rabeprazole (BioDeep_00000406005)
Main id: BioDeep_00000002584
代谢物信息卡片
rabeprazole
化学式: C18H21N3O3S (359.13035560000003)
中文名称: 雷贝拉唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CN=C1CS(=O)C2=NC3=CC=CC=C3N2)OCCCOC
InChI: InChI=1S/C18H21N3O3S/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18/h3-4,6-9H,5,10-12H2,1-2H3,(H,20,21)
描述信息
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BC - Proton pump inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29723 - Proton Pump Inhibitor
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D004791 - Enzyme Inhibitors > D054328 - Proton Pump Inhibitors
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:8768
- KEGG: C07864
- KEGGdrug: D08463
- PubChem: 5029
- DrugBank: DB01129
- ChEMBL: CHEMBL1219
- MeSH: Rabeprazole
- CAS: 117976-89-3
- MoNA: FiehnHILIC000724
- PubChem: 10066
- NIKKAJI: J395.966J
- RefMet: Rabeprazole
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yunfang Li, Jiayue Hao, Xianghui Kong, Weiyi Yuan, Yingying Shen, Zhaoyuan Hui, Xinliang Lu. Rabeprazole mitigates obesity-induced chronic inflammation and insulin resistance associated with increased M2-type macrophage polarization.
Biochimica et biophysica acta. Molecular basis of disease.
2024 Jun; 1870(5):167142. doi:
10.1016/j.bbadis.2024.167142. [PMID: 38565384] - Ying-Ying Han, Lin Zhou, Yun-Lian Hu, Xiang-Wu Ding, Hui Long, Fei Liu, Ming Xu, Zhen-Yu Zhang, Shuang-Ling Li, Qiu-Yan Wang, Cheng-Xia Su, Yan Chen, Jie Chen, Ya Lin, Pei-Yuan Li. Comparison of vonoprazan-based with rabeprazole-based dual therapy for treatment-naive patients of Helicobacter pylori infection: a prospective, multi-center, randomized controlled study.
Journal of gastroenterology.
2023 Oct; ?(?):. doi:
10.1007/s00535-023-02042-2. [PMID: 37777987] - Shasha Chen, Weina Shen, Yuhuan Liu, Qiang Dong, Yongquan Shi. Efficacy and safety of triple therapy containing berberine, amoxicillin, and vonoprazan for Helicobacter pylori initial treatment: A randomized controlled trial.
Chinese medical journal.
2023 Jul; 136(14):1690-1698. doi:
10.1097/cm9.0000000000002696. [PMID: 37469024] - Yi Du, Yinnan Wu, Yang Liu, Changhong Meng, Li Tan, Tiantian Cai, Yuxin Wang, Yihong Lu. Identification and genotoxicity evaluation of potential impurities in rabeprazole sodium using in silico and in vitro analyses.
Drug and chemical toxicology.
2022 Sep; 45(5):2116-2122. doi:
10.1080/01480545.2021.1908712. [PMID: 33829945] - Shi-Qing Chen, Bing-Feng Hu, Ya-Ru Yang, Yuan He, Lin Yue, Dong Guo, Ting-Ni Wu, Xiao-Wen Feng, Qing Li, Wei Zhang, Jia-Gen Wen. The protective effect of rabeprazole on cisplatin-induced apoptosis and necroptosis of renal proximal tubular cells.
Biochemical and biophysical research communications.
2022 07; 612(?):91-98. doi:
10.1016/j.bbrc.2022.04.107. [PMID: 35512462] - C Zeng, T Neogi, A T Chan, J Wei, D Misra, N Lu, H K Choi, G Lei, Y Zhang. Proton pump inhibitor therapy and risk of knee replacement surgery: a general population-based cohort study.
Osteoarthritis and cartilage.
2022 04; 30(4):559-569. doi:
10.1016/j.joca.2021.12.010. [PMID: 35031493] - Ting Zhang, Zhaowei Shan. A Retrospective Trial Exploring Erzhu Yiren Decoction in Gastric Ulcer with Spleen Deficiency and Dampness-Heat.
BioMed research international.
