Resolvin D2 (BioDeep_00000004031)
Secondary id: BioDeep_00000629695
human metabolite Endogenous
代谢物信息卡片
化学式: C22H32O5 (376.225)
中文名称:
谱图信息:
最多检出来源 Viridiplantae(plant) 3.1%
分子结构信息
SMILES: CC/C=C\C[C@@H]([C@@H](/C=C/C=C/C=C\C=C\[C@H](C/C=C\CCC(=O)O)O)O)O
InChI: InChI=1S/C22H32O5/c1-2-3-9-16-20(24)21(25)17-12-7-5-4-6-10-14-19(23)15-11-8-13-18-22(26)27/h3-12,14,17,19-21,23-25H,2,13,15-16,18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,11-8-,14-10+,17-12+/t19-,20+,21-/m1/s1
描述信息
Resolvin D2 is an autacoid resolvin. Autacoids are chemical mediators including the families of resolvins and protectins, defined by their potent bioactions and novel chemical structures. The bioactive local mediators, or autacoids, that require enzymatic generation from the omega-3 essential fatty acid EPA were first identified in resolving inflammatory exudates in vivo and carry potent stereoselective biological actions. Resolvins of the E (RvE) series are derived from eicosapentaenoic acid (EPA). Those derived from docosahexaenoic acid (DHA) were termed resolvins of the D series, for example resolvin D1 (RvD1).Resolvins and protectins have specific stereoselective actions which evoke biological actions in the nanogram range in vivo and are natural exudate products. Resolvins and protectins as distinct chemical families join the lipoxins as potent agonists of endogenous anti-inflammation and are proresolving chemical mediators of interest in human disease as potential new approaches to treatment. The term resolvins (resolution-phase interaction products) was first introduced to signify that these new structures were endogenous mediators, biosynthesized in the resolution phase of inflammatory exudates, possessing very potent anti-inflammatory and immunoregulatory actions. These actions include reducing neutrophil traffic, regulating cytokine and reactive oxygen species, and lowering the magnitude of the response. In recent years, investigators have recognized inflammation as playing a key role in many prevalent diseases not previously considered to be of inflammatory etiology. These include Alzheimers disease, cardiovascular disease, and cancer, which now join those well-appreciated inflammatory disorders such as arthritis and periodontal disease. Identifying the molecular mechanism(s) that underlie the many reports of the benefits of dietary omega-3 PUFAs remains an important challenge for nutrition and medicine. Thus, that these new mediator families, resolvins and protectins, are biosynthesized from EPA and DHA, act locally, and possess potent, novel bioactions is of interest to researchers. (PMID: 17090225) [HMDB]
Resolvin D2 is an autacoid resolvin. Autacoids are chemical mediators including the families of resolvins and protectins, defined by their potent bioactions and novel chemical structures. The bioactive local mediators, or autacoids, that require enzymatic generation from the omega-3 essential fatty acid EPA were first identified in resolving inflammatory exudates in vivo and carry potent stereoselective biological actions. Resolvins of the E (RvE) series are derived from eicosapentaenoic acid (EPA). Those derived from docosahexaenoic acid (DHA) were termed resolvins of the D series, for example resolvin D1 (RvD1).Resolvins and protectins have specific stereoselective actions which evoke biological actions in the nanogram range in vivo and are natural exudate products. Resolvins and protectins as distinct chemical families join the lipoxins as potent agonists of endogenous anti-inflammation and are proresolving chemical mediators of interest in human disease as potential new approaches to treatment. The term resolvins (resolution-phase interaction products) was first introduced to signify that these new structures were endogenous mediators, biosynthesized in the resolution phase of inflammatory exudates, possessing very potent anti-inflammatory and immunoregulatory actions. These actions include reducing neutrophil traffic, regulating cytokine and reactive oxygen species, and lowering the magnitude of the response. In recent years, investigators have recognized inflammation as playing a key role in many prevalent diseases not previously considered to be of inflammatory etiology. These include Alzheimers disease, cardiovascular disease, and cancer, which now join those well-appreciated inflammatory disorders such as arthritis and periodontal disease. Identifying the molecular mechanism(s) that underlie the many reports of the benefits of dietary omega-3 PUFAs remains an important challenge for nutrition and medicine. Thus, that these new mediator families, resolvins and protectins, are biosynthesized from EPA and DHA, act locally, and possess potent, novel bioactions is of interest to researchers. (PMID: 17090225).
