Deprenyl (BioDeep_00000402619)
Main id: BioDeep_00000001512
代谢物信息卡片
DEP_188.1433_10.1
化学式: C13H17N (187.1361)
中文名称: 1，N-二甲基-N-丙炔基-2-苯乙胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC1=CC=CC=C1)N(C)CC#C
InChI: InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
D020011 - Protective Agents
CONFIDENCE Parent Substance with Reference Standard (Level 1); INTERNAL_ID 500
同义名列表
3 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:50217
- PubChem: 5195
- ChEMBL: CHEMBL8663
- MeSH: Selegiline
- CAS: 2323-36-6
- MoNA: ET050005
- MoNA: ET050004
- MoNA: ET050003
- MoNA: ET050002
- MoNA: ET050001
- KEGG: C22821
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhen Tian, Xinyue Wang, Tianshu Han, Changhao Sun. Selegiline ameliorated dyslipidemia and hepatic steatosis in high-fat diet mice.
International immunopharmacology.
2023 Feb; 117(?):109901. doi:
10.1016/j.intimp.2023.109901. [PMID: 36822098] - Mohammad-Hadi Karimi-Harandi, Mehdi Shabani-Nooshabadi, Rozhin Darabi. Simultaneous determination of citalopram and selegiline using an efficient electrochemical sensor based on ZIF-8 decorated with RGO and g-C3N4 in real samples.
Analytica chimica acta.
2022 Apr; 1203(?):339662. doi:
10.1016/j.aca.2022.339662. [PMID: 35361426] - Yuehong Pu, Fenghua Qian, Jian Guo, Yuanyuan Sha, Yiming Qian. Selegiline Protects Against Lipopolysaccharide (LPS)-Induced Impairment of the Blood-Brain Barrier Through Regulating the NF-κB/MLCK/p-MLC Signaling Pathway.
Neurotoxicity research.
2022 Feb; 40(1):267-275. doi:
10.1007/s12640-021-00448-5. [PMID: 34981455] - Sid E O'Bryant, Melissa Petersen, Fan Zhang, Leigh Johnson, David Mason, James Hall. Analysis of a precision medicine approach to treating Parkinson's disease: Analysis of the DATATOP study.
Parkinsonism & related disorders.
2022 01; 94(?):15-21. doi:
10.1016/j.parkreldis.2021.11.027. [PMID: 34864471] - Zufika Qamar, Muhammad Usama Ashhar, Annu, Farheen Fatima Qizilibash, Pravat Kumar Sahoo, Asgar Ali, Javed Ali, Sanjula Baboota. Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin.
International journal of pharmaceutics.
2021 Nov; 609(?):121131. doi:
10.1016/j.ijpharm.2021.121131. [PMID: 34563617] - Ilchung Shin, Hyeyoung Choi, Seojin Kang, Jihyun Kim, Yuran Park, Wonkyung Yang. Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites.
Journal of analytical toxicology.
2021 Feb; 45(1):99-104. doi:
10.1093/jat/bkaa058. [PMID: 32476010] - Yogita Tyagi, N V Satheesh Madhav. Design of selegiline-loaded bio-nanosuspension for the management of depression using novel bio-retardant from Manilkara zapota.
Drug development and industrial pharmacy.
2019 Aug; 45(8):1351-1360. doi:
10.1080/03639045.2019.1619760. [PMID: 31084445] - Neeraj Mishra, Sawarni Sharma, Rahul Deshmukh, Anoop Kumar, Ruchika Sharma. Development and Characterization of Nasal Delivery of Selegiline Hydrochloride Loaded Nanolipid Carriers for the Management of Parkinson's Disease.
Central nervous system agents in medicinal chemistry.
2019; 19(1):46-56. doi:
10.2174/1871524919666181126124846. [PMID: 30474538] - Rajalakshmi Rukmangathen, Indira Muzib Yallamalli, Prasanna Raju Yalavarthi. Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease.
Current drug discovery technologies.
2019; 16(4):417-425. doi:
10.2174/1570163815666180418144019. [PMID: 29669501] - Vinay Sridhar, Ram Gaud, Amrita Bajaj, Sarika Wairkar. Pharmacokinetics and pharmacodynamics of intranasally administered selegiline nanoparticles with improved brain delivery in Parkinson's disease.
Nanomedicine : nanotechnology, biology, and medicine.