2022; 2022(?):6495181. doi:
10.1155/2022/6495181. [PMID: 35178451] - Huiping Xu, Melissa T O'Gorman, Sunil Nepal, Lee P James, Katherine Ginman, Yazdi K Pithavala. Phase 1 Study Evaluating the Effects of the Proton Pump Inhibitor Rabeprazole and Food on the Pharmacokinetics of Lorlatinib in Healthy Participants.
Clinical pharmacology in drug development.
2021 11; 10(11):1395-1404. doi:
10.1002/cpdd.1000. [PMID: 34288547] - Shogo Watari, Motoo Araki, Jun Matsumoto, Kasumi Yoshinaga, Takanori Sekito, Yuki Maruyama, Yosuke Mitsui, Takuya Sadahira, Risa Kubota, Shingo Nishimura, Koichiro Wada, Yasuyuki Kobayashi, Hidemi Takeuchi, Katsuyuki Tanabe, Masashi Kitagawa, Hiroshi Morinaga, Shinji Kitamura, Hitoshi Sugiyama, Noritaka Ariyoshi, Jun Wada, Masami Watanabe, Toyohiko Watanabe, Yasutomo Nasu. Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms.
Drug metabolism and pharmacokinetics.
2021 Oct; 40(?):100407. doi:
10.1016/j.dmpk.2021.100407. [PMID: 34352707] - Koki Kato, Tomohiro Mizuno, Takenao Koseki, Yoshimasa Ito, Masakazu Hatano, Kazuo Takahashi, Shigeki Yamada, Naotake Tsuboi. Concomitant Proton Pump Inhibitors and Immune Checkpoint Inhibitors Increase Nephritis Frequency.
In vivo (Athens, Greece).
2021 Sep; 35(5):2831-2840. doi:
10.21873/invivo.12570. [PMID: 34410975] - Gang Chen, Li-Juan Ning, Yan Qin, Bin Zhao, Dan Mei, Xue-Mei Li. Acute kidney injury following the use of different proton pump inhibitor regimens: A real-world analysis of post-marketing surveillance data.
Journal of gastroenterology and hepatology.
2021 Jan; 36(1):156-162. doi:
10.1111/jgh.15151. [PMID: 32542684] - Aditya A Joshi, Pankaj P Nerkar. Determination of Proton Pump Inhibitors by Spectrophotometric, Chromatographic and by Hyphenated Techniques: A Review.
Critical reviews in analytical chemistry.
2021; 51(6):527-548. doi:
10.1080/10408347.2020.1750339. [PMID: 32312104] - Meisi Lin, Siyuan Zhang, Minyue Zhang, Jinfeng Shi, Chen Zhang, Ruifeng Luo, Jieshu You, Jiayi Sun, Jinming Zhang, Fei Gao. Therapeutic efficacy and safety of Kangfuxin in combination with rabeprazole in the treatment of peptic ulcer: A systematic review and meta-analysis.
Medicine.
2020 Nov; 99(48):e23103. doi:
10.1097/md.0000000000023103. [PMID: 33235070] - Norihisa Takeda, Masaya Takemura, Yoshihiro Kanemitsu, Hisatoshi Hijikata, Kensuke Fukumitsu, Takamitsu Asano, Yusuke Yamaba, Motohiko Suzuki, Eiji Kubota, Takeshi Kamiya, Takashi Ueda, Akio Niimi. Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2020 11; 57(11):1202-1210. doi:
10.1080/02770903.2019.1641204. [PMID: 31303089] - Yao Chen, Qingyi Liu, Fulian Hu, Jizheng Ma. Identifying the best regimen for primary eradication of Helicobacter pylori: analysis of 240 cases.
MicrobiologyOpen.
