dihydrobiopterin (BioDeep_00000405189)

Main id: BioDeep_00000001500

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


7,8-Dihydro-L-biopterin

化学式: C9H13N5O3 (239.1018)
中文名称: 7,8-二氢生物蝶呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C(C1=NC2=C(NC1)N=C(NC2=O)N)O)O
InChI: InChI=1S/C9H13N5O3/c1-3(15)6(16)4-2-11-7-5(12-4)8(17)14-9(10)13-7/h3,6,15-16H,2H2,1H3,(H4,10,11,13,14,17)

描述信息

7,8-Dihydro-L-biopterin is an oxidation product of tetrahydrobiopterin.

同义名列表

3 个代谢物同义名

7,8-Dihydro-L-biopterin; dihydrobiopterin; 7,8-Dihydrobiopterin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 CAT, CTNNB1, DHFR, GCH1, GUCY1A1, NOS1, NOS2, NOS3, QDPR, SPR, TH, TYR, XDH
Peripheral membrane protein 2 HSD17B6, NOS1
Nucleus 6 CTNNB1, GCH1, NOS1, NOS2, NOS3, TH
cytosol 13 CAT, CTNNB1, DHFR, GCH1, GUCY1A1, NOS1, NOS2, NOS3, PAH, QDPR, SPR, TH, XDH
dendrite 2 C4A, TH
centrosome 1 CTNNB1
nucleoplasm 6 CTNNB1, GCH1, NOS1, NOS2, NOS3, SPR
Cell membrane 1 CTNNB1
lamellipodium 1 CTNNB1
Cell projection, axon 2 C4A, TH
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 SLC22A8
Synapse 3 C4A, CTNNB1, NOS1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 2 CTNNB1, GUCY1A1
Golgi apparatus 1 NOS3
Golgi membrane 2 INS, NOS3
neuronal cell body 1 C4A
presynaptic membrane 1 CTNNB1
sarcolemma 1 NOS1
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 1 NOS2
Lysosome 1 TYR
plasma membrane 7 C4A, CTNNB1, IFNLR1, NOS1, NOS2, NOS3, SLC22A8
terminal bouton 1 TH
Membrane 3 CAT, CTNNB1, IFNLR1
apical plasma membrane 1 SLC22A8
axon 2 C4A, TH
basolateral plasma membrane 2 CTNNB1, SLC22A8
caveola 1 NOS3
extracellular exosome 7 C4A, CAT, CTNNB1, QDPR, SLC22A8, SOD2, SPR
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 3 C4A, INS, XDH
perinuclear region of cytoplasm 6 CTNNB1, NOS1, NOS2, NOS3, TH, TYR
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 8 CAT, DHFR, GCH1, NOS1, QDPR, SOD2, SPR, TH
protein-containing complex 4 CAT, CTNNB1, GCH1, NOS1
intracellular membrane-bounded organelle 3 CAT, HSD17B6, TYR
Microsome membrane 1 HSD17B6
postsynaptic density 1 NOS1
Single-pass type I membrane protein 2 IFNLR1, TYR
Secreted 2 C4A, INS
extracellular region 3 C4A, CAT, INS
cytoplasmic side of plasma membrane 1 TH
Mitochondrion matrix 1 SOD2
mitochondrial matrix 2 CAT, SOD2
transcription regulator complex 1 CTNNB1
photoreceptor inner segment 1 NOS1
nuclear membrane 1 GCH1
dendritic spine 1 NOS1
perikaryon 1 TH
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
cytoplasmic vesicle 2 GCH1, TH
Wnt signalosome 1 CTNNB1
Melanosome membrane 2 TH, TYR
Cytoplasm, P-body 2 NOS2, NOS3
P-body 2 NOS2, NOS3
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
Golgi-associated vesicle 1 TYR
postsynaptic membrane 1 CTNNB1
Cell membrane, sarcolemma 1 NOS1
Cytoplasm, perinuclear region 3 NOS1, NOS2, TH
Membrane raft 1 NOS1
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 2 CAT, CTNNB1
GABA-ergic synapse 1 GUCY1A1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
mitochondrial nucleoid 1 SOD2
Peroxisome 3 CAT, NOS2, XDH
sarcoplasmic reticulum 2 NOS1, XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Cell projection, dendritic spine 1 NOS1
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CTNNB1, SLC22A8
neuron projection 1 TH
cell periphery 2 CTNNB1, NOS1
cytoskeleton 2 NOS1, NOS3
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
blood microparticle 1 C4A
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 SLC22A8
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
Cell projection, dendrite 1 C4A
Melanosome 1 TYR
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
euchromatin 1 CTNNB1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 C4A, INS
endocytic vesicle membrane 1 NOS3
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
presynaptic active zone cytoplasmic component 1 CTNNB1
protein-DNA complex 1 CTNNB1
catenin complex 1 CTNNB1
guanylate cyclase complex, soluble 1 GUCY1A1
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
neuron projection terminus 1 GCH1