2018 11; 14(8):2609-2618. doi:
10.1016/j.nano.2018.08.004. [PMID: 30171904] - Vinicius Figueiredo Sardela, Carina de Souza Anselmo, Isabelle Karine da Costa Nunes, Gabriel Reis Alves Carneiro, Gustavo Ramalho Cardoso Dos Santos, Aline Reis de Carvalho, Bruna de Jesus Labanca, Daniely Silva Oliveira, William Dias Ribeiro, Amanda Lessa Dutra de Araujo, Monica Costa Padilha, Cleverton Kleiton Freitas de Lima, Valeria Pereira de Sousa, Francisco Radler de Aquino Neto, Henrique Marcelo Gualberto Pereira. Zebrafish (Danio rerio) water tank model for the investigation of drug metabolism: Progress, outlook, and challenges.
Drug testing and analysis.
2018 Nov; 10(11-12):1657-1669. doi:
10.1002/dta.2523. [PMID: 30341930] - Michael Strupp, Ludwig Kraus, Franz Schautzer, Dan Rujescu. Menière's disease: combined pharmacotherapy with betahistine and the MAO-B inhibitor selegiline-an observational study.
Journal of neurology.
2018 Oct; 265(Suppl 1):80-85. doi:
10.1007/s00415-018-8809-8. [PMID: 29532287] - Csilla Terézia Nagy, Gábor Koncsos, Zoltán V Varga, Tamás Baranyai, Sebestyén Tuza, Ferenc Kassai, Aliz Judit Ernyey, István Gyertyán, Kornél Király, Attila Oláh, Tamás Radovits, Béla Merkely, Nóra Bukosza, Gábor Szénási, Péter Hamar, Domokos Mathé, Krisztián Szigeti, Csilla Pelyhe, Marek Jelemenský, Zsófia Onódi, Zsuzsanna Helyes, Rainer Schulz, Zoltán Giricz, Péter Ferdinandy. Selegiline reduces adiposity induced by high-fat, high-sucrose diet in male rats.
British journal of pharmacology.
2018 09; 175(18):3713-3726. doi:
10.1111/bph.14437. [PMID: 29971762] - Hiroko Tsunekawa, Kazue Takahata, Motoki Okano, Toshiko Ishikawa, Hiroshi Satoyoshi, Tetsuya Nishimura, Naoya Hoshino, Shizuko Muraoka. Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements.
Behavioural brain research.
2018 07; 347(?):350-359. doi:
10.1016/j.bbr.2018.03.002. [PMID: 29526790] - Chadwick W Christine, Peggy Auinger, Amelia Joslin, Yuora Yelpaala, Ralph Green. Vitamin B12 and Homocysteine Levels Predict Different Outcomes in Early Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society.
2018 05; 33(5):762-770. doi:
10.1002/mds.27301. [PMID: 29508904] - P Xiang, J Bu, Z Qiao, X Y Zhuo, H J Wu, M Shen. [Identification of Methamphetamine Abuse and Selegiline Use： Chiral Analysis of Methamphetamine and Amphetamine in Urine].
Fa yi xue za zhi.
2017 Dec; 33(6):599-603. doi:
10.3969/j.issn.1004-5619.2017.06.006. [PMID: 29441766] - Sara A Wahdan, Mariane G Tadros, Amani E Khalifa. Antioxidant and antiapoptotic actions of selegiline protect against 3-NP-induced neurotoxicity in rats.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Sep; 390(9):905-917. doi:
10.1007/s00210-017-1392-1. [PMID: 28643087] - Thomas Müller, Peter Riederer, Edna Grünblatt. Simultaneous determination of MAO-A and -B activity following first time intake of an irreversible MAO-B inhibitor in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2017 06; 124(6):745-748. doi:
10.1007/s00702-017-1705-z. [PMID: 28299453] - Christoffer Bundgaard, Liliana P Montezinho, Neil Anderson, Christian Thomsen, Arne Mørk. Selegiline induces a wake promoting effect in rats which is related to formation of its active metabolites.
Pharmacology, biochemistry, and behavior.
2016 Nov; 150-151(?):147-152. doi:
10.1016/j.pbb.2016.10.003. [PMID: 27984094] - Sangram Nag, Patrik Fazio, Lutz Lehmann, Georg Kettschau, Tobias Heinrich, Andrea Thiele, Marie Svedberg, Nahid Amini, Samira Leesch, Ana M Catafau, Jonas Hannestad, Andrea Varrone, Christer Halldin. In Vivo and In Vitro Characterization of a Novel MAO-B Inhibitor Radioligand, 18F-Labeled Deuterated Fluorodeprenyl.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2016 Feb; 57(2):315-20. doi:
10.2967/jnumed.115.161083. [PMID: 26585057] - Dina Popova, Andréas Forsblad, Sanaz Hashemian, Stig O P Jacobsson. Non-Serotonergic Neurotoxicity by MDMA (Ecstasy) in Neurons Derived from Mouse P19 Embryonal Carcinoma Cells.
