N-Acetyl-L-glutamic acid (BioDeep_00000405417)

Main id: BioDeep_00000001389

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


N-Acetyl-DL-glutamic acid

化学式: C7H11NO5 (189.0637196)
中文名称: N-乙酰-DL-谷氨酸, N-乙酰-L-谷氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)

描述信息

An N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group.
N-Acetyl-L-glutamic acid, a glutamic acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].
N-Acetyl-L-glutamic acid, a glutamic acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].

同义名列表

2 个代谢物同义名

N-Acetyl-DL-glutamic acid; N-Acetyl-L-glutamic acid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Katrine D Galsgaard, Jens Pedersen, Sasha A S Kjeldsen, Marie Winther-Sørensen, Elena Stojanovska, Hendrik Vilstrup, Cathrine Ørskov, Nicolai J Wewer Albrechtsen, Jens J Holst. Glucagon receptor signaling is not required for N-carbamoyl glutamate- and l-citrulline-induced ureagenesis in mice. American journal of physiology. Gastrointestinal and liver physiology. 2020 05; 318(5):G912-G927. doi: 10.1152/ajpgi.00294.2019. [PMID: 32174131]
  • Barbora Vorlova, Tomas Knedlik, Jan Tykvart, Jan Konvalinka. GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond. Frontiers in bioscience (Landmark edition). 2019 03; 24(4):648-687. doi: 10.2741/4742. [PMID: 30844704]
  • Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics. Scientific reports. 2018 07; 8(1):10056. doi: 10.1038/s41598-018-28477-9. [PMID: 29968805]
  • Birgitta C Burckhardt, Gerhard Burckhardt. Interaction of Excitatory Amino Acid Transporters 1 - 3 (EAAT1, EAAT2, EAAT3) with N-Carbamoylglutamate and N-Acetylglutamate. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 43(5):1907-1916. doi: 10.1159/000484110. [PMID: 29055942]
  • Primal Sharma, Priyanka A Shah, Mallika Sanyal, Pranav S Shrivastav. Challenges in optimizing sample preparation and LC-MS/MS conditions for the analysis of carglumic acid, an N-acetyl glutamate derivative in human plasma. Drug testing and analysis. 2015 Sep; 7(9):763-72. doi: 10.1002/dta.1774. [PMID: 25677217]
  • Yohannes Hagos, Gerhard Burckhardt, Birgitta C Burckhardt. Human organic anion transporter OAT1 is not responsible for glutathione transport but mediates transport of glutamate derivatives. American journal of physiology. Renal physiology. 2013 Feb; 304(4):F403-9. doi: 10.1152/ajprenal.00412.2012. [PMID: 23255614]
  • Gengxiang Zhao, Zhongmin Jin, Norma M Allewell, Mendel Tuchman, Dashuang Shi. Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms. PloS one. 2013; 8(7):e70369. doi: 10.1371/journal.pone.0070369. [PMID: 23894642]
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  • Wataru Takagi, Makiko Kajimura, Justin D Bell, Tes Toop, John A Donald, Susumu Hyodo. Hepatic and extrahepatic distribution of ornithine urea cycle enzymes in holocephalan elephant fish (Callorhinchus milii). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 2012 Apr; 161(4):331-40. doi: 10.1016/j.cbpb.2011.12.006. [PMID: 22227372]
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  • Luigi Atzori, Roberto Antonucci, Luigi Barberini, Emanuela Locci, Flaminia Cesare Marincola, Paola Scano, Patrizia Cortesi, Rino Agostiniani, Riccardo Defraia, Aalim Weljie, Diego Gazzolo, Adolfo Lai, Vassilios Fanos. 1H NMR-based metabolomic analysis of urine from preterm and term neonates. Frontiers in bioscience (Elite edition). 2011 06; 3(3):1005-12. doi: 10.2741/e306. [PMID: 21622109]