同义名列表
8 个代谢物同义名
(4Z,7R,8E,10Z,12E,14E,17S,19Z)-7,16,17-Trihydroxy-4,8,10,12,14,19-docosahexaenoic acid; (4Z,7R,8E,10Z,12E,14E,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid; (4Z,7R,8E,10Z,12E,14E,17S,19Z)-7,16,17-Trihydroxydocosa-4,8,10,12,14,19-hexaenoate; 7S,16,17S-trihydroxy-docosa-4Z,8E,10Z,12E,14E,19Z-hexaenoic acid; SCHEMBL19668456; RVD2 Compound; Resolvin D2; RVD2
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:184332
- ChEBI: CHEBI:81565
- KEGG: C18179
- PubChem: 11383310
- PubChem: 53394040
- PubChem: 16061136
- HMDB: HMDB0002294
- Metlin: METLIN36431
- Wikipedia: Resolvin
- foodb: FDB022952
- chemspider: 17216185
- CAS: 810668-37-2
- CAS: 82864-77-5
- PMhub: MS000014739
- PubChem: 96024395
- LipidMAPS: LMFA04030001
- NIKKAJI: J2.765.021J
- RefMet: Resolvin D2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Matthew Spite, Gabrielle Fredman. Insights into the role of the resolvin D2-GPR18 signaling axis in cardiovascular physiology and disease.
Advances in pharmacology (San Diego, Calif.).
2023; 97(?):257-281. doi:
10.1016/bs.apha.2022.12.005. [PMID: 37236761] - Lucia S Díaz Del Campo, Ana B García-Redondo, Cristina Rodríguez, Carlos Zaragoza, Santiago Duro-Sánchez, Francesco Palmas, Angela de Benito-Bueno, Paula G Socuéllamos, Diego A Peraza, Raquel Rodrigues-Díez, Carmen Valenzuela, Jesmond Dalli, Mercedes Salaices, Ana M Briones. Resolvin D2 Attenuates Cardiovascular Damage in Angiotensin II-Induced Hypertension.
Hypertension (Dallas, Tex. : 1979).
2023 01; 80(1):84-96. doi:
10.1161/hypertensionaha.122.19448. [PMID: 36337053] - Nora Botten, Robin R Hodges, Jeffrey Bair, Tor P Utheim, Charles N Serhan, Menglu Yang, Darlene A Dartt. Resolvin D2 uses multiple Ca2+ -dependent signaling pathways to stimulate mucin secretion in rat and human conjunctival goblet cells.
Journal of cellular physiology.
2022 10; 237(10):3816-3833. doi:
10.1002/jcp.30854. [PMID: 36066128] - Matthieu Bardin, Sven-Christian Pawelzik, Jeremy Lagrange, Ali Mahdi, Hildur Arnardottir, Véronique Regnault, Bruno Fève, Patrick Lacolley, Jean-Baptiste Michel, Nathalie Mercier, Magnus Bäck. The resolvin D2 - GPR18 axis is expressed in human coronary atherosclerosis and transduces atheroprotection in apolipoprotein E deficient mice.
Biochemical pharmacology.
2022 07; 201(?):115075. doi:
10.1016/j.bcp.2022.115075. [PMID: 35525326] - J M Walker, P Y Kadiyam Sundarasivarao, J M Thornton, K Sochacki, A Rodriguez, B W Spur, N K Acharya, K Yin. Resolvin D2 promotes host defense in a 2 - hit model of sepsis with secondary lung infection.
Prostaglandins & other lipid mediators.
2022 04; 159(?):106617. doi:
10.1016/j.prostaglandins.2022.106617. [PMID: 35007703] - Ellen C Keeley, Han J Li, Christopher R Cogle, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine. Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial).
The American journal of cardiology.
2022 01; 162(?):1-5. doi:
10.1016/j.amjcard.2021.09.015. [PMID: 34728061] - Hiroe Suzuki, Natsuko Hitora-Imamura, Satoshi Deyama, Masabumi Minami. Resolvin D2 attenuates chronic pain-induced depression-like behavior in mice.
Neuropsychopharmacology reports.