PloS one.
2016; 11(11):e0166750. doi:
10.1371/journal.pone.0166750. [PMID: 27861613] - Joanna S Fowler, Jean Logan, Nora D Volkow, Elena Shumay, Fred McCall-Perez, Millard Jayne, Gene-Jack Wang, David L Alexoff, Karen Apelskog-Torres, Barbara Hubbard, Pauline Carter, Payton King, Stanley Fahn, Michelle Gilmor, Frank Telang, Colleen Shea, Youwen Xu, Lisa Muench. Evidence that formulations of the selective MAO-B inhibitor, selegiline, which bypass first-pass metabolism, also inhibit MAO-A in the human brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2015 Feb; 40(3):650-7. doi:
10.1038/npp.2014.214. [PMID: 25249059] - Zita Pöstényi, Kornélia Tekes, Edit Tóth-Molnár, Huba Kalász. HPLC analysis of blood-brain barrier penetration of 4-fluorodeprenyl.
Journal of pharmaceutical and biomedical analysis.
2015 Jan; 102(?):529-34. doi:
10.1016/j.jpba.2014.09.035. [PMID: 25459953] - Soutarou Taguchi, Jun-ichi Niwa, Tohru Ibi, Manabu Doyu. [Dyskinesia-hyperpyrexia syndrome in a patient with Parkinson's disease: a case report].
Rinsho shinkeigaku = Clinical neurology.
2015; 55(3):182-4. doi:
10.5692/clinicalneurol.55.182. [PMID: 25786757] - Elizete De Moraes Reis, Francisco Waldomiro Schreiner Neto, Vitória Berg Cattani, Luis Ricardo Peroza, Alcindo Busanello, Caroline Queiroz Leal, Aline Augusti Boligon, Tássia Fontana Lehmen, Milena Libardoni, Margareth Linde Athayde, Roselei Fachinetto. Antidepressant-like effect of Ilex paraguariensis in rats.
BioMed research international.
2014; 2014(?):958209. doi:
10.1155/2014/958209. [PMID: 24895633] - Cheng-Ming Tsao, Jhih-Gang Jhang, Shiu-Jen Chen, Shuk-Man Ka, Tao-Cheng Wu, Wen-Jinn Liaw, Hsieh-Chou Huang, Chin-Chen Wu. Adjuvant potential of selegiline in attenuating organ dysfunction in septic rats with peritonitis.
PloS one.
2014; 9(9):e108455. doi:
10.1371/journal.pone.0108455. [PMID: 25268350] - Hideyuki Sawada, Tomoko Oeda, Atsushi Umemura, Satoshi Tomita, Ryutaro Hayashi, Masayuki Kohsaka, Kenji Yamamoto, Shinji Sudoh, Hiroshi Sugiyama. Subclinical elevation of plasma C-reactive protein and illusions/hallucinations in subjects with Parkinson's disease: case-control study.
PloS one.
2014; 9(1):e85886. doi:
10.1371/journal.pone.0085886. [PMID: 24497930] - Qing Zhao, Dingfang Cai, Yu Bai. Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease.
International journal of molecular medicine.
2013 Oct; 32(4):883-91. doi:
10.3892/ijmm.2013.1450. [PMID: 23877198] - W A Baumgartner, A M Baumgartner. Rationale for an experimental treatment of retinitis pigmentosa: 140-month test of hypothesis with one patient.
Medical hypotheses.
2013 Oct; 81(4):720-8. doi:
10.1016/j.mehy.2013.07.036. [PMID: 23948599] - Thomas Müller, Josef A Hoffmann, Walter Dimpfel, Christian Oehlwein. Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease.
Journal of neural transmission (Vienna, Austria : 1996).
2013 May; 120(5):761-5. doi:
10.1007/s00702-012-0927-3. [PMID: 23196982] - Hannah P Priyanka, Preetam Bala, Sindhu Ankisettipalle, Srinivasan ThyagaRajan. Bacopa monnieri and L-deprenyl differentially enhance the activities of antioxidant enzymes and the expression of tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-κB pathways in the spleen of female wistar rats.
Neurochemical research.
2013 Jan; 38(1):141-52. doi:
10.1007/s11064-012-0902-2. [PMID: 23076629] - Gabor Bekesi, Zsolt Tulassay, Gabriella Lengyel, Zsuzsa Schaff, Dezso Szombath, Julia Stark, Istvan Marczell, Peter Nagy-Repas, Ildiko Adler, Elek Dinya, Karoly Racz, Kalman Magyar. The effect of selegiline on total scavenger capacity and liver fat content: a preliminary study in an animal model.
