ondansetron (BioDeep_00000405968)

natural product

代谢物信息卡片

Ondansetron aka "9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one"

化学式: C18H19N3O (293.1528044)
中文名称: 昂丹司琼, 恩丹西酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C
InChI: InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3

描述信息

A - Alimentary tract and metabolism > A04 - Antiemetics and antinauseants > A04A - Antiemetics and antinauseants > A04AA - Serotonin (5ht3) antagonists
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist > C94726 - 5-HT3 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
D003879 - Dermatologic Agents > D000982 - Antipruritics
D002491 - Central Nervous System Agents
Ondansetron (GR 38032; SN 307) is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity[1][2][3][4][5][6][7][8].

同义名列表

4 个代谢物同义名

ondansetron; Ondansetron aka "9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one"; GR 38032; SN 307

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:7773
KEGG: C07325
KEGGdrug: D00456
PubChem: 4595
DrugBank: DB00904
ChEMBL: CHEMBL46
MeSH: Ondansetron
CAS: 116002-70-1
CAS: 99614-01-4
CAS: 99614-02-5
MoNA: CCMSLIB00000079015
MoNA: FiehnHILIC002202
MoNA: FiehnHILIC000636
PubChem: 9533
PDB-CCD: S87
NIKKAJI: J245.610I
RefMet: Ondansetron
medchemexpress: HY-B0002B

