L-Palmitoylcarnitine (BioDeep_00000405221)
Main id: BioDeep_00000003254
代谢物信息卡片
L-Palmitoylcarnitine
化学式: C23H45NO4 (399.33484100000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OC(CC(=O)[O-])C[N+](C)(C)C
InChI: InChI=1S/C23H45NO4/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4/h21H,5-20H2,1-4H3/t21-/m1/s1
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:17490
- KEGG: C02990
- PubChem: 11953816
- ChEMBL: CHEMBL3392050
- MeSH: Palmitoylcarnitine
- CAS: 2364-67-2
- MoNA: HMDB0000222_ms_ms_365
- MoNA: HMDB0000222_ms_ms_364
- MoNA: HMDB0000222_ms_ms_366
- PubChem: 5899
- LipidMAPS: LMFA07070004
- 3DMET: B00524
- NIKKAJI: J410.749G
分类词条
相关代谢途径
Reactome(7)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 9606 Homo sapiens:
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 9606 Homo sapiens:
- 7461 Apis cerana: 10.1371/JOURNAL.PONE.0175573
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ruirui Dong, Ningzhen Ye, Shaojie Zhao, Gaoying Wang, Yan Zhang, Tiejun Wang, Ping Zou, Jing Wang, Tingting Yao, Minjian Chen, Conghua Zhou, Ting Zhang, Liang Luo. Studies on Novel Diagnostic and Predictive Biomarkers of Intrahepatic Cholestasis of Pregnancy Through Metabolomics and Proteomics.
Frontiers in immunology.
2021; 12(?):733225. doi:
10.3389/fimmu.2021.733225. [PMID: 34721396] - YueTao Liu, XinQi Li, AiPing Li, Ke Li, XueMei Qin. UHPLC Q-Exactive MS-based spleen metabolomics and lipidomics to explore the effect mechanisms of Danggui Buxue Decoction in anemia mice.
Journal of pharmaceutical and biomedical analysis.
2020 Jun; 185(?):113234. doi:
10.1016/j.jpba.2020.113234. [PMID: 32171146] - Khalil Mallah, Jusal Quanico, Antonella Raffo-Romero, Tristan Cardon, Soulaimane Aboulouard, David Devos, Firas Kobeissy, Kazem Zibara, Michel Salzet, Isabelle Fournier. Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging of Lipids in Experimental Model of Traumatic Brain Injury Detecting Acylcarnitines as Injury Related Markers.
Analytical chemistry.
2019 09; 91(18):11879-11887. doi:
10.1021/acs.analchem.9b02633. [PMID: 31412203] - Shannon N Mostyn, Tristan Rawling, Sarasa Mohammadi, Susan Shimmon, Zachary J Frangos, Subhodeep Sarker, Arsalan Yousuf, Irina Vetter, Renae M Ryan, Macdonald J Christie, Robert J Vandenberg. Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.
Journal of medicinal chemistry.
2019 03; 62(5):2466-2484. doi:
10.1021/acs.jmedchem.8b01775. [PMID: 30714733] - Takashi Tsuji, Morio Matsumoto, Masaya Nakamura, Takeshi Miyamoto, Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Narihito Nagoshi, Osahiko Tsuji, Kota Watanabe. Metabolite profiling of plasma in patients with ossification of the posterior longitudinal ligament.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.
2018 Nov; 23(6):878-883. doi:
10.1016/j.jos.2018.07.001. [PMID: 30075996] - Sree V Chintapalli, Andriy Anishkin, Sean H Adams. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin.
Archives of biochemistry and biophysics.
2018 10; 655(?):56-66. doi:
10.1016/j.abb.2018.07.024. [PMID: 30092229] - Margot Riggi, Karolina Niewola-Staszkowska, Nicolas Chiaruttini, Adai Colom, Beata Kusmider, Vincent Mercier, Saeideh Soleimanpour, Michael Stahl, Stefan Matile, Aurélien Roux, Robbie Loewith. Decrease in plasma membrane tension triggers PtdIns(4,5)P2 phase separation to inactivate TORC2.
Nature cell biology.
2018 09; 20(9):1043-1051. doi:
10.1038/s41556-018-0150-z. [PMID: 30154550] - Fatima-Zahra Bouchouirab, Mélanie Fortin, Christophe Noll, Jean Dubé, André C Carpentier. Plasma Palmitoyl-Carnitine (AC16:0) Is a Marker of Increased Postprandial Nonesterified Incomplete Fatty Acid Oxidation Rate in Adults With Type 2 Diabetes.
