Selegiline (BioDeep_00000001512)

 

Secondary id: BioDeep_00000402619, BioDeep_00000406019

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


methyl(1-phenylpropan-2-yl)(prop-2-yn-1-yl)amine

化学式: C13H17N (187.1360922)
中文名称: 司来吉兰 盐酸盐, 1，N-二甲基-N-丙炔基-2-苯乙胺
谱图信息: 最多检出来源 Homo sapiens(blood) 2.8%

分子结构信息

SMILES: C#CCN(C)C(C)Cc1ccccc1
InChI: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3

描述信息

A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinsons disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl. [PubChem]
INTERNAL_ID 948; CONFIDENCE standard compound; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5917; ORIGINAL_PRECURSOR_SCAN_NO 5916
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5948; ORIGINAL_PRECURSOR_SCAN_NO 5946
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5965; ORIGINAL_PRECURSOR_SCAN_NO 5963
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5911; ORIGINAL_PRECURSOR_SCAN_NO 5909
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5941; ORIGINAL_PRECURSOR_SCAN_NO 5940
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5953; ORIGINAL_PRECURSOR_SCAN_NO 5952
CONFIDENCE standard compound; INTERNAL_ID 948; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5917; ORIGINAL_PRECURSOR_SCAN_NO 5916
N - Nervous system > N04 - Anti-parkinson drugs > N04B - Dopaminergic agents > N04BD - Monoamine oxidase b inhibitors
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3275
CONFIDENCE standard compound; INTERNAL_ID 2119
D020011 - Protective Agents

同义名列表

32 个代谢物同义名

methyl(1-phenylpropan-2-yl)(prop-2-yn-1-yl)amine; Bristol-myers squibb brand OF selegiline; Bristol myers squibb brand OF selegiline; Selegiline hydrochloride, (R,S)-isomer; Selegiline hydrochloride, (R)-isomer; Selegiline hydrochloride, (S)-isomer; Valeant brand OF selegiline; Hydrochloride, selegiline; Selegiline valeant brand; Selegiline, (R,S)-isomer; Selegiline hydrochloride; Selegiline, (S)-isomer; Selegiline, (R)-isomer; L-Deprenalin; Selegilinum; L-Deprenyl; Selegyline; D-deprenyl; Selegiline; Selegilina; Deprenalin; Eldepryl; Deprenil; Deprenyl; Zelapar; Humex; Yumex; Emsam; Jumex; Selegiline; Deprenyl; Selegiline