2021 09; 41(3):426-429. doi:
10.1002/npr2.12198. [PMID: 34291613] - Eluisa Perna, Javier Aguilera-Lizarraga, Morgane V Florens, Piyush Jain, Stavroula A Theofanous, Nikita Hanning, Joris G De Man, Maya Berg, Benedicte De Winter, Yeranddy A Alpizar, Karel Talavera, Pieter Vanden Berghe, Mira Wouters, Guy Boeckxstaens. Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS.
Gut.
2021 07; 70(7):1275-1286. doi:
10.1136/gutjnl-2020-321530. [PMID: 33023902] - Antonio Recchiuti, Sara Patruno, Domenico Mattoscio, Elisa Isopi, Antonella Pomilio, Alessia Lamolinara, Manuela Iezzi, Romina Pecce, Mario Romano. Resolvin D1 and D2 reduce SARS-CoV-2-induced inflammatory responses in cystic fibrosis macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 04; 35(4):e21441. doi:
10.1096/fj.202001952r. [PMID: 33749902] - Zhijuan Miao, Xin Tang, Marianne Schultzberg, Yuwu Zhao, Xiuzhe Wang. Plasma Resolvin D2 to Leukotriene B4 Ratio Is Reduced in Diabetic Patients with Ischemic Stroke and Related to Prognosis.
BioMed research international.
2021; 2021(?):6657646. doi:
10.1155/2021/6657646. [PMID: 33728336] - Maja Payrits, Ádám Horváth, Tünde Biró-Sütő, János Erostyák, Géza Makkai, Éva Sághy, Krisztina Pohóczky, Angéla Kecskés, Miklós Kecskés, János Szolcsányi, Zsuzsanna Helyes, Éva Szőke. Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21145019. [PMID: 32708653] - Jeevan B Gc, Christopher T Szlenk, Jin Gao, Xinyue Dong, Zhenjia Wang, Senthil Natesan. Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Proresolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles.
Molecular pharmaceutics.
2020 06; 17(6):2155-2164. doi:
10.1021/acs.molpharmaceut.0c00299. [PMID: 32374613] - Mariko Ashina, Kazumichi Fujioka, Kosuke Nishida, Saki Okubo, Toshihiko Ikuta, Masakazu Shinohara, Kazumoto Iijima. Recombinant human thrombomodulin attenuated sepsis severity in a non-surgical preterm mouse model.
Scientific reports.
2020 01; 10(1):333. doi:
10.1038/s41598-019-57265-2. [PMID: 31941991] - Arzu Ulu, Prakash K Sahoo, Ana G Yuil-Valdes, Maheswari Mukherjee, Matthew Van Ormer, Philma Glora Muthuraj, Maranda Thompson, Ann Anderson Berry, Corrine K Hanson, Sathish Kumar Natarajan, Tara M Nordgren. Omega-3 Fatty Acid-Derived Resolvin D2 Regulates Human Placental Vascular Smooth Muscle and Extravillous Trophoblast Activities.
International journal of molecular sciences.
2019 Sep; 20(18):. doi:
10.3390/ijms20184402. [PMID: 31500240] - Nikolas Giannakis, Brian E Sansbury, Andreas Patsalos, Tristan T Hays, Colin O Riley, Xianlin Han, Matthew Spite, Laszlo Nagy. Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration.
Nature immunology.
2019 05; 20(5):626-636. doi:
10.1038/s41590-019-0356-7. [PMID: 30936495] - Tara M Nordgren, Ann Anderson Berry, Matthew Van Ormer, Samuel Zoucha, Elizabeth Elliott, Rebecca Johnson, Elizabeth McGinn, Caleb Cave, Katherine Rilett, Kara Weishaar, Sai Sujana Maddipati, Harriet Appeah, Corrine Hanson. Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.
Nutrients.
2019 Jan; 11(1):. doi:
10.3390/nu11010098. [PMID: 30621269] - Yasir Dilshad Siddiqui, Kazuhiro Omori, Takashi Ito, Keisuke Yamashiro, Shin Nakamura, Kentaro Okamoto, Mitsuaki Ono, Tadashi Yamamoto, Thomas E Van Dyke, Shogo Takashiba. Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis.
Frontiers in immunology.
2019; 10(?):307. doi:
10.3389/fimmu.2019.00307. [PMID: 30863409] - F Echeverría, R Valenzuela, A Espinosa, A Bustamante, D Álvarez, D Gonzalez-Mañan, M Ortiz, S A Soto-Alarcon, L A Videla. Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2.