  • Hong Lin, Binghai Lou, Jonathan M Glynn, Harshavardhan Doddapaneni, Edwin L Civerolo, Chuanwu Chen, Yongping Duan, Lijuan Zhou, Cheryl M Vahling. The complete genome sequence of 'Candidatus Liberibacter solanacearum', the bacterium associated with potato zebra chip disease. PloS one. 2011 Apr; 6(4):e19135. doi: 10.1371/journal.pone.0019135. [PMID: 21552483]
  • Magdalena Stepien, Claire Gaudichon, Gilles Fromentin, Patrick Even, Daniel Tomé, Dalila Azzout-Marniche. Increasing protein at the expense of carbohydrate in the diet down-regulates glucose utilization as glucose sparing effect in rats. PloS one. 2011 Feb; 6(2):e14664. doi: 10.1371/journal.pone.0014664. [PMID: 21326875]
  • Marta Daniotti, Giancarlo la Marca, Patrizio Fiorini, Luca Filippi. New developments in the treatment of hyperammonemia: emerging use of carglumic acid. International journal of general medicine. 2011 Jan; 4(?):21-8. doi: 10.2147/ijgm.s10490. [PMID: 21403788]
  • Johannes Häberle. Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency. Therapeutics and clinical risk management. 2011; 7(?):327-32. doi: 10.2147/tcrm.s12703. [PMID: 21941437]
  • Kazuyo Tujioka, Miho Ohsumi, Kazutoshi Hayase, Hidehiko Yokogoshi. Effect of the quality of dietary amino acids composition on the urea synthesis in rats. Journal of nutritional science and vitaminology. 2011; 57(1):48-55. doi: 10.3177/jnsv.57.48. [PMID: 21512291]
  • Surjit Tarafdar, Mark Slee, Faisal Ameer, Matt Doogue. A case of valproate induced hyperammonemic encephalopathy. Case reports in medicine. 2011; 2011(?):969505. doi: 10.1155/2011/969505. [PMID: 21629819]
  • Harin Kanani, Bhaskar Dutta, Maria I Klapa. Individual vs. combinatorial effect of elevated CO2 conditions and salinity stress on Arabidopsis thaliana liquid cultures: comparing the early molecular response using time-series transcriptomic and metabolomic analyses. BMC systems biology. 2010 Dec; 4(?):177. doi: 10.1186/1752-0509-4-177. [PMID: 21190570]
  • Tong Wang, Erhua Zhang, Xiaoping Chen, Ling Li, Xuanqiang Liang. Identification of seed proteins associated with resistance to pre-harvested aflatoxin contamination in peanut (Arachis hypogaea L). BMC plant biology. 2010 Nov; 10(?):267. doi: 10.1186/1471-2229-10-267. [PMID: 21118527]
  • Sébastien Baud, Ana Belen Feria Bourrellier, Marianne Azzopardi, Adeline Berger, Julie Dechorgnat, Françoise Daniel-Vedele, Loïc Lepiniec, Martine Miquel, Christine Rochat, Michael Hodges, Sylvie Ferrario-Méry. PII is induced by WRINKLED1 and fine-tunes fatty acid composition in seeds of Arabidopsis thaliana. The Plant journal : for cell and molecular biology. 2010 Oct; 64(2):291-303. doi: 10.1111/j.1365-313x.2010.04332.x. [PMID: 21070409]
  • Markus Schrettl, Nicola Beckmann, John Varga, Thorsten Heinekamp, Ilse D Jacobsen, Christoph Jöchl, Tarek A Moussa, Shaohua Wang, Fabio Gsaller, Michael Blatzer, Ernst R Werner, William C Niermann, Axel A Brakhage, Hubertus Haas. HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS pathogens. 2010 Sep; 6(9):e1001124. doi: 10.1371/journal.ppat.1001124. [PMID: 20941352]