分类词条

Carbazole alkaloids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Kathleen M Job, André Dallmann, Samuel Parry, George Saade, David M Haas, Brenna Hughes, Pamela Berens, Jia-Yu Chen, Christina Fu, Kelsey Humphrey, Christoph Hornik, Stephen Balevic, Kanecia Zimmerman, Kevin Watt. Development of a Generic Physiologically-Based Pharmacokinetic Model for Lactation and Prediction of Maternal and Infant Exposure to Ondansetron via Breast Milk. Clinical pharmacology and therapeutics. 2022 05; 111(5):1111-1120. doi: 10.1002/cpt.2530. [PMID: 35076931]
Masato Aoyama, Minami Shioya, Yume Tsukamoto, Hitomi Hasegawa, Shoei Sugita. The effects of cisplatin, an emetic agent, on behavior and plasma cortisol levels in goats. Animal science journal = Nihon chikusan Gakkaiho. 2021 Dec; 92(1):e13607. doi: 10.1111/asj.13607. [PMID: 34318567]
Lili Tao, Shiyu Zhou, Ping Chang, Shengli An. Effects of ondansetron use on outcomes of acute kidney injury in critically ill patients: An analysis based on the MIMIC-IV database. Journal of critical care. 2021 12; 66(?):117-122. doi: 10.1016/j.jcrc.2021.07.015. [PMID: 34509800]
Ahmad Qasem, Abed Elrahman Naser, Saleh A Naser. Enteropathogenic infections modulate intestinal serotonin transporter (SERT) function by activating Toll-like receptor 2 (TLR-2) in Crohn's disease. Scientific reports. 2021 11; 11(1):22624. doi: 10.1038/s41598-021-02050-3. [PMID: 34799637]
Derek Blevins, Chamindi Seneviratne, Xin-Qun Wang, Bankole A Johnson, Nassima Ait-Daoud. A randomized, double-blind, placebo-controlled trial of ondansetron for the treatment of cocaine use disorder with post hoc pharmacogenetic analysis. Drug and alcohol dependence. 2021 11; 228(?):109074. doi: 10.1016/j.drugalcdep.2021.109074. [PMID: 34600264]
Lucia You, Shamsa Shafi, Gary Soffer. Concomitant cow's milk and beef food protein-induced enterocolitis syndrome in a young infant. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 10; 127(4):504-505. doi: 10.1016/j.anai.2021.06.009. [PMID: 34153445]
Mitsuhiro Goda, Masaya Kanda, Toshihiko Yoshioka, Ami Yoshida, Yoichi Murai, Yoshito Zamami, Fuka Aizawa, Takahiro Niimura, Hirofumi Hamano, Naoto Okada, Kenta Yagi, Masayuki Chuma, Yuki Izawa-Ishizawa, Keisuke Ishizawa. Effects of 5-HT₃ receptor antagonists on cisplatin-induced kidney injury. Clinical and translational science. 2021 09; 14(5):1906-1916. doi: 10.1111/cts.13045. [PMID: 33982438]
Parniyan Goodarzi, Mohammad Habibi, Kennedy Roberts, Julia Sutton, Cedrick Ndhumba Shili, Dingbo Lin, Adel Pezeshki. Dietary Tryptophan Supplementation Alters Fat and Glucose Metabolism in a Low-Birthweight Piglet Model. Nutrients. 2021 Jul; 13(8):. doi: 10.3390/nu13082561. [PMID: 34444719]
Joseph Miller, Stacey House, Luis Lovato, Andrew Meltzer, Barry Hahn, Jahn Avarello, Terry Plasse, Ira Kalfus, Reza Fathi, Robert Silverman. Absence of QT prolongation after administration of a 24-mg bimodal-release ondansetron pill (RHB-102). The American journal of emergency medicine. 2021 05; 43(?):205-209. doi: 10.1016/j.ajem.2020.02.057. [PMID: 32139212]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Manting D Chiang, Karen Frey, Chris Lee, Evan D Kharasch, Dani Tallchief, Christopher Sawyer, Jane Blood, Hyunmoon Back, Leonid Kagan, Simon Haroutounian. Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans. British journal of clinical pharmacology. 2021 02; 87(2):516-526. doi: 10.1111/bcp.14412. [PMID: 32495990]
Amira M El-Kosasy, Lobna A Hussein, Nesma M Mohamed, Nahla N Salama. New and validated RP-HPLC Method for Quantification of Safinamide Mesylate in Presence of Its Basic Degradate, Levodopa and Ondansetron: Application to Human Plasma. Journal of chromatographic science. 2020 Sep; 58(9):789-795. doi: 10.1093/chromsci/bmaa043. [PMID: 32776090]