The Journal of nutritional biochemistry.
2019 01; 63(?):35-43. doi:
10.1016/j.jnutbio.2018.09.012. [PMID: 30321750] - Aritz Lopategi, Roger Flores-Costa, Bibiana Rius, Cristina López-Vicario, José Alcaraz-Quiles, Esther Titos, Joan Clària. Frontline Science: Specialized proresolving lipid mediators inhibit the priming and activation of the macrophage NLRP3 inflammasome.
Journal of leukocyte biology.
2019 01; 105(1):25-36. doi:
10.1002/jlb.3hi0517-206rr. [PMID: 29601102] - Federica Frigerio, Giulia Pasqualini, Ilaria Craparotta, Sergio Marchini, Erwin A van Vliet, Patrick Foerch, Catherine Vandenplas, Karin Leclercq, Eleonora Aronica, Luca Porcu, Kimberly Pistorius, Romain A Colas, Trond V Hansen, Mauro Perretti, Rafal M Kaminski, Jesmond Dalli, Annamaria Vezzani. n-3 Docosapentaenoic acid-derived protectin D1 promotes resolution of neuroinflammation and arrests epileptogenesis.
Brain : a journal of neurology.
2018 11; 141(11):3130-3143. doi:
10.1093/brain/awy247. [PMID: 30307467] - Yi Ye, Nicole N Scheff, Daniel Bernabé, Elizabeth Salvo, Kentaro Ono, Cheng Liu, Ratna Veeramachaneni, Chi T Viet, Dan T Viet, John C Dolan, Brian L Schmidt. Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma.
Neuropharmacology.
2018 09; 139(?):182-193. doi:
10.1016/j.neuropharm.2018.07.016. [PMID: 30009833] - Jason Hellmann, Brian E Sansbury, Blenda Wong, Xiaofeng Li, Mansher Singh, Kristo Nuutila, Nan Chiang, Elof Eriksson, Charles N Serhan, Matthew Spite. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair.
The Journal of investigative dermatology.
2018 09; 138(9):2051-2060. doi:
10.1016/j.jid.2018.03.1498. [PMID: 29559341] - Sang-Nam Kim, Seun Akindehin, Hyun-Jung Kwon, Yeon-Ho Son, Abhirup Saha, Young-Suk Jung, Je-Kyung Seong, Kyung-Min Lim, Jong-Hyuk Sung, Krishna Rao Maddipati, Yun-Hee Lee. Anti-inflammatory role of 15-lipoxygenase contributes to the maintenance of skin integrity in mice.
Scientific reports.
2018 06; 8(1):8856. doi:
10.1038/s41598-018-27221-7. [PMID: 29891910] - Yoshitaka Inoue, Yuk Ming Liu, Masayuki Otawara, Isabel Chico Calero, Ahhyun Stephanie Nam, Yong-Ming Yu, Philip Chang, Kathryn L Butler, Rosalynn M Nazarian, Jeremy Goverman, Benjamin J Vakoc, Daniel Irimia. Resolvin D2 Limits Secondary Tissue Necrosis After Burn Wounds in Rats.
Journal of burn care & research : official publication of the American Burn Association.
2018 04; 39(3):423-432. doi:
10.1097/bcr.0000000000000617. [PMID: 28877131] - Melanie Jannaway, Christopher Torrens, Jane A Warner, Anthony P Sampson. Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619.
British journal of pharmacology.
2018 04; 175(7):1100-1108. doi:
10.1111/bph.14151. [PMID: 29352769] - Madhur P Motwani, Romain A Colas, Marc J George, Julia D Flint, Jesmond Dalli, Angela Richard-Loendt, Roel Ph De Maeyer, Charles N Serhan, Derek W Gilroy. Pro-resolving mediators promote resolution in a human skin model of UV-killed Escherichia coli-driven acute inflammation.
JCI insight.
2018 03; 3(6):. doi:
10.1172/jci.insight.94463. [PMID: 29563331] - Gabriel Mizraji, Oded Heyman, Thomas E Van Dyke, Asaf Wilensky. Resolvin D2 Restrains Th1 Immunity and Prevents Alveolar Bone Loss in Murine Periodontitis.
Frontiers in immunology.