Journal of neural transmission (Vienna, Austria : 1996).
2012 Jan; 119(1):25-30. doi:
10.1007/s00702-011-0666-x. [PMID: 21643961] - Xuemei Huang, Peggy Auinger, Shirley Eberly, David Oakes, Michael Schwarzschild, Alberto Ascherio, Richard Mailman, Honglei Chen. Serum cholesterol and the progression of Parkinson's disease: results from DATATOP.
PloS one.
2011; 6(8):e22854. doi:
10.1371/journal.pone.0022854. [PMID: 21853051] - Tamar Goren, Liat Adar, Nissim Sasson, Yoni M Weiss. Clinical pharmacology tyramine challenge study to determine the selectivity of the monoamine oxidase type B (MAO-B) inhibitor rasagiline.
Journal of clinical pharmacology.
2010 Dec; 50(12):1420-8. doi:
10.1177/0091270010369674. [PMID: 20445015] - Chandra Sekhar Kolli, Gurkishan Chadha, Jin Xiao, Daniel L Parsons, R Jayachandra Babu. Transdermal iontophoretic delivery of selegiline hydrochloride, in vitro.
Journal of drug targeting.
2010 Nov; 18(9):657-64. doi:
10.3109/10611860903494237. [PMID: 20038213] - Manju V Subramanian, T J James. Age-related protective effect of deprenyl on changes in the levels of diagnostic marker enzymes and antioxidant defense enzymes activities in cerebellar tissue in Wistar rats.
Cell stress & chaperones.
2010 Sep; 15(5):743-51. doi:
10.1007/s12192-010-0177-y. [PMID: 20224915] - B Szende, G Barna, Kálmán Magyar. Cytoprotective effect of (-)-deprenyl, (-)desmethyl-deprenyl and (-)deprenyl-N-oxide on glutathione depleted A-2058 melanoma cells.
Journal of neural transmission (Vienna, Austria : 1996).
2010 Jun; 117(6):695-8. doi:
10.1007/s00702-010-0413-8. [PMID: 20454984] - Andrea H Weinberger, Erin L Reutenauer, Peter I Jatlow, Stephanie S O'Malley, Marc N Potenza, Tony P George. A double-blind, placebo-controlled, randomized clinical trial of oral selegiline hydrochloride for smoking cessation in nicotine-dependent cigarette smokers.
Drug and alcohol dependence.
2010 Mar; 107(2-3):188-95. doi:
10.1016/j.drugalcdep.2009.10.009. [PMID: 19939587] - V E Tseilikman, A I Sinitsky, K A Poyarkov, E V Vojdaev. Effect of deprenyl on free radical oxidation in rat brain during immobilization stress.
Bulletin of experimental biology and medicine.
2009 Dec; 148(6):856-8. doi:
10.1007/s10517-010-0835-1. [PMID: 21116490] - J Greg Whaley, Binu Tharakan, Benjamin Smith, Felicia A Hunter, Ed W Childs. (-)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells.
Journal of burn care & research : official publication of the American Burn Association.
2009 Nov; 30(6):1018-27. doi:
10.1097/bcr.0b013e3181bfb825. [PMID: 19826263] - Debra S Harris, Thomas Everhart, Peyton Jacob, Emil Lin, John E Mendelson, Reese T Jones. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.
BMC clinical pharmacology.
2009 Aug; 9(?):13. doi:
10.1186/1472-6904-9-13. [PMID: 19646280] - Muge Kiray, H A Bagriyanik, B U Ergur, C Pekcetin, Ayca Topcu. Antioxidant and antiapoptotic activities of deprenyl and estradiol co-administration in aged rat kidney.
Acta biologica Hungarica.
2009 Mar; 60(1):69-77. doi:
10.1556/abiol.60.2009.1.7. [PMID: 19378925] - Banthit Chetsawang, Patcharee Kooncumchoo, Piyarat Govitrapong, Manuchair Ebadi. 1-Methyl-4-phenyl-pyridinium ion-induced oxidative stress, c-Jun phosphorylation and DNA fragmentation factor-45 cleavage in SK-N-SH cells are averted by selegiline.
Neurochemistry international.
2008 Dec; 53(6-8):283-8. doi:
10.1016/j.neuint.2008.08.007. [PMID: 18805449] - D Concolino, G Muzzi, M Rapsomaniki, M T Moricca, M G Pascale, P Strisciuglio. Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients.
Journal of inherited metabolic disease.
2008 Dec; 31 Suppl 2(?):S193-7. doi:
10.1007/s10545-007-0788-3. [PMID: 18425437] - Muge Kiray, Husnu Alper Bagriyanik, Cetin Pekcetin, Bekir Ugur Ergur, Nazan Uysal. Protective effects of deprenyl in transient cerebral ischemia in rats.