Canadian journal of diabetes.
2018 Aug; 42(4):382-388.e1. doi:
10.1016/j.jcjd.2017.09.002. [PMID: 29129455] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
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PloS one.
2018; 13(8):e0201591. doi:
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Molecular medicine reports.
2017 Nov; 16(5):6828-6836. doi:
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Clinical nutrition (Edinburgh, Scotland).
2017 10; 36(5):1310-1319. doi:
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BioFactors (Oxford, England).
2017 Sep; 43(5):718-730. doi:
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The Biochemical journal.
2017 02; 474(4):557-569. doi:
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Brain & development.
2017 Jan; 39(1):48-57. doi:
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International journal of epidemiology.
2016 10; 45(5):1507-1516. doi:
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American journal of physiology. Endocrinology and metabolism.
2015 Aug; 309(3):E256-64. doi:
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Molecular and cellular biochemistry.
2014 Oct; 395(1-2):1-10. doi:
10.1007/s11010-014-2106-3. [PMID: 24878991] - Yangzhen Shao, Bjorn Redfors, David Benoist, Sigfus Gizurarson, Elmir Omerovic. Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology.
Molecular and cellular biochemistry.
2014 Aug; 393(1-2):191-7. doi:
10.1007/s11010-014-2060-0. [PMID: 24771065] - Réjane Morand, Massimiliano Donzelli, Manuel Haschke, Stephan Krähenbühl. Quantification of plasma carnitine and acylcarnitines by high-performance liquid chromatography-tandem mass spectrometry using online solid-phase extraction.
Analytical and bioanalytical chemistry.
2013 Nov; 405(27):8829-36. doi:
10.1007/s00216-013-7309-z. [PMID: 23995505] - Thor Ueland, Asbjørn Svardal, Erik Øie, Erik T Askevold, Ståle H Nymoen, Bodil Bjørndal, Christen P Dahl, Lars Gullestad, Rolf K Berge, Pål Aukrust. Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis.
International journal of cardiology.
2013 Sep; 167(5):1892-9. doi:
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American journal of physiology. Endocrinology and metabolism.
2013 Aug; 305(4):E540-8. doi:
10.1152/ajpendo.00143.2013. [PMID: 23820622] - Karolina Tułodziecka, Magdalena Czeredys, Katarzyna A Nałęcz. Palmitoylcarnitine affects localization of growth associated protein GAP-43 in plasma membrane subdomains and its interaction with Gα(o) in neuroblastoma NB-2a cells.
Neurochemical research.
2013 Mar; 38(3):519-29. doi:
10.1007/s11064-012-0944-5. [PMID: 23224819] - Karen Dixen, Astrid L Basse, Maria Murholm, Marie S Isidor, Lillian H L Hansen, M Christine H Petersen, Lise Madsen, Natasa Petrovic, Jan Nedergaard, Bjørn Quistorff, Jacob B Hansen. ERRγ enhances UCP1 expression and fatty acid oxidation in brown adipocytes.
Obesity (Silver Spring, Md.).
2013 Mar; 21(3):516-24. doi:
10.1002/oby.20067. [PMID: 23404793] - Ulrikke Voss, Elin Sand, Björn Olde, Eva Ekblad. Enteric neuropathy can be induced by high fat diet in vivo and palmitic acid exposure in vitro.
PloS one.
2013; 8(12):e81413. doi:
10.1371/journal.pone.0081413. [PMID: 24312551] - Xiaolei Shi, Dan Yao, Blake A Gosnell, Chi Chen. Lipidomic profiling reveals protective function of fatty acid oxidation in cocaine-induced hepatotoxicity.
Journal of lipid research.
2012 Nov; 53(11):2318-30. doi:
10.1194/jlr.m027656. [PMID: 22904346] - Wenche Jørgensen, Peter Jelnes, Kasper A Rud, Lillian L Hansen, Niels Grunnet, Bjørn Quistorff. Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of complex II flux is observed in liver only.
American journal of physiology. Endocrinology and metabolism.
2012 Aug; 303(4):E515-23. doi:
10.1152/ajpendo.00103.2012. [PMID: 22713504] - Xiao-Jun Zhang, Noe A Rodriguez, Lijian Wang, Demidmaa Tuvdendorj, Zhanpin Wu, Alai Tan, David N Herndon, Robert R Wolfe. Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate.
Journal of lipid research.