Manting Chiang, Hyun-Moon Back, Jong Bong Lee, Sarah Oh, Tiffany Guo, Simone Girgis, Celine Park, Simon Haroutounian, Leonid Kagan. Pharmacokinetic Modeling of the Impact of P-glycoprotein on Ondansetron Disposition in the Central Nervous System. Pharmaceutical research. 2020 Sep; 37(10):205. doi: 10.1007/s11095-020-02929-2. [PMID: 32989520]
Mohammad Reza Zirak, Gholamreza Karimi, Reza Rahimian, Amir Hossein Jafarian, A Wallace Hayes, Soghra Mehri. Tropisetron ameliorates cyclophosphamide-induced hemorrhagic cystitis in rats. European journal of pharmacology. 2020 Sep; 883(?):173310. doi: 10.1016/j.ejphar.2020.173310. [PMID: 32619674]
Jéssica Iara Gall, Amália Gonçalves Alves, Luiz Roberto Carraro Júnior, Taís da Silva Teixeira Rech, José Sebastião Dos Santos Neto, Diego Alves, Mayara Sandrielly Pereira Soares, Luiza Spohr, Rosélia Maria Spanevello, César Augusto Brüning, Cristiani Folharini Bortolatto. Insights into serotonergic and antioxidant mechanisms involved in antidepressant-like action of 2-phenyl-3-(phenylselanyl)benzofuran in mice. Progress in neuro-psychopharmacology & biological psychiatry. 2020 08; 102(?):109956. doi: 10.1016/j.pnpbp.2020.109956. [PMID: 32371105]
Cynthia Kwan, Dominique Bédard, Imane Frouni, Fleur Gaudette, Francis Beaudry, Adjia Hamadjida, Philippe Huot. Pharmacokinetic profile of the selective 5-HT3 receptor antagonist ondansetron in the rat: an original study and a minireview of the behavioural pharmacological literature in the rat. Canadian journal of physiology and pharmacology. 2020 Jul; 98(7):431-440. doi: 10.1139/cjpp-2019-0551. [PMID: 32017606]
Dandan Feng, Rui Jia, Zhengliang Ma, Xiaoping Gu. [Risk factors for nausea and vomiting after adolescent idiopathic scoliosis surgery]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2020 Mar; 40(3):394-399. doi: 10.12122/j.issn.1673-4254.2020.03.18. [PMID: 32376591]
Ramakant Gundu, Sanjay Pekamwar, Santosh Shelke, Santosh Shep, Deepak Kulkarni. Sustained release formulation of Ondansetron HCl using osmotic drug delivery approach. Drug development and industrial pharmacy. 2020 Mar; 46(3):343-355. doi: 10.1080/03639045.2020.1716372. [PMID: 31937128]
Bridget L Morse, Anil Kolur, Loyd R Hudson, Andrew T Hogan, Lisa Hong Chen, Ryan M Brackman, Geri A Sawada, John K Fallon, Philip C Smith, Kathleen M Hillgren. Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake. Drug metabolism and disposition: the biological fate of chemicals. 2020 02; 48(2):93-105. doi: 10.1124/dmd.119.088781. [PMID: 31771949]
Thi-Thao-Linh Nguyen, Van-An Duong, Han-Joo Maeng, Sang-Cheol Chi. Preparation of an oil suspension containing ondansetron hydrochloride as a sustained release parenteral formulation. Drug delivery and translational research. 2020 02; 10(1):282-295. doi: 10.1007/s13346-019-00687-2. [PMID: 31659599]
Yae Eun Chong, Manting Chiang, Kiran Deshpande, Simon Haroutounian, Leonid Kagan, Jong Bong Lee. Simultaneous quantification of ondansetron and tariquidar in rat and human plasma using a high performance liquid chromatography-ultraviolet method. Biomedical chromatography : BMC. 2019 Nov; 33(11):e4653. doi: 10.1002/bmc.4653. [PMID: 31322284]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Fleur Gaudette, Dominique Bédard, Cynthia Kwan, Imane Frouni, Adjia Hamadjida, Francis Beaudry, Philippe Huot. Highly sensitive HPLC-MS/MS assay for the quantitation of ondansetron in rat plasma and rat brain tissue homogenate following administration of a very low subcutaneous dose. Journal of pharmaceutical and biomedical analysis. 2019 Oct; 175(?):112766. doi: 10.1016/j.jpba.2019.07.014. [PMID: 31330277]