  • Preetinder K Dhanoa, Lynn G L Richardson, Matthew D Smith, Satinder K Gidda, Matthew P A Henderson, David W Andrews, Robert T Mullen. Distinct pathways mediate the sorting of tail-anchored proteins to the plastid outer envelope. PloS one. 2010 Apr; 5(4):e10098. doi: 10.1371/journal.pone.0010098. [PMID: 20418952]
  • Hui Dai, Chaoni Xiao, Hongbing Liu, Fuhua Hao, Huiru Tang. Combined NMR and LC-DAD-MS analysis reveals comprehensive metabonomic variations for three phenotypic cultivars of Salvia Miltiorrhiza Bunge. Journal of proteome research. 2010 Mar; 9(3):1565-78. doi: 10.1021/pr901045c. [PMID: 20067324]
  • Giulia Friso, Wojciech Majeran, Mingshu Huang, Qi Sun, Klaas J van Wijk. Reconstruction of metabolic pathways, protein expression, and homeostasis machineries across maize bundle sheath and mesophyll chloroplasts: large-scale quantitative proteomics using the first maize genome assembly. Plant physiology. 2010 Mar; 152(3):1219-50. doi: 10.1104/pp.109.152694. [PMID: 20089766]
  • Paul E Verslues, Sandeep Sharma. Proline metabolism and its implications for plant-environment interaction. The arabidopsis book. 2010; 8(?):e0140. doi: 10.1199/tab.0140. [PMID: 22303265]
  • Sema Kalkan Ucar, Mahmut Coker, Sara Habif, Eylem Ulas Saz, Bulent Karapinar, Hakan Ucar, Omer Kitis, Marinus Duran. The first use of N-carbamylglutamate in a patient with decompensated maple syrup urine disease. Metabolic brain disease. 2009 Sep; 24(3):409-14. doi: 10.1007/s11011-009-9155-4. [PMID: 19688253]
  • R Glen Uhrig, Kenneth K S Ng, Greg B G Moorhead. PII in higher plants: a modern role for an ancient protein. Trends in plant science. 2009 Sep; 14(9):505-11. doi: 10.1016/j.tplants.2009.07.003. [PMID: 19720555]
  • Tammy Laberge, Patrick J Walsh, M Danielle McDonald. Effects of crowding on ornithine-urea cycle enzyme mRNA expression and activity in gulf toadfish (Opsanus beta). The Journal of experimental biology. 2009 Aug; 212(Pt 15):2394-402. doi: 10.1242/jeb.030411. [PMID: 19617432]
  • Sabine Beez, Oleksandra Fokina, Christina Herrmann, Karl Forchhammer. N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control. Journal of molecular biology. 2009 Jun; 389(4):748-58. doi: 10.1016/j.jmb.2009.04.053. [PMID: 19409905]
  • Aurélie Huser, Hiroyuki Takahara, Wolfgang Schmalenbach, Richard O'Connell. Discovery of pathogenicity genes in the crucifer anthracnose fungus Colletotrichum higginsianum, using random insertional mutagenesis. Molecular plant-microbe interactions : MPMI. 2009 Feb; 22(2):143-56. doi: 10.1094/mpmi-22-2-0143. [PMID: 19132867]
  • Widodo, John H Patterson, Ed Newbigin, Mark Tester, Antony Bacic, Ute Roessner. Metabolic responses to salt stress of barley (Hordeum vulgare L.) cultivars, Sahara and Clipper, which differ in salinity tolerance. Journal of experimental botany. 2009; 60(14):4089-103. doi: 10.1093/jxb/erp243. [PMID: 19666960]
  • Kazuyo Tujioka, Tamami Tuchiya, Xianglan Shi, Miho Ohsumi, Kazutoshi Hayase, Hidehiko Yokogoshi. Changes in N-acetylglutamate are involved in regulating urea synthesis in rats given a low gluten diet supplemented with L-lysine, L-methinone and L-threonine. Journal of nutritional science and vitaminology. 2009; 55(5):417-22. doi: 10.3177/jnsv.55.417. [PMID: 19926928]
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