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Muriel Bouly, Marie-Pierre Bourguignon, Susanne Roesch, Pascal Rigouin, Willy Gosgnach, Elodie Bossard, Emilie Royere, Nicolas Diguet, Patricia Sansilvestri-Morel, Ariane Bonnin, Laura Xuereb, Pascal Berson, Michel Komajda, Peter Bernhardt, Benoit Tyl. Aging increases circulating BH2 without modifying BH4 levels and impairs peripheral vascular function in healthy adults. Translational research : the journal of laboratory and clinical medicine. 2021 12; 238(?):36-48. doi: 10.1016/j.trsl.2021.07.004. [PMID: 34332154]
  • Tae Woong Cha, Minjoo Kim, Minkyung Kim, Jey Sook Chae, Jong Ho Lee. Blood pressure-lowering effect of Korean red ginseng associated with decreased circulating Lp-PLA2 activity and lysophosphatidylcholines and increased dihydrobiopterin level in prehypertensive subjects. Hypertension research : official journal of the Japanese Society of Hypertension. 2016 Jun; 39(6):449-56. doi: 10.1038/hr.2016.7. [PMID: 26843120]
  • M J Reimann, J Häggström, A Mortensen, J Lykkesfeldt, J E Møller, T Falk, L H Olsen. Biopterin status in dogs with myxomatous mitral valve disease is associated with disease severity and cardiovascular risk factors. Journal of veterinary internal medicine. 2014 Sep; 28(5):1520-6. doi: 10.1111/jvim.12425. [PMID: 25274442]
  • Ana María Gámez-Méndez, Hilda Vargas-Robles, Mónica Arellano-Mendoza, Erika Cruz-Laguna, Amelia Rios, Bruno Escalante. Early stage of obesity potentiates nitric oxide reduction during the development of renal failure. Journal of nephrology. 2014 Jun; 27(3):281-7. doi: 10.1007/s40620-013-0029-9. [PMID: 24446346]
  • Hemi Luan, Nan Meng, Ping Liu, Qiang Feng, Shuhai Lin, Jin Fu, Robert Davidson, Xiaomin Chen, Weiqiao Rao, Fang Chen, Hui Jiang, Xun Xu, Zongwei Cai, Jun Wang. Pregnancy-induced metabolic phenotype variations in maternal plasma. Journal of proteome research. 2014 Mar; 13(3):1527-36. doi: 10.1021/pr401068k. [PMID: 24450375]
  • Alan Mortensen, Stine Hasselholt, Pernille Tveden-Nyborg, Jens Lykkesfeldt. Guinea pig ascorbate status predicts tetrahydrobiopterin plasma concentration and oxidation ratio in vivo. Nutrition research (New York, N.Y.). 2013 Oct; 33(10):859-67. doi: 10.1016/j.nutres.2013.07.006. [PMID: 24074744]
  • Luz Graciela Cervantes-Pérez, María de la Luz Ibarra-Lara, Bruno Escalante, Leonardo Del Valle-Mondragón, Hilda Vargas-Robles, Francisca Pérez-Severiano, Gustavo Pastelín, María Alicia Sánchez-Mendoza. Endothelial nitric oxide synthase impairment is restored by clofibrate treatment in an animal model of hypertension. European journal of pharmacology. 2012 Jun; 685(1-3):108-15. doi: 10.1016/j.ejphar.2012.04.006. [PMID: 22542661]
  • Yi-Chen Liao, Ying-Ho Lee, Lea-Yea Chuang, Jinn-Yuh Guh, Ming-Der Shi, Jau-Shyang Huang. Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells. Molecular and cellular endocrinology. 2012 May; 355(1):71-7. doi: 10.1016/j.mce.2012.01.018. [PMID: 22326994]
  • Hiromi Jo, Hajime Otani, Fusakazu Jo, Takayuki Shimazu, Toru Okazaki, Kei Yoshioka, Masanori Fujita, Atsushi Kosaki, Toshiji Iwasaka. Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clinical and experimental pharmacology & physiology. 2011 Aug; 38(8):485-93. doi: 10.1111/j.1440-1681.2011.05535.x. [PMID: 21554376]
  • Akiko Ohashi, Yuko Sugawara, Kaori Mamada, Yoshinori Harada, Tomomi Sumi, Naohiko Anzai, Shin Aizawa, Hiroyuki Hasegawa. Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis. Molecular genetics and metabolism. 2011 Jan; 102(1):18-28. doi: 10.1016/j.ymgme.2010.09.005. [PMID: 20956085]
  • Keitaro Yokoyama, Tatsuo Hosoya. The hypothesis that abnormal BH₄ metabolism impairs kidney function. Kidney international. 2010 Nov; 78(10):1050; author reply 1050. doi: 10.1038/ki.2010.304. [PMID: 21030979]
  • Hye-Lim Kim, Do Hyung Kim, Yeol Kun Lee, Sun Ok Park, Yong-Woo Lee, O-Seob Kwon, Young Shik Park. An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase. Analytical biochemistry. 2010 Feb; 397(1):79-83. doi: 10.1016/j.ab.2009.10.007. [PMID: 19819217]
  • Florentina Cañada-Cañada, Anunciación Espinosa-Mansilla, Arsenio Muñoz de la Peña, Alicia Mancha de Llanos. Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method. Analytica chimica acta. 2009 Aug; 648(1):113-22. doi: 10.1016/j.aca.2009.06.045. [PMID: 19616696]
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