Mingyu Duan, Li Qin, Dafang Zhong, Peng Zhang. Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MSn. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4618. doi: 10.1002/bmc.4618. [PMID: 31174234]
David Gunn, Klara Garsed, Ching Lam, Gulzar Singh, Melanie Lingaya, Verena Wahl, Beate Niesler, Amanda Henry, Ian P Hall, Peter Whorwell, Robin Spiller. Abnormalities of mucosal serotonin metabolism and 5-HT3 receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron. Alimentary pharmacology & therapeutics. 2019 09; 50(5):538-546. doi: 10.1111/apt.15420. [PMID: 31342534]
Mojtaba Shakibaie, Hamid Forootanfar, Atoosa Ghaseminejad, Azad Salimi, Atefeh Ameri, Mohsen Doostmohammadi, Elham Jafari, Hamid-Reza Rahimi. Ondansetron enhanced diclofenac-induced nephrotoxicity in mice. Journal of biochemical and molecular toxicology. 2019 Sep; 33(9):e22378. doi: 10.1002/jbt.22378. [PMID: 31332906]
Van-An Duong, Thi-Thao-Linh Nguyen, Han-Joo Maeng, Sang-Cheol Chi. Preparation of Ondansetron Hydrochloride-Loaded Nanostructured Lipid Carriers Using Solvent Injection Method for Enhancement of Pharmacokinetic Properties. Pharmaceutical research. 2019 Jul; 36(10):138. doi: 10.1007/s11095-019-2672-x. [PMID: 31350675]
Wei Zheng, Dong-Bin Cai, Qing-E Zhang, Jie He, Li-Yun Zhong, Kang Sim, Gabor S Ungvari, Yu-Ping Ning, Yu-Tao Xiang. Adjunctive ondansetron for schizophrenia: A systematic review and meta-analysis of randomized controlled trials. Journal of psychiatric research. 2019 06; 113(?):27-33. doi: 10.1016/j.jpsychires.2019.02.024. [PMID: 30878789]
Seyed Mostafa Mirakbari, Mohammad Hadi Shirazi. Poisoning with Tasty and Sweet Seed Pods of Bird of Paradise Plant Caesalpinia gilliessii. Wilderness & environmental medicine. 2019 Mar; 30(1):99-100. doi: 10.1016/j.wem.2018.09.001. [PMID: 30528075]
Mingyu Duan, Qi Zhao, Dafang Zhong, Yue Yuan. Pharmacokinetics of R-(-)ondansetron compared with that of S-(-)ondansetron in rats using an LC-MS/MS method. Biomedical chromatography : BMC. 2019 Mar; 33(3):e4426. doi: 10.1002/bmc.4426. [PMID: 30408206]
Scott Hartman, Elizabeth Brown, Elizabeth Loomis, Holly Ann Russell. Gastroenteritis in Children. American family physician. 2019 02; 99(3):159-165. doi: NULL. [PMID: 30702253]
Xiaodi Feng, Qianqian Cheng, Qi Meng, Yanhong Yang, Ke Nie. Effects of ondansetron and [6]-gingerol on pica and gut microbiota in rats treated with cisplatin. Drug design, development and therapy. 2019; 13(?):2633-2641. doi: 10.2147/dddt.s211845. [PMID: 31534312]
Sambhani Naga Gayatri, Valsala Madhavan Nair Biju, Ambrose Maria Starvin. Determination of Ondansetron by Spectrofluorimetry: Application to Forced Degradation Study, Pharmaceuticals and Human Plasma. Journal of fluorescence. 2019 Jan; 29(1):203-209. doi: 10.1007/s10895-018-2329-x. [PMID: 30483905]
Peng Zhu, Zhi Ye, Dong Guo, Zongping Xiong, Shiqiong Huang, Jun Guo, Wei Zhang, James E Polli, Honghao Zhou, Qing Li, Yan Shu. Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2). Pharmaceutical research. 2018 Oct; 35(12):243. doi: 10.1007/s11095-018-2526-y. [PMID: 30361780]
Mingyu Duan, Li Qin, Dafang Zhong, Peng Zhang. Identification of novel ondansetron metabolites using LC/MSn and NMR. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):138-141. doi: 10.1016/j.jchromb.2018.07.013. [PMID: 30077093]
Cunying Huang, Huihui Wan, Jing Zhang, Hongmin Zhong, Juan Li, YuMing Sun, Qing Wang, Hua Zhang. Quantification of ondansetron, granisetron and tropisetron in goat plasma using hydrophilic interaction liquid chromatography-solid phase extraction coupled with hydrophilic interaction liquid chromatography-triple quadrupole tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Sep; 1095(?):50-58. doi: 10.1016/j.jchromb.2018.07.009. [PMID: 30053687]