The Chinese journal of physiology.
2008 Oct; 51(5):275-81. doi:
. [PMID: 19175183] - Yuji Fujita, Katsuo Takahashi, Masao Takei, Hisae Niitsu, Yasuhiro Aoki, Makoto Onodera, Yasuhisa Fujino, Yoshihiro Inoue, Shigeatsu Endo. Detection of levorotatory methamphetamine and levorotatory amphetamine in urine after ingestion of an overdose of selegiline.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Oct; 128(10):1507-12. doi:
10.1248/yakushi.128.1507. [PMID: 18827472] - Eric C K Siu, Rachel F Tyndale. Selegiline is a mechanism-based inactivator of CYP2A6 inhibiting nicotine metabolism in humans and mice.
The Journal of pharmacology and experimental therapeutics.
2008 Mar; 324(3):992-9. doi:
10.1124/jpet.107.133900. [PMID: 18065502] - Eva Toronyi. [Role of apoptosis in the kidney after reperfusion].
Orvosi hetilap.
2008 Feb; 149(7):305-15. doi:
10.1556/oh.2008.28212. [PMID: 18258561] - Sabina Strano-Rossi, Cristiana Colamonici, Francesco Botrè. Parallel analysis of stimulants in saliva and urine by gas chromatography/mass spectrometry: perspectives for 'in competition' anti-doping analysis.
Analytica chimica acta.
2008 Jan; 606(2):217-22. doi:
10.1016/j.aca.2007.10.053. [PMID: 18082653] - Kiyoshi Ando, Jun Maeda, Motoki Inaji, Takashi Okauchi, Shigeru Obayashi, Makoto Higuchi, Tetsuya Suhara, Yoshikuni Tanioka. Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets.
Psychopharmacology.
2008 Jan; 195(4):509-16. doi:
10.1007/s00213-007-0929-2. [PMID: 17879087] - Jakub Drozak, Marcin Kozlowski, Renata Doroszewska, Lukasz Pera, Rafal Derlacz, Robert Jarzyna, Jadwiga Bryla. Differential effects of selegiline on glucose synthesis in rabbit kidney-cortex tubules and hepatocytes. In vitro and in vivo studies.
Chemico-biological interactions.
2007 Dec; 170(3):162-76. doi:
10.1016/j.cbi.2007.07.013. [PMID: 17767924] - Albert J Azzaro, John Ziemniak, Eva Kemper, Bryan J Campbell, Chad VanDenBerg. Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules.
Journal of clinical pharmacology.
2007 Oct; 47(10):1256-67. doi:
10.1177/0091270007304779. [PMID: 17715422] - Tua Annanmaki, Antti Muuronen, Kari Murros. Low plasma uric acid level in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society.
2007 Jun; 22(8):1133-7. doi:
10.1002/mds.21502. [PMID: 17443703] - Ashwin A Patkar, Chi-Un Pae, Michael Zarzar. Transdermal selegiline.
Drugs of today (Barcelona, Spain : 1998).
2007 Jun; 43(6):361-77. doi:
10.1358/dot.2006.43.6.1050794. [PMID: 17612708] - Amar Jyoti, Pallavi Sethi, Deepak Sharma. Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain.
Journal of ethnopharmacology.
2007 Apr; 111(1):56-62. doi:
10.1016/j.jep.2006.10.037. [PMID: 17189676] - Muge Kiray, Bekir Ugur Ergur, Alper Bagriyanik, Cetin Pekcetin, Ilkay Aksu, Zisan Buldan. Suppression of apoptosis and oxidative stress by deprenyl and estradiol in aged rat liver.
Acta histochemica.
2007; 109(6):480-5. doi:
10.1016/j.acthis.2007.04.008. [PMID: 17698173] - K Magyar, I Szatmáry, G Szebeni, J Lengyel. Pharmacokinetic studies of (-)-deprenyl and some of its metabolites in mouse.
Journal of neural transmission. Supplementum.
2007; ?(72):165-73. doi:
10.1007/978-3-211-73574-9_21. [PMID: 17982891] - Ayako Kuriki, Takeshi Kumazawa, Xiao-Pen Lee, Chika Hasegawa, Mitsuru Kawamura, Osamu Suzuki, Keizo Sato. Simultaneous determination of selegiline and desmethylselegiline in human body fluids by headspace solid-phase microextraction and gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Dec; 844(2):283-91. doi:
10.1016/j.jchromb.2006.07.019. [PMID: 16893687] - Ahmed Elkashef, Paul J Fudala, Liza Gorgon, Shou-Hua Li, Roberta Kahn, Nora Chiang, Frank Vocci, Joseph Collins, Karen Jones, Kathy Boardman, Mike Sather. Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence.