2018; 9(?):785. doi:
10.3389/fimmu.2018.00785. [PMID: 29922275] - Yuka Ishikawa, Satoshi Deyama, Kento Shimoda, Kotomi Yoshikawa, Soichiro Ide, Masamichi Satoh, Masabumi Minami. Rapid and sustained antidepressant effects of resolvin D1 and D2 in a chronic unpredictable stress model.
Behavioural brain research.
2017 08; 332(?):233-236. doi:
10.1016/j.bbr.2017.06.010. [PMID: 28610917] - Satoshi Deyama, Yuka Ishikawa, Kotomi Yoshikawa, Kento Shimoda, Soichiro Ide, Masamichi Satoh, Masabumi Minami. Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway.
The international journal of neuropsychopharmacology.
2017 07; 20(7):575-584. doi:
10.1093/ijnp/pyx023. [PMID: 28419244] - K L Lannan, S L Spinelli, N Blumberg, R P Phipps. Maresin 1 induces a novel pro-resolving phenotype in human platelets.
Journal of thrombosis and haemostasis : JTH.
2017 04; 15(4):802-813. doi:
10.1111/jth.13620. [PMID: 28079976] - Naveen K V Gundala, Vegi G M Naidu, Undurti N Das. Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo.
Nutrition (Burbank, Los Angeles County, Calif.).
2017 Mar; 35(?):61-80. doi:
10.1016/j.nut.2016.10.004. [PMID: 28241993] - Nan Chiang, Xavier de la Rosa, Stephania Libreros, Charles N Serhan. Novel Resolvin D2 Receptor Axis in Infectious Inflammation.
Journal of immunology (Baltimore, Md. : 1950).
2017 01; 198(2):842-851. doi:
10.4049/jimmunol.1601650. [PMID: 27994074] - Joana R Viola, Patricia Lemnitzer, Yvonne Jansen, Gergely Csaba, Carla Winter, Carlos Neideck, Carlos Silvestre-Roig, Gunnar Dittmar, Yvonne Döring, Maik Drechsler, Christian Weber, Ralf Zimmer, Nicolas Cenac, Oliver Soehnlein. Resolving Lipid Mediators Maresin 1 and Resolvin D2 Prevent Atheroprogression in Mice.
Circulation research.
2016 Oct; 119(9):1030-1038. doi:
10.1161/circresaha.116.309492. [PMID: 27531933] - Michael J Zhang, Brian E Sansbury, Jason Hellmann, James F Baker, Luping Guo, Caitlin M Parmer, Joshua C Prenner, Daniel J Conklin, Aruni Bhatnagar, Mark A Creager, Matthew Spite. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation.
Circulation.
2016 Aug; 134(9):666-680. doi:
10.1161/circulationaha.116.021894. [PMID: 27507404] - Valerio Chiurchiù, Alessandro Leuti, Jesmond Dalli, Anders Jacobsson, Luca Battistini, Mauro Maccarrone, Charles N Serhan. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.
Science translational medicine.
2016 08; 8(353):353ra111. doi:
10.1126/scitranslmed.aaf7483. [PMID: 27559094] - Hildur Arnardottir, Sarah K Orr, Jesmond Dalli, Charles N Serhan. Human milk proresolving mediators stimulate resolution of acute inflammation.
Mucosal immunology.
2016 05; 9(3):757-766. doi:
10.1038/mi.2015.99. [PMID: 26462421] - Yoshitaka Inoue, Yong-Ming Yu, Tomohiro Kurihara, Aleksandr Vasilyev, Amir Ibrahim, Rahmi Oklu, Gaofeng Zhao, Anil V Nair, Dennis Brown, Alan J Fischman, Ronald G Tompkins, Daniel Irimia. Kidney and Liver Injuries After Major Burns in Rats Are Prevented by Resolvin D2.
Critical care medicine.
2016 May; 44(5):e241-52. doi:
10.1097/ccm.0000000000001397. [PMID: 26509319] - Emilie Mas, Anne Barden, Valerie Burke, Lawrence J Beilin, Gerald F Watts, Rae-Chi Huang, Ian B Puddey, Ashley B Irish, Trevor A Mori. A randomized controlled trial of the effects of n-3 fatty acids on resolvins in chronic kidney disease.
Clinical nutrition (Edinburgh, Scotland).
