzuki, Keizo Sato. Simultaneous determination of selegiline and desmethylselegiline in human body fluids by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Dec; 844(2):283-91. doi:
10.1016/j.jchromb.2006.07.019. [PMID: 16893687] - Ahmed Elkashef, Paul J Fudala, Liza Gorgon, Shou-Hua Li, Roberta Kahn, Nora Chiang, Frank Vocci, Joseph Collins, Karen Jones, Kathy Boardman, Mike Sather. Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence.
Drug and alcohol dependence.
2006 Dec; 85(3):191-7. doi:
10.1016/j.drugalcdep.2006.04.010. [PMID: 16730924] - Brandy L Wilkinson, Gary E Landreth. The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease.
Journal of neuroinflammation.
2006 Nov; 3(?):30. doi:
10.1186/1742-2094-3-30. [PMID: 17094809] - Manuchair Ebadi, Holly Brown-Borg, Jun Ren, Sushil Sharma, Shaik Shavali, Hesham El ReFaey, Edward C Carlson. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases.
Current drug targets.
2006 Nov; 7(11):1513-29. doi:
10.2174/1389450110607011513. [PMID: 17100591]