Drug and alcohol dependence.
2006 Dec; 85(3):191-7. doi:
10.1016/j.drugalcdep.2006.04.010. [PMID: 16730924] - Manuchair Ebadi, Holly Brown-Borg, Jun Ren, Sushil Sharma, Shaik Shavali, Hesham El ReFaey, Edward C Carlson. Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases.
Current drug targets.
2006 Nov; 7(11):1513-29. doi:
10.2174/1389450110607011513. [PMID: 17100591] - Jadwiga Turchan-Cholewo, Yiling Liu, Suzanne Gartner, Rollie Reid, Chunfa Jie, Xuejun Peng, Kuey Chu C Chen, Ashok Chauhan, Norman Haughey, Roy Cutler, Mark P Mattson, Carlos Pardo, Katherine Conant, Ned Sacktor, Justin C McArthur, Kurt F Hauser, Chandra Gairola, Avindra Nath. Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.
Neurobiology of disease.
2006 Jul; 23(1):109-19. doi:
10.1016/j.nbd.2006.02.005. [PMID: 16697650] - Amar Jyoti, Deepak Sharma. Neuroprotective role of Bacopa monniera extract against aluminium-induced oxidative stress in the hippocampus of rat brain.
Neurotoxicology.
2006 Jul; 27(4):451-7. doi:
10.1016/j.neuro.2005.12.007. [PMID: 16500707] - Ashwin A Patkar, C-U Pae, Prakash S Masand. Transdermal selegiline: the new generation of monoamine oxidase inhibitors.
CNS spectrums.
2006 May; 11(5):363-75. doi:
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Physiological research.
2006; 55(2):205-212. doi:
10.33549/physiolres.930742. [PMID: 15910165] - Thomas F Newton, Richard De La Garza, Tim Fong, Nora Chiang, Tyson H Holmes, Daniel A Bloch, Ann Anderson, Ahmed Elkashef. A comprehensive assessment of the safety of intravenous methamphetamine administration during treatment with selegiline.
Pharmacology, biochemistry, and behavior.
2005 Dec; 82(4):704-11. doi:
10.1016/j.pbb.2005.11.012. [PMID: 16413604] - Enid T McKinley, Timothy C Baranowski, Delali O Blavo, Candace Cato, Thanh N Doan, Amy L Rubinstein. Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons.
Brain research. Molecular brain research.
2005 Nov; 141(2):128-37. doi:
10.1016/j.molbrainres.2005.08.014. [PMID: 16209898] - Tsugunobu Andoh, P Boon Chock, Dennis L Murphy, Chuang C Chiueh. Role of the redox protein thioredoxin in cytoprotective mechanism evoked by (-)-deprenyl.
Molecular pharmacology.
2005 Nov; 68(5):1408-14. doi:
10.1124/mol.105.012302. [PMID: 16099847] - Claire Henchcliffe, H Christian Schumacher, F Tuna Burgut. Recent advances in Parkinson's disease therapy: use of monoamine oxidase inhibitors.
Expert review of neurotherapeutics.
2005 Nov; 5(6):811-21. doi:
10.1586/14737175.5.6.811. [PMID: 16274338] - Mark F Lew. Selegiline orally disintegrating tablets for the treatment of Parkinson's disease.
Expert review of neurotherapeutics.
2005 Nov; 5(6):705-12. doi:
10.1586/14737175.5.6.705. [PMID: 16274328] - Jean Logan, Joanna S Fowler. Evidence for reduced arterial plasma input, prolonged lung retention and reduced lung monoamine oxidase in smokers.
Nuclear medicine and biology.
2005 Jul; 32(5):521-9. doi:
10.1016/j.nucmedbio.2005.03.004. [PMID: 15982583] - Jakub Drozak, Renata Doroszewska, Katarzyna Chodnicka, Katarzyna Winiarska, Jadwiga Bryla. Contribution of L-3,4-dihydroxyphenylalanine metabolism to the inhibition of gluconeogenesis in rabbit kidney-cortex tubules.
The international journal of biochemistry & cell biology.
2005 Jun; 37(6):1269-80. doi:
10.1016/j.biocel.2004.12.009. [PMID: 15778090] - Huba Kalász, Imre Klebovich, Katalin Balogh-Nemes, Agnes Szilágyi, Mária Tihanyi, Tibor Szarvas, József Lengyel. Detection of N-monomethyl-lysine generated by metabolic transmethylation.