2016 Apr; 35(2):331-336. doi:
10.1016/j.clnu.2015.04.004. [PMID: 25908532] - Kathy Stein, Melissa Stoffels, Mariola Lysson, Bianca Schneiker, Oliver Dewald, Gerhard Krönke, Jörg C Kalff, Sven Wehner. A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.
Journal of leukocyte biology.
2016 Feb; 99(2):231-9. doi:
10.1189/jlb.3hi0515-189r. [PMID: 26292977] - Bruno S Herrera, Alpdogan Kantarci, Ahmed Zarrough, Hatice Hasturk, Kai P Leung, Thomas E Van Dyke. LXA4 actions direct fibroblast function and wound closure.
Biochemical and biophysical research communications.
2015 Sep; 464(4):1072-1077. doi:
10.1016/j.bbrc.2015.07.076. [PMID: 26188508] - Daisuke Akagi, Mian Chen, Robert Toy, Anuran Chatterjee, Michael S Conte. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2015 Jun; 29(6):2504-13. doi:
10.1096/fj.14-265363. [PMID: 25777995] - Caroline P Klein, Nathalia D M Sperotto, Izaque S Maciel, Carlos E Leite, Alessandra H Souza, Maria M Campos. Effects of D-series resolvins on behavioral and neurochemical changes in a fibromyalgia-like model in mice.
Neuropharmacology.
2014 Nov; 86(?):57-66. doi:
10.1016/j.neuropharm.2014.05.043. [PMID: 24929111] - Nuha Al-Zaubai, Cameron N Johnstone, May May Leong, John Li, Mark Rizzacasa, Alastair G Stewart. Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor.
The Journal of pharmacology and experimental therapeutics.
2014 Oct; 351(1):172-80. doi:
10.1124/jpet.114.214403. [PMID: 25077525] - Laurie K McCauley, Jesmond Dalli, Amy J Koh, Nan Chiang, Charles N Serhan. Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2.
Journal of immunology (Baltimore, Md. : 1950).
2014 Jul; 193(1):26-9. doi:
10.4049/jimmunol.1301945. [PMID: 24890726] - Clark D Russell, Jürgen Schwarze. The role of pro-resolution lipid mediators in infectious disease.
Immunology.
2014 Feb; 141(2):166-73. doi:
10.1111/imm.12206. [PMID: 24400794] - Takuya Miyahara, Sara Runge, Anuran Chatterjee, Mian Chen, Giorgio Mottola, Jonathan M Fitzgerald, Charles N Serhan, Michael S Conte. D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2013 Jun; 27(6):2220-32. doi:
10.1096/fj.12-225615. [PMID: 23407709] - Emilie Mas, Kevin D Croft, Paul Zahra, Anne Barden, Trevor A Mori. Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation.
Clinical chemistry.
2012 Oct; 58(10):1476-84. doi:
10.1373/clinchem.2012.190199. [PMID: 22912397] - Joan Clària, Jesmond Dalli, Stephanie Yacoubian, Fei Gao, Charles N Serhan. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat.
Journal of immunology (Baltimore, Md. : 1950).
2012 Sep; 189(5):2597-605. doi:
10.4049/jimmunol.1201272. [PMID: 22844113] - Neil Martin, Andrew Ruddick, Greer K Arthur, Heidi Wan, Lucy Woodman, Christopher E Brightling, Don J L Jones, Ian D Pavord, Peter Bradding. Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation.
PloS one.
2012; 7(8):e43545. doi:
10.1371/journal.pone.0043545. [PMID: 22970103] - Chul-Kyu Park, Zhen-Zhong Xu, Tong Liu, Ning Lü, Charles N Serhan, Ru-Rong Ji. Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Dec; 31(50):18433-8. doi:
10.1523/jneurosci.4192-11.2011. [PMID: 22171045] - Allisson Freire Bento, Rafaela Franco Claudino, Rafael Cypriano Dutra, Rodrigo Marcon, João B Calixto. Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice.
Journal of immunology (Baltimore, Md. : 1950).
2011 Aug; 187(4):1957-69. doi:
10.4049/jimmunol.1101305. [PMID: 21724996] - Matthew Spite, Lucy V Norling, Lisa Summers, Rong Yang, Dianne Cooper, Nicos A Petasis, Roderick J Flower, Mauro Perretti, Charles N Serhan. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis.
Nature.
2009 Oct; 461(7268):1287-91. doi:
10.1038/nature08541. [PMID: 19865173]