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhen Tian, Xinyue Wang, Tianshu Han, Changhao Sun. Selegiline ameliorated dyslipidemia and hepatic steatosis in high-fat diet mice. International immunopharmacology. 2023 Feb; 117(?):109901. doi: 10.1016/j.intimp.2023.109901. [PMID: 36822098]
  • Mohammad-Hadi Karimi-Harandi, Mehdi Shabani-Nooshabadi, Rozhin Darabi. Simultaneous determination of citalopram and selegiline using an efficient electrochemical sensor based on ZIF-8 decorated with RGO and g-C3N4 in real samples. Analytica chimica acta. 2022 Apr; 1203(?):339662. doi: 10.1016/j.aca.2022.339662. [PMID: 35361426]
  • Yuehong Pu, Fenghua Qian, Jian Guo, Yuanyuan Sha, Yiming Qian. Selegiline Protects Against Lipopolysaccharide (LPS)-Induced Impairment of the Blood-Brain Barrier Through Regulating the NF-κB/MLCK/p-MLC Signaling Pathway. Neurotoxicity research. 2022 Feb; 40(1):267-275. doi: 10.1007/s12640-021-00448-5. [PMID: 34981455]
  • Sid E O'Bryant, Melissa Petersen, Fan Zhang, Leigh Johnson, David Mason, James Hall. Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study. Parkinsonism & related disorders. 2022 01; 94(?):15-21. doi: 10.1016/j.parkreldis.2021.11.027. [PMID: 34864471]
  • Zufika Qamar, Muhammad Usama Ashhar, Annu, Farheen Fatima Qizilibash, Pravat Kumar Sahoo, Asgar Ali, Javed Ali, Sanjula Baboota. Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin. International journal of pharmaceutics. 2021 Nov; 609(?):121131. doi: 10.1016/j.ijpharm.2021.121131. [PMID: 34563617]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ilchung Shin, Hyeyoung Choi, Seojin Kang, Jihyun Kim, Yuran Park, Wonkyung Yang. Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. Journal of analytical toxicology. 2021 Feb; 45(1):99-104. doi: 10.1093/jat/bkaa058. [PMID: 32476010]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Pradeep Paudel, Su Hui Seong, Hyun Ah Jung, Jae Sue Choi. Characterizing fucoxanthin as a selective dopamine D3/D4 receptor agonist: Relevance to Parkinson's disease. Chemico-biological interactions. 2019 Sep; 310(?):108757. doi: 10.1016/j.cbi.2019.108757. [PMID: 31323226]
  • Yogita Tyagi, N V Satheesh Madhav. Design of selegiline-loaded bio-nanosuspension for the management of depression using novel bio-retardant from Manilkara zapota. Drug development and industrial pharmacy. 2019 Aug; 45(8):1351-1360. doi: 10.1080/03639045.2019.1619760. [PMID: 31084445]
  • Rajalakshmi Rukmangathen, Indira Muzib Yallamalli, Prasanna Raju Yalavarthi. Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease. Current drug discovery technologies. 2019; 16(4):417-425. doi: 10.2174/1570163815666180418144019. [PMID: 29669501]
  • Neeraj Mishra, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar, Ruchika Sharma. Development and Characterization of Nasal Delivery of Selegiline Hydrochloride Loaded Nanolipid Carriers for the Management of Parkinson's Disease. Central nervous system agents in medicinal chemistry. 2019; 19(1):46-56. doi: 10.2174/1871524919666181126124846. [PMID: 30474538]
  • Vinay Sridhar, Ram Gaud, Amrita Bajaj, Sarika Wairkar. Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease. Nanomedicine : nanotechnology, biology, and medicine. 2018 11; 14(8):2609-2618. doi: 10.1016/j.nano.2018.08.004. [PMID: 30171904]
  • Vinicius Figueiredo Sardela, Carina de Souza Anselmo, Isabelle Karine da Costa Nunes, Gabriel Reis Alves Carneiro, Gustavo Ramalho Cardoso Dos Santos, Aline Reis de Carvalho, Bruna de Jesus Labanca, Daniely Silva Oliveira, William Dias Ribeiro, Amanda Lessa Dutra de Araujo, Monica Costa Padilha, Cleverton Kleiton Freitas de Lima, Valeria Pereira de Sousa, Francisco Radler de Aquino Neto, Henrique Marcelo Gualberto Pereira. Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges. Drug testing and analysis. 2018 Nov; 10(11-12):1657-1669. doi: 10.1002/dta.2523. [PMID: 30341930]
  • Carolina Noble, Niels Bjerre Holm, Marie Mardal, Kristian Linnet. Bromo-dragonfly, a psychoactive benzodifuran, is resistant to hepatic metabolism and potently inhibits monoamine oxidase A. Toxicology letters. 2018 Oct; 295(?):397-407. doi: 10.1016/j.toxlet.2018.07.018. [PMID: 30036687]
  • Michael Strupp, Ludwig Kraus, Franz Schautzer, Dan Rujescu. Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study. Journal of neurology. 2018 Oct; 265(Suppl 1):80-85. doi: 10.1007/s00415-018-8809-8. [PMID: 29532287]
  • Csilla Terézia Nagy, Gábor Koncsos, Zoltán V Varga, Tamás Baranyai, Sebestyén Tuza, Ferenc Kassai, Aliz Judit Ernyey, István Gyertyán, Kornél Király, Attila Oláh, Tamás Radovits, Béla Merkely, Nóra Bukosza, Gábor Szénási, Péter Hamar, Domokos Mathé, Krisztián Szigeti, Csilla Pelyhe, Marek Jelemenský, Zsófia Onódi, Zsuzsanna Helyes, Rainer Schulz, Zoltán Giricz, Péter Ferdinandy. Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats. British journal of pharmacology. 2018 09; 175(18):3713-3726. doi: 10.1111/bph.14437. [PMID: 29971762]
  • Ronan Gealageas, Alice Devineau, Pauline P L So, Catrina M J Kim, Jayakumar Surendradoss, Christian Buchwalder, Markus Heller, Verena Goebeler, Edith M Dullaghan, David S Grierson, Edward E Putnins. Development of Novel Monoamine Oxidase-B (MAO-B) Inhibitors with Reduced Blood-Brain Barrier Permeability for the Potential Management of Noncentral Nervous System (CNS) Diseases. Journal of medicinal chemistry. 2018 08; 61(16):7043-7064. doi: 10.1021/acs.jmedchem.7b01588. [PMID: 30016860]
  • Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka. Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements. Behavioural brain research. 2018 07; 347(?):350-359. doi: 10.1016/j.bbr.2018.03.002. [PMID: 29526790]
  • Chadwick W Christine, Peggy Auinger, Amelia Joslin, Yuora Yelpaala, Ralph Green. Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease. Movement disorders : official journal of the Movement Disorder Society. 2018 05; 33(5):762-770. doi: 10.1002/mds.27301. [PMID: 29508904]
  • P Xiang, J Bu, Z Qiao, X Y Zhuo, H J Wu, M Shen. [Identification of Methamphetamine Abuse and Selegiline Use： Chiral Analysis of Methamphetamine and Amphetamine in Urine]. Fa yi xue za zhi. 2017 Dec; 33(6):599-603. doi: 10.3969/j.issn.1004-5619.2017.06.006. [PMID: 29441766]
  • Sara A Wahdan, Mariane G Tadros, Amani E Khalifa. Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2017 Sep; 390(9):905-917. doi: 10.1007/s00210-017-1392-1. [PMID: 28643087]
  • Thomas Müller, Peter Riederer, Edna Grünblatt. Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2017 06; 124(6):745-748. doi: 10.1007/s00702-017-1705-z. [PMID: 28299453]
  • Yun-Song Wang, Bi-Tao Li, Shi-Xi Liu, Zheng-Qi Wen, Jing-Hua Yang, Hong-Bin Zhang, Xiao-Jiang Hao. Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens. Journal of natural products. 2017 04; 80(4):798-804. doi: 10.1021/acs.jnatprod.6b00391. [PMID: 28368606]
  • Christoffer Bundgaard, Liliana P Montezinho, Neil Anderson, Christian Thomsen, Arne Mørk. Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites. Pharmacology, biochemistry, and behavior. 2016 Nov; 150-151(?):147-152. doi: 10.1016/j.pbb.2016.10.003. [PMID: 27984094]
  • Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M Catafau, Jonas Hannestad, Andrea Varrone, Christer Halldin. In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 Feb; 57(2):315-20. doi: 10.2967/jnumed.115.161083. [PMID: 26585057]
  • Andrea E Steuer, Martina I Boxler, Lorena Stock, Thomas Kraemer. Inhibition potential of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolites on the in vitro monoamine oxidase (MAO)-catalyzed deamination of the neurotransmitters serotonin and dopamine. Toxicology letters. 2016 Jan; 243(?):48-55. doi: 10.1016/j.toxlet.2015.12.001. [PMID: 26721607]
  • Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells. PloS one. 2016; 11(11):e0166750. doi: 10.1371/journal.pone.0166750. [PMID: 27861613]
  • Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muench. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2015 Feb; 40(3):650-7. doi: 10.1038/npp.2014.214. [PMID: 25249059]
  • Zita Pöstényi, Kornélia Tekes, Edit Tóth-Molnár, Huba Kalász. HPLC analysis of blood-brain barrier penetration of 4-fluorodeprenyl. Journal of pharmaceutical and biomedical analysis. 2015 Jan; 102(?):529-34. doi: 10.1016/j.jpba.2014.09.035. [PMID: 25459953]
  • Soutarou Taguchi, Jun-ichi Niwa, Tohru Ibi, Manabu Doyu. [Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report]. Rinsho shinkeigaku = Clinical neurology. 2015; 55(3):182-4. doi: 10.5692/clinicalneurol.55.182. [PMID: 25786757]
  • Hideyuki Sawada, Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Kenji Yamamoto, Shinji Sudoh, Hiroshi Sugiyama. Subclinical elevation of plasma C-reactive protein and illusions/hallucinations in subjects with Parkinson's disease: case-control study. PloS one. 2014; 9(1):e85886. doi: 10.1371/journal.pone.0085886. [PMID: 24497930]
  • Elizete De Moraes Reis, Francisco Waldomiro Schreiner Neto, Vitória Berg Cattani, Luis Ricardo Peroza, Alcindo Busanello, Caroline Queiroz Leal, Aline Augusti Boligon, Tássia Fontana Lehmen, Milena Libardoni, Margareth Linde Athayde, Roselei Fachinetto. Antidepressant-like effect of Ilex paraguariensis in rats. BioMed research international. 2014; 2014(?):958209. doi: 10.1155/2014/958209. [PMID: 24895633]
  • Cheng-Ming Tsao, Jhih-Gang Jhang, Shiu-Jen Chen, Shuk-Man Ka, Tao-Cheng Wu, Wen-Jinn Liaw, Hsieh-Chou Huang, Chin-Chen Wu. Adjuvant potential of selegiline in attenuating organ dysfunction in septic rats with peritonitis. PloS one. 2014; 9(9):e108455. doi: 10.1371/journal.pone.0108455. [PMID: 25268350]
  • Qing Zhao, Dingfang Cai, Yu Bai. Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease. International journal of molecular medicine. 2013 Oct; 32(4):883-91. doi: 10.3892/ijmm.2013.1450. [PMID: 23877198]
  • W A Baumgartner, A M Baumgartner. Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient. Medical hypotheses. 2013 Oct; 81(4):720-8. doi: 10.1016/j.mehy.2013.07.036. [PMID: 23948599]
  • Thomas Müller, Josef A Hoffmann, Walter Dimpfel, Christian Oehlwein. Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease. Journal of neural transmission (Vienna, Austria : 1996). 2013 May; 120(5):761-5. doi: 10.1007/s00702-012-0927-3. [PMID: 23196982]
  • Hannah P Priyanka, Preetam Bala, Sindhu Ankisettipalle, Srinivasan ThyagaRajan. Bacopa monnieri and L-deprenyl differentially enhance the activities of antioxidant enzymes and the expression of tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-κB pathways in the spleen of female wistar rats. Neurochemical research. 2013 Jan; 38(1):141-52. doi: 10.1007/s11064-012-0902-2. [PMID: 23076629]
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