Analytical and bioanalytical chemistry.
2005 Jun; 382(3):760-4. doi:
10.1007/s00216-005-3089-4. [PMID: 15756599] - H Kalász, A Benkö, Z Szücsp, A Szilágyi, T Szarvas, J Lengyel. HPLC and HPLC-MS analysis of urinary N(epsilon)-monomethyl-lysine.
Journal of chromatographic science.
2005 Apr; 43(4):165-8. doi:
10.1093/chromsci/43.4.165. [PMID: 15975230] - Atsushi Mori, Satoshi Ohashi, Masami Nakai, Tetsuji Moriizumi, Yasuhide Mitsumoto. Neural mechanisms underlying motor dysfunction as detected by the tail suspension test in MPTP-treated C57BL/6 mice.
Neuroscience research.
2005 Mar; 51(3):265-74. doi:
10.1016/j.neures.2004.11.008. [PMID: 15710490] - R Stryjer, C Klein, T A Treves, J M Rabey. The effects of acute loading with levodopa and levodopa with selegiline on blood pressure and plasma norepinephrine levels in chronic Parkinson's disease patients.
Acta neurologica Scandinavica.
2005 Feb; 111(2):89-94. doi:
10.1111/j.1600-0404.2005.00294.x. [PMID: 15644067] - Gulinnaz Alper, Seda Irer, Erdal Duman, Osman Caglayan, Candeger Yilmaz. Effect of I-deprenyl and gliclazide on oxidant stress/antioxidant status and dna damage in a diabetic rat model.
Endocrine research.
2005; 31(3):199-212. doi:
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The European journal of neuroscience.
2005 Jan; 21(2):301-16. doi:
10.1111/j.1460-9568.2005.03859.x. [PMID: 15673431] - Markku Anttila, Eero A Sotaniemi, Olavi Pelkonen, Arja Rautio. Marked effect of liver and kidney function on the pharmacokinetics of selegiline.
Clinical pharmacology and therapeutics.
2005 Jan; 77(1):54-62. doi:
10.1016/j.clpt.2004.09.004. [PMID: 15637531] - Soon Chul Lee, Pham Tuan Linh, Zhang Jing, Shi Yong Ryu, Chang-Seon Myung, Young Ho Kim, Jong Seong Kang. Effects of repeated administration of Uncaria hooks on the acquisition and central neuronal activities in ethanol-treated mice.
Journal of ethnopharmacology.
2004 Sep; 94(1):123-8. doi:
10.1016/j.jep.2004.05.003. [PMID: 15261972] - Sandra L Hrometz, Andrew W Brown, David E Nichols, Jon E Sprague. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B.
Neuroscience letters.
2004 Aug; 367(1):56-9. doi:
10.1016/j.neulet.2004.05.075. [PMID: 15308297] - Y S Kwon, H S Ann, T Nabeshima, E J Shin, W K Kim, J H Jhoo, W K Jhoo, M B Wie, Y S Kim, K J Jang, H C Kim. Selegiline potentiates the effects of EGb 761 in response to ischemic brain injury.
Neurochemistry international.
2004 Jul; 45(1):157-70. doi:
10.1016/j.neuint.2003.10.005. [PMID: 15082233] - J A Braddock, D B Church, I D Robertson, A D J Watson. Inefficacy of selegiline in treatment of canine pituitary-dependent hyperadrenocorticism.
Australian veterinary journal.
2004 May; 82(5):272-7. doi:
10.1111/j.1751-0813.2004.tb12702.x. [PMID: 15181926] - Cheryl H Waters, Kapil D Sethi, Robert A Hauser, Eric Molho, John M Bertoni. Zydis selegiline reduces off time in Parkinson's disease patients with motor fluctuations: a 3-month, randomized, placebo-controlled study.
Movement disorders : official journal of the Movement Disorder Society.
2004 Apr; 19(4):426-32. doi:
10.1002/mds.20036. [PMID: 15077240] - Joanna S Fowler, Jean Logan, Gene-Jack Wang, Nora D Volkow, Frank Telang, Yu-Shin Ding, Colleen Shea, Victor Garza, Youwen Xu, Zizhong Li, David Alexoff, Paul Vaska, Richard Ferrieri, David Schlyer, Wei Zhu, S John Gatley. Comparison of the binding of the irreversible monoamine oxidase tracers, [(11)C]clorgyline and [(11)C]l-deprenyl in brain and peripheral organs in humans.
Nuclear medicine and biology.
2004 Apr; 31(3):313-9. doi:
10.1016/j.nucmedbio.2003.10.003. [PMID: 15028243] - F D Maia, B S S Pitombeira, D T Aráujo, G M A Cunha, G S B Viana. l-Deprenyl prevents lipid peroxidation and memory deficits produced by cerebral ischemia in rats.