Jum-Suk Ko, Shuai Guo, Jonathan Hassel, Patricia Celestino-Soper, Ty C Lynnes, James E Tisdale, James J Zheng, Stanley E Taylor, Tatiana Foroud, Michael D Murray, Richard J Kovacs, Xiaochun Li, Shien-Fong Lin, Zhenhui Chen, Matteo Vatta, Peng-Sheng Chen, Michael Rubart. Ondansetron blocks wild-type and p.F503L variant small-conductance Ca2+-activated K+ channels. American journal of physiology. Heart and circulatory physiology. 2018 08; 315(2):H375-H388. doi: 10.1152/ajpheart.00479.2017. [PMID: 29677462]
Wangda Zhou, Trevor N Johnson, Khanh H Bui, S Y Amy Cheung, Jianguo Li, Hongmei Xu, Nidal Al-Huniti, Diansong Zhou. Predictive Performance of Physiologically Based Pharmacokinetic (PBPK) Modeling of Drugs Extensively Metabolized by Major Cytochrome P450s in Children. Clinical pharmacology and therapeutics. 2018 07; 104(1):188-200. doi: 10.1002/cpt.905. [PMID: 29027194]
André Dallmann, Ibrahim Ince, Katrin Coboeken, Thomas Eissing, Georg Hempel. A Physiologically Based Pharmacokinetic Model for Pregnant Women to Predict the Pharmacokinetics of Drugs Metabolized Via Several Enzymatic Pathways. Clinical pharmacokinetics. 2018 06; 57(6):749-768. doi: 10.1007/s40262-017-0594-5. [PMID: 28924743]
Wen Kou, Hongyan Qin, Shahbaz Hanif, Xinan Wu. Nephrotoxicity Evaluation on Cisplatin Combined with 5-HT3 Receptor Antagonists: A Retrospective Study. BioMed research international. 2018; 2018(?):1024324. doi: 10.1155/2018/1024324. [PMID: 29977907]
Lara B Zajic, Andrea K Herndon, Liberty G Sieberg, Amber L Caress, Paula K Morgan, Ryan J Hansen, Luke A Wittenburg, Daniel L Gustafson, Jessica M Quimby. Assessment of absorption of transdermal ondansetron in normal research cats. Journal of feline medicine and surgery. 2017 Dec; 19(12):1245-1248. doi: 10.1177/1098612x16688807. [PMID: 28112563]
Hannah Kenward, Jonathan Elliott, Terry Lee, Ludovic Pelligand. Anti-nausea effects and pharmacokinetics of ondansetron, maropitant and metoclopramide in a low-dose cisplatin model of nausea and vomiting in the dog: a blinded crossover study. BMC veterinary research. 2017 Aug; 13(1):244. doi: 10.1186/s12917-017-1156-7. [PMID: 28814338]
M Mansour, A O Kamel, S Mansour, N D Mortada. Novel polyglycerol-dioleate based cubosomal dispersion with tailored physical characteristics for controlled delivery of ondansetron. Colloids and surfaces. B, Biointerfaces. 2017 Aug; 156(?):44-54. doi: 10.1016/j.colsurfb.2017.04.052. [PMID: 28500978]
Atsushi Tsukamoto, Takuto Sugimoto, Yuta Onuki, Hajime Shinoda, Taiki Mihara, Masatoshi Hori, Tomo Inomata. The 5-HT3 Receptor Antagonist Ondansetron Attenuates Pancreatic Injury in Cerulein-Induced Acute Pancreatitis Model. Inflammation. 2017 Aug; 40(4):1409-1415. doi: 10.1007/s10753-017-0584-7. [PMID: 28493078]
Adb Vliegenthart, R A Kimmitt, J H Seymour, N Z Homer, J I Clarke, M Eddleston, A Gray, D M Wood, P I Dargan, J G Cooper, D J Antoine, D J Webb, S C Lewis, D N Bateman, J W Dear. Circulating acetaminophen metabolites are toxicokinetic biomarkers of acute liver injury. Clinical pharmacology and therapeutics. 2017 04; 101(4):531-540. doi: 10.1002/cpt.541. [PMID: 27770431]
Ambreena Riyaz, Shahid Nazir, Mohammad Khushtar, Anuradha Mishra, Yasmeen Jahan, Asad Ahmad. Effect of Nigella sativa L. seed extract on cisplatin-induced delay in gastric emptying in Sprague-Dawley rats. Natural product research. 2017 Mar; 31(5):588-592. doi: 10.1080/14786419.2016.1201670. [PMID: 27348571]
Lara S Lemon, Hongfei Zhang, Mary F Hebert, Gary D Hankins, David M Haas, Steve N Caritis, Raman Venkataramanan. Ondansetron Exposure Changes in a Pregnant Woman. Pharmacotherapy. 2016 09; 36(9):e139-41. doi: 10.1002/phar.1796. [PMID: 27374186]