2020 11; 9(11):e1120. doi:
10.1002/mbo3.1120. [PMID: 33026166] - Lu-Ning Sun, Ye Zhang, Yu-Qing Yang, Ye Shen, Yu-Wen Ying, Yu-Wen Su, Xue-Hui Zhang, Yun Liu, Xu Huang, Yong-Qing Wang. Simultaneous enantioselective determination of omeprazole, rabeprazole, lansoprazole, and pantoprazole enantiomers in human plasma by chiral liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2020 Aug; 43(16):3183-3196. doi:
10.1002/jssc.202000226. [PMID: 32495501] - Dolores Ochoa, Manuel Román, Teresa Cabaleiro, Miriam Saiz-Rodríguez, Gina Mejía, Francisco Abad-Santos. Effect of food on the pharmacokinetics of omeprazole, pantoprazole and rabeprazole.
BMC pharmacology & toxicology.
2020 07; 21(1):54. doi:
10.1186/s40360-020-00433-2. [PMID: 32711578] - Shingo Takashima, Fumio Tanaka, Yunosuke Kawaguchi, Yuki Usui, Kosuke Fujimoto, Yuji Nadatani, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Noriko Kamata, Koichi Taira, Tetsuya Tanigawa, Toshio Watanabe, Seiya Imoto, Satoshi Uematsu, Yasuhiro Fujiwara. Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2020 07; 32(7):e13841. doi:
10.1111/nmo.13841. [PMID: 32319196] - Akiko Harada, Ippei Ikushima, Miwa Haranaka, Aki Yanagihara, Daisuke Nakayama. Bioequivalence of a Newly Developed Dabigatran Etexilate Tablet Versus the Commercial Capsule and Impact of Rabeprazole-Induced Elevated Gastric pH on Exposure in Healthy Subjects.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2020 Jun; 20(3):249-258. doi:
10.1007/s40256-019-00377-x. [PMID: 31667735] - Lina A Dahabiyeh, Eman Y Abu-Rish, Mutasem O Taha. Inhibition of monoglyceride lipase by proton pump inhibitors: investigation using docking and in vitro experiments.
Pharmacological reports : PR.
2020 Apr; 72(2):435-442. doi:
10.1007/s43440-019-00013-0. [PMID: 32048247] - Tianxiang Shen, Xindong Jiang, Zhaolei Jin, Qiuzhi Ji, Chunlong Li, Qingpo Li, Hongxin Long, Weigen Qiu, Wei Wang, Xuemei Hou, Jian You. The study of intestinal absorption and biodistribution in vivo of proton pump inhibitors.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2020 Apr; 149(?):135-144. doi:
10.1016/j.ejpb.2020.01.015. [PMID: 32007590] - Sukh Bahadur Gurung, Shiva Raj Kc, Purnima Gyawali, Gyanendra Lal Amatya. Comparative Study on Effect of Rabeprazole Versus Omeprazole in Acid-peptic Disorder with Helicobacter pylori Infection.
Journal of Nepal Health Research Council.
2020 Jan; 17(4):479-484. doi:
10.33314/jnhrc.v17i4.1961. [PMID: 32001852] - Bhuvanachandra Pasupuleti, Vamshikrishna Gone, Ravali Baddam, Raj Kumar Venisetty, Om Prakash Prasad. Clinical Impact of Co-medication of Levetiracetam and Clobazam with Proton Pump Inhibitors: A Drug Interaction Study.
Current drug metabolism.
2020; 21(2):126-131. doi:
10.2174/1389200221666200218121050. [PMID: 32067615] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Li Fan, Qin Xianghong, Wang Ling, Han Ying, Xia Jielai, Hu Haitang. Ilaprazole Compared With Rabeprazole in the Treatment of Duodenal Ulcer: A Randomized, Double-blind, Active-controlled, Multicenter Study.
Journal of clinical gastroenterology.
2019 10; 53(9):641-647. doi:
10.1097/mcg.0000000000001186. [PMID: 30789856] - Jie Ying, Liu-Cheng Li, Cui-Yun Wu, Zhen-Wei Yu, Lian-Di Kan. The status of proton pump inhibitor use: a prescription survey of 45 hospitals in China.
Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.
2019 Oct; 111(10):738-743. doi:
10.17235/reed.2019.6155/2019. [PMID: 31373505] - Harilal Patel, Nirmal Desai, Prakash Patel, Nirav Modi, Krunal Soni, Jitendrakumar Rameshchandra Patel, Gaurav Navinbhai Mistry, Jitendrakumar D Patel, Manish Chawla, Nuggehally R Srinivas. Pharmacokinetic evaluation of differential drug release formulations of rabeprazole in dogs.