Cellular and molecular neurobiology.
2004 Feb; 24(1):87-100. doi:
10.1023/b:cemn.0000012727.59502.c5. [PMID: 15049513] - Orit Bar Am, Tamar Amit, Moussa B H Youdim. Contrasting neuroprotective and neurotoxic actions of respective metabolites of anti-Parkinson drugs rasagiline and selegiline.
Neuroscience letters.
2004 Jan; 355(3):169-72. doi:
10.1016/j.neulet.2003.10.067. [PMID: 14732458] - Müge Kiray, Nazan Uysal, Ataç Sönmez, Osman Açikgöz, Sevil Gönenç. Positive effects of deprenyl and estradiol on spatial memory and oxidant stress in aged female rat brains.
Neuroscience letters.
2004 Jan; 354(3):225-8. doi:
10.1016/j.neulet.2003.10.019. [PMID: 14700737] - Kálmán Magyar, Béla Szende. (-)-Deprenyl, a selective MAO-B inhibitor, with apoptotic and anti-apoptotic properties.
Neurotoxicology.
2004 Jan; 25(1-2):233-42. doi:
10.1016/s0161-813x(03)00102-5. [PMID: 14697898] - Seung-Woon Myung, Sung-Ho Yoon, Myungsoo Kim. Analysis of benzene ethylamine derivatives in urine using the programmable dynamic liquid-phase microextraction (LPME) device.
The Analyst.
2003 Dec; 128(12):1443-6. doi:
10.1039/b312227c. [PMID: 14737229] - Charles W Schindler, Joanne P Gilman, Zofi Graczyk, Ganfeng Wang, Winnie L Gee. Reduced cardiovascular effects of methamphetamine following treatment with selegiline.
Drug and alcohol dependence.
2003 Nov; 72(2):133-9. doi:
10.1016/s0376-8716(03)00197-2. [PMID: 14636968] - A Clarke, F Brewer, E S Johnson, N Mallard, F Hartig, S Taylor, T H Corn. A new formulation of selegiline: improved bioavailability and selectivity for MAO-B inhibition.
Journal of neural transmission (Vienna, Austria : 1996).
2003 Nov; 110(11):1241-55. doi:
10.1007/s00702-003-0036-4. [PMID: 14628189] - Tamás Tábi, Kálmán Magyar, Eva Szöko. Chiral characterization of deprenyl-N-oxide and other deprenyl metabolites by capillary electrophoresis using a dual cyclodextrin system in rat urine.
Electrophoresis.
2003 Aug; 24(15):2665-73. doi:
10.1002/elps.200305468. [PMID: 12900880] - K Shimizu, K Matsubara, K Ohtaki, S Fujimaru, O Saito, H Shiono. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats.
Brain research.
2003 Jun; 976(2):243-52. doi:
10.1016/s0006-8993(03)02750-1. [PMID: 12763259] - Sushil K Sharma, Manuchair Ebadi. Metallothionein attenuates 3-morpholinosydnonimine (SIN-1)-induced oxidative stress in dopaminergic neurons.
Antioxidants & redox signaling.
2003 Jun; 5(3):251-64. doi:
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Journal of neurocytology.
2003 May; 32(4):329-43. doi:
10.1023/b:neur.0000011327.23739.1b. [PMID: 14724376] - Hoda Khaldy, Germaine Escames, Josefa León, Leila Bikjdaouene, Darío Acuña-Castroviejo. Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion.
Neurobiology of aging.
2003 May; 24(3):491-500. doi:
10.1016/s0197-4580(02)00133-1. [PMID: 12600724] - Robert Kronstrand, Johan Ahlner, Nil Dizdar, Göran Larson. Quantitative analysis of desmethylselegiline, methamphetamine, and amphetamine in hair and plasma from Parkinson patients on long-term selegiline medication.
Journal of analytical toxicology.
2003 Apr; 27(3):135-41. doi:
10.1093/jat/27.3.135. [PMID: 12731653] - Fuzhong Qin, Junya Shite, Weike Mao, Chang-seng Liang. Selegiline attenuates cardiac oxidative stress and apoptosis in heart failure: association with improvement of cardiac function.
European journal of pharmacology.
2003 Feb; 461(2-3):149-58. doi:
10.1016/s0014-2999(03)01306-2. [PMID: 12586210] - Paolo Del Dotto, Ubaldo Bonuccelli. Clinical pharmacokinetics of cabergoline.
Clinical pharmacokinetics.
2003; 42(7):633-45. doi:
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