2012 Jan; 53(1):119-25. doi:
10.1194/jlr.m019901. [PMID: 21934122] - Xudong Wang, Gail J Mick, Edmund Maser, Kenneth McCormick. Manifold effects of palmitoylcarnitine on endoplasmic reticulum metabolism: 11β-hydroxysteroid dehydrogenase 1, flux through hexose-6-phosphate dehydrogenase and NADPH concentration.
The Biochemical journal.
2011 Jul; 437(1):109-15. doi:
10.1042/bj20102069. [PMID: 21492096] - Nolwenn Brandhonneur, Gilles Dollo, Maja Ratajczak-Enselme, Anne Laure Deniau, François Chevanne, Jean Pierre Estèbe, Alain Legrand, Pascal Le Corre. Ex vivo and in vivo diffusion of ropivacaine through spinal meninges: influence of absorption enhancers.
International journal of pharmaceutics.
2011 Feb; 404(1-2):36-41. doi:
10.1016/j.ijpharm.2010.10.049. [PMID: 21056096] - Nobuyuki Doi, Mikio Tomita, Masahiro Hayashi. Absorption enhancement effect of acylcarnitines through changes in tight junction protein in Caco-2 cell monolayers.
Drug metabolism and pharmacokinetics.
2011; 26(2):162-70. doi:
10.2133/dmpk.dmpk-10-rg-071. [PMID: 21206134] - Jean-Paul Bonnefont, Jean Bastin, Anthony Behin, Fatima Djouadi. Bezafibrate for an inborn mitochondrial beta-oxidation defect.
The New England journal of medicine.
2009 Feb; 360(8):838-40. doi:
10.1056/nejmc0806334. [PMID: 19228633] - Zhi Liu, Abdul E Mutlib, Jianyao Wang, Rasmy E Talaat. Liquid chromatography/mass spectrometry determination of endogenous plasma acetyl and palmitoyl carnitines as potential biomarkers of beta-oxidation in mice.
Rapid communications in mass spectrometry : RCM.
2008 Nov; 22(21):3434-42. doi:
10.1002/rcm.3755. [PMID: 18837479] - Muhammad A Abdul-Ghani, Florian L Muller, Yuhong Liu, Alberto O Chavez, Bogdan Balas, Pengou Zuo, Zhi Chang, Devjit Tripathy, Rucha Jani, Marjorie Molina-Carrion, Adriana Monroy, Franco Folli, Holly Van Remmen, Ralph A DeFronzo. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance.
American journal of physiology. Endocrinology and metabolism.
2008 Sep; 295(3):E678-85. doi:
10.1152/ajpendo.90287.2008. [PMID: 18593850] - John J Lehman, Sihem Boudina, Natasha Hausler Banke, Nandakumar Sambandam, Xianlin Han, Deanna M Young, Teresa C Leone, Richard W Gross, E Douglas Lewandowski, E Dale Abel, Daniel P Kelly. The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H185-96. doi:
10.1152/ajpheart.00081.2008. [PMID: 18487436] - Hiromutsu Tominaga, Hideki Katoh, Keiichi Odagiri, Yasuyo Takeuchi, Hirotaka Kawashima, Masao Saotome, Tsuyoshi Urushida, Hiroshi Satoh, Hideharu Hayashi. Different effects of palmitoyl-L-carnitine and palmitoyl-CoA on mitochondrial function in rat ventricular myocytes.
American journal of physiology. Heart and circulatory physiology.
2008 Jul; 295(1):H105-12. doi:
10.1152/ajpheart.01307.2007. [PMID: 18469143] - Sonja Primassin, Frank Ter Veld, Ertan Mayatepek, Ute Spiekerkoetter. Carnitine supplementation induces acylcarnitine production in tissues of very long-chain acyl-CoA dehydrogenase-deficient mice, without replenishing low free carnitine.
Pediatric research.
2008 Jun; 63(6):632-7. doi:
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Journal of pharmaceutical sciences.
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Eksperimental'naia i klinicheskaia farmakologiia.
2008 May; 71(3):26-30. doi:
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FEBS letters.
2007 Aug; 581(21):3950-4. doi:
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Obesity (Silver Spring, Md.).
2006 Jul; 14(7):1201-10. doi:
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Journal of lipid research.
2006 Feb; 47(2):431-9. doi:
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2005 Mar; 579(7):1639-45. doi:
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Analytical chemistry.
2005 Mar; 77(5):1448-57. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2003 Nov; 337(1-2):103-13. doi:
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The Journal of biological chemistry.
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