Drug development and industrial pharmacy.
2019 Sep; 45(9):1459-1467. doi:
10.1080/03639045.2019.1628249. [PMID: 31216902] - Masae Sekido, Ken-Ichi Fujita, Yutaro Kubota, Hiroo Ishida, Takehiro Takahashi, Ryotaro Ohkuma, Takuya Tsunoda, Fumihiro Ishikawa, Motoko Shibanuma, Yasutsuna Sasaki. Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Cancer chemotherapy and pharmacology.
2019 06; 83(6):1127-1135. doi:
10.1007/s00280-019-03837-y. [PMID: 30972456] - Lu-Ning Sun, Yi-Wen Shen, Yu-Wen Ying, Duo Li, Teng-Fei Li, Xue-Hui Zhang, Ping Zhao, Li Ding, Yong-Qing Wang. Stereoselective pharmacokinetics of (R)-(+)- and (S)-(-)-rabeprazole in human using chiral LC-MS/MS after administration of rabeprazole sodium enteric-coated tablet.
Chirality.
2018 12; 30(12):1277-1286. doi:
10.1002/chir.23022. [PMID: 30321480] - Yutaka Nagata, Kazuhiko Nagasaka, Syunpei Koyama, Mai Murase, Minoru Saito, Toshinori Yazaki, Nobutoshi Komatsu, Takayuki Murase, Toshiki Uehara, Norihide Taniuchi. Successful eradication of Helicobacter pylori with a herbal medicine, goshuyuto (Wu Zhu Yu Tang), plus rabeprazole after failure of triplet therapy with vonoprazan: A report of three cases.
Journal of digestive diseases.
2018 Jul; 19(7):439-442. doi:
10.1111/1751-2980.12537. [PMID: 28845910] - Teppei Okamoto, Shingo Hatakeyama, Shogo Hosogoe, Yoshimi Tanaka, Kengo Imanishi, Toru Takashima, Fumitada Saitoh, Tadashi Suzuki, Chikara Ohyama. Proton pump inhibitor as an independent factor of progression of abdominal aortic calcification in patients on maintenance hemodialysis.
PloS one.
2018; 13(7):e0199160. doi:
10.1371/journal.pone.0199160. [PMID: 29969455] - Wan Sun, Karen J Klamerus, Lisa M Yuhas, Sylvester Pawlak, Anna Plotka, Melissa O'Gorman, Leonid Kirkovsky, Maha Kosa, Diane Wang. Impact of Acid-Reducing Agents on the Pharmacokinetics of Palbociclib, a Weak Base With pH-Dependent Solubility, With Different Food Intake Conditions.
Clinical pharmacology in drug development.
2017 Nov; 6(6):614-626. doi:
10.1002/cpdd.356. [PMID: 28430398] - H S Ciftci, M S Karadeniz, T Tefik, Y Caliskan, H Yazıcı, E Demir, A Turkmen, I Nane, F S Oguz, F Aydin. Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism.
Transplantation proceedings.
2017 Apr; 49(3):490-496. doi:
10.1016/j.transproceed.2017.01.029. [PMID: 28340819] - Chong Su, Hong Yang, Xiangjun Meng, J Paul Fawcett, Jianming Cao, Yan Yang, Jingkai Gu. Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of separation science.
2017 Feb; 40(4):1010-1016. doi:
10.1002/jssc.201601232. [PMID: 27991740] - Tadashi Shimoyama, Daisuke Chinda, Yoshihiko Sawada, Kazuo Komai, Hironobu Chiba, Yoshiharu Saito, Yoshio Sasaki, Masashi Matsuzaka, Shinsaku Fukuda. Randomized Trial Comparing Esomeprazole and Rabeprazole in First-line Eradication Therapy for Helicobacter pylori Infection based on the Serum Levels of Pepsinogens.
Internal medicine (Tokyo, Japan).