Khalid Ibrahim, Khalid Al Ansari. Flavored Intravenous Ondansetron Administered Orally for the Treatment of Persistent Vomiting in Children. Journal of tropical pediatrics. 2016 08; 62(4):288-92. doi: 10.1093/tropej/fmw009. [PMID: 26984872]
R L Fitzpatrick, L A Wittenburg, R J Hansen, D L Gustafson, J M Quimby. Limited sampling pharmacokinetics of subcutaneous ondansetron in healthy geriatric cats, cats with chronic kidney disease, and cats with liver disease. Journal of veterinary pharmacology and therapeutics. 2016 Aug; 39(4):350-5. doi: 10.1111/jvp.12286. [PMID: 26667224]
Qi Shi, Wen Li, Hongjia Li, Qiqi Le, Shanshan Liu, Shaoqi Zong, Leizhen Zheng, Fenggang Hou. Prevention of cisplatin-based chemotherapy-induced delayed nausea and vomiting using triple antiemetic regimens: a mixed treatment comparison. Oncotarget. 2016 Apr; 7(17):24402-14. doi: 10.18632/oncotarget.8255. [PMID: 27015550]
Miles D Thompson, George A Kenna. Variation in the Serotonin Transporter Gene and Alcoholism: Risk and Response to Pharmacotherapy. Alcohol and alcoholism (Oxford, Oxfordshire). 2016 Mar; 51(2):164-71. doi: 10.1093/alcalc/agv090. [PMID: 26311211]
Yoonjin Nam, Jong Mi Lee, Yiyi Wang, Hyun Su Ha, Uy Dong Sohn. The effect of Flos Lonicerae Japonicae extract on gastro-intestinal motility function. Journal of ethnopharmacology. 2016 Feb; 179(?):280-90. doi: 10.1016/j.jep.2015.12.056. [PMID: 26743226]
Hemlata Patil, Roshan V Tiwari, Sampada B Upadhye, Ronald S Vladyka, Michael A Repka. Formulation and development of pH-independent/dependent sustained release matrix tablets of ondansetron HCl by a continuous twin-screw melt granulation process. International journal of pharmaceutics. 2015 Dec; 496(1):33-41. doi: 10.1016/j.ijpharm.2015.04.009. [PMID: 25863118]
Aruna Sharma, Dafin F Muresanu, José V Lafuente, Ranjana Patnaik, Z Ryan Tian, Anca D Buzoianu, Hari S Sharma. Sleep Deprivation-Induced Blood-Brain Barrier Breakdown and Brain Dysfunction are Exacerbated by Size-Related Exposure to Ag and Cu Nanoparticles. Neuroprotective Effects of a 5-HT3 Receptor Antagonist Ondansetron. Molecular neurobiology. 2015 Oct; 52(2):867-81. doi: 10.1007/s12035-015-9236-9. [PMID: 26133300]
Hiroshi Kitamura, Atsushi Takahashi, Hiroshi Hotta, Ryuichi Kato, Yasuharu Kunishima, Fumiyasu Takei, Hiroki Horita, Naoya Masumori. Palonosetron with aprepitant plus dexamethasone to prevent chemotherapy-induced nausea and vomiting during gemcitabine/cisplatin in urothelial cancer patients. International journal of urology : official journal of the Japanese Urological Association. 2015 Oct; 22(10):911-4. doi: 10.1111/iju.12842. [PMID: 26087891]
Yeshwant Kurhe, Radhakrishnan Mahesh. Ondansetron attenuates co-morbid depression and anxiety associated with obesity by inhibiting the biochemical alterations and improving serotonergic neurotransmission. Pharmacology, biochemistry, and behavior. 2015 Sep; 136(?):107-16. doi: 10.1016/j.pbb.2015.07.004. [PMID: 26188166]
Jue Hou, Chamindi Seneviratne, Xiaogang Su, Jeremy Taylor, Bankole Johnson, Xin-Qun Wang, Heping Zhang, Henry R Kranzler, Joseph Kang, Lei Liu. Subgroup Identification in Personalized Treatment of Alcohol Dependence. Alcoholism, clinical and experimental research. 2015 Jul; 39(7):1253-9. doi: 10.1111/acer.12759. [PMID: 26031187]
Dipal R Patel, Amit Joshi, Hiren H Patel, Grazia Stagni. Development and in-vivo evaluation of ondansetron gels for transdermal delivery. Drug development and industrial pharmacy. 2015 Jun; 41(6):1030-6. doi: 10.3109/03639045.2014.925916. [PMID: 24919508]
I-H Baek, B-Y Lee, J Kang, K-I Kwon. Pharmacokinetic modeling and Monte Carlo simulation of ondansetron following oral administration in dogs. Journal of veterinary pharmacology and therapeutics. 2015 Apr; 38(2):199-202. doi: 10.1111/jvp.12147. [PMID: 25131428]
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