2017; 56(13):1621-1627. doi:
10.2169/internalmedicine.56.7823. [PMID: 28674348] - Guojing Liu, Jiagen Wen, Dong Guo, Zhenmin Wang, Xiaolei Hu, Jie Tang, Zhaoqian Liu, Honghao Zhou, Wei Zhang. The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers.
Journal of pharmacological sciences.
2016 Dec; 132(4):244-248. doi:
10.1016/j.jphs.2016.04.016. [PMID: 27245553] - Takeo Yasu, Takaaki Konuma, Seiko Kato, Yosuke Kurokawa, Satoshi Takahashi, Arinobu Tojo. Different effects of lansoprazole and rabeprazole on the plasma voriconazole trough levels in allogeneic hematopoietic cell transplant recipients.
Annals of hematology.
2016 Oct; 95(11):1845-51. doi:
10.1007/s00277-016-2782-z. [PMID: 27535751] - X Sun, W Shang, Z Wang, X Liu, X Fang, M Ke. Short-term and long-term effect of diaphragm biofeedback training in gastroesophageal reflux disease: an open-label, pilot, randomized trial.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.
2016 Oct; 29(7):829-836. doi:
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Scientific reports.
2016 09; 6(?):32126. doi:
10.1038/srep32126. [PMID: 27581096] - Ana Ruiz-Garcia, Joanna C Masters, Laure Mendes da Costa, Robert R LaBadie, Yali Liang, Grace Ni, Craig A Ellery, Tanya Boutros, Zelanna Goldberg, Carlo L Bello. Effect of food or proton pump inhibitor treatment on the bioavailability of dacomitinib in healthy volunteers.
Journal of clinical pharmacology.
2016 02; 56(2):223-30. doi:
10.1002/jcph.588. [PMID: 26179237] - Edouard Ollier, Sophie Hodin, Thierry Basset, Sandrine Accassat, Laurent Bertoletti, Patrick Mismetti, Xavier Delavenne. In vitro and in vivo evaluation of drug-drug interaction between dabigatran and proton pump inhibitors.
Fundamental & clinical pharmacology.
2015 Dec; 29(6):604-14. doi:
10.1111/fcp.12154. [PMID: 26392328] - Masaru Murasawa, Tsutomu Sakurada, Daisuke Oishi, Tomo Suzuki, Naoto Tominaga, Hiroo Kawarazaki, Sayuri Shirai, Yugo Shibagaki, Kenjiro Kimura. Collagenous Colitis Associated with Rabeprazole in a Peritoneal Dialysis Patient.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2015 Sep; 35(5):588-90. doi:
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British journal of clinical pharmacology.
2015 May; 79(5):744-55. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Apr; 988(?):75-80. doi:
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Clinical journal of gastroenterology.
2015 Apr; 8(2):77-81. doi:
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Journal of gastrointestinal and liver diseases : JGLD.
2014 Dec; 23(4):367-70. doi:
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Clinical pharmacokinetics.
2014 Oct; 53(10):943-57. doi:
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Clinical pharmacology in drug development.
2014 09; 3(5):406-16. doi:
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Journal of separation science.
2014 Aug; 37(15):1951-6. doi:
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BMC gastroenterology.
2014 Jul; 14(?):116. doi:
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Pharmacogenomics.
2014; 15(15):1893-901. doi:
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Biomedical chromatography : BMC.
2013 Nov; 27(11):1380-6. doi:
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Journal of pediatric gastroenterology and nutrition.
2013 Oct; 57(4):520-6. doi:
10.1097/mpg.0b013e31829b6914. [PMID: 23689261] - T D Nykula, V V Furleta. [Rationale for improved treatment of ulcerative disease complicated by chronic pyelonephritis].
Likars'ka sprava.
2013 Jun; ?(4):71-6. doi:
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Molecular cancer therapeutics.
2013 Feb; 12(2):131-40. doi:
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European journal of clinical pharmacology.
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Journal of gastroenterology and hepatology.
2012 May; 27(5):888-92. doi:
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Evidence-based complementary and alternative medicine : eCAM.
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Indian journal of pharmacology.
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PloS one.
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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
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